Cited by 396

The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.

Manufacturing Exosomes: A Promising Therapeutic Platform

Colao, Ivano Luigi, Corteling, Randolph, Bracewell, Daniel, Wall, Ivan·2018·Trends in Molecular Medicine

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.molmed.2018.01.006

Cites

5 of 5 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 5 references

Research works printed but not linked: 74

  1. Collino, 2010, Microvesicles derived from adult human bone marrow and tissue specific mesenchymal stem cells shuttle selected pattern of miRNAs, PLoS One, 5, 10.1371/journal.pone.0011803 · DOI · Paper page
  2. Heijnen, 1999, Activated platelets release two types of membrane vesicles, Blood, 94, 3791, 10.1182/blood.V94.11.3791 · DOI
  3. Raiborg, 2009, The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins, Nature, 458, 445, 10.1038/nature07961 · DOI · Paper page
  4. Trajkovic, 2008, Ceramide triggers budding of exosome vesicles into multivesicular endosomes, Science, 319, 1244, 10.1126/science.1153124 · DOI
  5. Vlassov, 2012, Exosomes: current knowledge of their composition, biological functions, and diagnostic and therapeutic potentials, Biochim. Biophys. Acta, 1820, 940, 10.1016/j.bbagen.2012.03.017 · DOI
  6. Schageman, 2013, The complete exosome workflow solution: from isolation to characterization of RNA cargo, BioMed Res. Int., 2013, 253957, 10.1155/2013/253957 · DOI
  7. Conde-Vancells, 2008, Characterization and comprehensive proteome profiling of exosomes secreted by hepatocytes, J. Proteome Res., 7, 5157, 10.1021/pr8004887 · DOI
  8. Yu, 2006, The regulation of exosome secretion: a novel function of the p53 protein, Cancer Res., 66, 4795, 10.1158/0008-5472.CAN-05-4579 · DOI
  9. Lopez-Verrilli, 2013, Exosomes: mediators of communication in eukaryotes, Biol. Res., 46, 5, 10.4067/S0716-97602013000100001 · DOI
  10. Koga, 2005, Purification, characterization and biological significance of tumor-derived exosomes, Anticancer Res., 25, 3703
  11. Mears, 2004, Proteomic analysis of melanoma-derived exosomes by two-dimensional polyacrylamide gel electrophoresis and mass spectrometry, Proteomics, 4, 4019, 10.1002/pmic.200400876 · DOI
  12. Doeppner, 2015, Extracellular vesicles improve post-stroke neuroregeneration and prevent postischemic immunosuppression, Stem Cells Transl. Med., 4, 1131, 10.5966/sctm.2015-0078 · DOI
  13. Kim, 2015, Chromatographically isolated CD63+CD81+ extracellular vesicles from mesenchymal stromal cells rescue cognitive impairments after TBI, Proc Natl. Acad. Sci. U. S. A., 113, 1
  14. Lee, 2012, Exosomes mediate the cytoprotective action of mesenchymal stromal cells on hypoxia-induced pulmonary hypertension, Circulation, 126, 2601, 10.1161/CIRCULATIONAHA.112.114173 · DOI
  15. Zhang, 2015, Exosomes released from human induced pluripotent stem cells-derived MSCs facilitate cutaneous wound healing by promoting collagen synthesis and angiogenesis, J. Transl. Med., 13, 1, 10.1186/s12967-015-0417-0 · DOI
  16. Skog, 2008, Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers, Nat. Cell Biol., 10, 1470, 10.1038/ncb1800 · DOI · Paper page
  17. Lee, 2012, Exosomes and microvesicles: extracellular vesicles for genetic information transfer and gene therapy, Hum. Mol. Genet., 21, R125, 10.1093/hmg/dds317 · DOI
  18. Yanez-Mo, 2015, Biological properties of extracellular vesicles and their physiological functions, J. Extracell. Vesicles, 1, 1
  19. Taylor, 2005, Tumour-derived exosomes and their role in cancer-associated T-cell signalling defects, Br. J. Cancer, 92, 305, 10.1038/sj.bjc.6602316 · DOI
  20. Taylor, 2008, MicroRNA signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer, Gynecol. Oncol., 110, 13, 10.1016/j.ygyno.2008.04.033 · DOI
  21. Logozzi, 2009, High levels of exosomes expressing CD63 and caveolin- 1 in plasma of melanoma patients, PLoS One, 4, 10.1371/journal.pone.0005219 · DOI
  22. Logozzi, 2017, Increased PSA expression on prostate cancer exosomes in in vitro condition and in cancer patients, Cancer Lett., 403, 318, 10.1016/j.canlet.2017.06.036 · DOI
  23. Huber, 2005, Human colorectal cancer cells induce T-cell death through, Gastroenterology, 128, 1796, 10.1053/j.gastro.2005.03.045 · DOI
  24. Bukong, 2014, Exosomes from hepatitis C infected patients transmit HCV infection and contain replication competent viral RNA in complex with Ago2-miR122-HSP90, PLoS Pathog., 10, 10.1371/journal.ppat.1004424 · DOI
  25. Ratajczak, 2006, Embryonic stem cell-derived microvesicles reprogram hematopoietic progenitors: evidence for horizontal transfer of mRNA and protein delivery, Leukemia, 20, 847, 10.1038/sj.leu.2404132 · DOI
  26. Bianco, 2009, Therapeutic effect of exosomes from indoleamine 2,3-dioxygenase-positive dendritic cells in collagen-induced arthritis and delayed-type hypersensitivity disease models, Arthritis Rheum., 60, 380, 10.1002/art.24229 · DOI
  27. Lai, 2010, Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury, Stem Cell Res., 4, 214, 10.1016/j.scr.2009.12.003 · DOI · Paper page
  28. Xin, 2013, Systemic administration of exosomes released from mesenchymal stromal cells promote functional recovery and neurovascular plasticity after stroke in rats, J. Cereb. Blood Flow Metab., 33, 1711, 10.1038/jcbfm.2013.152 · DOI
  29. Viaud, 2011, Updated technology to produce highly immunogenic dendritic cell-derived exosomes of clinical grade: a critical role of interferon-γ, J. Immunother., 34, 65, 10.1097/CJI.0b013e3181fe535b · DOI
  30. Besse, 2016, Dendritic cell-derived exosomes as maintenance immunotherapy after first line chemotherapy in NSCLC, Oncoimmunology, 5, 10.1080/2162402X.2015.1071008 · DOI · Paper page
  31. Nassar, 2016, Umbilical cord mesenchymal stem cells derived extracellular vesicles can safely ameliorate the progression of chronic kidney diseases, Biomater. Res., 20, 21, 10.1186/s40824-016-0068-0 · DOI
  32. Kordelas, 2014, MSC-derived exosomes: a novel tool to treat therapy-refractory graft-versus-host disease, Leukemia, 28, 970, 10.1038/leu.2014.41 · DOI
  33. Kirouac, 2008, The systematic production of cells for cell therapies, Cell Stem Cell, 3, 369, 10.1016/j.stem.2008.09.001 · DOI
  34. Ahrlund-Richter, 2008, Perspective isolation and production of cells suitable for human therapy: challenges ahead, Cell Stem Cell, 4, 20, 10.1016/j.stem.2008.11.012 · DOI
  35. Bergman, 2007, The global stem cell patent landscape: implications for efficient technology transfer and commercial development, Nat. Biotechnol., 25, 419, 10.1038/nbt0407-419 · DOI
  36. Lau, 2008, Correspondence stem cell clinics online: the direct-to-consumer portrayal of stem cell medicine, Cell Stem Cell, 3, 591, 10.1016/j.stem.2008.11.001 · DOI
  37. Isasi, 2016, Uncertainty and innovation: understanding the role of cell-based manufacturing facilities in shaping regulatory and commercialization environments, Appl. Transl. Genomics, 11, 27, 10.1016/j.atg.2016.11.001 · DOI
  38. Li, 2014, The global landscape of stem cell clinical trials, Regen. Med., 9, 27, 10.2217/rme.13.80 · DOI
  39. Vishnubhatla, 2014, The development of stem cell-derived exosomes as a cell-free regenerative medicine, J. Circ. Biomark., 3, 58597, 10.5772/58597 · DOI
  40. Gardiner, 2016, Techniques used for the isolation and characterization of extracellular vesicles: results of a worldwide survey, J. Extracell. Vesicles, 5, 1, 10.3402/jev.v5.32945 · DOI
  41. Chen, 2011, Critical microcarrier properties affecting the expansion of undifferentiated human embryonic stem cells, Stem Cell Res., 7, 97, 10.1016/j.scr.2011.04.007 · DOI
  42. Fernandes, 2007, Mouse embryonic stem cell expansion in a microcarrier-based stirred culture system, J. Biotechnol., 132, 227, 10.1016/j.jbiotec.2007.05.031 · DOI
  43. Gerlach, 2012, Adipogenesis of human adipose-derived stem cells, Tissue Eng. C Methods, 18, 54, 10.1089/ten.tec.2011.0216 · DOI
  44. Carswell, 2000, Culture of human T cells in stirred bioreactors for cellular immunotherapy applications: shear, proliferation, and the IL-2 receptor, Biotechnol. Bioeng., 68, 328, 10.1002/(SICI)1097-0290(20000505)68:3<328::AID-BIT11>3.0.CO;2-V · DOI
  45. Brindley, 2011, Bioprocess forces and their impact on cell behavior: implications for bone regeneration therapy, J. Tissue Eng., 2011, 620247
  46. Bollini, 2013, The regenerative role of the fetal and adult stem cell secretome, J. Clin. Med., 2, 302, 10.3390/jcm2040302 · DOI
  47. Crescitelli, 2013, Distinct RNA profiles in subpopulations of extracellular vesicles: apoptotic bodies, microvesicles and exosomes 3, J. Extracell. Vesicles, 2, 1, 10.3402/jev.v2i0.20677 · DOI · Paper page
  48. Théry, 2001, Proteomic analysis of dendritic cell-derived exosomes: a secreted subcellular compartment distinct from apoptotic vesicles, J. Immunol., 166, 7309, 10.4049/jimmunol.166.12.7309 · DOI
  49. Wen, 2011, Collection of in vivo-like liver cell secretome with alternative sample enrichment method using a hollow fiber bioreactor culture system combined with tangential flow filtration for secretomics analysis, Anal. Chim. Acta, 684, 2010, 10.1016/j.aca.2010.10.040 · DOI
  50. Mitchell, 2008, Increased exosome production from tumour cell cultures using the Integra CELLine Culture System, J. Immunol. Methods, 335, 98, 10.1016/j.jim.2008.03.001 · DOI
  51. Jeon, 2012, Decreased contact inhibition in mouse adipose mesenchymal stem cells, Dev. Reprod., 16, 329, 10.12717/DR.2012.16.4.329 · DOI
  52. Shelke, 2014, Importance of exosome depletion protocols to eliminate functional and RNA-containing extracellular vesicles from fetal bovine serum, J. Extracell. Vesicles, 1, 1
  53. Li, 2015, Serum-free culture alters the quantity and protein composition of neuroblastoma-derived extracellular vesicles, J. Extracell. Vesicles, 4, 1, 10.3402/jev.v4.26883 · DOI
  54. Schnitzler, 2017, Harvest of human mesenchymal stem cells from microcarriers, BioPharm Int., 2017
  55. Li, 2017, Progress in exosome isolation techniques, Theranostics, 7, 789, 10.7150/thno.18133 · DOI
  56. Reimer, 1967, Purification of large quantities of influenza virus by density gradient centrifugation, J. Virol., 1, 1207, 10.1128/jvi.1.6.1207-1216.1967 · DOI
  57. Morenweiser, 2005, Downstream processing of viral vectors and vaccines, Gene Ther., 12, S103, 10.1038/sj.gt.3302624 · DOI
  58. Cvjetkovic, 2014, The influence of rotor type and centrifugation time on the yield and purity of extracellular vesicles, J. Extracell. Vesicles, 3, 1, 10.3402/jev.v3.23111 · DOI
  59. Witwer, 2013, Standardization of sample collection, isolation and analysis methods in extracellular vesicle research, J. Extracell. Vesicles, 2, 1, 10.3402/jev.v2i0.20360 · DOI
  60. Linares, 2015, High-speed centrifugation induces aggregation of extracellular vesicles, J. Extracell. Vesicles, 4, 1, 10.3402/jev.v4.29509 · DOI
  61. van der Pol, 2015, Recent developments in the nomenclature, presence, isolation, detection and clinical impact of extracellular vesicles, J. Thromb. Haemost., 14, 48, 10.1111/jth.13190 · DOI
  62. Welton, 2015, Ready-made chromatography columns for extracellular vesicle isolation from plasma, J. Extracell., 1, 1
  63. Li, 2017, Progress in exosome isolation techniques, Theranostics, 7, 789, 10.7150/thno.18133 · DOI
  64. Tan, 2013, Therapeutic MSC exosomes are derived from lipid raft microdomains in the plasma membrane, J. Extracell. Vesicles, 2, 1, 10.3402/jev.v2i0.22614 · DOI
  65. Nordin, 2015, Ultrafiltration with size-exclusion liquid chromatography for high yield isolation of extracellular vesicles preserving intact biophysical and functional properties, Nanomedicine, 11, 879, 10.1016/j.nano.2015.01.003 · DOI
  66. Tauro, 2012, Comparison of ultracentrifugation, density gradient separation, and immunoaffinity capture methods for isolating human colon cancer cell line LIM1863-derived exosomes, Methods, 56, 293, 10.1016/j.ymeth.2012.01.002 · DOI
  67. Webber, 2013, How pure are your vesicles?, J. Extracell. Vesicles, 2, 1, 10.3402/jev.v2i0.19861 · DOI · Paper page
  68. Helwa, 2017, A comparative study of serum exosome isolation using differential ultracentrifugation and three commercial reagents, PLoS One, 12, 10.1371/journal.pone.0170628 · DOI
  69. Yavuz, 2009, Magnetic separations: from steel plants to biotechnology, Chem. Eng. Sci., 64, 2510, 10.1016/j.ces.2008.11.018 · DOI
  70. Kosanovic, 2017, Ion-exchange chromatography purification of extracellular vesicles, Biotechniques, 63, 65, 10.2144/000114575 · DOI
  71. Burden, 2012, A monolith purification process for virus-like particles from yeast homogenate, J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci., 880, 82, 10.1016/j.jchromb.2011.10.044 · DOI
  72. Lotvall, 2014, Minimal experimental requirements for definition of extracellular vesicles and their functions: a position statement from the International Society for Extracellular Vesicles, J. Extracell. Vesicles, 3, 1, 10.3402/jev.v3.26913 · DOI · Paper page
  73. Suárez, 2017, A bead-assisted flow cytometry method for the semi-quantitative analysis of extracellular vesicles, Sci. Rep., 7, 11271, 10.1038/s41598-017-11249-2 · DOI
  74. Sofer, 2003, Virus inactivation in the 1990 — and into the 21st century, BioPharm, 15, 28

Cited by

Sorted by citations

See all 396

Metadata

Authors
Colao, I. L., Corteling, R., Bracewell, D., & Wall, I.
Venue
Trends in Molecular Medicine
Publisher
Elsevier BV
Published
2018-03
Volume
24
Issue
3
Pages
242-256
ISSN
1471-4914
Cited by
396
References
5
Language
en
Funders
  • Engineering and Physical Sciences Research Council (EP/G034656/1)
  • National Research Foundation of Korea
  • Ministry of Education, Science and Technology (2009-0093829)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Manufacturing Exosomes: A Promising Therapeutic Platform. https://app.cochat.ai/papers/10.1016/j.molmed.2018.01.006
The paper
Colao, I. L., Corteling, R., Bracewell, D., & Wall, I. (2018). Manufacturing Exosomes: A Promising Therapeutic Platform. Trends in Molecular Medicine. https://doi.org/10.1016/j.molmed.2018.01.006