Cited by 229Fatty Acid Research and HealthPhagocytosis and Immune RegulationImmune Response and Inflammation

Is resolution the end of inflammation?

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Feehan, Karen T., Gilroy, Derek W.·2019·Trends in Molecular Medicine

Abstract

Deciphering the origins of chronic inflammatory and autoimmune diseases remains elusive with reliance on therapies aimed at halting inflammation in its tracks. In recent years, an appreciation of targeting pathways by which inflammation is resolved has begun to rouse interest. Resolution of inflammation is driven by a complex set of mediators that regulate cellular events required to clear inflammatory cells from sites of infection or injury to restore tissue function. However, recent studies suggest that resolution is not the end of innate mediated immune responses to infection/injury. There is further immunological activity occurring after the resolution cascade is complete that alters the immune physiology of tissues, redefining what was once termed restorative homeostasis as adapted homeostasis.

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Crossref · 10.1016/j.molmed.2019.01.006

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  • Turning off inflammation is an active process with distinct signalling and effector pathways that affect downstream immune responses.

    “We now appreciate that switching off inflammation is an equally involved process with distinct signalling and effector pathways all of which impact downstream immune responses (32).”

    From The impact of ageing on monocytes and macrophages (2021) · cites this paper as [32]

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Authors
Feehan, K. T., & Gilroy, D. W.
Affiliations
University College London (GB)
Corresponding author
Gilroy, Derek W.
Venue
Trends in Molecular Medicine
Publisher
Elsevier BV
Published
2019-03
Volume
25
Issue
3
Pages
198-214
ISSN
1471-4914 (ISSN-L)
OpenAlex
W2918019780
Cited by
229
References
148
Citations by year
2026: 22 · 2025: 32 · 2024: 40 · 2023: 43 · 2022: 37 · 2021: 30 · 2020: 22 · 2019: 3
FWCI
3.11
Type
journal article
Language
en
Open access
Locations
  • Trends in Molecular Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • UCL Discovery (University College London) (submittedVersion)
Funders
Biotechnology and Biological Sciences Research Council (1788941)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
  • Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords
inflammation resolution, chronic inflammation, autoimmune disease, innate immunity, adaptive homeostasis, tissue repair, inflammatory mediators
MeSH terms
Acute Disease, Animals, Chronic Disease, Disease Susceptibility, Humans, Immunity, Inflammation, Signal Transduction, Biomarkers, Cytokines, Inflammation Mediators

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