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Telomerase regulation
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“Conversely, in somatic cells, telomerase activity is minimal or non-existent, largely due to the tightly controlled regulation of hTERT [111].”
From Cell Immortality: In Vitro Effective Techniques to Achieve and Investigate Its Applications and Challenges (2024) · cites this paper as [111]
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“Due to its complexity, TERT is regulated at various levels, including transcriptional, post-transcriptional, and post-translational mechanisms (Figure 4) [111,112,113].”
From Cell Immortality: In Vitro Effective Techniques to Achieve and Investigate Its Applications and Challenges (2024) · cites this paper as [111]
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Shelterin: the protein complex that shapes and safeguards human telomeres
de Lange, T. (2005) · Genes & Development · doi:10.1101/gad.1346005 · Cited by 3,056
The RNA Component of Human Telomerase
Feng, J., Funk, W. D., Wang, S.-S., Weinrich, S. L., Avilion, A. A., Chiu, C.-P., Adams, R. R., Chang, E., Allsopp, R. C., Yu, J., et al. (1995) · Science · doi:10.1126/science.7544491 · Cited by 2,227
The POT1-TPP1 telomere complex is a telomerase processivity factor.
Wang, F., Podell, E. R., Zaug, A. J., Yang, Y., Baciu, P., Cech, T. R., & Lei, M. (2007) · Nature · doi:10.1038/nature05454 · Cited by 704
A Human Telomerase Holoenzyme Protein Required for Cajal Body Localization and Telomere Synthesis
Venteicher, A. S., Abreu, E. B., Meng, Z., McCann, K. E., Terns, R. M., Veenstra, T. D., Terns, M. P., & Artandi, S. E. (2009) · Science · doi:10.1126/science.1165357 · Cited by 522
Horikawa, I., & Barrett, J. C. (2003) · Carcinogenesis · doi:10.1093/carcin/bgg085 · Cited by 211
Ubiquitin ligase MKRN1 modulates telomere length homeostasis through a proteolysis of hTERT
Kim, J. H., Park, S.-M., Kang, M. R., Oh, S.-Y., Lee, T. H., Muller, M. T., & Chung, I. K. (2005) · Genes & Development · doi:10.1101/gad.1289405 · Cited by 197
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p53-dependent Down-regulation of Telomerase Is Mediated by p21
Shats, I., Milyavsky, M., Tang, X., Stambolsky, P., Erez, N., Brosh, R., Kogan, I., Braunstein, I., Tzukerman, M., Ginsberg, D., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402502200 · Cited by 133
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Metadata
- Authors
- Cifuentes-Rojas, C., & Shippen, D. E.
- Venue
- Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
- Publisher
- Elsevier BV
- Published
- 2012-02
- Volume
- 730
- Issue
- 1-2
- Pages
- 20-27
- ISSN
- 1386-1964
- PMC
- PMC3256259
- Cited by
- 64
- References
- 10
- Language
- en
- Licence
- Funders
- National Science Foundation (MCB-0843399, MCB-1052018)
- National Institutes of Health (GM065383)
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