Investigation of PPIX-Lipo-MnO2 to enhance photodynamic therapy by improving tumor hypoxia
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The efficacy of photodynamic therapy (PDT) is reduced in the context of hypoxic environments. This is problematic, considering that hypoxia is exhibited in the vast majority of malignant tumors. Thus, increasing the concentration of oxygen in malignant tumors improves PDT treatment outcomes. Studies show that MnO 2 nanoparticles can produce oxygen when it reacts with endogenous H 2 O 2. Herein, we encapsulated Protoporphyrin IX (PPIX) in the liposome bilayer (PPIX-Lipo), which was then coated with MnO 2 nanoparticles to construct PPIX-Lipo-MnO 2 (PPIX-Lipo-M) in order to enhance PDT efficacy under tumor hypoxia. The PDT results show that PPIX-Lipo-M was more cytotoxic to breast cancer cells than PPIX-Lipo while under hypoxic conditions, indicating that the production of oxygen gas in hypoxic conditions improved treatment outcomes. Upon encapsulating PPIX into the liposome, the aqueous solubility of PPIX significantly improved. Consequently, the cellular uptake of both PPIX-Lipo and PPIX-Lipo-M also increased significantly compared to that of bare PPIX. Overall, PPIX-Lipo-M has the capacity to act as a therapeutic agent that relieves hypoxia and hence improve PDT efficacy.
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Lalit Chudal encapsulated protoporphyrin IX in a liposome bilayer coated with MnO2 nanoparticles to improve photodynamic therapy efficacy under tumor hypoxia.
“Lalit Chudal encapsulated protoporphyrin IX in a liposome bilayer and then coated the lipid bilayer with MnO2 nanoparticles to improve the efficacy of photodynamic therapy under tumor hypoxia.”
From Hypoxia signaling in cancer: Implications for therapeutic interventions (2023) · cites this paper as [239]
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- Authors
- Chudal, L., Pandey, N. K., Phan, J., Johnson, O., Li, X., & Chen, W.
- Affiliations
- The University of Texas at Arlington (US)
- The University of Texas at Dallas (US)
- Corresponding author
- Chen, Wei
- Venue
- Materials Science and Engineering: C
- Publisher
- Elsevier BV
- Published
- 2019-11
- Volume
- 104
- Pages
- 109979
- ISSN
- 0928-4931 (ISSN-L)
- OpenAlex
- W2961206541
- Cited by
- 73
- References
- 43
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 14 · 2023: 16 · 2022: 12 · 2021: 12 · 2020: 9
- FWCI
- 6.06
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Materials Science and Engineering C (acceptedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Army Medical Research Acquisition Activity (W81XWH-10-1-0279, W81XWH-10-1-023)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Photodynamic Therapy Research Studies
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Physical Sciences › Materials Science › Materials Chemistry › Porphyrin and Phthalocyanine Chemistry
- Keywords
- photodynamic therapy, tumor hypoxia, protoporphyrin IX, MnO2 nanoparticles, liposome encapsulation, oxygen production, hydrogen peroxide, breast cancer cells, cellular uptake, drug solubility, hypoxia alleviation
- MeSH terms
- Tumor Hypoxia, Antineoplastic Agents, Breast Neoplasms, Female, Humans, Hydrogen Peroxide, Liposomes, Oxides, Oxygen, Photochemotherapy, Protoporphyrins, Manganese Compounds, Cell Line, Tumor, Nanoparticles, MCF-7 Cells
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