Microwave-Triggered Smart Drug Release from Liposomes Co-encapsulating Doxorubicin and Salt for Local Combined Hyperthermia and Chemotherapy of Cancer
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The microwave and temperature sensitive liposomes were fabricated successfully from 1,2-dipalmityol-sn-glycero-3-phosphocholine (DPPC), cholesterol, and 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000 (DSPE-PEG2000) with a molar ratio of 4:1:0.26 by co-encapsulating NaCl and doxorubicin (DOX) through the thin-film hydration method to externally manipulate drug release at a predetermined location in the body at a desired time in the right dosage for combination microwave hyperthermia and chemotherapy of cancer to afford a synergistic therapeutic effect. It was found that the confinement of the high concentration of NaCl ions inside the small size of the liposomes led to a more-rapid temperature elevation than the dissociative ions upon microwave treatment. More than 67.6% doxorubicin was released from the DOX and NaCl co-loaded liposomes (DOX&NaCl@liposomes) upon microwave irradiation for 2 min. After incubation with 2 mg/mL DOX&NaCl@liposomes for 4 h followed by treatment with microwave for 2 min, the inhibition rate of human breast cancer cell MDA-MB-231 was evaluated as 76.1%, much higher than that for NaCl@liposomes (29.8%) and DOX@liposomes (40.2%). The tumor growth inhibition was evaluated to be 73.4% after intravenous injection of DOX&NaCl@liposomes followed by microwave irradiation, much higher than that with only NaCl@liposomes (41.5%) or DOX@liposomes (45.5%) combined with microwave irradiation. Therefore, DOX&NaCl@liposomes could serve as a promising thermochemotherapy nanomedicine for cancer treatment because of its excellent microwave susceptible property and good biocompatibility.
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Smart liposomes that have been functionally changed are sensitive to a variety of internal and external stimuli, such as enzyme transformations, pH changes, redox reactions, microwaves, ultrasound, and light.
“Smart liposomes that have been functionally changed are also sensitive to a variety of internal and external stimuli, such as enzyme transformations, pH changes, redox reactions, microwaves, ultrasound, and light.50,51”
From Smart nanoparticles for cancer therapy (2023) · cites this paper as [50]
Cites
Diffusion of univalent ions across the lamellae of swollen phospholipids
Bangham, A. D., Standish, M. M., & Watkins, J. C. (1965) · Journal of Molecular Biology · doi:10.1016/s0022-2836(65)80093-6 · Cited by 4,664 · see citing works
Drug Delivery Systems: Entering the Mainstream
Allen, T. M., & Cullis, P. R. (2004) · Science · doi:10.1126/science.1095833 · Cited by 4,552 · see citing works
Regulation of transport pathways in tumor vessels: Role of tumor type and microenvironment
Hobbs, S. K., Monsky, W. L., Yuan, F., Roberts, W. G., Griffith, L., Torchilin, V. P., & Jain, R. K. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.8.4607 · Cited by 2,438 · see citing works
A review of stimuli-responsive nanocarriers for drug and gene delivery
Ganta, S., Devalapally, H., Shahiwala, A., & Amiji, M. M. (2008) · Journal of Controlled Release · doi:10.1016/j.jconrel.2007.12.017 · Cited by 2,157 · see citing works
Nutrition and physical activity guidelines for cancer survivors
Rock, C. L., Doyle, C., Demark‐Wahnefried, W., Meyerhardt, J., Courneya, K. S., Schwartz, A. L., Bandera, E. V., Hamilton, K. K., Grant, B., McCullough, M., et al. (2012) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.21142 · Cited by 1,995 · see citing works
Thermal ablation of tumours: biological mechanisms and advances in therapy
Chu, K. F., & Dupuy, D. E. (2014) · Nature reviews. Cancer · doi:10.1038/nrc3672 · Cited by 1,990 · see citing works
Ulbrich, K., Holá, K., Šubr, V., Bakandritsos, A., Tuček, J., & Zbořil, R. (2016) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00589 · Cited by 1,741 · see citing works
Torchilin, V. P. (2006) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2006.09.009 · Cited by 1,274 · see citing works
Papahadjopoulos, D., Jacobson, K., Nir, S., & Isac, I. (1973) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(73)90314-3 · Cited by 998 · see citing works
Ge, Z., & Liu, S. (2013) · Chemical Society Reviews · doi:10.1039/c3cs60048c · Cited by 917 · see citing works
Microwave Tumor Ablation: Mechanism of Action, Clinical Results, and Devices
Lubner, M. G., Brace, C. L., Hinshaw, J. L., & Lee, F. T. (2010) · Journal of Vascular and Interventional Radiology · doi:10.1016/j.jvir.2010.04.007 · Cited by 764 · see citing works
Lin, J., Wang, S., Huang, P., Wang, Z., Chen, S., Niu, G., Li, W., He, J., Cui, D., Lu, G., et al. (2013) · ACS Nano · doi:10.1021/nn4011686 · Cited by 661 · see citing works
Needham, D., & Dewhirst, M. W. (2001) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(01)00233-2 · Cited by 572 · see citing works
Light‐sensitive Intelligent Drug Delivery Systems<sup>†</sup>
Alvarez‐Lorenzo, C., Bromberg, L., & Concheiro, A. (2009) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.2008.00530.x · Cited by 519 · see citing works
Kong, G., Anyarambhatla, G., Petros, W. P., Braun, R. D., Colvin, O. M., Needham, D., & Dewhirst, M. W. (2000) · PubMed · Cited by 505 · see citing works
Dromi, S. A., Frenkel, V., Luk, A., Traughber, B. J., Angstadt, M., Bur, M., Poff, J. A., Xie, J., Libutti, S. K., Li, K. C., et al. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-2443 · Cited by 494 · see citing works
Setyawati, M. I., Tay, C. Y., Chia, S. L., Goh, S. L. G., Fang, W., Neo, M. J., Chong, H. C., Tan, S., Loo, S. C. J., Ng, K. W., et al. (2013) · Nature Communications · doi:10.1038/ncomms2655 · Cited by 458 · see citing works
Liposomes and Local Hyperthermia: Selective Delivery of Methotrexate to Heated Tumors
Weinstein, J. N., Magin, R. L., Yatvin, M. B., & Zaharko, D. S. (1979) · Science · doi:10.1126/science.432641 · Cited by 363 · see citing works
de Smet, M., Heijman, E., Langereis, S., Hijnen, N. M., & Grüll, H. (2010) · Journal of Controlled Release · doi:10.1016/j.jconrel.2010.10.036 · Cited by 331 · see citing works
Wright, A. S., Lee, F. T., & Mahvi, D. M. (2003) · Annals of Surgical Oncology · doi:10.1245/aso.2003.03.045 · Cited by 317 · see citing works
Understanding and exploiting nanoparticles' intimacy with the blood vessel and blood
Setyawati, M. I., Tay, C. Y., Docter, D., Stauber, R. H., & Leong, D. T. (2015) · Chemical Society Reviews · doi:10.1039/c5cs00499c · Cited by 308 · see citing works
Delivery of antibiotics with polymeric particles
Xiong, M., Bao, Y., Yang, X., Zhu, Y., & Wang, J. (2014) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2014.02.002 · Cited by 304 · see citing works
Zhu, D., Tao, W., Zhang, H., Liu, G., Wang, T., Zhang, L., Zeng, X., & Mei, L. (2015) · Acta Biomaterialia · doi:10.1016/j.actbio.2015.11.031 · Cited by 278 · see citing works
Ma, Y., Liang, X., Tong, S., Bao, G., Ren, Q., & Dai, Z. (2012) · Advanced Functional Materials · doi:10.1002/adfm.201201663 · Cited by 258 · see citing works
Self-citationLiu, J., Wei, T., Zhao, J., Huang, Y., Deng, H., Kumar, A., Wang, C., Liang, Z., Ma, X., & Liang, X. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.03.013 · Cited by 208 · see citing works
Self-citationGaber, M. H., Hong, K., Huang, S. K., & Papahadjopoulos, D. (1995) · Pharmaceutical Research · doi:10.1023/a:1016206631006 · Cited by 206 · see citing works
Stimulus-responsive macromolecules and nanoparticles for cancer drug delivery
MacEwan, S. R., Callahan, D. J., & Chilkoti, A. (2010) · Nanomedicine · doi:10.2217/nnm.10.50 · Cited by 205 · see citing works
MR‐guided laser‐induced thermal therapy (LITT) for recurrent glioblastomas
Carpentier, A. C., Chauvet, D., Reina, V., Beccaria, K., Leclerq, D., McNichols, R. J., Gowda, A., Cornu, P., & Delattre, J. (2012) · Lasers in Surgery and Medicine · doi:10.1002/lsm.22025 · Cited by 194 · see citing works
Local Surgical, Ablative, and Radiation Treatment of Metastases
Timmerman, R. D., Bizekis, C. S., Pass, H. I., Fong, Y., Dupuy, D. E., Dawson, L. A., & Lu, D. (2009) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.20013 · Cited by 190 · see citing works
Microwave heating of water, ice, and saline solution: Molecular dynamics study
Tanaka, M., & Sato, M. (2007) · The Journal of Chemical Physics · doi:10.1063/1.2403870 · Cited by 171 · see citing works
Zha, Z., Zhang, S., Deng, Z., Li, Y., Li, C., & Dai, Z. (2013) · Chemical Communications · doi:10.1039/c3cc40608c · Cited by 165 · see citing works
Self-citationLiang, X., Gao, J., Jiang, L., Luo, J., Jing, L., Li, X., Jin, Y., & Dai, Z. (2015) · ACS Nano · doi:10.1021/nn507482w · Cited by 156 · see citing works
Self-citationMaruyama, K., Unezaki, S., Takahashi, N., & Iwatsuru, M. (1993) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(93)90203-c · Cited by 140 · see citing works
Rational Design of Polyion Complex Nanoparticles to Overcome Cisplatin Resistance in Cancer Therapy
Yang, X., Du, X., Liu, Y., Zhu, Y., Liu, Y., Li, Y., & Wang, J. (2013) · Advanced Materials · doi:10.1002/adma.201303360 · Cited by 140 · see citing works
Meng, Y., Wang, S., Li, C., Qian, M., Yan, X., Yao, S., Peng, X., Wang, Y., & Huang, R. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.05.033 · Cited by 113 · see citing works
Wan, Z., Mao, H., Guo, M., Li, Y., Zhu, A., Yang, H., He, H., Shen, J., Zhou, L., Jiang, Z., et al. (2014) · Theranostics · doi:10.7150/thno.8171 · Cited by 112 · see citing works
Gasselhuber, A., Dreher, M. R., Negussie, A. H., Wood, B. J., Rattay, F., & Haemmerich, D. (2010) · International Journal of Hyperthermia · doi:10.3109/02656731003623590 · Cited by 109 · see citing works
Gasselhuber, A., Dreher, M. R., Rattay, F., Wood, B. J., & Haemmerich, D. (2012) · PLoS ONE · doi:10.1371/journal.pone.0047453 · Cited by 99 · see citing works
Nanoscale Thermal Phenomena in the Vicinity of Magnetic Nanoparticles in Alternating Magnetic Fields
Chiu‐Lam, A., & Rinaldi, C. (2016) · Advanced Functional Materials · doi:10.1002/adfm.201505256 · Cited by 93 · see citing works
Tan, L., Tang, W., Liu, T., Ren, X., Fu, C., Liu, B., Ren, J., & Meng, X. (2016) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.5b12329 · Cited by 89 · see citing works
Martin, S. K., Pu, H., Penticuff, J. C., Cao, Z., Horbinski, C., & Kyprianou, N. (2015) · Cancer Research · doi:10.1158/0008-5472.can-15-2078 · Cited by 86 · see citing works
de Smet, M., Langereis, S., van den Bosch, S., Bitter, K., Hijnen, N. M., Heijman, E., & Grüll, H. (2013) · Journal of Controlled Release · doi:10.1016/j.jconrel.2013.04.005 · Cited by 76 · see citing works
Tan, G., Feng, S., & Leong, D. T. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2013.12.033 · Cited by 72 · see citing works
SiRNA-phospholipid conjugates for gene and drug delivery in cancer treatment
Liu, H., Li, Y., Mozhi, A., Zhang, L., Liu, Y., Xu, X., Xing, J., Liang, X., Ma, G., Yang, J., et al. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.04.033 · Cited by 64 · see citing works
Self-citationPhotoresponsive liposomal nanohybrid cerasomes
Liang, X., Yue, X., Dai, Z., & Kikuchi, J. (2011) · Chemical Communications · doi:10.1039/c1cc00063b · Cited by 63 · see citing works
Self-citationMcNichols, R. J., Kangasniemi, M., Gowda, A., Bankson, J. A., Price, R. E., & Hazle, J. D. (2003) · International Journal of Hyperthermia · doi:10.1080/02656730310001611035 · Cited by 56 · see citing works
Jin, Y., Ma, X., Feng, S., Liang, X. Y., Dai, Z., Tian, J., & Yue, X. (2015) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.5b00551 · Cited by 53 · see citing works
Self-citationRusthoven, C. G., Koshy, M., Sher, D. J., Ney, D. E., Gaspar, L. E., Jones, B. L., Karam, S. D., Amini, A., Ormond, D. R., Youssef, A. S., et al. (2016) · JAMA Neurology · doi:10.1001/jamaneurol.2016.0839 · Cited by 53 · see citing works
Cerasomal doxorubicin with long-term storage stability and controllable sustained release
Jin, Y., Yue, X., Zhang, Q., Wu, X., Cao, Z., & Dai, Z. (2012) · Acta Biomaterialia · doi:10.1016/j.actbio.2012.05.022 · Cited by 51 · see citing works
Self-citationBariana, M., Aw, M. S., Moore, E., Voelcker, N. H., & Lošić, D. (2013) · Nanomedicine · doi:10.2217/nnm.13.93 · Cited by 47 · see citing works
Accumulation, internalization and therapeutic efficacy of neuropilin-1-targeted liposomes
Paoli, E. E., Ingham, E. S., Zhang, H., Mahakian, L. M., Fite, B. Z., Gagnon, M.-H., Tam, S. M., Kheirolomoom, A., Cardiff, R. D., & Ferrara, K. W. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.01.005 · Cited by 35 · see citing works
Nanoparticles improve profile of molecularly targeted cancer drug
Cully, M. (2016) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.60 · Cited by 33 · see citing works
Methotrexate conjugated magnetic nanoparticle for targeted drug delivery and thermal therapy
Gupta, J., Bhargava, P., & Bahadur, D. (2014) · Journal of Applied Physics · doi:10.1063/1.4866080 · Cited by 29 · see citing works
Microwave spectroscopic observation of distinct electron solid phases in wide quantum wells
Hatke, A. T., Liu, Y., Magill, B. A., Moon, B. H., Engel, L. W., SHAYEGAN, M., Pfeiffer, L. N., West, K. W., & Baldwin, K. W. (2014) · Nature Communications · doi:10.1038/ncomms5154 · Cited by 23 · see citing works
Combined Hyperthermia and Photodynamic Therapy Using a Sub-THz Gyrotron as a Radiation Source
Miyoshi, N., Idehara, T., Khutoryan, E. M., Fukunaga, Y., Andriana, B. B., Ito, S., & Sabchevski, S. P. (2016) · Journal of Infrared Millimeter and Terahertz Waves · doi:10.1007/s10762-016-0271-z · Cited by 19 · see citing works
Trigger-Responsive Nanoparticles: Control Switches for Cancer Therapy
Banerjee, R. (2011) · Nanomedicine · doi:10.2217/nnm.11.161 · Cited by 16 · see citing works
Rodzinski, A., Hadjikhani, A., Stewart, T. S.-J., Stimphil, E., Guduru, R., Liang, P., Runowicz, C. D., & Khizroev, S. (2016) · Cancer Research · doi:10.1158/1538-7445.fbcr15-b47 · Cited by 7 · see citing works
Change of overoxidation environment and cytokine of high power microwave radiation rats
Yanxia, J., Xu, J., Xiaojing, L., Nan, S., & Lv, S. (2011) · International Conference on Human Health and Biomedical Engineering · doi:10.1109/hhbe.2011.6028402 · Cited by 1 · see citing works
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Sun, L., Liu, H., Ye, Y., Lei, Y., Islam, R., Tan, S., Tong, R., Miao, Y.-B., & Cai, L. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01642-x · Cited by 1,073 · see citing works
Smart nanocarrier-based drug delivery systems for cancer therapy and toxicity studies: A review
Hossen, S., Hossain, M. K., Basher, M. K., Mia, M. N. H., Rahman, M. T., & Uddin, M. J. (2019) · Journal of Advanced Research · doi:10.1016/j.jare.2018.06.005 · Cited by 998 · see citing works
Tailoring Gelation Mechanisms for Advanced Hydrogel Applications
Nele, V., Wojciechowski, J. P., Armstrong, J. P. K., & Stevens, M. M. (2020) · Advanced Functional Materials · doi:10.1002/adfm.202002759 · Cited by 298 · see citing works
Multifunctional phototheranostic nanomedicine for cancer imaging and treatment
Gao, D., Guo, X., Zhang, X., Chen, S., Wang, Y., Chen, T., Huang, G. J., Gao, Y. F., Tian, Z., & Yang, Z. (2019) · Materials Today Bio · doi:10.1016/j.mtbio.2019.100035 · Cited by 274 · see citing works
Recent advances in stimuli-responsive polymer systems for remotely controlled drug release
Zhang, A., Jung, K., Li, A., Liu, J., & Boyer, C. A. (2019) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2019.101164 · Cited by 269 · see citing works
Synergic effects of nanoparticles-mediated hyperthermia in radiotherapy/chemotherapy of cancer
Mortezaee, K., Narmani, A., Salehi, M., Bagheri, H., Farhood, B., Haghi‐Aminjan, H., & Najafi, M. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.119020 · Cited by 163 · see citing works
Targeted Liposomal Drug Delivery: Overview of the Current Applications and Challenges
Gatto, M. S., Johnson, M. P., & Najahi‐Missaoui, W. (2024) · Life · doi:10.3390/life14060672 · Cited by 115 · see citing works
Liu, Y., Zhou, J., Li, Q., Li, L., Jia, Y., Geng, F., Zhou, J., & Yin, T. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.02.019 · Cited by 103 · see citing works
“Smart” drug delivery: A window to future of translational medicine
Rana, A., Adhikary, M., Singh, P. K., Das, B. C., & Bhatnagar, S. (2023) · Frontiers in Chemistry · doi:10.3389/fchem.2022.1095598 · Cited by 95 · see citing works
Liu, C., Liu, X., Wang, G., Hei, Y., Meng, S., Yang, L., Yuan, L., & Xie, Y. (2017) · International Journal of Nanomedicine · doi:10.2147/ijn.s131367 · Cited by 92 · see citing works
Recent advances in anti-angiogenic nanomedicines for cancer therapy
Bhattarai, P., Hameed, S., & Dai, Z. (2018) · Nanoscale · doi:10.1039/c7nr09612g · Cited by 88 · see citing works
Self-citationNanoparticles‐Mediated Combination Therapies for Cancer Treatment
Shrestha, B., Tang, L., & Romero, G. (2019) · Advanced Therapeutics · doi:10.1002/adtp.201900076 · Cited by 87 · see citing works
Investigation of PPIX-Lipo-MnO2 to enhance photodynamic therapy by improving tumor hypoxia
Chudal, L., Pandey, N. K., Phan, J., Johnson, O., Li, X., & Chen, W. (2019) · Materials Science and Engineering: C · doi:10.1016/j.msec.2019.109979 · Cited by 73 · see citing works
Zhou, Y., & Dai, Z. (2018) · Chemistry - An Asian Journal · doi:10.1002/asia.201800149 · Cited by 72 · see citing works
Self-citationHou, Q., Zhang, K., Chen, S., Chen, J., Zhang, Y., Gong, N., Guo, W., Fang, C., Wang, L., Jiang, J. D., et al. (2022) · ACS Nano · doi:10.1021/acsnano.1c10714 · Cited by 64 · see citing works
Self-citationFatima, S. F., Sabouni, R., Garg, R., & Gomaa, H. (2023) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2023.113266 · Cited by 63 · see citing works
Rehman, M., Madni, A., Shi, D., Ihsan, A., Tahir, N., Chang, R., Javed, I., & Webster, T. J. (2017) · Nanoscale · doi:10.1039/c7nr05216b · Cited by 54 · see citing works
Guo, W., Chen, Z., Tan, L., Gu, D., Ren, X., Fu, C., Wu, Q., & Meng, X. (2021) · Open Research (University of Surrey) · doi:10.1002/viw.20200174 · Cited by 53 · see citing works
Gao, C., Liang, X., Mo, S., Zhang, N., Sun, D., & Dai, Z. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b14125 · Cited by 50 · see citing works
Self-citationHameed, S., Bhattarai, P., & Dai, Z. (2018) · Frontiers in Chemistry · doi:10.3389/fchem.2018.00127 · Cited by 43 · see citing works
Self-citationLuo, F., Fan, Z., Yin, W., Liu, Y., Li, T., Zhong, L.-B., Li, Y., Wang, S., Yan, J., Hou, Z., et al. (2019) · Materials Science and Engineering C · doi:10.1016/j.msec.2019.110107 · Cited by 43 · see citing works
Adabbo, G., Andreozzi, A., Iasiello, M., Netti, P. A., & Vanoli, G. P. (2023) · International Journal of Thermal Sciences · doi:10.1016/j.ijthermalsci.2023.108528 · Cited by 38 · see citing works
Bio-nanomaterials: Promising anticancer properties and treatment strategies
Elemike, E. E., Onunkwo, I. C., Ughumiakpor, O., Alawuru, F., Mukoro, A., Ishom, P., Obarakpor, F., Hossain, I., & Aziza, A. E. (2025) · Nano TransMed · doi:10.1016/j.ntm.2025.100076 · Cited by 41 · see citing works
Tang, S., Fu, C., Tan, L., Liu, T., Mao, J., Ren, X., Su, H., Long, D., Chai, Q., Huang, Z., et al. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.04.027 · Cited by 38 · see citing works
Yu, J., Xiao, H., Yang, Z., Qiao, C., Zhou, B., Jia, Q., Wang, Z., Wang, X., Zhang, R., Yang, Y., et al. (2021) · Small · doi:10.1002/smll.202106100 · Cited by 37 · see citing works
ZnO capped flower-like porous carbon-Fe3O4 composite as carrier for bi-triggered drug delivery
Yang, Z., Wang, L., Liu, Y., Liu, S., Tang, D., Li, M., & Cui, B. (2019) · Materials Science and Engineering C · doi:10.1016/j.msec.2019.110256 · Cited by 36 · see citing works
Zhang, Y., Guo, L., Kong, F., Duan, L., Li, H., Fang, C., & Zhang, K. (2021) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1733 · Cited by 36 · see citing works
García‐Hevia, L., Casafont, Í., Oliveira, J. R. P., Terán, N., Fanárraga, M. L., Gallo, J., & Bañobre‐López, M. (2021) · Bioactive Materials · doi:10.1016/j.bioactmat.2021.06.009 · Cited by 36 · see citing works
Mao, J., Tang, S., Hong, D., Zhao, F., Niu, M., Han, X., Qi, J., Bao, H., Yutian, J., Fu, C., et al. (2017) · Nanoscale · doi:10.1039/c6nr09862b · Cited by 33 · see citing works
Du, C., Li, S., Li, Y., Galons, H., Guo, N., Teng, Y., Zhang, Y., Li, M., & Yu, P. (2020) · Drug Delivery · doi:10.1080/10717544.2020.1772409 · Cited by 33 · see citing works
Shi, Z., Yang, C., Li, R., & Ruan, L. (2020) · Journal of Materials Science · doi:10.1007/s10853-020-04428-6 · Cited by 33 · see citing works
Chen, Z., Guo, W., Tan, L., Fu, C., Wu, Q., Ren, X., Jiang, G., Ma, T., & Meng, X. (2024) · Advanced Functional Materials · doi:10.1002/adfm.202401359 · Cited by 29 · see citing works
Adabbo, G., Andreozzi, A., Iasiello, M., & Vanoli, G. P. (2023) · International Journal of Heat and Mass Transfer · doi:10.1016/j.ijheatmasstransfer.2023.124942 · Cited by 27 · see citing works
Zhou, Q., Wu, S., Gong, N., Li, X., Dou, J., Mu, M., Yu, X., Yu, J., & Liang, P. (2017) · Nanoscale · doi:10.1039/c7nr02955a · Cited by 24 · see citing works
Fatima, S. F., Sabouni, R., Husseini, G. A., Paul, V., Gomaa, H., & Radha, R. (2024) · Nanomaterials · doi:10.3390/nano14131081 · Cited by 23 · see citing works
Guo, W., Niu, M., Chen, Z., Wu, Q., Tan, L., Ren, X., Fu, C., Ren, J., Gu, D., & Meng, X. (2022) · Advanced Healthcare Materials · doi:10.1002/adhm.202201441 · Cited by 23 · see citing works
Chen, P., Cui, B., Bu, Y., Yang, Z., & Wang, Y. (2017) · Journal of Nanoparticle Research · doi:10.1007/s11051-017-4096-z · Cited by 23 · see citing works
Hosseini, S. H., Alipour, S., & Zohreh, N. (2018) · Langmuir · doi:10.1021/acs.langmuir.8b02390 · Cited by 20 · see citing works
Applications of phase change materials in smart drug delivery for cancer treatment
Bao, J., Tu, H., Li, J., Li, Y., Yu, S., Gao, J., Lei, K., Zhang, F., & Li, J. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.991005 · Cited by 19 · see citing works
Sahu, R., Jha, S., & Pattanayak, S. P. (2022) · British Journal of Cancer · doi:10.1038/s41416-022-02011-1 · Cited by 16 · see citing works
Shu, M., Wang, J., Xu, Z., Lu, T., He, Y., Li, R., Zhong, G., Yan, Y., Zhang, Y., Chu, X., et al. (2024) · Bioactive Materials · doi:10.1016/j.bioactmat.2024.04.016 · Cited by 15 · see citing works
Guo, F., Shang, J., Hai, Z., Lai, K., Li, Y., Fan, Z., Hou, Z., & Su, G. (2017) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2017.10.013 · Cited by 15 · see citing works
Li, X., Yang, C., Tao, Y., Hou, X., Liu, Y., Sang, H., & Jiang, G. (2021) · OncoTargets and Therapy · doi:10.2147/ott.s287272 · Cited by 13 · see citing works
Structural Changes in Liposomal Vesicles in Association with Sodium Taurodeoxycholate
Kumar, D., Suna, A., Ray, D., Aswal, V. K., Bahadur, P., & Tiwari, S. (2023) · AAPS PharmSciTech · doi:10.1208/s12249-023-02550-7 · Cited by 13 · see citing works
Cui, X., Du, K., Yuan, X., Xiao, W. F., Tao, Y., Xu, D., & Hu, H. (2021) · Drug Development Research · doi:10.1002/ddr.21896 · Cited by 11 · see citing works
Thermosensitive Liposomes for Gemcitabine Delivery to Pancreatic Ductal Adenocarcinoma
Aparicio-Lopez, C. B., Timmerman, S. A., Lorino, G., Rogers, T., Pyle, M. M., Shrestha, T. B., & Basel, M. T. (2024) · Cancers · doi:10.3390/cancers16173048 · Cited by 9 · see citing works
In Vitro Release Method for Liposome Drug Products
Yamamoto, E. (2019) · YAKUGAKU ZASSHI · doi:10.1248/yakushi.18-00171-2 · Cited by 8 · see citing works
Integration of TaOx with Bi2S3 for Targeted Multimodality Breast Cancer Theranostics
Jin, Y., Tang, C. C., Tian, J., & Shao, B. (2020) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.0c00594 · Cited by 7 · see citing works
Self-citationChen, Z.-Z., Guo, W.-N., Liang, T., Zheng, Y.-J., Niu, M., Yang, D., Tan, L., Fu, C., Wu, Q., Ren, X., et al. (2023) · Biomaterials · doi:10.1016/j.biomaterials.2023.122299 · Cited by 7 · see citing works
He, Y., Wang, C., Wu, Q., & Zhang, G. (2024) · Nanotechnology · doi:10.1088/1361-6528/ad42a3 · Cited by 7 · see citing works
Externally Triggered Drug Delivery Techniques Using Micro and Nanoparticles
Shaikh, M. S., Donnan, R. S., & Дубровка, Р. Ф. (2022) · IEEE Journal of Electromagnetics RF and Microwaves in Medicine and Biology · doi:10.1109/jerm.2022.3149685 · Cited by 7 · see citing works
Nanocarriers and their Types for Targeted Drug Delivery
Shaik, N., & Prasanth., Y. (2022) · International Journal of Pharmaceutical Sciences Review and Research · doi:10.47583/ijpsrr.2022.v77i01.004 · Cited by 6 · see citing works
Wang, Y., Zhang, B., Shen, X., Li, Q., Su, F., & Li, S. (2021) · Polymers for Advanced Technologies · doi:10.1002/pat.5423 · Cited by 5 · see citing works
Mills, H., Acquah, R., Tang, N., Cheung, L., Klenk, S., Glassen, R., Pirson, M. A., Albert, A., Hoang, D. T., & Van, T. (2022) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2022/7702512 · Cited by 3 · see citing works
RetractedNanostructures for Externally Triggered Chemo/Thermal Therapies
Parchur, A. K., Jagtap, J. M. M., Sharma, G., Gogineni, V. R., Hansen, C. P., White, S. B., & Joshi, A. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-813906-6.00006-8 · Cited by 3 · see citing works
Progress in the Application of Nanobiotechnology in the Ablation Therapy of Hepatic Carcinoma
Gao, Z., Yao, L., Wei, X., Wang, S., Cao, W., Deng, W., Li, X., Zhang, Z., Wang, S., Zhang, Y., et al. (2025) · International Journal of Nanomedicine · doi:10.2147/ijn.s551980 · Cited by 2 · see citing works
Tripathi, A., Vaishnaw, B., Jaishwal, P., Samal, P. K., Verma, A., & Singh, N. (2025) · Current Materials Science · doi:10.2174/0126661454366845250618053301 · Cited by 2 · see citing works
Gold Nanoclusters as Smart Nanoplatforms for Targeted Cancer Therapy
Farkhani, S. M., Rudd, D. A., Thissen, H. W., Ali, M. A., Yuce, M. R., Cifuentes‐Rius, A., & Voelcker, N. H. (2025) · Advanced NanoBiomed Research · doi:10.1002/anbr.202500037 · Cited by 2 · see citing works
Shrestha, A., Karmacharya, P., Shrestha, S., Mishra, S. K., Patil, R. S., Kim, B., Luong, H. X., Ku, S. K., Kim, J., Patil, B. R., et al. (2025) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2025.115294 · Cited by 1 · see citing works
Targeted drug delivery strategies for oral cancer: the role of liposomes in drug delivery systems
Saberian, E., Amiri, F., Ghanbarikondori, P., زفره, ع. ا. ح., Zare‐Zardini, H., Goodarzi, M. K., Mokhtari, T., Forood, A. M. K., & Far, M. E. (2026) · BioMedical Engineering OnLine · doi:10.1186/s12938-026-01531-8 · Cited by 1 · see citing works
Preliminary Assessment of a Microwave System to Detect Contrast Enhancing Agents
Rahman, M. W., Ahsan, S., Lahri, R., Thanou, M., & Kosmas, P. (2018) · Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) · doi:10.1109/embc.2018.8512313 · Cited by 1 · see citing works
Increasing doxorubicin (DOX) release from liposomes
HANOĞLU, B. D. (2019) · IYTE GCRIS Database (Izmir Institute of Technology) · Cited by 1 · see citing works
Nanomedicine: Development and Challenges in Cancer Treatment
Biswal, N. C. (2019) · American Journal of Biomedical Science & Research · doi:10.34297/ajbsr.2019.06.001036
Yu, Z., Wang, Y., Cai, M., Chen, J., Zou, Q., Fan, Q., & Zhang, L. (2023) · Journal of Materials Chemistry B · doi:10.1039/d3tb02255b
Eslamirad, Z., Hajihossein, R., Fathi, Y., & Soleimani, H. (2025) · Turkish Journal of Parasitology · doi:10.4274/tpd.galenos.2025.50490
Askarizadeh, A., Mirhadi, M., Jaafari, M. R., Tamaddon, A. M., & Mirhadi, E. (2025) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2025.107489
Microwave-Assisted Drug Delivery Systems: Mechanisms, Challenges, and Biomedical Applications
Mathew, B. B., Fazal, J., Raj, P. A., Shivashirin, G., Prakash, S., & More, S. S. (2026) · Materials horizons · doi:10.1007/978-981-95-4005-1_8
PID controller system development to enhance hyperthermia-mediated drug delivery
Adabbo, G., Andreozzi, A., Iasiello, M., Napoli, G., & Vanoli, G. P. (2026) · Applied Mathematical Modelling · doi:10.1016/j.apm.2026.117031
Advances in nanomaterial-enhanced ablation therapy for hepatocellular carcinoma
Li, H., Lan, J., Qiu, Y., Kang, W., Han, T., Zhang, X., Yang, Z., & Niu, M. (2026) · The Innovation Oncology · doi:10.59717/j.xinn-oncol.2026.100029
Abishek, K. G., Swain, B. K., Jauhari, S., Padil, V. V. T., Gupta, G., Leharwani, M., Kesharwani, P., & Dandela, R. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-33641-6.01002-2
Single-Frequency Microwave-Assisted Nanogel–Protein Complexation for Hybrid Biomaterial Fabrication
Ma, Y., Takaya, H., Mizuta, R., Akiyoshi, K., & Sasaki, Y. (2026) · ACS Omega · doi:10.1021/acsomega.6c04598
Ma, Y., Sha, Y., Takaya, H., Mizuta, R., Akiyoshi, K., & Sasaki, Y. (2026) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2026.154718
- Authors
- Jin, Y., Liang, X., An, Y., & Dai, Z.
- Affiliations
- Peking University (CN)
- Corresponding author
- Dai, Zhifei
- Venue
- Bioconjugate Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2016-11-09
- Volume
- 27
- Issue
- 12
- Pages
- 2931-2942
- ISSN
- 1043-1802 (ISSN-L)
- 1520-4812
- OpenAlex
- W2550281505
- Cited by
- 72
- References
- 58
- Citations by year
- 2026: 7 · 2025: 7 · 2024: 6 · 2023: 8 · 2022: 7 · 2021: 9 · 2020: 4 · 2019: 9 · 2018: 8 · 2017: 7
- FWCI
- 3.27
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Bioconjugate Chemistry (publishedVersion, other-oa)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (21273014, 81225011, 81230036, 81421004)
- Ministry of Science and Technology of the People's Republic of China (2016YFA0201400)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Engineering › Biomedical Engineering › Ultrasound and Hyperthermia Applications
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Keywords
- liposomes, doxorubicin, sodium chloride, hyperthermia, thermochemotherapy, breast cancer, MDA-MB-231 cells, tumor growth inhibition, thin-film hydration, nanomedicine
- MeSH terms
- Animals, Antibiotics, Antineoplastic, Breast Neoplasms, Doxorubicin, Female, Hemolysis, Humans, Hyperthermia, Induced, Liposomes, Mice, Inbred BALB C, Mice, Nude, Microwaves, Sodium Chloride, Xenograft Model Antitumor Assays, Human Umbilical Vein Endothelial Cells, Drug Liberation
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