Is resolution the end of inflammation?
Open accessAbstract
Deciphering the origins of chronic inflammatory and autoimmune diseases remains elusive with reliance on therapies aimed at halting inflammation in its tracks. In recent years, an appreciation of targeting pathways by which inflammation is resolved has begun to rouse interest. Resolution of inflammation is driven by a complex set of mediators that regulate cellular events required to clear inflammatory cells from sites of infection or injury to restore tissue function. However, recent studies suggest that resolution is not the end of innate mediated immune responses to infection/injury. There is further immunological activity occurring after the resolution cascade is complete that alters the immune physiology of tissues, redefining what was once termed restorative homeostasis as adapted homeostasis.
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Turning off inflammation is an active process with distinct signalling and effector pathways that affect downstream immune responses.
“We now appreciate that switching off inflammation is an equally involved process with distinct signalling and effector pathways all of which impact downstream immune responses (32).”
From The impact of ageing on monocytes and macrophages (2021) · cites this paper as [32]
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Inflammation and tumor progression: signaling pathways and targeted intervention
Zhao, H., Wu, L., Yan, G., Chen, Y., Zhou, M., Wu, Y., & Li, Y. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00658-5 · Cited by 2,907 · see citing works
Modulation of the Inflammatory Response and Bone Healing
Maruyama, M., Rhee, C., Utsunomiya, T., Zhang, N., Ueno, M., Yao, Z., & Goodman, S. B. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00386 · Cited by 541 · see citing works
“However, more recently, the resolution of inflammation is thought to be an active process, regulated by various mediators and immune cells (13).”
BackgroundFlavonoids and their role in oxidative stress, inflammation, and human diseases
Jomová, K., Alomar, S. Y., Valko, R., Líška, J., Nepovimová, E., Kuča, K., & Valko, M. (2025) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2025.111489 · Cited by 413 · see citing works
Inhibition of inflammation by berberine: Molecular mechanism and network pharmacology analysis
Wang, K., Yin, J., Chen, J., Ma, J., Si, H., & Xia, D. (2024) · Phytomedicine · doi:10.1016/j.phymed.2023.155258 · Cited by 301 · see citing works
The impact of ageing on monocytes and macrophages
De Maeyer, R. P. H., & Chambers, E. S. (2021) · Immunology Letters · doi:10.1016/j.imlet.2020.12.003 · Cited by 275 · see citing works
“6 | P a g e pathways all of which impact downstream immune responses (32).”
BackgroundEmerging Role of cAMP/AMPK Signaling
Aslam, M., & Ladilov, Y. (2022) · Cells · doi:10.3390/cells11020308 · Cited by 241 · see citing works
“Inflammation is an adaptive response triggered by noxious stimuli and conditions such as infection and tissue injury [89].”
BackgroundPillon, N. J., Loos, R. J. F., Marshall, S. M., & Zierath, J. R. (2021) · Cell · doi:10.1016/j.cell.2021.02.012 · Cited by 238 · see citing works
“The immune response comes in waves, starting with a pro-inflammatory activation and finishing with a resolving anti-inflammatory phase (Feehan and Gilroy, 2019).”
Ge, J., Liu, Z., Zhong, Z., Wang, L., Zhuo, X., Li, J., Jiang, X., Ye, X., Xie, T., & Bai, R. (2022) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2022.105817 · Cited by 183 · see citing works
Richard, S. A. (2021) · Mediators of Inflammation · doi:10.1155/2021/6699560 · Cited by 177 · see citing works
“The fundamental processes involved in the eradication of threats posed to the host to organisms like bacterial and viral infections are the triggering of an acute inflammatory response [35].”
Inflammatory Networks Linking Oral Microbiome with Systemic Health and Disease
Kleinstein, S. E., Nelson, K. E., & Freire, M. (2020) · Journal of Dental Research · doi:10.1177/0022034520926126 · Cited by 170 · see citing works
Reactive Oxygen Species Bridge the Gap between Chronic Inflammation and Tumor Development
Yu, W., Tu, Y., Long, Z., Liu, J., Kong, D., Peng, J., Wu, H., Zheng, G., Zhao, J., Chen, Y., et al. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/2606928 · Cited by 161 · see citing works
“If the irritations persist, aggregation of inflammatory cells and cytokines can transform acute inflammation into the chronic stage, potentially inducing local and systemic deleterious effects [62].”
NLRP3 inflammasome in neurodegenerative disease
Anderson, F. L., Biggs, K. E., Rankin, B. E., & Havrda, M. C. (2022) · Translational research · doi:10.1016/j.trsl.2022.08.006 · Cited by 143 · see citing works
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Biological processes and factors involved in soft and hard tissue healing
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Role of Histone Post-Translational Modifications in Inflammatory Diseases
Lin, Y., Qiu, T., Wei, G., Que, Y., Wang, W., Kong, Y., Xie, T., & Chen, X. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.852272 · Cited by 95 · see citing works
“It is a frequent occurrence to protect organisms from the spread of infection and recover the affected compartments to a normal state, which is called “resolution” (2).”
BackgroundYao, Z., Qi, W., Zhang, H., Zhang, Z., Liu, L., Shao, Y., Zeng, H., Yin, J., Pan, H., Guo, X., et al. (2023) · eLife · doi:10.7554/elife.83069 · Cited by 88 · see citing works
“The balance of progression and regression that controls the state of local inflammation has recently been in the spotlight ( Oishi and Manabe, 2018 ; Feehan and Gilroy, 2019 ).”
Negreiros-Lima, G. L., Lima, K. M., Moreira, I. Z., Jardim, B. L. O., Vago, J. P., Galvão, I., Teixeira, L. C. R., Pinho, V., Teixeira, M. M., Sugimoto, M. A., et al. (2020) · Cells · doi:10.3390/cells9010128 · Cited by 80 · see citing works
“If successful, the inflammatory response tends to progress from the onset to the post-resolution phase through a coordinated series of molecular and cellular events that lead to the restoration of tissue structure, organ function, and ‘adapted homeostasis’ [5].”
BackgroundWei, Y., Meng, Y., Li, N., Wang, Q., & Chen, L.-Y. (2020) · Food & Function · doi:10.1039/d0fo01976c · Cited by 64 · see citing works
Targeting epigenetic regulators for inflammation: Mechanisms and intervention therapy
Zhang, S., Meng, Y., Zhou, L., Qiu, L., Wang, H., Su, D., Zhang, B., Chan, K. M., & Han, J. (2022) · MedComm · doi:10.1002/mco2.173 · Cited by 82 · see citing works
Liu, F., Wu, J., Gong, L.-J., Yang, H.-S., & Chen, H. (2024) · Frontiers in Neuroscience · doi:10.3389/fnins.2024.1490300 · Cited by 80 · see citing works
Desmosomes as Signaling Hubs in the Regulation of Cell Behavior
Müller, L., Hatzfeld, M., & Keil, R. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.745670 · Cited by 78 · see citing works
Therapeutic Potential of Lipoxin A4 in Chronic Inflammation: Focus on Cardiometabolic Disease
Fu, T., Mohan, M., Brennan, E. P., Woodman, O. L., Godson, C., Kantharidis, P., Ritchie, R. H., & Qin, C. X. (2020) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.9b00097 · Cited by 76 · see citing works
Medical Cannabis Activity Against Inflammation: Active Compounds and Modes of Action
Anil, S. M., Peeri, H., & Koltai, H. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.908198 · Cited by 76 · see citing works
Myeloid-derived suppressor cells (MDSC): When good intentions go awry
Sanchez‐Pino, M. D., Dean, M. J., & Ochoa, A. C. (2021) · Cellular Immunology · doi:10.1016/j.cellimm.2021.104302 · Cited by 72 · see citing works
Potential use of antioxidants for the treatment of chronic inflammatory diseases
Blagov, A. V., Summerhill, V. I., Sukhorukov, V. N., Zhigmitova, E. B., Postnov, A. Y., & Orekhov, A. N. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1378335 · Cited by 72 · see citing works
Nanotechnology in inflammation: cutting-edge advances in diagnostics, therapeutics and theranostics
Liu, Y., Lin, Z., Wang, Y., Chen, L., Wang, Y., & Luo, C. (2024) · Theranostics · doi:10.7150/thno.91394 · Cited by 69 · see citing works
“However, long-term inflammatory reactions can lead to the dysfunction of cells, tissues, organs and living systems, and also increase the risks of chronic diseases [2].”
BackgroundThe Impact of the CB2 Cannabinoid Receptor in Inflammatory Diseases: An Update
Rakotoarivelo, V., Mayer, T. Z., Simard, M., Flamand, N., & Marzo, V. D. (2024) · Molecules · doi:10.3390/molecules29143381 · Cited by 69 · see citing works
“These disorders evolve from a sustained activation of the immune system that can be localized and/or disseminated throughout the body [3].”
BackgroundTargeting AhR as a Novel Therapeutic Modality against Inflammatory Diseases
Cannon, A. S., Nagarkatti, P. S., & Nagarkatti, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms23010288 · Cited by 67 · see citing works
Cerebrospinal Fluid Profile of Lipid Mediators in Alzheimer’s Disease
Do, K. V., Hjorth, E., Wang, Y., Jun, B., Kautzmann, M.-A. I., Ohshima, M., Eriksdotter, M., Schultzberg, M., & Bazan, N. G. (2022) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-022-01216-5 · Cited by 65 · see citing works
“However, in addition to the role of PGs at the initiation of an inflammatory response (Serhan and Savill 2005), it is hypothesized that there is a post-resolution immunological activity during which PGE2 may exert modulatory and anti-inflammatory effects (Feehan and Gilroy 2019).”
BackgroundAnti-inflammatory potential of ulvan
Flórez-Fernández, N., Rodríguez-Coello, A., Latire, T., Bourgougnon, N., Torres, M. D., Buján, M., Muíños, A., Muiños, A., Meijide-Faílde, R., Blanco, F. J., et al. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.126936 · Cited by 66 · see citing works
Carvalheiro, T., García, S., Ramos, M., Giovannone, B., Radstake, T., Marut, W., & Meyaard, L. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01793 · Cited by 60 · see citing works
“Uncontrolled inflammation is a key player in the pathogenesis of many chronic conditions and a persistent inflammatory response can lead to significant tissue and organ damage (3, 4).”
BackgroundAlterations of Lipid Profile in COVID-19: A Narrative Review
Rezaei, A., Neshat, S., & Heshmat‐Ghahdarijani, K. (2021) · Current Problems in Cardiology · doi:10.1016/j.cpcardiol.2021.100907 · Cited by 61 · see citing works
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Gao, J., Dong, X., Su, Y., & Wang, Z. (2021) · Acta Biomaterialia · doi:10.1016/j.actbio.2021.01.020 · Cited by 60 · see citing works
“Inflammatory diseases are associated with the failure of inflammation resolution after infections [34, 35].”
BackgroundLipoxin Mimetics and the Resolution of Inflammation
Godson, C., Guiry, P. J., & Brennan, E. P. (2023) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-051921-085407 · Cited by 58 · see citing works
Parenteral fish oil: An adjuvant pharmacotherapy for coronavirus disease 2019?
Torrinhas, R. S., Calder, P. C., Lemos, G., & Waitzberg, D. L. (2020) · Nutrition · doi:10.1016/j.nut.2020.110900 · Cited by 57 · see citing works
“Although they decrease proinflammatory mediator synthesis and neutrophil recruitment, they activate macrophages with an antiinflammatory phenotype (M2) and stimulate phagocytosis in a non-phlogistic manner [32].”
BackgroundImmune Response to Borrelia : Lessons from Lyme Disease Spirochetes
Bockenstedt, L. K., Wooten, R. M., & Baumgarth, N. (2020) · Current Issues in Molecular Biology · doi:10.21775/cimb.042.145 · Cited by 54 · see citing works
Livshits, G., & Kalinkovich, A. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.101852 · Cited by 55 · see citing works
Inflammation, Mitochondria and Natural Compounds Together in the Circle of Trust
Nesci, S., Spagnoletta, A., & Oppedisano, F. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076106 · Cited by 56 · see citing works
“Dysregulation of these processes can lead to uncontrolled chronic inflammation, resulting in the development of several associated diseases such as cardiovascular disease, atherosclerosis, Type 2 diabetes, rheumatoid arthritis, and cancers [37,38].”
BackgroundWylezinski, L. S., Gray, J. D., Polk, J. B., Harmata, A. J., & Spurlock, C. F. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8040493 · Cited by 49 · see citing works
“However, when the immune system becomes dysregulated, it can cause serious harm and even lead to tissue and organ system destruction in the case of prolonged inflammation [1].”
BackgroundSong, Y., Hu, J., Ma, C., Liu, H., Li, Z., & Yang, Y. (2024) · International Journal of Nanomedicine · doi:10.2147/ijn.s449388 · Cited by 45 · see citing works
“(5 ) Most previous studies about inflammation have focused on the therapeutic effects of M-Exos on miRNAs, but proteins, lncRNAs, circRNAs and some other bioactive molecules may also participate in the function of exosomes.”
BackgroundFélix, F. B., Vago, J. P., Fernandes, D. D. O., Martins, D. G., Zaidan, I., Gonçalves, W. A., Costa, W. C., Araújo, J. M. D., Queiroz‐Junior, C. M., Campolina-Silva, G. H., et al. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.662308 · Cited by 44 · see citing works
“The resolution of inflammation is a complex process and actively orchestrated by specialized pro-resolving mediators that collaborate efficiently to inhibit the influx of leukocytes to the inflamed site, shutting down molecules of intracellular pathways associated with cytokine production and leukocyte survival (espec…”
BackgroundCarvalho, J. D. S., Ramadan, D., Gonçalves, V. D. P., Maquera-Huacho, P. M., Assis, R. P., Lima, T. F. O., Brunetti, I. L., Spolidório, D. M. P., Cesar, T. B., Manthey, J. A., et al. (2021) · Food & Function · doi:10.1039/d0fo03338c · Cited by 43 · see citing works
Macrophage Activation in the Synovium of Healthy and Osteoarthritic Equine Joints
Menarim, B. C., Gillis, K. H., Oliver, A., Ngo, Y., Werre, S. R., Barrett, S. H., Rodgerson, D. H., & Dahlgren, L. A. (2020) · Frontiers in Veterinary Science · doi:10.3389/fvets.2020.568756 · Cited by 45 · see citing works
Effects of Anthraquinones on Immune Responses and Inflammatory Diseases
Xin, D., Li, H., Zhou, S., Zhong, H., & Pu, W. (2022) · Molecules · doi:10.3390/molecules27123831 · Cited by 45 · see citing works
“Inflammation is a defense response of the body to stimuli, manifested as redness, swelling, heat, pain and dysfunction [7].”
BackgroundGonzalez, A. L., Dungan, M. M., Smart, C. D., Madhur, M. S., & Doran, A. C. (2023) · Antioxidants and Redox Signaling · doi:10.1089/ars.2023.0284 · Cited by 41 · see citing works
“Cytokines and chemokines already present within the tissue undergo cleavage and sequestration, preventing them from binding and activating their cognate receptors (Charo and Ransohoff, 2006; Feehan and Gilroy, 2019).”
Moreira, V., Leiguez, E., Janovits, P. M., Maia-Marques, R., Fernándes, C. M., & Teixeira, C. (2021) · Toxins · doi:10.3390/toxins13120868 · Cited by 40 · see citing works
How do sphingosine-1-phosphate affect immune cells to resolve inflammation?
Sun, G., Wang, B., Wu, X., Cheng, J., Ye, J., Wang, C., Zhu, H., & Liu, X. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1362459 · Cited by 38 · see citing works
Local Immunomodulatory Effects of Intracanal Medications in Apical Periodontitis
Hussein, H., & Kishen, A. (2022) · Journal of Endodontics · doi:10.1016/j.joen.2022.01.003 · Cited by 38 · see citing works
Gugliandolo, E., Peritore, A. F., Piras, C., Cuzzocrea, S., & Crupi, R. (2020) · Veterinary Sciences · doi:10.3390/vetsci7020078 · Cited by 36 · see citing works
“It is generally believed that a controlled inflammatory response is beneficial, but it can become detrimental if dysregulated, with uncontrolled inflammation being a key player in the pathogenesis of several diseases [110,111].”
BackgroundWang, R., Shi, X. L., Li, K., Bunker, A., & Li, C. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.125120 · Cited by 36 · see citing works
Anti-Inflammatory Activity of a Peptide from Skipjack (Katsuwonus pelamis)
Wang, Z., Ying, X., Gao, P., Wang, C., Wang, Y., Yu, X.-W., Chen, J., Wang, B., & Luo, H. (2019) · Marine Drugs · doi:10.3390/md17100582 · Cited by 35 · see citing works
“The most widely used inflammation treatment approach is to inhibit the synthesis or action of mediators that drive inflammation using drugs including nonsteroidal anti-inflammatory drugs (NSAIDs) and anticytokine therapies, such as anti-tumor necrosis factor (TNF)-α [4].”
BackgroundTomiyama, T., Itoh, S., Iseda, N., Toshida, K., Morinaga, A., Yugawa, K., Kosai‐Fujimoto, Y., Tomino, T., Kurihara, T., Nagao, Y., et al. (2022) · Oncology Letters · doi:10.3892/ol.2022.13213 · Cited by 33 · see citing works
Proresolving Lipid Mediators and Receptors in Stem Cell Biology: Concise Review
Romano, M., Patruno, S., Pomilio, A., & Recchiuti, A. (2019) · Stem Cells Translational Medicine · doi:10.1002/sctm.19-0078 · Cited by 32 · see citing works
Sousa, L. P., Pinho, V., & Teixeira, M. M. (2020) · British Journal of Pharmacology · doi:10.1111/bph.15164 · Cited by 32 · see citing works
“However, tissues tend not to return completely to their pre-inflamed state, in terms of cellular composition and phenotype, as previously thought, but to a state of “adapted homoeostasis,” which modifies the severity of subsequent inflammatory responses (Feehan & Gilroy, 2019).”
BackgroundNon-inflammatory Physiology of “Inflammatory” Mediators – Unalamation, a New Paradigm
Maddipati, K. R. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.580117 · Cited by 32 · see citing works
“While antiinflammatory properties also were attributed to COX-2, its role is in the resolution of inflammation rather than its inhibition (6, 15, 66).”
BackgroundLin, Y., Liu, S., Sun, Y., Chen, C., Yang, S., Pei, G., Lin, M., Yu, J., Liu, X., Wang, H., et al. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102286 · Cited by 31 · see citing works
Transcriptomics of type 2 diabetic and healthy human neutrophils
Kleinstein, S. E., McCorrison, J., Ahmed, A. R., Hastürk, H., Dyke, T. E. V., & Freire, M. (2021) · BMC Immunology · doi:10.1186/s12865-021-00428-6 · Cited by 31 · see citing works
Friuli, M., Eramo, B., Valenza, M., Scuderi, C., Provensi, G., & Romano, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910250 · Cited by 32 · see citing works
Qin, F., Zhang, H., Di, Q., Wang, Y., Yan, Y., Chen, W., & Cheng, Y. (2020) · Organic Letters · doi:10.1021/acs.orglett.0c00452 · Cited by 30 · see citing works
Tissue compartmentalization enables Salmonella persistence during chemotherapy
Li, J., Claudi, B., Fanous, J., Chicherova, N., Cianfanelli, F. R., Campbell, R. A. A., & Bumann, D. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2113951118 · Cited by 29 · see citing works
Inflammation resolution in environmental pulmonary health and morbidity
Marzec, J. M., & Nadadur, S. S. (2022) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2022.116070 · Cited by 29 · see citing works
Ferreira, B. L., Ferreira, D. P., Borges, S. F., Ferreira, A. M., Holanda, F. H., Ucella-Filho, J. G. M., Cruz, R. A. S., Birolli, W. G., Luque, R., & Ferreira, I. M. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1207664 · Cited by 28 · see citing works
“This process aims to block, inactivate, or eliminate harmful agents (Borges et al., 2018; Feehan and Gilroy, 2019).”
BackgroundAmador‐Martínez, I., Aparicio‐Trejo, O. E., Bernabe-Yepes, B., Aranda‐Rivera, A. K., Cruz‐Gregorio, A., Sánchez‐Lozada, L. G., Pedraza‐Chaverrí, J., & Tapia, E. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242115875 · Cited by 28 · see citing works
Manginstar, C., Tallei, T. E., Niode, N. J., Salaki, C. L., & Hessel, S. S. (2023) · Phytotherapy Research · doi:10.1002/ptr.8092 · Cited by 31 · see citing works
“Inflammation resolution is the process of restoring tissue homeostasis and preventing the development of chronic inflammation (Feehan & Gilroy, 2019).”
BackgroundLi, H., Ruan, J., Huang, J., Yang, D., Yu, H., Wu, Y. C., Zhang, Y., & Wang, T. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242417538 · Cited by 28 · see citing works
Role of Tristetraprolin in the Resolution of Inflammation
Rappl, P., Brüne, B., & Schmid, T. (2021) · Biology · doi:10.3390/biology10010066 · Cited by 26 · see citing works
“In fact, successful resolution is not the end of this dynamic process, but recent reports indicate that it is followed by a prolonged post-resolution phase characterized by an altered, immune suppressive environment [28,29].”
BackgroundLiu, Z., Yu, W., Zhou, H., Lan, Z., Wu, T., Xiong, S., Yan, L., & Liu, H. (2021) · Journal of Food Biochemistry · doi:10.1111/jfbc.13889 · Cited by 27 · see citing works
Menarim, B. C., Gillis, K. H., Oliver, A., Mason, C., Werre, S. R., Luo, X., Byron, C. R., Kalbfleisch, T., MacLeod, J. N., & Dahlgren, L. A. (2020) · The FASEB Journal · doi:10.1096/fj.201902698r · Cited by 26 · see citing works
Hydroxytyrosol: A Promising Therapeutic Agent for Mitigating Inflammation and Apoptosis
Batarfi, W. A., Yunus, M. H. M., Hamid, A. A., Lee, Y. T., & Maarof, M. (2024) · Pharmaceutics · doi:10.3390/pharmaceutics16121504 · Cited by 25 · see citing works
Lipoxins and synthetic lipoxin mimetics: Therapeutic potential in renal diseases
Andrews, D. C., & Godson, C. (2021) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2021.158940 · Cited by 26 · see citing works
Complement activation links inflammation to dental tissue regeneration
Bergmann, M., Jeanneau, C., Giraud, T., Richard, G., & About, I. (2020) · Clinical Oral Investigations · doi:10.1007/s00784-020-03621-w · Cited by 24 · see citing works
“This is followed by the inflammation resolution which is regulated by multiple mediators and immune cells [3].”
BackgroundBlood-based biomarkers of chronic inflammation
Pritzker, K. P. H. (2023) · Expert Review of Molecular Diagnostics · doi:10.1080/14737159.2023.2215928 · Cited by 24 · see citing works
Promising Antioxidant Activity of Erythrina Genus: An Alternative Treatment for Inflammatory Pain?
Cabrera, T. J., Bautista, M., Velázquez, C., Jaramillo‐Morales, O. A., Guerrero-Solano, J. A., Urrutia-Hernández, T. A., & la O‐Arciniega, M. D. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms22010248 · Cited by 23 · see citing works
“Several mediators are involved in the inflammatory pathway, prostaglandins, leukotrienes, cytokines, plateletactivating factor, and chemokines [89].”
BackgroundThe role of miR-155 on liver diseases by modulating immunity, inflammation and tumorigenesis
Xue, X., Wang, J., Fu, K., Dai, S., Wu, R. T., Peng, C., & Li, Y. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.109775 · Cited by 24 · see citing works
Effects of fermented dairy products on inflammatory biomarkers: A meta-analysis
Zhang, X., Luo, Q., Guan, X.-X., Tang, Y., Chen, X., Deng, J., & Fan, J. (2022) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2022.12.014 · Cited by 25 · see citing works
Epithelial Barrier: Protector and Trigger of Allergic Disorders
Izquierdo, E., Rodríguez‐Coira, J., Dolset, M. I. D., Gómez‐Casado, C., Barber, D., & Escribese, M. M. (2022) · Journal of Investigational Allergology and Clinical Immunology · doi:10.18176/jiaci.0779 · Cited by 22 · see citing works
“…tissue does not return to previous homeostasis, but rather achieves an adapted homeostatic state in which, despite recovery of organ architecture and function, there are changes in cellular composition and phenotype, thus affecting the severity of future inflammatory responses [143,158,159].”
BackgroundLuo, J., Zhang, W.-Y., Li, H., Zhang, P.-H., Tian, C., Wu, C.-H., Zhao, A.-N., Chen, M.-L., Guo, Y.-F., Cho, Y.-C., et al. (2021) · Shock · doi:10.1097/shk.0000000000001865 · Cited by 21 · see citing works
“Previous studies report that ChemR23 and BLT1 are specific receptors for RvE1 (20).”
BackgroundInflammation and Exosomes in Fabry Disease Pathogenesis
Coelho-Ribeiro, B., Silva, H., Sampaio‐Marques, B., Fraga, A. G., Azevedo, O. M., Pedrosa, J., & Ludovico, P. (2024) · Cells · doi:10.3390/cells13080654 · Cited by 20 · see citing works
Radbakhsh, S., Katsiki, N., Santos, R. D., Mikhailidis, D. P., Mantzoros, C. S., & Sahebkar, A. (2022) · Metabolism · doi:10.1016/j.metabol.2022.155211 · Cited by 20 · see citing works
A multifunctional nanoparticle for efferocytosis and pro-resolving-mediated endometriosis therapy
Sun, Q., Lei, Y., Zhang, H., Ding, X., Yang, M., Zhang, T., Chen, J., Huang, Z., Wang, L., Lan, J., et al. (2022) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2022.112893 · Cited by 22 · see citing works
Resolution pharmacology and the treatment of infectious diseases
Costa, V. V., Resende, F., Melo, E. M., & Teixeira, M. M. (2024) · British Journal of Pharmacology · doi:10.1111/bph.16323 · Cited by 20 · see citing works
“A review of the data that has led to their classification as pro-resolving molecules is beyond the scope of the current review but can be found in other recent reviews on the subject (see Feehan & Gilroy, 2019; Panigrahy et al., 2021; Sugimoto et al., 2019).”
BackgroundWu, J., Xie, J., Chen, Y., Fu, X., Wang, R., Deng, Y.-Y., Wang, S., Yu, H., Liang, C., & Yu, Z. (2022) · Phytomedicine · doi:10.1016/j.phymed.2022.154194 · Cited by 20 · see citing works
The Use of Specialized Pro-Resolving Mediators in Biomaterial-Based Immunomodulation
Sousa, A. B., & Barbosa, J. N. (2023) · Journal of Functional Biomaterials · doi:10.3390/jfb14040223 · Cited by 19 · see citing works
“(Cys-SPMs) and n-3 docosapentaenoic acid (DPA)-derived SPMs (n-3 DPA-derived SPMs) [18].”
BackgroundInfluentialHou, C., Zhang, X., Wei, J., Wang, J.-N., Gao, J., Wang, Z.-J., Xie, S.-S., Chen, T., Sun, T., Pu, T., et al. (2025) · Science Immunology · doi:10.1126/sciimmunol.adv4810 · Cited by 19 · see citing works
NLRP3 Inflammasome: a Novel Insight into Heart Failure
Wang, Y., Li, Y., Zhang, W., Yuan, Z., Lv, S., & Zhang, J. (2022) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-022-10286-1 · Cited by 19 · see citing works
“Inflammation is the organism’s first immune defense against harmful stimuli, which occurs when the organism receives exogenous infection and endogenous cell tissue damage [11, 12].”
BackgroundHawkshaw, N. J., Pilkington, S. M., Murphy, S. A., Al‐Gazaq, N., Farrar, M. D., Watson, R. E. B., Nicolaou, A., & Rhodes, L. E. (2020) · Clinical & Translational Immunology · doi:10.1002/cti2.1104 · Cited by 17 · see citing works
“initiating inflammatory signal has subsided, a beneficial state of local immunosuppression remains.(8) This post-resolution phase is characterised by either a secondary infiltrate(9,10) or retention of immune cells following inflammatory resolution, and maintains an immunosuppressive environment.”
BackgroundWang, J.-Y., Xing, Y.-X., Li, M.-Y., Zhang, Z.-H., Jin, H.-L., Ma, J., Lee, J., Zhong, Y., Zuo, H.-X., & Jin, X.-J. (2021) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2021.114715 · Cited by 16 · see citing works
Signaling Pathways in Inflammation and Its Resolution: New Insights and Therapeutic Challenges
Cicala, C., & Morello, S. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241311055 · Cited by 16 · see citing works
“In recent years, the research in this field has been working towards clarifying these pro-resolving pathways and signaling pathways that may be targets for therapeutic intervention [1,2].”
BackgroundSalminen, A. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102926 · Cited by 15 · see citing works
Menarim, B. C., MacLeod, J. N., & Dahlgren, L. A. (2021) · World Journal of Stem Cells · doi:10.4252/wjsc.v13.i7.825 · Cited by 15 · see citing works
Han, L., Wu, X., Wang, O., Luan, X., Velander, W. H., Aynardi, M. C., Halstead, E. S., Bonavia, A. S., Jin, R., Li, G., et al. (2023) · Theranostics · doi:10.7150/thno.83942 · Cited by 15 · see citing works
“These mechanisms, designed to work together to prevent severe inflammation, often fail in patients with severe medical comorbidities and/or compromised immunity [3,4].”
Xu, J., Zhou, L., Sun, L., Wang, Z., Wang, Y., Wang, Y., & He, X. (2020) · Journal of Natural Products · doi:10.1021/acs.jnatprod.0c00990 · Cited by 15 · see citing works
Diversity-oriented synthesis of diterpenoid alkaloids yields a potent anti-inflammatory agent
Li, X., Zhang, J., Chen, Q., Tang, P., Zhang, T., Feng, Q., Chen, J., Liu, Y., Peng, C. Y., Peng, C. Y., et al. (2023) · Phytomedicine · doi:10.1016/j.phymed.2023.154907 · Cited by 14 · see citing works
Tonic Meningeal Interleukin-10 Upregulates Delta Opioid Receptor to Prevent Relapse to Pain
Inyang, K. E., Sim, J., Clark, K. B., Geron, M., Monahan, K., Evans, C., O’Connell, P., Laumet, S., Peng, B., Ma, J., et al. (2023) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2024.09.031 · Cited by 14 · see citing works
Flaxseed Ethanol Extract Effect in Acute Experimental Inflammation
Chera, E. I., Pop, T. I., Pop, R. M., Pârvu, M., Uifălean, A., Cătoi, A. F., Cecan, A. D., Mîrza, C.-M., Achimaș-Cădariu, P., & Pârvu, A. E. (2022) · Medicina · doi:10.3390/medicina58050582 · Cited by 13 · see citing works
“Moreover, it was suggested that this can be a risk for the development of chronic inflammation [1], because, in many chronic conditions, the”
Backgroundde Oliveira, V. L. S., Pollenus, E., Berghmans, N., Queiroz‐Junior, C. M., Blanter, M., Mattos, M. S., Teixeira, M. M., Proost, P., den Steen, P. E. V., Amaral, F. A., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232112920 · Cited by 14 · see citing works
“The resolution of lung inflammation requires an orchestrated immune response and several control mechanisms to avoid excessive inflammation and chronic disease [28,29].”
BackgroundControlling Inflammation Improves Aging Skeletal Muscle Health
Fountain, W. A., Naruse, M., Claiborne, A., Trappe, S. W., & Trappe, T. A. (2023) · Exercise and Sport Sciences Reviews · doi:10.1249/jes.0000000000000313 · Cited by 13 · see citing works
Zhuo, X., Wu, Y., Fu, X., Li, J., Xiang, Y., Liang, X., Mao, C., & Jiang, Y. (2023) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2023.08.013 · Cited by 12 · see citing works
Magalhães, G. S., Gregório, J. F., Beltrami, V. A., Félix, F. B., Oliveira-Campos, L., Bonilha, C. S., Righetti, R. F., Tibério, I. D. F. L. C., Sousa, F. B. D., Rezende, B. M., et al. (2024) · Inflammation Research · doi:10.1007/s00011-024-01880-x · Cited by 12 · see citing works
- Authors
- Feehan, K. T., & Gilroy, D. W.
- Affiliations
- University College London (GB)
- Corresponding author
- Gilroy, Derek W.
- Venue
- Trends in Molecular Medicine
- Publisher
- Elsevier BV
- Published
- 2019-03
- Volume
- 25
- Issue
- 3
- Pages
- 198-214
- ISSN
- 1471-4914 (ISSN-L)
- OpenAlex
- W2918019780
- Cited by
- 229
- References
- 148
- Citations by year
- 2026: 22 · 2025: 32 · 2024: 40 · 2023: 43 · 2022: 37 · 2021: 30 · 2020: 22 · 2019: 3
- FWCI
- 3.11
- Type
- journal article
- Language
- en
- Open access
- green
- discovery.ucl.ac.uk
- Locations
- Trends in Molecular Medicine (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Biotechnology and Biological Sciences Research Council (1788941)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- inflammation resolution, chronic inflammation, autoimmune disease, innate immunity, adaptive homeostasis, tissue repair, inflammatory mediators
- MeSH terms
- Acute Disease, Animals, Chronic Disease, Disease Susceptibility, Humans, Immunity, Inflammation, Signal Transduction, Biomarkers, Cytokines, Inflammation Mediators
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