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Cited by 31Multiple Sclerosis Research StudiesCancer survivorship and careHealth Systems, Economic Evaluations, Quality of Life

Depression mediates the relationship between fatigue and mental health-related quality of life in multiple sclerosis

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Fidao, Alexander, De Livera, Alysha, Nag, Nupur, Neate, Sandra, Jelinek, George A, Simpson-Yap, Steve·2021·Multiple Sclerosis and Related Disorders
DOI 10.1016/j.msard.2020.102620
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Abstract

Background Fatigue is among the most prevalent symptoms for people with multiple sclerosis (pwMS) and is significantly detrimental to mental health-related (mental) quality of life (QoL). We examined the role of depression and physical activity as mediators in the fatigue-QoL relationship in pwMS. Methods Using baseline cross-sectional data from an international cohort of 2,104 pwMS, characteristics of fatigue and mental QoL, measured by Fatigue Severity Scale and MSQOL-54 respectively, were assessed using linear and log-binomial regression. Structural Equation Models (SEM) were used to explore the mediating roles of depression and physical activity between fatigue and mental QoL. Results The median mental QoL score was 71.9/100. The mean fatigue score was 41.5/63, with 65.6% participants having clinically significant fatigue. In the SEM evaluating depression as a mediator of the fatigue-QoL relationship, mental QoL was 14.72 points lower (95% CI: -16.43 -13.01, p Conclusion Depression accounted for the majority of the fatigue-mental QoL relationship when modelled as a mediator, while physical activity had only a minor role. Our findings may inform the development of treatments for reducing the impacts of fatigue and improving mental QoL in pwMS.

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  • Psychological inflexibility has a significant effect on negative emotions like anxiety and depression.

    “psychological inflexibility significantly affects negative emotions such as anxiety and depression, leading to a range of psychological problems such as emotional distress, post-traumatic stress disorder (PTSD), and burnout (Fidao et al., 2021).”

    From Mental fatigue and negative emotion among nurses during the COVID-19 pandemic (2022) · cites this paper as Fidao et al., 2021

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Authors
Fidao, A., De Livera, A., Nag, N., Neate, S., Jelinek, G. A., & Simpson-Yap, S.
Affiliations
The University of Melbourne (AU)
ORCID
Venue
Multiple Sclerosis and Related Disorders
Publisher
Elsevier BV
Published
2021-01
Volume
47
Pages
102620
ISSN
2211-0348 (ISSN-L)
DOI
10.1016/j.msard.2020.102620
OpenAlex
W3101402950
Cited by
31
References
10
Citations by year
2026: 3 · 2025: 6 · 2024: 12 · 2023: 2 · 2022: 6 · 2021: 2
FWCI
1.64
Type
journal article
Language
en
Open access
Licence
Locations
  • Multiple Sclerosis and Related Disorders (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • UTAS Research Repository (acceptedVersion)
  • RMIT Research Repository (RMIT University Library) (submittedVersion, other-oa)
  • Figshare (submittedVersion)
  • Minerva Access (University of Melbourne) (submittedVersion, cc-by-nc-nd)
Funders
SN
Topics
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
  • Health Sciences › Medicine › Oncology › Cancer survivorship and care
  • Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Health Systems, Economic Evaluations, Quality of Life
Keywords
multiple sclerosis, fatigue, depression, mental health-related quality of life, physical activity, mediation analysis, Fatigue Severity Scale, MSQOL-54
MeSH terms
Cross-Sectional Studies, Depression, Fatigue, Humans, Multiple Sclerosis, Quality of Life

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