Elevated histone expression promotes life span extension

Feser, Jason; Truong, David; Das, Chandrima; Carson, Joshua J.; Kieft, Jeffrey; Harkness, Troy; Tyler, Jessica K.

doi:10.1016/j.molcel.2010.08.015

Cited by 435Genetics, Aging, and Longevity in Model OrganismsGenomics and Chromatin DynamicsNuclear Structure and Function

Elevated histone expression promotes life span extension

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Feser, Jason, Truong, David, Das, Chandrima, Carson, Joshua J., Kieft, Jeffrey, Harkness, Troy, Tyler, Jessica K.·2010·Molecular Cell

DOI 10.1016/j.molcel.2010.08.015PMC PMC3966075

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Abstract

Changes to the chromatin structure accompany aging, but the molecular mechanisms underlying aging and the accompanying changes to the chromatin are unclear. Here, we report a mechanism whereby altering chromatin structure regulates life span. We show that normal aging is accompanied by a profound loss of histone proteins from the genome. Indeed, yeast lacking the histone chaperone Asf1 or acetylation of histone H3 on lysine 56 are short lived, and this appears to be at least partly due to their having decreased histone levels. Conversely, increasing the histone supply by inactivation of the histone information regulator (Hir) complex or overexpression of histones dramatically extends life span via a pathway that is distinct from previously known pathways of life span extension. This study indicates that maintenance of the fundamental chromatin structure is critical for slowing down the aging process and reveals that increasing the histone supply extends life span.

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Overexpression of SIR2 or histones, or deletion of SET2, extends yeast lifespan, indicating epigenetic changes are a cause, not merely a biomarker, of yeast aging.
“Overexpression of SIR2, histones, or deletion of the histone methyltransferase gene SET2, extends yeast lifespan, indicating that epigenetic changes are not merely a biomarker, but a cause of yeast aging (Dang et al., 2009; Feser et al., 2010; Hu et al., 2014; Kaeberlein et al., 1999; Ryu et al., 2014).”
From Loss of epigenetic information as a cause of mammalian aging (2023) · cites this paper as Feser et al., 2010
Nucleosome occupancy can decrease with age, and ameliorating this loss in yeast increases lifespan.
“Nucleosome occupancy can decrease with age (Figure 2), and ameliorating this loss in yeast increases lifespan (Feser et al., 2010; Hu et al., 2014; Ivanov et al., 2013).”
From The Aging Epigenome (2016) · cites this paper as Feser et al., 2010

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Crystal structure of the nucleosome core particle at 2.8 Å resolution
Luger, K., Mäder, A. W., Richmond, R. K., Sargent, D. F., & Richmond, T. J. (1997) · Nature · doi:10.1038/38444 · Cited by 9,466 · see citing works
Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
Imai, S.-I., Armstrong, C. M., Kaeberlein, M., & Guarente, L. (2000) · Nature · doi:10.1038/35001622 · Cited by 3,510 · see citing works
The Role of Chromatin during Transcription
Li, B., Carey, M., & Workman, J. L. (2007) · Cell · doi:10.1016/j.cell.2007.01.015 · Cited by 3,503 · see citing works
The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms
Kaeberlein, M., McVey, M., & Guarente, L. (1999) · Genes & Development · doi:10.1101/gad.13.19.2570 · Cited by 2,253 · cited 9× · see citing works
“Collectively, these data indicate that extra histone supply is unlikely to extend life span via the identical pathways by which ERC accumulation and Sir2 influence life span. ram (aged) from strain UCC5181 were subject to ChIP analysis for histone H3 pendent experiments, whose results are shown individually in Figures…”
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Shogren‐Knaak, M. A., Ishii, H., Sun, J.-M., Pazin, M. J., Davie, J., & Peterson, C. L. (2006) · Science · doi:10.1126/science.1124000 · Cited by 1,876 · see citing works
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Kaeberlein, M., Powers, R. W., Steffen, K. K., Westman, E. A., Hu, D., Dang, N., Kerr, E. O., Kirkland, K. T., Fields, S., & Kennedy, B. K. (2005) · Science · doi:10.1126/science.1115535 · Cited by 1,293 · see citing works
Chromatin Challenges during DNA Replication and Repair
Groth, A., Rocha, W., Verreault, A., & Almouzni, G. (2007) · Cell · doi:10.1016/j.cell.2007.01.030 · Cited by 733 · see citing works
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Dang, W., Steffen, K. K., Perry, R., Dorsey, J. A., Johnson, F. B., Shilatifard, A., Kaeberlein, M., Kennedy, B. K., & Berger, S. L. (2009) · Nature · doi:10.1038/nature08085 · Cited by 667 · see citing works
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Fuks, F. (2005) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2005.08.002 · Cited by 643 · see citing works
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Tyler, J. K., Adams, C. R., Chen, S.-R., Kobayashi, R., Kamakaka, R. T., & Kadonaga, J. T. (1999) · Nature · doi:10.1038/990147 · Cited by 555 · see citing works
Self-citation
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Gottlieb, S., & Esposito, R. E. (1989) · Cell · doi:10.1016/0092-8674(89)90681-8 · Cited by 545 · see citing works
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Steffen, K. K., MacKay, V. L., Kerr, E. O., Tsuchiya, M., Hu, D., Fox, L. A., Dang, N., Johnston, E. D., Oakes, J. A., Tchao, B. N., et al. (2008) · Cell · doi:10.1016/j.cell.2008.02.037 · Cited by 465 · see citing works
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Singer, M. S., Kahana, A., Wolf, A. J., Meisinger, L. L., Peterson, S. E., Goggin, C., Mahowald, M., & Gottschling, D. E. (1998) · Genetics · doi:10.1093/genetics/150.2.613 · Cited by 463 · see citing works
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Li, Q., Zhou, H., Wurtele, H., Davies, B., Horazdovsky, B., Verreault, A., & Zhang, Z. (2008) · Cell · doi:10.1016/j.cell.2008.06.018 · Cited by 447 · see citing works
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Chen, C., Carson, J. J., Feser, J., Tamburini, B. A. J., Zabaronick, S., Linger, J. G., & Tyler, J. K. (2008) · Cell · doi:10.1016/j.cell.2008.06.035 · Cited by 426 · see citing works
Self-citation
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Han, J., Zhou, H., Horazdovsky, B. F., Zhang, K., Xu, R.-M., & Zhang, Z. (2007) · Science · doi:10.1126/science.1133234 · Cited by 421 · see citing works
Genomewide studies of histone deacetylase function in yeast
Bernstein, B., Tong, J. K., & Schreiber, S. L. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.250477697 · Cited by 419 · see citing works
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Rea, S. L., Wu, D., Cypser, J. R., Vaupel, J. W., & Johnson, T. E. (2005) · Nature Genetics · doi:10.1038/ng1608 · Cited by 411 · see citing works
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Defossez, P., Prusty, R., Kaeberlein, M. R., Lin, S.-J., Ferrigno, P. K., Silver, P. A., Keil, R., & Guarente, L. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80472-4 · Cited by 401 · see citing works
Chromosomal landscape of nucleosome-dependent gene expression and silencing in yeast
Wyrick, J. J., Holstege, F. C. P., Jennings, E. G., Causton, H. C., Shore, D., Grunstein, M. R., Lander, E. S., & Young, R. A. (1999) · Nature · doi:10.1038/46567 · Cited by 394 · see citing works
Acetylation in Histone H3 Globular Domain Regulates Gene Expression in Yeast
Xu, F., Zhang, K., & Grunstein, M. R. (2005) · Cell · doi:10.1016/j.cell.2005.03.011 · Cited by 394 · see citing works
Ultraviolet radiation sensitivity and reduction of telomeric silencing in Saccharomyces cerevisiae cells lacking chromatin assembly factor-I.Preprint
Kaufman, P. D., Kobayashi, R., & Stillman, B. (1997) · Genes & Development · doi:10.1101/gad.11.3.345 · Cited by 380 · see citing works
Daughter cells of Saccharomyces cerevisiae from old mothers display a reduced life span.
Kennedy, B. K., Austriaco, N. P. G., & Guarente, L. (1994) · The Journal of Cell Biology · doi:10.1083/jcb.127.6.1985 · Cited by 305 · see citing works
Replicative Aging in Yeast: The Means to the End
Steinkraus, K. A., Kaeberlein, M. R., & Kennedy, B. K. (2008) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.23.090506.123509 · Cited by 279 · see citing works
Longevity Regulation by Drosophila Rpd3 Deacetylase and Caloric Restriction
Rogina, B., Helfand, S. L., & Frankel, S. A. (2002) · Science · doi:10.1126/science.1078986 · Cited by 276 · see citing works
The yeast Sgs1p helicase acts upstream of Rad53p in the DNA replication checkpoint and colocalizes with Rad53p in S-phase-specific fociPreprint
Frei, C., & Gasser, S. M. (2000) · Genes & Development · doi:10.1101/gad.14.1.81 · Cited by 264 · see citing works
Cell Cycle and Checkpoint Regulation of Histone H3 K56 Acetylation by Hst3 and Hst4
Maas, N. L., Miller, K. M., DeFazio, L. G., & Toczyski, D. P. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.06.006 · Cited by 237 · see citing works
HST2 Mediates SIR2 -Independent Life-Span Extension by Calorie Restriction
Lamming, D. W., Latorre‐Esteves, M., Medvedik, O., Wong, S. N., Tsang, F. A., Wang, C., Lin, S.-J., & Sinclair, D. A. (2005) · Science · doi:10.1126/science.1113611 · Cited by 228 · see citing works
A Genetic Screen for Ribosomal DNA Silencing Defects Identifies Multiple DNA Replication and Chromatin-Modulating Factors
Smith, J. S., Caputo, E. M., & Boeke, J. D. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.4.3184 · Cited by 225 · see citing works
Replication-Independent Histone Deposition by the HIR Complex and Asf1
Green, E. M., Antczak, A. J., Bailey, A. O., Franco, A. A., Wu, K. J., Yates, J. R., & Kaufman, P. D. (2005) · Current Biology · doi:10.1016/j.cub.2005.10.053 · Cited by 219 · see citing works
Acetylation in the globular core of histone H3 on lysine-56 promotes chromatin disassembly during transcriptional activation
Williams, S. K., Truong, D. M., & Tyler, J. K. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0800057105 · Cited by 218 · see citing works
Self-citation
Modulation of Life-span by Histone Deacetylase Genes inSaccharomyces cerevisiae
Kim, S., Benguría, A., Lai, C.-Y., & Jazwinski, S. M. (1999) · Molecular Biology of the Cell · doi:10.1091/mbc.10.10.3125 · Cited by 212 · see citing works
Pharmacogenetic analysis of lithium-induced delayed aging in Caenorhabditis elegans
McColl, G., Killilea, D. W., Hubbard, A. E., Vantipalli, M. C., Melov, S., & Lithgow, G. J. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m705028200 · Cited by 202 · see citing works
Quantitative evidence for conserved longevity pathways between divergent eukaryotic speciesPreprint
Smith, E. D., Tsuchiya, M., Fox, L. A., Dang, N., Hu, D., Kerr, E. O., Johnston, E. D., Tchao, B. N., Pak, D. N., Welton, K. L., et al. (2008) · Genome Research · doi:10.1101/gr.074724.107 · Cited by 198 · see citing works
The Mother Enrichment Program: A Genetic System for Facile Replicative Life Span Analysis in Saccharomyces cerevisiae
Lindstrom, D. L., & Gottschling, D. E. (2009) · Genetics · doi:10.1534/genetics.109.106229 · Cited by 197 · see citing works
Enhanced Gluconeogenesis and Increased Energy Storage as Hallmarks of Aging in Saccharomyces cerevisiae
Lin, S., Manchester, J. K., & Gordon, J. I. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m103509200 · Cited by 188 · see citing works
Chaperone Control of the Activity and Specificity of the Histone H3 Acetyltransferase Rtt109
Fillingham, J., Recht, J., Silva, A. C., Suter, B., Emili, A., Štagljar, I., Krogan, N. J., Allis, C. D., Keogh, M., & Greenblatt, J. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.00182-08 · Cited by 183 · see citing works
Acetylation of Lysine 56 of Histone H3 Catalyzed by RTT109 and Regulated by ASF1 Is Required for Replisome Integrity
Han, J., Zhou, H., Li, Z., Xu, R.-M., & Zhang, Z. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m702496200 · Cited by 179 · see citing works
Hir Proteins Are Required for Position-Dependent Gene Silencing in Saccharomyces cerevisiae in the Absence of Chromatin Assembly Factor I
Kaufman, P. D., Cohen, J. L., & Osley, M. A. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.8.4793 · Cited by 168 · see citing works
Sir2 Deacetylates Histone H3 Lysine 56 to Regulate Telomeric Heterochromatin Structure in Yeast
Xu, F., Zhang, Q., Zhang, K., Xie, W., & Grunstein, M. R. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.07.021 · Cited by 161 · see citing works
Enzymatic activities of Sir2 and chromatin silencing
Moazed, D. (2001) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(00)00202-7 · Cited by 160 · see citing works
DNA methylation in aging of mice
Singhal, R. P., Mays-Hoopes, L. L., & Eichhorn, G. L. (1987) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(87)90040-6 · Cited by 156 · see citing works
Yeast ASF1 Protein Is Required for Cell Cycle Regulation of Histone Gene Transcription
Sutton, A., Bucaria, J., Osley, M. A., & Sternglanz, R. (2001) · Genetics · doi:10.1093/genetics/158.2.587 · Cited by 150 · see citing works
Saccharomyces cerevisiae chromatin-assembly factors that act during DNA replication function in the maintenance of genome stability
Myung, K., Pennaneach, V., Kats, E. S., & Kolodner, R. D. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1232239100 · Cited by 137 · see citing works
Hir1p and Hir2p Function as Transcriptional Corepressors To Regulate Histone Gene Transcription in the Saccharomyces cerevisiae Cell Cycle
Spector, M. S., Raff, A. C., DeSilva, H., Lee, K. M. L., & Osley, M. A. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.2.545 · Cited by 135 · see citing works
Genome instability, cancer and aging
Maslov, A. Y., & Vijg, J. (2009) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2009.03.020 · Cited by 127 · see citing works
Sirtuin‐independent effects of nicotinamide on lifespan extension from calorie restriction in yeast
Tsuchiya, M., Dang, N., Kerr, E. O., Hu, D., Steffen, K. K., Oakes, J. A., Kennedy, B. K., & Kaeberlein, M. R. (2006) · Aging Cell · doi:10.1111/j.1474-9726.2006.00240.x · Cited by 115 · see citing works
Mrc1 and Srs2 are major actors in the regulation of spontaneous crossover
Robert, T., Ravault, D., Fabre, F., & Gangloff, S. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601158 · Cited by 107 · see citing works
Activation of the DNA Damage Checkpoint in Yeast Lacking the Histone Chaperone Anti-Silencing Function 1
Ramey, C. J., Howar, S. R., Adkins, M. W., Linger, J. G., Spicer, J., & Tyler, J. K. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.23.10313-10327.2004 · Cited by 95 · see citing works
Self-citation
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Adkins, M. W., Carson, J. J., English, C. M., Ramey, C. J., & Tyler, J. K. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m608025200 · Cited by 91 · see citing works
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Barger, J. L., Kayo, T., Pugh, T. D., Prolla, T. A., & Weindruch, R. H. (2008) · Experimental Gerontology · doi:10.1016/j.exger.2008.06.013 · Cited by 89 · see citing works
Effect of Replicative Age on Transcriptional Silencing Near Telomeres inSaccharomyces cerevisiae
Kim, S., Villeponteau, B., & Jazwinski, S. M. (1996) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1996.0240 · Cited by 73 · see citing works
Methylation and rearrangement of mouse intracisternal a particle genes in development, aging, and myeloma.
Mays-Hoopes, L. L., Brown, A., & Huang, R. C. C. (1983) · Molecular and Cellular Biology · doi:10.1128/mcb.3.8.1371 · Cited by 65 · see citing works
Genome-wide identification of conserved longevity genes in yeast and worms
Smith, E. D., Kennedy, B. K., & Kaeberlein, M. R. (2006) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2006.11.017 · Cited by 61 · see citing works
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Warren, L. A., Rossi, D. J., Schiebinger, G. R., Weissman, I. L., Kim, S. K., & Quake, S. R. (2007) · Aging Cell · doi:10.1111/j.1474-9726.2007.00337.x · Cited by 56 · see citing works
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Zahn, J. M., & Kim, S. K. (2007) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2007.07.004 · Cited by 56 · see citing works
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Zabaronick, S., & Tyler, J. K. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.2.652-660.2005 · Cited by 53 · see citing works
Self-citation
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Busuttil, R. A., Bahar, R., & Vijg, J. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.09.060 · Cited by 49 · see citing works
Pathways Change in Expression During Replicative Aging in Saccharomyces cerevisiae
Yiu, G., McCord, A., Wise, A., Jindal, R., Hardee, J. J., Kuo, A., Shimogawa, M. M., Cahoon, L. A., Wu, M., Kloke, J., et al. (2008) · The Journals of Gerontology Series A · doi:10.1093/gerona/63.1.21 · Cited by 49 · see citing works
Drosophila longevity is not affected by heterochromatin‐mediated gene silencing
Frankel, S. A., & Rogina, B. (2005) · Aging Cell · doi:10.1111/j.1474-9726.2005.00143.x · Cited by 17 · see citing works
The HIR4-1 mutation defines a new class of histone regulatory genes in Saccharomyces cerevisiae.
Spector, M. S., & Osley, M. A. (1993) · Genetics · doi:10.1093/genetics/135.1.25 · Cited by 17 · see citing works
Sequence Analysis of 203 Kilobases from Saccharomyces cerevisiae Chromosome VII
Rieger, M. A., Brückner, M., Schäfer, M., & Müller-Auer, S. (1997) · Yeast · doi:10.1002/(sici)1097-0061(19970915)13:11 · Cited by 5 · see citing works

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Kane, A. E., & Sinclair, D. A. (2019) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409238.2019.1570075 · Cited by 283 · see citing works
Cellular and epigenetic drivers of stem cell ageing
Ermolaeva, M., Neri, F., Ori, A., & Rudolph, K. L. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0020-3 · Cited by 272 · see citing works
Journal of Mammary Gland Biology and Neoplasia
(2013) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1007/10911.1573-7039 · Cited by 245 · see citing works
H3K36 methylation promotes longevity by enhancing transcriptional fidelity
Sen, P., Dang, W., Donahue, G., Dai, J., Dorsey, J., Cao, X., Liu, W., Cao, K., Perry, R., Lee, J. Y., et al. (2015) · Genes & Development · doi:10.1101/gad.263707.115 · Cited by 233 · see citing works
Nutritional influences on epigenetics and age-related disease
Park, L. K., Friso, S., & Choi, S. (2011) · Proceedings of The Nutrition Society · doi:10.1017/s0029665111003302 · Cited by 237 · see citing works
Lipid Droplets Control the Maternal Histone Supply of Drosophila Embryos
Li, Z., Thiel, K., Thul, P. J., Beller, M., Kühnlein, R. P., & Welte, M. A. (2012) · Current Biology · doi:10.1016/j.cub.2012.09.018 · Cited by 221 · see citing works
Histone Chaperones: Modulators of Chromatin Marks
Avvakumov, N., Nourani, A., & Côté, J. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.02.013 · Cited by 212 · see citing works
The Overlooked Fact: Fundamental Need for Spike-In Control for Virtually All Genome-Wide Analyses
Chen, K., Hu, Z., Xia, Z., Zhao, D., Li, W., & Tyler, J. K. (2015) · Molecular and Cellular Biology · doi:10.1128/mcb.00970-14 · Cited by 212 · see citing works
Self-citation
The pleiotropic neuroprotective effects of resveratrol in cognitive decline and Alzheimer’s disease pathology: From antioxidant to epigenetic therapy
Griñán-Ferré, C., Bellver-Sanchis, A., Izquierdo, V., Corpas, R., Roig-Soriano, J., Chillón, M., Andres-Lacueva, C., Somogyvári, M., Sőti, C., Sanfeliu, C., et al. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101271 · Cited by 208 · see citing works
Ageing-associated changes in transcriptional elongation influence longevity
Debès, C., Papadakis, A., Grönke, S., Karalay, Ö., Tain, L. S., Mizi, A., Nakamura, S., Hahn, O., Weigelt, C. M., Josipović, N., et al. (2023) · Nature · doi:10.1038/s41586-023-05922-y · Cited by 209 · see citing works
Budding yeast as a model organism to study the effects of age
Denoth‐Lippuner, A., Julou, T., & Barral, Y. (2014) · FEMS Microbiology Reviews · doi:10.1111/1574-6976.12060 · Cited by 200 · see citing works
Substantial Histone Reduction Modulates Genomewide Nucleosomal Occupancy and Global Transcriptional Output
Celona, B., Weiner, A., Felice, F. D., Mancuso, F. M., Cesarini, E., Rossi, R. L., Gregory, L., Baban, D. F., Rossetti, G., Grianti, P., et al. (2011) · PLoS Biology · doi:10.1371/journal.pbio.1001086 · Cited by 198 · see citing works
Chromatin structure as a mediator of aging
Feser, J., & Tyler, J. K. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.11.016 · Cited by 200 · see citing works
Self-citation
Acetyl-CoA Metabolism and Histone Acetylation in the Regulation of Aging and Lifespan
Bradshaw, P. (2021) · Antioxidants · doi:10.3390/antiox10040572 · Cited by 162 · see citing works
Nuclear interferon-inducible protein 16 promotes silencing of herpesviral and transfected DNA
Orzalli, M. H., Conwell, S. E., Berrios, C. J., DeCaprio, J. A., & Knipe, D. M. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1316194110 · Cited by 180 · see citing works
The Metabolic Impact on Histone Acetylation and Transcription in Ageing
Peleg, S., Feller, C., Ladurner, A. G., & Imhof, A. (2016) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2016.05.008 · Cited by 178 · see citing works
Proteostasis collapse is a driver of cell aging and death
Santra, M., Dill, K. A., & de Graff, A. M. R. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1906592116 · Cited by 175 · see citing works
Aging and reprogramming: a two-way street
Mahmoudi, S., & Brunet, A. (2012) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2012.10.004 · Cited by 171 · see citing works
A Specific Function for the Histone Chaperone NASP to Fine-Tune a Reservoir of Soluble H3-H4 in the Histone Supply Chain
Cook, A. J. L., Gurard‐Levin, Z. A., Vassias, I., & Almouzni, G. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.11.021 · Cited by 171 · see citing works
Cardiac ageing: extrinsic and intrinsic factors in cellular renewal and senescence
Gude, N. A., Broughton, K. M., Firouzi, F., & Sussman, M. A. (2018) · Nature Reviews Cardiology · doi:10.1038/s41569-018-0061-5 · Cited by 166 · see citing works
New histone supply regulates replication fork speed and PCNA unloading
Mejlvang, J., Feng, Y., Alabert, C., Neelsen, K. J., Jasencakova, Z., Zhao, X., Lees, M. J., Sandelin, A., Pasero, P., Lopes, M., et al. (2013) · The Journal of Cell Biology · doi:10.1083/jcb.201305017 · Cited by 166 · see citing works
BiT age: A transcriptome‐based aging clock near the theoretical limit of accuracy
Meyer, D. H., & Schumacher, B. (2021) · Aging Cell · doi:10.1111/acel.13320 · Cited by 165 · see citing works
HIRA orchestrates a dynamic chromatin landscape in senescence and is required for suppression of neoplasia
Rai, T. S., Cole, J. J., Nelson, D. M., Dikovskaya, D., Faller, W. J., Vizioli, M. G., Hewitt, R. N., Anannya, O., McBryan, T., Manoharan, I., et al. (2014) · Genes & Development · doi:10.1101/gad.247528.114 · Cited by 162 · see citing works
Competition between histone and transcription factor binding regulates the onset of transcription in zebrafish embryos
Joseph, S. R., Pálfy, M., Hilbert, L., Kumar, M., Karschau, J., Zaburdaev, V., Shevchenko, A., & Vastenhouw, N. L. (2017) · eLife · doi:10.7554/elife.23326 · Cited by 145 · see citing works
Two SET domain containing genes link epigenetic changes and aging in Caenorhabditis elegans
Ni, Z., Ebata, A., Alipanahiramandi, E., & Lee, S. S. (2011) · Aging Cell · doi:10.1111/j.1474-9726.2011.00785.x · Cited by 154 · see citing works
Epigenetic Regulation of Cellular Senescence and Aging
Sidler, C. L., Kovalchuk, O., & Kovalchuk, I. (2017) · Frontiers in Genetics · doi:10.3389/fgene.2017.00138 · Cited by 147 · see citing works
Heterochromatin: an epigenetic point of view in aging
Lee, J., Kim, E. W., Croteau, D. L., & Bohr, V. A. (2020) · Experimental & Molecular Medicine · doi:10.1038/s12276-020-00497-4 · Cited by 150 · see citing works
Transcriptional Signatures of Aging
Stegeman, R., & Weake, V. M. (2017) · Journal of Molecular Biology · doi:10.1016/j.jmb.2017.06.019 · Cited by 146 · see citing works
DAMPs, ageing, and cancer: The ‘DAMP Hypothesis’
Huang, J., Xie, Y., Sun, X., Zeh, H. J., Kang, R., Lotze, M. T., & Tang, D. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2014.10.004 · Cited by 144 · see citing works
Mechanism of transcription through a nucleosome by RNA polymerase II
Kulaeva, O. I., Hsieh, F., Chang, H.-W., Luse, D. S., & Studitsky, V. M. (2012) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2012.08.015 · Cited by 144 · see citing works
The Information Theory of Aging
Lu, Y. R., Tian, X., & Sinclair, D. A. (2023) · Nature Aging · doi:10.1038/s43587-023-00527-6 · Cited by 141 · see citing works
Metabolic Signaling to ChromatinPreprint
Berger, S. L., & Sassone‐Corsi, P. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a019463 · Cited by 142 · see citing works
POLE3-POLE4 Is a Histone H3-H4 Chaperone that Maintains Chromatin Integrity during DNA Replication
Bellelli, R., Beláň, O., Pye, V. E., Clement, C., Maslen, S., Skehel, M. J., Cherepanov, P., Almouzni, G., & Boulton, S. J. (2018) · Molecular Cell · doi:10.1016/j.molcel.2018.08.043 · Cited by 139 · see citing works
New Insights into the Role of Histone Changes in Aging
Yi, S.-J., & Kim, K. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21218241 · Cited by 133 · see citing works
Chromatin structure and transposable elements in organismal aging
Wood, J. G., & Helfand, S. L. (2013) · Frontiers in Genetics · doi:10.3389/fgene.2013.00274 · Cited by 124 · see citing works
Histone H3 Lysine 56 Methylation Regulates DNA Replication through Its Interaction with PCNA
Yu, Y., Song, C., Zhang, Q., DiMaggio, P. A., Garcia, B. A., York, A. G., Carey, M., & Grunstein, M. R. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.01.019 · Cited by 126 · see citing works
Deterioration of nuclear morphology and architecture: A hallmark of senescence and aging
Pathak, R. U., Soujanya, M., & Mishra, R. K. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101264 · Cited by 119 · see citing works
Long noncoding RNAs in aging and age-related diseases
Kour, S., & Rath, P. C. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2015.12.001 · Cited by 119 · see citing works
The great unravelling: chromatin as a modulator of the aging process
O’Sullivan, R. J., & Karlseder, J. (2012) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2012.08.001 · Cited by 115 · see citing works
Suppression of transcriptional drift extends C. elegans lifespan by postponing the onset of mortality
Rangaraju, S., Solis, G. M., Thompson, R. C., Gomez-Amaro, R. L., Kurian, L., Encalada, S. E., Niculescu, A. B., Salomon, D. R., & Petrascheck, M. (2015) · eLife · doi:10.7554/elife.08833 · Cited by 111 · see citing works
Age‐associated de‐repression of retrotransposons in the <i>Drosophila</i> fat body, its potential cause and consequence
Chen, H., Zheng, X., Xiao, D., & Zheng, Y. (2016) · Aging Cell · doi:10.1111/acel.12465 · Cited by 107 · see citing works
Dynamic Incorporation of Histone H3 Variants into Chromatin Is Essential for Acquisition of Aggressive Traits and Metastatic Colonization
Gomes, A. P., Ilter, D., Low, V., Rosenzweig, A., Shen, Z.-J., Schild, T., Rivas, M. A., Er, E. E., McNally, D. R., Mutvei, A. P., et al. (2019) · Cancer Cell · doi:10.1016/j.ccell.2019.08.006 · Cited by 108 · see citing works
Self-citation
Genomic Instability and Epigenetic Changes during Aging
López-Gil, L., Pascual‐Ahuir, A., & Proft, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241814279 · Cited by 120 · see citing works
Cardiac cell senescence: molecular mechanisms, key proteins and therapeutic targets
Luan, Y., Zhu, X., Jiao, Y., Liu, H., Huang, Z., Pei, J., Xu, Y., Yang, Y., & Ren, K. (2024) · Cell Death Discovery · doi:10.1038/s41420-023-01792-5 · Cited by 106 · see citing works
Replication Stress Shapes a Protective Chromatin Environment across Fragile Genomic Regions
Kim, J., Sturgill, D. M., Sebastian, R., Khurana, S., Tran, A. D., Edwards, G. B., Kruswick, A., Burkett, S. S., Hosogane, E. K., Hannon, W. W., et al. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.11.021 · Cited by 94 · see citing works
The yeast replicative aging model
He, C. Z., Zhou, C., & Kennedy, B. K. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.02.023 · Cited by 91 · see citing works
Histone exchange and histone modifications during transcription and aging
Das, C., & Tyler, J. K. (2011) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2011.08.001 · Cited by 97 · see citing works
Self-citation
Tri-methylation of histone H3 lysine 4 facilitates gene expression in ageing cells
Cruz, C., Rosa, M. D., Krueger, C., Gao, Q., Horkai, D., King, M. R., Field, L., & Houseley, J. M. (2018) · eLife · doi:10.7554/elife.34081 · Cited by 95 · see citing works
Chd1 chromatin remodelers maintain nucleosome organization and repress cryptic transcription
Hennig, B. P., Bendrin, K., Zhou, Y., & Fischer, T. (2012) · EMBO Reports · doi:10.1038/embor.2012.146 · Cited by 94 · see citing works
Histone methylation and aging: Lessons learned from model systems
McCauley, B. S., & Dang, W. (2014) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2014.05.008 · Cited by 93 · see citing works
The Histone Code of Senescence
Paluvai, H., Giorgio, E. D., & Brancolini, C. (2020) · Cells · doi:10.3390/cells9020466 · Cited by 94 · see citing works
Epigenetic Mechanisms Impacting Aging: A Focus on Histone Levels and Telomeres
Song, S., & Johnson, F. B. (2018) · Genes · doi:10.3390/genes9040201 · Cited by 91 · see citing works
Histone Modifications as an Intersection Between Diet and Longevity
Molina‐Serrano, D., Kyriakou, D., & Kirmizis, A. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00192 · Cited by 91 · see citing works
Rap1 relocalization contributes to the chromatin-mediated gene expression profile and pace of cell senescencePreprint
Platt, J. M., Ryvkin, P., Wanat, J. J., Donahue, G., Ricketts, M. D., Barrett, S. P., Waters, H. J., Song, S., Chavez, A., Abdallah, K. O., et al. (2013) · Genes & Development · doi:10.1101/gad.218776.113 · Cited by 89 · see citing works
The budding yeast Centromere DNA Element II wraps a stable Cse4 hemisome in either orientation in vivo
Henikoff, S., Ramachandran, S., Krassovsky, K., Bryson, T. D., Codomo, C. A., Brogaard, K., Widom, J., Wang, J.-P., & Henikoff, J. G. (2014) · eLife · doi:10.7554/elife.01861 · Cited by 88 · see citing works
DNA double strand break repair, aging and the chromatin connection
Gorbunova, V., & Seluanov, A. (2016) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis · doi:10.1016/j.mrfmmm.2016.02.004 · Cited by 87 · see citing works
The Epigenetic Link between Polyphenols, Aging and Age-Related Diseases
Arora, I., Sharma, M., Sun, L.-O. Y., & Tollefsbol, T. (2020) · Genes · doi:10.3390/genes11091094 · Cited by 72 · see citing works
Chromatin Architectural Changes during Cellular Senescence and Aging
Sun, L., Yu, R., & Dang, W. (2018) · Genes · doi:10.3390/genes9040211 · Cited by 83 · see citing works
Proteomics Study of Peripheral Blood Mononuclear Cells in Down Syndrome Children
Lanzillotta, C., Greco, V., Valentini, D., Villani, A., Folgiero, V., Caforio, M., Locatelli, F., Pagnotta, S. E., Barone, E., Urbani, A., et al. (2020) · Antioxidants · doi:10.3390/antiox9111112 · Cited by 85 · see citing works
Transcriptional elongation control in developmental gene expression, aging, and disease
Aoi, Y., & Shilatifard, A. (2023) · Molecular Cell · doi:10.1016/j.molcel.2023.10.004 · Cited by 83 · see citing works
Acetylated histone H3K56 interacts with Oct4 to promote mouse embryonic stem cell pluripotency
Tan, Y., Xue, Y., Song, C., & Grunstein, M. R. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1309914110 · Cited by 83 · see citing works
Genomic Instabilities, Cellular Senescence, and Aging: In Vitro, In Vivo and Aging-Like Human Syndromes
Lidzbarsky, G. A., Gutman, D., Shekhidem, H. A., Sharvit, L. E., & Atzmon, G. (2018) · Frontiers in Medicine · doi:10.3389/fmed.2018.00104 · Cited by 80 · see citing works
Ssd1 and Gcn2 suppress global translation efficiency in replicatively aged yeast while their activation extends lifespan
Hu, Z., Xia, B., Postnikoff, S. D. L., Shen, Z.-J., Tomoiaga, A. S., Harkness, T. A. A., Seol, J. H., Li, W., Chen, K., & Tyler, J. K. (2018) · eLife · doi:10.7554/elife.35551 · Cited by 82 · see citing works
Self-citation
Emerging topics in C. elegans aging research: Transcriptional regulation, stress response and epigenetics
Denzel, M. S., Lapierre, L. R., & Mack, H. I. D. (2018) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2018.08.001 · Cited by 81 · see citing works
Defective histone supply causes changes in RNA polymerase II elongation rate and cotranscriptional pre-mRNA splicing
Jimeno-González, S., Payán-Bravo, L., Muñoz-Cabello, A. M., Guijo, M., Gutierrez, G., Prado, F., & Reyes, J. C. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1506760112 · Cited by 80 · see citing works
Common features of chromatin in aging and cancer: cause or coincidence?
Zane, L. K., Sharma, V., & Misteli, T. (2014) · Trends in Cell Biology · doi:10.1016/j.tcb.2014.07.001 · Cited by 77 · see citing works
Changes in nucleosome occupancy associated with metabolic alterations in aged mammalian liver
Bochkis, I. M., Przybylski, D., Chen, J., & Regev, A. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.09.048 · Cited by 78 · see citing works
Evidence for the hallmarks of human aging in replicatively aging yeast
Janssens, G. E., & Veenhoff, L. M. (2016) · Microbial Cell · doi:10.15698/mic2016.07.510 · Cited by 76 · see citing works
A TORC1-histone axis regulates chromatin organisation and non-canonical induction of autophagy to ameliorate ageing
Lu, Y., Regan, J. C., Eßer, J., Drews, L. F., Weinseis, T., Stinn, J., Hahn, O., Miller, R. A., Grönke, S., & Partridge, L. (2021) · eLife · doi:10.7554/elife.62233 · Cited by 73 · see citing works
Highly Charged Proteins: The Achilles' Heel of Aging Proteomes
de Graff, A. M. R., Hazoglou, M. J., & Dill, K. A. (2015) · Structure · doi:10.1016/j.str.2015.11.006 · Cited by 75 · see citing works
Some highlights of research on aging with invertebrates, 2010
Partridge, L. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2010.00649.x · Cited by 74 · see citing works
Epigenetics and aging
D’Aquila, P., Rose, G., Bellizzi, D., & Passarino, G. (2012) · Maturitas · doi:10.1016/j.maturitas.2012.11.005 · Cited by 72 · see citing works
Voluntary Wheel Running Reverses Age-Induced Changes in Hippocampal Gene Expression
Kohman, R. A., Rodriguez‐Zas, S. L., Southey, B. R., Kelley, K. W., Dantzer, R., & Rhodes, J. S. (2011) · PLoS ONE · doi:10.1371/journal.pone.0022654 · Cited by 73 · see citing works
DNA damage, chromatin, and transcription: the trinity of aging
Burgess, R. C., Misteli, T., & Oberdoerffer, P. (2012) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2012.07.005 · Cited by 72 · see citing works
Variation in transcriptome size: are we getting the message?
Coate, J. E., & Doyle, J. J. (2014) · Chromosoma · doi:10.1007/s00412-014-0496-3 · Cited by 69 · see citing works
Intermittent fasting from dawn to sunset for four consecutive weeks induces anticancer serum proteome response and improves metabolic syndrome
Mindikoglu, A. L., Abdulsada, M. M., Jain, A., Jalal, P. K., Devaraj, S., Wilhelm, Z. R., Opekun, A. R., & Jung, S. Y. (2020) · Scientific Reports · doi:10.1038/s41598-020-73767-w · Cited by 69 · see citing works
Regulation of DNA replication-coupled histone gene expression
Mei, Q., Huang, J., Chen, W., Tang, J., Xu, C., Yu, Q., Cheng, Y., Ma, L., Yu, X., & Li, S. (2017) · Oncotarget · doi:10.18632/oncotarget.21887 · Cited by 69 · see citing works
Epigenetic Regulation of Bone Marrow Stem Cell Aging: Revealing Epigenetic Signatures associated with Hematopoietic and Mesenchymal Stem Cell Aging
Cakouros, D., & Gronthos, S. (2018) · Aging and Disease · doi:10.14336/ad.2017.1213 · Cited by 68 · see citing works
More than 10% of yeast genes are related to genome stability and influence cellular senescence via rDNA maintenance
Saka, K., Takahashi, A., Sasaki, M., & Kobayashi, T. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw110 · Cited by 68 · see citing works

Chromatin structure as a mediator of aging
Feser, J., & Tyler, J. K. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.11.016 · Cited by 200 · see citing works
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Research Article Saccharomyces cerevisiae Linker Histone—Hho1p Maintains Chromatin Loop
Organization During Ageing, Uzunova, K. H., Georgieva, M., & Miloshev, G. A. (2013)
Saccharomyces cerevisiaeLinker Histone—Hho1p Maintains Chromatin Loop Organization during Ageing
Uzunova, K. H., Georgieva, M., & Miloshev, G. A. (2013) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2013/437146 · Cited by 14 · see citing works
Old Yeast Can't Handle the Noise
McCormick, M. A., & Kennedy, B. K. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.08.033 · Cited by 1 · see citing works
Set1-catalyzed H3K4 trimethylation antagonizes the HIR/Asf1/Rtt106 repressor complex to promote histone gene expression and chronological life span
Mei, Q., Xu, C., Gogol, M., Tang, J., Chen, W., Yu, X., Workman, J. L., & Li, S. (2019) · Nucleic Acids Research · doi:10.1093/nar/gkz101 · Cited by 35 · see citing works

Authors: Feser, J., Truong, D., Das, C., Carson, J. J., Kieft, J., Harkness, T., & Tyler, J. K.
Affiliations: University of Colorado Anschutz (US)
Howard Hughes Medical Institute (US)
University of Saskatchewan (CA)
The University of Texas MD Anderson Cancer Center (US)
Corresponding author: Tyler, Jessica K.
ORCID: Truong, David
Das, Chandrima
Kieft, Jeffrey
Harkness, Troy
Tyler, Jessica K.
Venue: Molecular Cell
Publisher: Elsevier BV
Published: 2010-09
Volume: 39
Issue: 5
Pages: 724-735
ISSN: 1097-2765 (ISSN-L)
DOI: 10.1016/j.molcel.2010.08.015
PMC: PMC3966075
OpenAlex: W1990955843
Cited by: 435
References: 62
Citations by year: 2026: 8 · 2025: 22 · 2024: 21 · 2023: 29 · 2022: 19 · 2021: 48 · 2020: 33 · 2019: 27 · 2018: 36 · 2017: 23 · 2016: 28 · 2015: 32 · 2014: 25 · 2013: 30 · 2012: 25
FWCI: 8.97
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 1086 d)
Locations: Molecular Cell (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
Cancer Center, University of Colorado
National Cancer Institute (R01CA095641)
National Institute of General Medical Sciences (GM64475, R01GM064475, T32-GM08370)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
Keywords: histone expression, lifespan extension, aging, chromatin structure, histone H3 lysine 56 acetylation, yeast
MeSH terms: Chromatin, Histones, Saccharomyces cerevisiae, Gene Expression Regulation, Fungal, Saccharomyces cerevisiae Proteins

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Elevated histone expression promotes life span extension

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