Cited by 72Nanoparticle-Based Drug DeliveryUltrasound and Hyperthermia ApplicationsNanoplatforms for cancer theranostics

Microwave-Triggered Smart Drug Release from Liposomes Co-encapsulating Doxorubicin and Salt for Local Combined Hyperthermia and Chemotherapy of Cancer

Open access
Jin, Yushen, Liang, Xiaolong, An, Yunkun, Dai, Zhifei·2016·Bioconjugate Chemistry

Abstract

The microwave and temperature sensitive liposomes were fabricated successfully from 1,2-dipalmityol-sn-glycero-3-phosphocholine (DPPC), cholesterol, and 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000 (DSPE-PEG2000) with a molar ratio of 4:1:0.26 by co-encapsulating NaCl and doxorubicin (DOX) through the thin-film hydration method to externally manipulate drug release at a predetermined location in the body at a desired time in the right dosage for combination microwave hyperthermia and chemotherapy of cancer to afford a synergistic therapeutic effect. It was found that the confinement of the high concentration of NaCl ions inside the small size of the liposomes led to a more-rapid temperature elevation than the dissociative ions upon microwave treatment. More than 67.6% doxorubicin was released from the DOX and NaCl co-loaded liposomes (DOX&NaCl@liposomes) upon microwave irradiation for 2 min. After incubation with 2 mg/mL DOX&NaCl@liposomes for 4 h followed by treatment with microwave for 2 min, the inhibition rate of human breast cancer cell MDA-MB-231 was evaluated as 76.1%, much higher than that for NaCl@liposomes (29.8%) and DOX@liposomes (40.2%). The tumor growth inhibition was evaluated to be 73.4% after intravenous injection of DOX&NaCl@liposomes followed by microwave irradiation, much higher than that with only NaCl@liposomes (41.5%) or DOX@liposomes (45.5%) combined with microwave irradiation. Therefore, DOX&NaCl@liposomes could serve as a promising thermochemotherapy nanomedicine for cancer treatment because of its excellent microwave susceptible property and good biocompatibility.

Integrity signals

Registry

Crossref · 10.1021/acs.bioconjchem.6b00603

Cites

58 of 58 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Smart liposomes that have been functionally changed are sensitive to a variety of internal and external stimuli, such as enzyme transformations, pH changes, redox reactions, microwaves, ultrasound, and light.

    “Smart liposomes that have been functionally changed are also sensitive to a variety of internal and external stimuli, such as enzyme transformations, pH changes, redox reactions, microwaves, ultrasound, and light.50,51”

    From Smart nanoparticles for cancer therapy (2023) · cites this paper as [50]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Jin, Y., Liang, X., An, Y., & Dai, Z.
Affiliations
Peking University (CN)
Corresponding author
Dai, Zhifei
Venue
Bioconjugate Chemistry
Published
2016-11-09
Volume
27
Issue
12
Pages
2931-2942
ISSN
  • 1043-1802 (ISSN-L)
  • 1520-4812
OpenAlex
W2550281505
Cited by
72
References
58
Citations by year
2026: 7 · 2025: 7 · 2024: 6 · 2023: 8 · 2022: 7 · 2021: 9 · 2020: 4 · 2019: 9 · 2018: 8 · 2017: 7
FWCI
3.27
Type
journal article
Language
en
Open access
Locations
  • Bioconjugate Chemistry (publishedVersion, other-oa)
  • PubMed (publishedVersion)
Funders
  • National Natural Science Foundation of China (21273014, 81225011, 81230036, 81421004)
  • Ministry of Science and Technology of the People's Republic of China (2016YFA0201400)
Topics
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Physical Sciences › Engineering › Biomedical Engineering › Ultrasound and Hyperthermia Applications
  • Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
Keywords
liposomes, doxorubicin, sodium chloride, hyperthermia, thermochemotherapy, breast cancer, MDA-MB-231 cells, tumor growth inhibition, thin-film hydration, nanomedicine
MeSH terms
Animals, Antibiotics, Antineoplastic, Breast Neoplasms, Doxorubicin, Female, Hemolysis, Humans, Hyperthermia, Induced, Liposomes, Mice, Inbred BALB C, Mice, Nude, Microwaves, Sodium Chloride, Xenograft Model Antitumor Assays, Human Umbilical Vein Endothelial Cells, Drug Liberation

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review