Cited by 73Photodynamic Therapy Research StudiesNanoplatforms for cancer theranosticsPorphyrin and Phthalocyanine Chemistry

Investigation of PPIX-Lipo-MnO2 to enhance photodynamic therapy by improving tumor hypoxia

Open access
Chudal, Lalit, Pandey, Nil Kanatha, Phan, Jonathan, Johnson, Omar, Li, Xiuying, Chen, Wei·2019·Materials Science and Engineering: C

Abstract

The efficacy of photodynamic therapy (PDT) is reduced in the context of hypoxic environments. This is problematic, considering that hypoxia is exhibited in the vast majority of malignant tumors. Thus, increasing the concentration of oxygen in malignant tumors improves PDT treatment outcomes. Studies show that MnO 2 nanoparticles can produce oxygen when it reacts with endogenous H 2 O 2. Herein, we encapsulated Protoporphyrin IX (PPIX) in the liposome bilayer (PPIX-Lipo), which was then coated with MnO 2 nanoparticles to construct PPIX-Lipo-MnO 2 (PPIX-Lipo-M) in order to enhance PDT efficacy under tumor hypoxia. The PDT results show that PPIX-Lipo-M was more cytotoxic to breast cancer cells than PPIX-Lipo while under hypoxic conditions, indicating that the production of oxygen gas in hypoxic conditions improved treatment outcomes. Upon encapsulating PPIX into the liposome, the aqueous solubility of PPIX significantly improved. Consequently, the cellular uptake of both PPIX-Lipo and PPIX-Lipo-M also increased significantly compared to that of bare PPIX. Overall, PPIX-Lipo-M has the capacity to act as a therapeutic agent that relieves hypoxia and hence improve PDT efficacy.

Integrity signals

Registry

Crossref · 10.1016/j.msec.2019.109979

Cites

43 of 43 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Lalit Chudal encapsulated protoporphyrin IX in a liposome bilayer coated with MnO2 nanoparticles to improve photodynamic therapy efficacy under tumor hypoxia.

    “Lalit Chudal encapsulated protoporphyrin IX in a liposome bilayer and then coated the lipid bilayer with MnO2 nanoparticles to improve the efficacy of photodynamic therapy under tumor hypoxia.”

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Chudal, L., Pandey, N. K., Phan, J., Johnson, O., Li, X., & Chen, W.
Affiliations
  • The University of Texas at Arlington (US)
  • The University of Texas at Dallas (US)
Corresponding author
Chen, Wei
Venue
Materials Science and Engineering: C
Publisher
Elsevier BV
Published
2019-11
Volume
104
Pages
109979
ISSN
0928-4931 (ISSN-L)
OpenAlex
W2961206541
Cited by
73
References
43
Citations by year
2026: 3 · 2025: 7 · 2024: 14 · 2023: 16 · 2022: 12 · 2021: 12 · 2020: 9
FWCI
6.06
Type
journal article
Language
en
Open access
Locations
  • Materials Science and Engineering C (acceptedVersion)
  • PubMed (publishedVersion)
Funders
U.S. Army Medical Research Acquisition Activity (W81XWH-10-1-0279, W81XWH-10-1-023)
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Photodynamic Therapy Research Studies
  • Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
  • Physical Sciences › Materials Science › Materials Chemistry › Porphyrin and Phthalocyanine Chemistry
Keywords
photodynamic therapy, tumor hypoxia, protoporphyrin IX, MnO2 nanoparticles, liposome encapsulation, oxygen production, hydrogen peroxide, breast cancer cells, cellular uptake, drug solubility, hypoxia alleviation
MeSH terms
Tumor Hypoxia, Antineoplastic Agents, Breast Neoplasms, Female, Humans, Hydrogen Peroxide, Liposomes, Oxides, Oxygen, Photochemotherapy, Protoporphyrins, Manganese Compounds, Cell Line, Tumor, Nanoparticles, MCF-7 Cells

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review