The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Regenerative medicine for retinal diseases: activating endogenous repair mechanisms
Open accessAbstract
The retina is subject to degenerative diseases that often lead to significant visual impairment. Non-mammalian vertebrates have a remarkable ability to replace neurons lost through damage. Fish, and to a limited extent birds, replace lost neurons by de-differentiation of Müller glia to a progenitor state followed by replication of these neuronal progenitor cells. Over the past five years, studies have investigated whether regeneration can be stimulated in the mouse and rat retina. Several groups have reported that at least some types of neurons can be regenerated in the mammalian retina in vivo or in vitro, and that the regeneration of neurons can be stimulated using growth factors, transcription factors or subtoxic levels of excitatory amino acids. These recent results suggest that some part of the regenerative program that occurs in non-mammalian vertebrates remains in the mammalian retina, and may provide a basis to develop new strategies for retinal repair in patients with retinal degenerations.
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Cites
Direct conversion of fibroblasts to functional neurons by defined factors
Vierbuchen, T., Ostermeier, A., Pang, Z. P., Kokubu, Y., Südhof, T. C., & Wernig, M. (2010) · Nature · doi:10.1038/nature08797 · Cited by 3,017
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Retinal remodeling triggered by photoreceptor degenerations
Jones, B. W., Watt, C. B., Frederick, J. M., Baehr, W., Chen, C., Levine, E. M., Milam, A. H., Lavail, M. M., & Marc, R. E. (2003) · Journal of Comparative Neurology · doi:10.1002/cne.10703 · Cited by 476
Wnt signaling promotes regeneration in the retina of adult mammals
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The search for the retinoblastoma cell of origin
Dyer, M. A., & Bremner, R. (2005) · Nature Reviews Cancer · doi:10.1038/nrc1545 · Cited by 170 · cited 1×
“Lastly, retinoblastoma, a childhood tumor of the retina, is a potential result from uncontrolled proliferation of cells that are not unlike retinal progenitors in many respects [45].”
BackgroundNotch signaling regulates regeneration in the avian retina
Hayes, S., Nelson, B. R., Buckingham, B., & Reh, T. A. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2007.09.046 · Cited by 141
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Cited by
Consequences of oxidative stress in age-related macular degeneration
Jarrett, S. G., & Boulton, M. E. (2012) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2012.03.009 · Cited by 538
Stimulation of functional neuronal regeneration from Müller glia in adult mice
Jorstad, N. L., Wilken, M. S., Grimes, W. N., Wohl, S. G., VandenBosch, L. S., Yoshimatsu, T., Wong, R. O., Rieke, F., & Reh, T. A. (2017) · Nature · doi:10.1038/nature23283 · Cited by 499
Self-citationUeki, Y., Wilken, M. S., Cox, K. E., Chipman, L., Jorstad, N., Sternhagen, K., Simic, M., Ullom, K., Nakafuku, M., & Reh, T. A. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1510595112 · Cited by 265
Self-citationGlial Cells as Progenitors and Stem Cells: New Roles in the Healthy and Diseased Brain
Dimou, L., & Götz, M. (2014) · Physiological Reviews · doi:10.1152/physrev.00036.2013 · Cited by 264
Bharti, K., Gasper, M., Ou, J., Brucato, M., Clore-Gronenborn, K., Pickel, J., & Arnheiter, H. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002757 · Cited by 158
Metadata
- Authors
- Karl, M. O., & Reh, T. A.
- Venue
- Trends in Molecular Medicine
- Publisher
- Elsevier BV
- Published
- 2010-04
- Volume
- 16
- Issue
- 4
- Pages
- 193-202
- ISSN
- 1471-4914 (ISSN-L)
- OpenAlex
- W1983159993
- Cited by
- 203
- References
- 10
- FWCI
- 0.97
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
