The DOI matches its Crossref record; 167 of the 167 references it cites were found in a registry or an index.
Dosing-Time Makes the Poison: Circadian Regulation and Pharmacotherapy
Open accessAbstract
Daily rhythms in physiology significantly modulate drug pharmacokinetics and pharmacodynamics according to the time-of-day, a finding that has led to the concept of chronopharmacology. The importance of biological clocks for xenobiotic metabolism has gained increased attention with the discovery of the molecular circadian clockwork. Mechanistic understanding of the cell-autonomous molecular circadian oscillator and the circadian timing system as a whole has opened new conceptual and methodological lines of investigation to understand first, the clock's impact on a specific drug's daily variations or the effects/side effects of environmental substances, and second, how clock-controlled pathways are coordinated within a given tissue or organism. Today, there is an increased understanding of the circadian modulation of drug effects. Moreover, several molecular strategies are being developed to treat disease-dependent and drug-induced clock disruptions in humans.
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1 retracted
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Cited by
Circadian physiology of metabolism
Panda, S. (2016) · Science · doi:10.1126/science.aah4967 · Cited by 1,092
The emerging link between cancer, metabolism, and circadian rhythms
Masri, S., & Sassone-Corsi, P. (2018) · Nature Medicine · doi:10.1038/s41591-018-0271-8 · Cited by 404
Medicine in the Fourth Dimension
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Metadata
- Authors
- Dallmann, R., Okyar, A., & Lévi, F.
- Venue
- Trends in Molecular Medicine
- Publisher
- Elsevier BV
- Published
- 2016-05
- Volume
- 22
- Issue
- 5
- Pages
- 430-445
- ISSN
- 1471-4914 (ISSN-L)
- OpenAlex
- W2333798941
- Cited by
- 293
- References
- 167
- FWCI
- 2.48
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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