Intranasal brain delivery of cationic nanoemulsion-encapsulated TNFα siRNA in prevention of experimental neuroinflammation

The rat brain in stereotaxic coordinates

Palkovits, M. (1983) · Neuropeptides · doi:10.1016/0143-4179(83)90049-5 · Cited by 28,959

The Rat Brain in Stereotaxic Coordinates

Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585

AChE-stained horizontal sections of the rat brain in stereotaxic coordinates

Paxinos, G., WATSON, C. R. R., & Emson, P. C. (1980) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(80)90021-7 · Cited by 4,501

Reactive microglia are positive for HLA‐DR in the substantia nigra of Parkinson's and Alzheimer's disease brains

McGeer, P. L., Itagaki, S., Boyes, B. E., & McGeer, E. G. (1988) · Neurology · doi:10.1212/wnl.38.8.1285 · Cited by 2,990

The blood-brain barrier: Bottleneck in brain drug development

Pardridge, W. M. (2005) · NeuroRX · doi:10.1602/neurorx.2.1.3 · Cited by 2,798

Tumor necrosis factor-α (TNF-α) increases both in the brain and in the cerebrospinal fluid from parkinsonian patients

Mogi, M., Harada, M., Riederer, P., Narabayashi, H., Fujita, K., & Nagatsu, T. (1994) · Neuroscience Letters · doi:10.1016/0304-3940(94)90746-3 · Cited by 986

Transport of drugs from the nasal cavity to the central nervous system

Illum, L. (2000) · European Journal of Pharmaceutical Sciences · doi:10.1016/s0928-0987(00)00087-7 · Cited by 907

Regional Difference in Susceptibility to Lipopolysaccharide-Induced Neurotoxicity in the Rat Brain: Role of Microglia

Kim, W., Mohney, R. P., Wilson, B. C., Jeohn, G., Liu, B., & Hong, J. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-16-06309.2000 · Cited by 881

Expression of immune system-associated antigens by cells of the human central nervous system: Relationship to the pathology of Alzheimer's disease

Rogers, J., Luber-Narod, J., Styren, S. D., & Civin, W. H. (1988) · Neurobiology of Aging · doi:10.1016/s0197-4580(88)80079-4 · Cited by 743

Microglial activation‐mediated delayed and progressive degeneration of rat nigral dopaminergic neurons: relevance to Parkinson's disease

Gao, H., Jiang, J., Wilson, B. C., Zhang, W., Hong, J., & Liu, B. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.00928.x · Cited by 690

Nanoemulsion: Concepts, development and applications in drug delivery

Singh, Y., Meher, J. G., Raval, K., Khan, F. A., Chaurasia, M., Jain, N. K., & Chourasia, M. K. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.03.008 · Cited by 1,358

Progress in brain targeting drug delivery system by nasal route

Khan, A. R., Liu, M., Khan, M. W., & Zhai, G. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.09.001 · Cited by 402

Nanoemulsions for “Nose-to-Brain” Drug Delivery

Bonferoni, M. C., Rossi, S., Sandri, G., Ferrari, F., Gavini, E., Rassu, G., & Giunchedi, P. (2019) · Pharmaceutics · doi:10.3390/pharmaceutics11020084 · Cited by 269

Advanced nanomedicines for the treatment of inflammatory diseases

Brusini, R., Varna, M., & Couvreur, P. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.07.010 · Cited by 250

Nose-to-brain delivery of BACE1 siRNA loaded in solid lipid nanoparticles for Alzheimer’s therapy

Rassu, G., Soddu, E., Posadino, A. M., Pintus, G., Sarmento, B., Giunchedi, P., & Gavini, E. (2017) · Colloids and Surfaces B: Biointerfaces · doi:10.1016/j.colsurfb.2017.01.031 · Cited by 239

The impact of high and low dose ionising radiation on the central nervous system

Betlazar, C., Middleton, R. J., Banati, R. B., & Liu, G.-J. (2016) · Redox Biology · doi:10.1016/j.redox.2016.08.002 · Cited by 196

A critical review of synthesis procedures, applications and future potential of nanoemulsions

Naseema, A., Kovooru, L., Behera, A. K., Kumar, K. P. P., & Srivastava, P. (2020) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2020.102318 · Cited by 186

Intranasal Nanoemulsions for Direct Nose-to-Brain Delivery of Actives for CNS Disorders

Bahadur, S., Pardhi, D. M., Rautio, J., Rosenholm, J. M., & Pathak, K. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12121230 · Cited by 178

Updated Progress of Nanocarrier-Based Intranasal Drug Delivery Systems for Treatment of Brain Diseases

Fan, Y., Chen, M., Zhang, J., Maincent, P., Xia, X., & Wu, W. (2018) · Critical Reviews in Therapeutic Drug Carrier Systems · doi:10.1615/critrevtherdrugcarriersyst.2018024697 · Cited by 113

Progress and perspectives of brain-targeting lipid-based nanosystems via the nasal route in Alzheimer’s disease

Akel, H., Ismail, R., & Csóka, I. (2020) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2019.12.014 · Cited by 113

Nucleic acid drug vectors for diagnosis and treatment of brain diseases

Lü, Z., Shen, J., Yang, H. J., Wang, J., Zhao, R., Zhang, T.-L., Guo, J. R., & Zhang, X. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01298-z · Cited by 116

Nanoparticles: A Hope for the Treatment of Inflammation in CNS

Zhu, F., Hu, Y.-J., Yu, L., Zhou, X., Wu, J., Tang, Y., Qin, D., Fan, Q., & Wu, A. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.683935 · Cited by 110

Nanoemulsions in CNS drug delivery: recent developments, impacts and challenges

Karami, Z., Zanjani, M. R. S., & Hamidi, M. (2019) · Drug Discovery Today · doi:10.1016/j.drudis.2019.03.021 · Cited by 102

Nose-to-brain delivery of enveloped RNA - cell permeating peptide nanocomplexes for the treatment of neurodegenerative diseases

Samaridou, E., Walgrave, H., Salta, E., Álvarez, D. M., Castro-López, V., Loza, M. I., & Alonso, M. J. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.119657 · Cited by 100

Nose-to-brain delivery of teriflunomide-loaded lipid-based carbopol-gellan gum nanogel for glioma: Pharmacological and in vitro cytotoxicity studies

Gadhave, D., Rasal, N., Sonawane, R., Sekar, M., & Kokare, C. (2021) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.11.047 · Cited by 97

Nasal Administration of Cationic Nanoemulsions as CD73-siRNA Delivery System for Glioblastoma Treatment: a New Therapeutical Approach

Azambuja, J. H., Schuh, R. S., Michels, L. R., Gelsleichter, N. E., Beckenkamp, L. R., Iser, I. C., Lenz, G. S., de Oliveira, F. H., Venturin, G. T., Greggio, S., et al. (2019) · Molecular Neurobiology · doi:10.1007/s12035-019-01730-6 · Cited by 96

Different Methods and Formulations of Drugs and Vaccines for Nasal Administration

Tai, J., Han, M. S., Lee, D., Park, I., Lee, S. H., & Kim, T. H. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14051073 · Cited by 104

Transformative Impact of Nanocarrier‐Mediated Drug Delivery: Overcoming Biological Barriers and Expanding Therapeutic Horizons

Kim, M., Shin, M., Zhao, Y., Ghosh, M., & Son, Y. (2024) · Small Science · doi:10.1002/smsc.202400280 · Cited by 97

Intranasal Drug Delivery by Nanotechnology: Advances in and Challenges for Alzheimer’s Disease Management

Dighe, S., Jog, S., Momin, M. M., Sawarkar, S. P., & Omri, A. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics16010058 · Cited by 95

Intranasal Nanoparticulate Systems as Alternative Route of Drug Delivery

Alshweiat, A., Ambrus, R., & Csóka, I. (2019) · Current Medicinal Chemistry · doi:10.2174/0929867326666190827151741 · Cited by 85

Hypoxia-specific anti-RAGE exosomes for nose-to-brain delivery of anti-miR-181a oligonucleotide in an ischemic stroke model

Kim, M., Lee, Y., & Lee, M. (2021) · Nanoscale · doi:10.1039/d0nr07516g · Cited by 85

Critical Review of Lipid-Based Nanoparticles as Carriers of Neuroprotective Drugs and Extracts

Fernandes, F., Dias-Teixeira, M., Delerue-Matos, C. M., & Grosso, C. (2021) · Nanomaterials · doi:10.3390/nano11030563 · Cited by 81

Nanomodulation of Macrophages in Multiple Sclerosis

Nally, F. K., Santi, C. D., & McCoy, C. E. (2019) · Cells · doi:10.3390/cells8060543 · Cited by 80

Cationic nanoemulsions as nucleic acids delivery systems

Teixeira, H. F., Bruxel, F., Fraga, M., Schuh, R. S., Zorzi, G. K., Matte, Ú. D. S., & Fattal, E. (2017) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2017.10.030 · Cited by 75

Emerging paradigms in nanotechnology for imaging and treatment of cerebral ischemia

Kaviarasi, S., Yuba, E., Harada, A., & Krishnan, U. M. (2019) · Journal of Controlled Release · doi:10.1016/j.jconrel.2019.02.031 · Cited by 75

Sepsis: developing new alternatives to reduce neuroinflammation and attenuate brain injury

Meneses, G., Cárdenas, G., Espinosa, A., Rassy, D., Pérez‐Osorio, I. N., Bárcena, B., Fleury, A., Besedovsky, H. O., Fragoso, G., & Sciutto, E. (2018) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13985 · Cited by 74

Nose-to-Brain (N2B) Delivery: An Alternative Route for the Delivery of Biologics in the Management and Treatment of Central Nervous System Disorders

Patharapankal, E. J., Ajiboye, A. L., Mattern, C., & Trivedi, V. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics16010066 · Cited by 75

Developments in lncRNA drug discovery: where are we heading?

Blokhin, I. O., Khorkova, O., Hsiao, J. H., & Wahlestedt, C. (2018) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2018.1501024 · Cited by 56

Nanomedicines, an emerging therapeutic regimen for treatment of ischemic cerebral stroke: A review

Chen, W., Jiang, L., Hu, Y., Fang, G., Yang, B., Li, J., Liang, N., Wu, L., & Hussain, Z. (2021) · Journal of Controlled Release · doi:10.1016/j.jconrel.2021.10.020 · Cited by 54

Impact of nanoparticles on neuron biology: current research trends

Khan, F. A., Almohazey, D., Alomari, M., & Almofty, S. A. (2018) · International Journal of Nanomedicine · doi:10.2147/ijn.s165675 · Cited by 51

CNS Delivery of Nucleic Acid Therapeutics: Beyond the Blood–Brain Barrier and Towards Specific Cellular Targeting

D’souza, A. A., Nozohouri, S., Bleier, B. S., & Amiji, M. M. (2022) · Pharmaceutical Research · doi:10.1007/s11095-022-03433-5 · Cited by 49

Intranasal delivery: An attractive route for the administration of nucleic acid based therapeutics for CNS disorders

Shah, P., Lalan, M. S., & Barve, K. H. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.974666 · Cited by 46

Nanoparticle-Based Strategies to Treat Neuro-Inflammation

Poupot, R., Bergozza, D., & Fruchon, S. (2018) · Materials · doi:10.3390/ma11020270 · Cited by 48

Application of Nanoemulsions in Drug Delivery

Pathak, K., Pattnaik, S., & Swain, K. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-811838-2.00013-8 · Cited by 46

Nanoemulsion preparation, characterization, and application in the field of biomedicine

Chircov, C., & Grumezescu, A. M. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-816200-2.00019-0 · Cited by 37

Targeting neuroinflammation by intranasal delivery of nanoparticles in neurological diseases: a comprehensive review

Moradi, F., & Dashti, N. (2022) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-021-02196-x · Cited by 37

Intranasal delivery of mucoadhesive nanocarriers: a viable option for Parkinson’s disease treatment?

Rehman, S., Nabi, B., Zafar, A., Baboota, S., & Ali, J. (2019) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2019.1684895 · Cited by 37

Evaluation of Drug Permeation Enhancement by Using In Vitro and Ex Vivo Models

Steyn, D., Haasbroek‐Pheiffer, A., Pheiffer, W., Weyers, M., Niekerk, S. E. V., Hamman, J. H., & van Staden, D. (2025) · Pharmaceuticals · doi:10.3390/ph18020195 · Cited by 37

Nanoemulsions Based Therapeutic Strategies: Enhancing Targeted Drug Delivery against Breast Cancer Cells

Izadiyan, Z., Webster, T. J., Kia, P., Kalantari, K., Misran, M., Rasouli, E., Esfahan, Z. M., & Shameli, K. (2025) · International Journal of Nanomedicine · doi:10.2147/ijn.s488545 · Cited by 34

Recent advances in modification of novel carbon-based composites: Synthesis, properties, and biotechnological/ biomedical applications

Elkodous, M. A., Olojede, S. O., Sahoo, S., & Kumar, R. (2023) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2023.110517 · Cited by 33

Intranasal delivery of a Fas-blocking peptide attenuates Fas-mediated apoptosis in brain ischemia

Ullah, I., Chung, K., Oh, J., Beloor, J., Bae, S., Lee, S. C., Lee, M., Kumar, P., & Lee, S. (2018) · Scientific Reports · doi:10.1038/s41598-018-33296-z · Cited by 31

Recent advancements in nanoparticle-mediated approaches for restoration of multiple sclerosis

Rahiman, N., Mohammadi, M., Alavizadeh, S. H., Arabi, L., Badiee, A., & Jaafari, M. R. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.02.009 · Cited by 30

Nucleic acid therapies for CNS diseases: Pathophysiology, targets, barriers, and delivery strategies

Padmakumar, S., D’souza, A. A., Parayath, N. N., Bleier, B. S., & Amiji, M. M. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.10.018 · Cited by 30

Nasal Administration of Cationic Nanoemulsions as Nucleic Acids Delivery Systems Aiming at Mucopolysaccharidosis Type I Gene Therapy

Schuh, R. S., Bidone, J., Poletto, É., Pinheiro, C. V., Pasqualim, G., de Carvalho, T. G., Farinon, M., Diel, D. D. S., Xavier, R. M., Baldo, G., et al. (2018) · Pharmaceutical Research · doi:10.1007/s11095-018-2503-5 · Cited by 29

Nose-to-brain delivery of paliperidone palmitate poloxamer-guar gum nanogel: Formulation, optimization and pharmacological studies in rats

Gadhave, D., Gupta, A., Khot, S., Tagalpallewar, A., & Kokare, C. (2023) · Annales Pharmaceutiques Françaises · doi:10.1016/j.pharma.2022.08.010 · Cited by 29

Nanotechnology prospects in brain therapeutics concerning gene-targeting and nose-to-brain administration

Wu, D., Salah, Y. A., Ngowi, E. E., Zhang, Y., Khattak, S., Khan, N. H., Wang, Y., Li, T., Guo, Z.-H., Wang, Y., et al. (2023) · iScience · doi:10.1016/j.isci.2023.107321 · Cited by 30

Nanocarrier facilitated drug delivery to the brain through intranasal route: A promising approach to transcend bio-obstacles and alleviate neurodegenerative conditions

Koduru, T. S., Gupta, N. V., Sharadha, M., Chakraborty, S., Kumar, H., Chand, P., Balamuralidhara, V., & Gowda, D. V. (2022) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2022.103656 · Cited by 28

Multifunctional Nanocarriers for Alzheimer’s Disease: Befriending the Barriers

Ansari, M. A., Tripathi, T., Venkidasamy, B., Monziani, A., Rajakumar, G., Alomary, M. N., Alyahya, S. A., Onimus, O., D’souza, N., Barkat, M. A., et al. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03730-z · Cited by 29

In vivo methods for acute modulation of gene expression in the central nervous system

Cwetsch, A. W., Pinto, B., Savardi, A., & Cancedda, L. (2018) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2018.04.008 · Cited by 26

Brain Delivery Strategies for Biomacromolecular Drugs: Intranasal Administration

Wu, H., Li, C., Yuan, H., Zhao, J., & Li, S. (2025) · International Journal of Nanomedicine · doi:10.2147/ijn.s520768 · Cited by 26

Noninvasive delivery of oligonucleotide by penetratin-modified polyplexes to inhibit protein expression of intraocular tumor

Tai, L., Liu, C., Jiang, K., Chen, X., Wei, G., Lu, W., & Pan, W. (2017) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2017.04.011 · Cited by 24

Study on Formulation, in vivo Exposure, and Passive Targeting of Intravenous Itraconazole Nanosuspensions

Yuan, Q., Wang, Y., Song, R., Hou, X., Yu, K., Zheng, J., Zhang, J., Pu, X., Han, J., & Zong, L. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00225 · Cited by 23

Eplerenone nanoemulsions for treatment of hypertension. Part I: Experimental design for optimization of formulations and physical characterization

Özdemir, S., Çelik, B., Acar, E. T., Duman, G., & Üner, M. (2018) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2018.03.011 · Cited by 21

A quality by design approach for optimization of Lecithin/Span® 80 based nanoemulsions loaded with hydrophobic drugs

Real, D. A., Hoffmann, S. R. K., Leonardi, D., Goycoolea, F. M., & Salomon, C. J. (2020) · Journal of Molecular Liquids · doi:10.1016/j.molliq.2020.114743 · Cited by 22

Cell type-targeting nanoparticles in treating central nervous system diseases: Challenges and hopes

Guo, S., & Yi, C. (2023) · Nanotechnology Reviews · doi:10.1515/ntrev-2023-0158 · Cited by 25

Characterization of Gastrointestinal Fate of Nanoemulsions

Zhang, R., & McClements, D. J. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-811838-2.00018-7 · Cited by 22

Mathematical Modeling and Simulation to Investigate the CNS Transport Characteristics of Nanoemulsion-Based Drug Delivery Following Intranasal Administration

Kadakia, E., Bottino, D. C., & Amiji, M. M. (2019) · Pharmaceutical Research · doi:10.1007/s11095-019-2610-y · Cited by 20

Flavonoids, the Family of Plant-Derived Antioxidants Making Inroads into Novel Therapeutic Design Against Ionizing Radiation-Induced Oxidative Stress in Parkinson’s Disease

Behl, T., Kaur, G., Sehgal, A., Zengin, G., Singh, S., Ahmadi, A., & BUNGAU, S. G. (2021) · Current Neuropharmacology · doi:10.2174/1570159x19666210524152817 · Cited by 22

Nanocarriers for effective drug delivery

Theochari, I., Xenakis, A., & Papadimitriou, V. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-816770-0.00019-8 · Cited by 22

Progress and perspectives on nanoplatforms for drug delivery to the brain

Xu, Y., Wei, L., & Wang, H. (2020) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2020.101636 · Cited by 20

Nanotechnology-driven therapies for neurodegenerative diseases: a comprehensive review

Espinosa, J. L., Park, P., Holcomb, M., Godin, B., & Villapol, S. (2024) · Therapeutic Delivery · doi:10.1080/20415990.2024.2401307 · Cited by 19

Biohybrid nanointerfaces for neuromodulation

Filippi, M., Balciunaite, A., & Katzschmann, R. K. (2023) · Nano Today · doi:10.1016/j.nantod.2023.102094 · Cited by 19

Brain-Targeted Polymers for Gene Delivery in the Treatment of Brain Diseases

Lü, Y., & Jiang, C. (2017) · Topics in Current Chemistry · doi:10.1007/s41061-017-0138-3 · Cited by 19

Emerging paradigms in treating cerebral infarction with nanotheranostics: opportunities and clinical challenges

Almalki, W. H., Alghamdi, S. A., Alzahrani, A., & Zhang, W. (2020) · Drug Discovery Today · doi:10.1016/j.drudis.2020.12.018 · Cited by 17

Nanoemulsions for drug delivery

Atanase, L. I. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-91864-0.00009-7 · Cited by 17

Ionizable nanoemulsions for RNA delivery into the central nervous system – importance of diffusivity

Borrajo, M. L., Quijano, A., Lapuhs, P., Rodriguez-Perez, A. I., Anthiya, S., Labandeira-García, J. L., Valenzuela, R., & Alonso, M. J. (2024) · Journal of Controlled Release · doi:10.1016/j.jconrel.2024.06.051 · Cited by 18

Nano-based approaches for the treatment of neuro-immunological disorders: a special emphasis on multiple sclerosis

Panghal, A., & Flora, S. J. S. (2024) · Discover Nano · doi:10.1186/s11671-024-04135-0 · Cited by 20

GastroPlus- and HSPiP-Oriented Predictive Parameters as the Basis of Valproic Acid-Loaded Mucoadhesive Cationic Nanoemulsion Gel for Improved Nose-to-Brain Delivery to Control Convulsion in Humans

Hussain, A., Altamimi, M. A., Mirza, M. A., Ramzan, M., & Khuroo, T. (2023) · Gels · doi:10.3390/gels9080603 · Cited by 16

Therapeutic Approaches for the Delivery ofTNF-αsiRNA

Pandi, P., Jain, A., Saka, R., & Khan, W. (2017) · Therapeutic Delivery · doi:10.4155/tde-2017-0011 · Cited by 16

Emerging Perspectives on Prime Editor Delivery to the Brain

BenDavid, E., Ramezanian, S., Lu, Y., Rousseau, J., Schroeder, A., Lavertu, M., & Tremblay, J. P. (2024) · Pharmaceuticals · doi:10.3390/ph17060763 · Cited by 16

Brain-targeted intranasal delivery of biologics: a perspective for Alzheimer's disease treatment

Li, H., Shen, X., Zhang, B., Li, Y., Alexander, C., Harvey, P., & Zhu, Z. (2025) · RSC Pharmaceutics · doi:10.1039/d5pm00148j · Cited by 18

Advances in Nanomedicines: A Promising Therapeutic Strategy for Ischemic Cerebral Stroke Treatment

Li, J., Xie, F., & Ma, X. (2024) · Nanomedicine · doi:10.2217/nnm-2023-0266 · Cited by 14

Revolutionizing Stroke Care: Nanotechnology-Based Brain Delivery as a Novel Paradigm for Treatment and Diagnosis

Balaji, P. G., Bhimrao, L. S., & Yadav, A. K. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04215-3 · Cited by 17

A Cell-Based Nasal Model for Screening the Deposition, Biocompatibility, and Transport of Aerosolized PLGA Nanoparticles

Maaz, A., Blagbrough, I. S., & Bank, P. D. (2024) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.3c00639 · Cited by 13

A comprehensive review on carrier mediated nose to brain targeting: emphasis on molecular targets, current trends, future prospects, and challenges

Tomar, S., Yadav, R. K., Shah, K., & Dewangan, H. K. (2022) · International Journal of Polymeric Materials · doi:10.1080/00914037.2022.2124255 · Cited by 12

Biomaterial-based osteoimmunomodulatory strategies via the TLR4-NF-κB signaling pathway: A review

Xing, H., Li, R., Qing, Y., Ying, B., & Qin, Y. (2021) · Applied Materials Today · doi:10.1016/j.apmt.2021.100969 · Cited by 13

Intranasal delivery of iron chelators and management of central nervous system disease

Cheng, R., & Kim, J. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1709259 · Cited by 13

Nose-to-brain delivery of biologics and stem cells

Agrawal, M., Konwar, A. N., Alexander, A., & Borse, V. B. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822522-6.00015-1 · Cited by 9

Research advances of in vivo biological fate of food bioactives delivered by colloidal systems

Zhao, C., Liu, D., Feng, L., Cui, J., Du, H., Wang, Y., Xiao, H., & Zheng, J. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2154741 · Cited by 9

Development of nanomedicines for the treatment of Alzheimer’s disease: Raison d’être, strategies, challenges and regulatory aspects

Mazahir, F., Alam, M. I., & Yadav, A. K. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102318 · Cited by 9

Tailor-made nanocargoes as promising tool for brain targeting: Modulated approaches with better therapeutic outcomes

Kumar, V., & Gupta, U. D. (2023) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2023.104466 · Cited by 8

Cholesterol-Conjugated siRNA Silencing Tnf for the Treatment of Liver Macrophage-Mediated Acute Inflammation in Nonalcoholic Fatty Liver Disease

Craig, K. P., Abrams, M. T., & Amiji, M. M. (2022) · Nucleic Acid Therapeutics · doi:10.1089/nat.2022.0038 · Cited by 6

Intranasal delivery systems for traumatic brain injury: Advancements and perspectives

Yoo, S. H., Heo, S. C., Bae, J. S., Lee, J. H., Knowles, J. C., & Kim, H. (2025) · Journal of Tissue Engineering · doi:10.1177/20417314251372373 · Cited by 5

Nanoparticle-based strategies for overcoming the blood-brain barrier in CNS disorders and brain cancer: precision diagnostics and therapeutics for Alzheimer’s, Parkinson’s, multiple sclerosis, and glioblastoma

Feyzbakhsh, H. (2025) · Tissue Barriers · doi:10.1080/21688370.2025.2599564 · Cited by 5

Drug delivery systems for neural tissue engineering

Güler, E., Polat, E. B., & Çam, M. E. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-90554-1.00012-4 · Cited by 4

Recent Advances in Nose-to-Brain Gene Delivery for Central Nervous System Disorders

Fachel, F. N. S., Salatino‐Oliveira, A., Carniel, W. D. S., Zimmermann, R., Matte, Ú. D. S., Teixeira, H. F., Baldo, G., & Schuh, R. S. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17091177 · Cited by 8

Strategies for enhanced direct nose-to-brain drug delivery

Madav, Y., & Wairkar, S. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822522-6.00014-x · Cited by 4

Molecular dynamics simulation of siRNA loading into a nanoemulsion as a potential carrier

Pirhadi, S., & Amani, A. (2020) · Journal of Molecular Modeling · doi:10.1007/s00894-020-04471-9 · Cited by 4

Protective effect of nanoemulsions containing CdTe quantum dots with potential application as a diagnostic agent

Gusmão, L. A., Köster, R. W., & Tedesco, A. C. (2024) · Microchimica Acta · doi:10.1007/s00604-024-06690-w · Cited by 3

Microorganisms and cationic surfactants

Kula, N., Mazurkiewicz, E., & Obłąk, E. (2020) · Postępy Higieny i Medycyny Doświadczalnej · doi:10.5604/01.3001.0014.5776 · Cited by 3

Genetic background and diagnosis of Fanconi anemia

Repczyńska, A., & Haus, O. (2020) · Postępy Higieny i Medycyny Doświadczalnej · doi:10.5604/01.3001.0014.6332 · Cited by 3

Applications of direct nose-to-brain drug delivery in biomedicine, biotechnology, tissue engineering, and immunology

Patil, S. B. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822522-6.00012-6 · Cited by 3

Nucleus targeting-functionalized cell-membrane nanovesicles for intranasal delivery of therapeutic plasmid DNA into the brain for the treatment of glioblastoma

Park, J. Y., Son, M., Zhuang, C., Choi, U., Park, K., Ahn, S. B., Kang, M., Oh, J., Lee, C., Choi, J. S., et al. (2025) · Journal of Industrial and Engineering Chemistry · doi:10.1016/j.jiec.2025.07.034 · Cited by 3

Nanotherapeutic strategies for mitigating sepsis-induced multiorgan dysfunctions

Kumari, A., Kumar, S., & Shukla, R. (2026) · Nanomedicine · doi:10.1080/17435889.2026.2659343 · Cited by 2

Bone-Marrow-Targeted Nanocomposite Abrogates C-Myb-Survivin Cross Talk in MLL-AF9-Rearranged Acute Myeloid Leukemia in In Vitro and In Vivo Patient-Derived Xenograft Models

Kushwaha, A. C., Boddu, M., Malhotra, P., Karmakar, S., & Choudhury, S. R. (2024) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.4c18737 · Cited by 2

Nanobiotechnologies for stroke treatment

Wan, G., Gu, L., Chen, Y., Wang, Y., Sun, Y., Li, Z., Ma, W., Bao, X., & Wang, R. (2025) · Nanomedicine · doi:10.1080/17435889.2025.2501514 · Cited by 2

On Overcoming Barriers to Application of Neuroinflammation Research

Tobinick, E., Ignatowski, T., & Spengler, R. (2017) · InTech eBooks · doi:10.5772/intechopen.68940 · Cited by 3

Particulate carriers for nose-to-brain delivery

Bahadur, S., & Pathak, K. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822522-6.00009-6 · Cited by 2

Current advancements in nasopulmonary drug delivery systems

Ibrahim, A., Aziz, O. A. A., Dena, A. S. A., & El-sherbiny, I. M. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-91668-4.00027-7 · Cited by 2

Bridging the nano-Frontier: revolutionizing lung cancer diagnosis and therapy with nanoparticles

Joseph, J. R., Pavithra, S., Selvakumar, K., & Venkatesh, D. P. (2024) · International Journal of Polymeric Materials · doi:10.1080/00914037.2024.2355182 · Cited by 2

CNS Delivery and Anti-Inflammatory Effects of Intranasally Administered Cyclosporine-A in Cationic Nanoformulations

Yadav, S. K., Pawar, G. N., Kulkarni, P. P., Ferris, C. F., & Amiji, M. M. (2018) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.118.254672 · Cited by 23

Intranasal delivery of cyclosporine to the brain using lipid-based nanocarriers for the treatment of neuro-inflammation

(n.d.) · Digital Repository Service (Northeastern University)

Intranasal Delivery of HMGB1 siRNA Confers Target Gene Knockdown and Robust Neuroprotection in the Postischemic Brain

Kim, I., Shin, J., Kim, S.-W., Choi, S., Ahn, J., Han, P., Park, J. S., & Lee, J.-K. (2012) · Molecular Therapy · doi:10.1038/mt.2011.291 · Cited by 150

Intranasal Tat-modified PEG-PCL nanomicelles delivering anti-RelA siRNA attenuate ischemia-reperfusion injury

Fukuda, M., Oguma, T., Nagatomo, T., Yamaguchi, T., Kosuge, Y., Suzuki, T., & Kanazawa, T. (2026) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2026.103028

Therapeutic Effects in a Transient Middle Cerebral Artery Occlusion Rat Model by Nose-To-Brain Delivery of Anti-TNF-Alpha siRNA with Cell-Penetrating Peptide-Modified Polymer Micelles

Kanazawa, T., Kurano, T., Ibaraki, H., Takashima, Y., Suzuki, T., & Seta, Y. (2019) · Pharmaceutics · doi:10.3390/pharmaceutics11090478 · Cited by 55