Nose-to-brain delivery of BACE1 siRNA loaded in solid lipid nanoparticles for Alzheimer’s therapy

Solid lipid nanoparticles (SLN) for controlled drug delivery – a review of the state of the art

Müller, R. (2000) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/s0939-6411(00)00087-4 · Cited by 3,759 · see citing works

Transvascular delivery of small interfering RNA to the central nervous system

Kumar, P., Wu, H., McBride, J. L., Jung, K.-E., Hee Kim, M., Davidson, B. L., Kyung Lee, S., Shankar, P., & Manjunath, N. (2007) · Nature · doi:10.1038/nature05901 · Cited by 1,246 · see citing works

Intranasal delivery of biologics to the central nervous system

Lochhead, J. J., & Thorne, R. G. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2011.11.002 · Cited by 1,214 · see citing works

Nasal drug delivery—possibilities, problems and solutions

Illum, L. (2003) · Journal of Controlled Release · doi:10.1016/s0168-3659(02)00363-2 · Cited by 1,107 · see citing works

Nanoparticles for direct nose-to-brain delivery of drugs

Mistry, A., Stolnik, S., & Illum, L. (2009) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2009.06.019 · Cited by 734 · see citing works

Progress towards in Vivo Use of siRNAs

Behlke, M. A. (2006) · Molecular Therapy · doi:10.1016/j.ymthe.2006.01.001 · Cited by 677 · see citing works

Direct nose to brain drug delivery <i>via</i> integrated nerve pathways bypassing the blood–brain barrier: an excellent platform for brain targeting

Pardeshi, C. V., & Belgamwar, V. S. (2013) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2013.790887 · Cited by 482 · see citing works

Chitosan in nasal delivery systems for therapeutic drugs

Casettari, L., & Illum, L. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.05.003 · Cited by 448 · see citing works

The Nasal Approach to Delivering Treatment for Brain Diseases: An Anatomic, Physiologic, and Delivery Technology Overview

Djupesland, P. G., Messina, J. C., & Mahmoud, R. A. (2014) · Therapeutic Delivery · doi:10.4155/tde.14.41 · Cited by 297 · see citing works

Lectin-modified solid lipid nanoparticles as carriers for oral administration of insulin

Zhang, N., Ping, Q. N., Huang, G., Xu, W., Cheng, Y., & Han, X. (2006) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2006.07.026 · Cited by 286 · see citing works

Design of lipid nanoparticles for the oral delivery of hydrophilic macromolecules

García-Fuentes, M., Torres, D., & Alonso, M. J. (2002) · Colloids and Surfaces B Biointerfaces · doi:10.1016/s0927-7765(02)00053-x · Cited by 273 · see citing works

Delivery of siRNA to the brain using a combination of nose-to-brain delivery and cell-penetrating peptide-modified nano-micelles

Kanazawa, T., Akiyama, F., Kakizaki, S., Takashima, Y., & Seta, Y. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.08.036 · Cited by 242 · see citing works

Cell penetrating peptides: overview and applications to the delivery of oligonucleotides

Hassane, F. S., Saleh, A. F. A., Abes, R., Gait, M. J., & Lebleu, B. (2009) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-009-0186-0 · Cited by 211 · see citing works

Nose-to-Brain Delivery: Investigation of the Transport of Nanoparticles with Different Surface Characteristics and Sizes in Excised Porcine Olfactory Epithelium

Mistry, A., Stolnik, S., & Illum, L. (2015) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.5b00088 · Cited by 178 · see citing works

Cell-Penetrating Peptide-Mediated Therapeutic Molecule Delivery into the Central Nervous System

Zou, L., Ma, J.-L., Wang, T., Yang, T., & Liu, C.-B. (2013) · Current Neuropharmacology · doi:10.2174/1570159x11311020006 · Cited by 163 · see citing works

The impact of nanoparticles on the mucosal translocation and transport of GLP-1 across the intestinal epithelium

Araújo, F., Shrestha, N., Shahbazi, M., Fonte, P., Mäkilä, E. M., Salonen, J., Hirvonen, J. J., Granja, P. L., Santos, H. A., & Sarmento, B. F. C. C. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.07.026 · Cited by 152 · see citing works

Solid microparticles based on chitosan or methyl-β-cyclodextrin: A first formulative approach to increase the nose-to-brain transport of deferoxamine mesylate

Rassu, G., Soddu, E., Cossu, M., Brundu, A., Cerri, G., Marchetti, N., Ferraro, L., Regan, R. F., Giunchedi, P., Gavini, E., et al. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.01.025 · Cited by 143 · see citing works

Prolongation of Life in Rats with Malignant Glioma by Intranasal siRNA/Drug Codelivery to the Brain with Cell-Penetrating Peptide-Modified Micelles

Kanazawa, T., Morisaki, K., Suzuki, S., & Takashima, Y. (2014) · Molecular Pharmaceutics · doi:10.1021/mp400644e · Cited by 133 · see citing works

Ultrastructure of substance P‐ and CGRP‐immunoreactive nerve fibers in the nasal epithelium of rodents

Finger, T. E., Jeor, V. L. S., Kinnamon, J. C., & Silver, W. L. (1990) · The Journal of Comparative Neurology · doi:10.1002/cne.902940212 · Cited by 127 · see citing works

Intranasal brain delivery of cationic nanoemulsion-encapsulated TNFα siRNA in prevention of experimental neuroinflammation

Yadav, S., Gandham, S. K., Panicucci, R., & Amiji, M. M. (2016) · Nanomedicine: Nanotechnology, Biology and Medicine · doi:10.1016/j.nano.2015.12.374 · Cited by 125 · see citing works

Evidence for Nicotinic Acetylcholine Receptors on Nasal Trigeminal Nerve Endings of the Rat

Alimohammadi, H. (2000) · Chemical Senses · doi:10.1093/chemse/25.1.61 · Cited by 110 · see citing works

Nanoparticle transport across in vitro olfactory cell monolayers

Gartziandia, O., Egusquiaguirre, S. P., Bianco, J. I., Pedraz, J. L., Igartúa, M., Hernández, R. M., Véronique Préat, A., & Beloqui, A. (2015) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2015.12.046 · Cited by 97 · see citing works

Formulation and optimization of solid lipid nanoparticle formulation for pulmonary delivery of budesonide using Taguchi and Box-Behnken design.

Emami, J., Mohiti, H., Hamishehkar, H., et al. (2015) · PubMed · Cited by 88 · see citing works

Particulate formulations based on chitosan for nose-to-brain delivery of drugs. A review

Rassu, G., Soddu, E., Cossu, M., Gavini, E., Giunchedi, P., & Dalpiaz, A. (2016) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2015.05.002 · Cited by 87 · see citing works

Nose-to-brain delivery of macromolecules mediated by cell-penetrating peptides

Lin, T., Liu, E., He, H., Shin, M. C., Moon, C., Yang, V. C.-M., & Huang, Y. (2016) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2016.04.001 · Cited by 85 · see citing works

Effect of freeze-drying, cryoprotectants and storage conditions on the stability of secondary structure of insulin-loaded solid lipid nanoparticles

Soares, S. S., Fonte, P., Costa, A., Andrade, J. C., Seabra, V., Ferreira, D., Reis, S., & Sarmento, B. F. C. C. (2013) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2013.08.076 · Cited by 77 · see citing works

Nasal chitosan microparticles target a zidovudine prodrug to brain HIV sanctuaries

Dalpiaz, A., Fogagnolo, M., Ferraro, L., Capuzzo, A., Pavan, B., Rassu, G., Salis, A., Giunchedi, P., & Gavini, E. (2015) · Antiviral Research · doi:10.1016/j.antiviral.2015.09.013 · Cited by 63 · see citing works

Influence of polymeric microcarriers on the in vivo intranasal uptake of an anti-migraine drug for brain targeting

Gavini, E., Rassu, G., Ferraro, L., Beggiato, S., Alhalaweh, A., Velaga, S., Marchetti, N., Bandiera, P., Giunchedi, P., & Dalpiaz, A. (2013) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2012.10.010 · Cited by 62 · see citing works

Intranasal delivery of siRNA to the olfactory bulbs of mice via the olfactory nerve pathway

Renner, D. B., Frey, W. H., & Hanson, L. R. (2012) · Neuroscience Letters · doi:10.1016/j.neulet.2012.02.037 · Cited by 62 · see citing works

Bioengineered nanoparticles for siRNA delivery

Kozielski, K., Tzeng, S. Y., & Green, J. J. (2013) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1233 · Cited by 54 · see citing works

Influence of Chitosan Glutamate on the in vivo Intranasal Absorption of Rokitamycin from Microspheres

Gavini, E., Rassu, G., Ferraro, L., Generosi, A., Rau, J. V., Brunetti, A., Giunchedi, P., & Dalpiaz, A. (2010) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.22382 · Cited by 54 · see citing works

Altered β‐secretase enzyme kinetics and levels of both BACE1 and BACE2 in the Alzheimer's disease brain

Stockley, J. H., Ravid, R., & O’Neill, C. (2006) · FEBS Letters · doi:10.1016/j.febslet.2006.10.076 · Cited by 50 · see citing works

Transepithelial Electrical Resistance is Not a Reliable Measurement of the Caco-2 Monolayer Integrity in Transwell

Mukherjee, T., Squillantea, E., Gillespieb, M., & Shao, J. (2004) · Drug Delivery · doi:10.1080/10717540490280345 · Cited by 49 · see citing works

The temperature effect on electrokinetic properties of the silica–polyvinyl alcohol (PVA) system

Wisniewska, M. A. (2010) · Colloid & Polymer Science · doi:10.1007/s00396-010-2341-4 · Cited by 48 · see citing works

RNA Interference as a Tool for Alzheimers Disease Therapy

Orlacchio, A., Bernardi, G., Orlacchio, A., et al. (2007) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/138955707782331678 · Cited by 45 · see citing works

Mucoadhesive microspheres for nasal administration of cyclodextrins

Gavini, E., Rassu, G., Haukvik, T., Lanni, C., Racchi, M., & Giunchedi, P. (2008) · Journal of drug targeting · doi:10.1080/10611860802556842 · Cited by 43 · see citing works

Robust neuroprotective effects of intranasally delivered iNOS siRNA encapsulated in gelatin nanoparticles in the postischemic brain

Kim, I., Sawicki, E., Lee, H., Lee, E. H., Park, H. J., Han, P., Kim, K., Choi, H., & Lee, J.-K. (2016) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2016.01.002 · Cited by 43 · see citing works

Neuroprotective Effects of Engineered Polymeric Nasal Microspheres Containing Hydroxypropyl-β-cyclodextrin on β-Amyloid (1-42)-Induced Toxicity

Yalcin, A., Soddu, E., Turunc Bayrakdar, E., Uyanikgil, Y., Kanit, L., Armagan, G., Rassu, G., Gavini, E., & Giunchedi, P. (2016) · Journal of Pharmaceutical Sciences · doi:10.1016/j.xphs.2016.05.017 · Cited by 37 · see citing works

From naturally-occurring neurotoxic agents to CNS shuttles for drug delivery

Soddu, E., Rassu, G., Giunchedi, P., Sarmento, B. F. C. C., & Gavini, E. (2015) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2015.04.005 · Cited by 21 · see citing works

Mucoadhesive Drug Delivery Systems for Nose-to-Brain Targeting of Dopamine

Gavini, E., Rassu, G., Ciarnelli, V., et al. (2012) · Journal of Nanoneuroscience · doi:10.1166/jns.2012.1015 · Cited by 7 · see citing works

Recent advances in carrier mediated nose-to-brain delivery of pharmaceutics

Bourganis, V., Kammona, O., Alexopoulos, A., & Kiparissides, C. (2018) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2018.05.009 · Cited by 357 · see citing works

Surface-Modified Nanocarriers for Nose-To-Brain Delivery: From Bioadhesion to Targeting

Sonvico, F., Clementino, A. R., Buttini, F., Colombo, G., Pescina, S., Stanisçuaski Guterres, S., Raffin Pohlmann, A., & Nicoli, S. (2018) · doi:10.20944/preprints201802.0077.v1 · Cited by 306 · see citing works

Nanoemulsions for “Nose-to-Brain” Drug Delivery

Bonferoni, M. C., Rossi, S., Sandri, G., Ferrari, F., Gavini, E., Rassu, G., & Giunchedi, P. (2019) · Pharmaceutics · doi:10.3390/pharmaceutics11020084 · Cited by 269 · see citing works

Nanotechnology-based strategies for siRNA brain delivery for disease therapy

Zheng, M., Tao, W., Zou, Y., Farokhzad, O. C., & Shi, B. (2018) · Trends in biotechnology · doi:10.1016/j.tibtech.2018.01.006 · Cited by 210 · see citing works

Neurotheranostics as Personalized Medicines

Kevadiya, B. D., Ottemann, B. M., Thomas, M. B., Mukadam, I., Nigam, S., McMillan, J., Gorantla, S., Bronich, T. K., Edagwa, B., & Gendelman, H. E. (2019) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.10.011 · Cited by 124 · see citing works

Intranasal Delivery of Genistein-Loaded Nanoparticles as a Potential Preventive System against Neurodegenerative Disorders

Rassu, G., Porcu, E. P., Fancello, S., Obinu, A., Senes, N., Galleri, G., Migheli, R., Gavini, E., & Giunchedi, P. (2018) · Pharmaceutics · doi:10.3390/pharmaceutics11010008 · Cited by 107 · see citing works

Enhancing the therapeutic delivery of oligonucleotides by chemical modification and nanoparticle encapsulation

Sun, Y., Zhao, Y., Zhao, X., Lee, R. J., Teng, L., & Zhou, C. (2017) · Molecules · doi:10.3390/molecules22101724 · Cited by 56 · see citing works

Novel Therapeutic Strategies for Alzheimer’s Disease: Implications from Cell-Based Therapy and Nanotherapy

Derakhshankhah, H., Sajadimajd, S., Jafari, S., Izadi, Z., Sarvari, S., Sharifi, M., Falahati, M., Moakedi, F., Muganda, W. C. A., Müller, M., et al. (2020) · Nanomedicine: Nanotechnology, Biology and Medicine · doi:10.1016/j.nano.2020.102149 · Cited by 48 · see citing works

Mesoporous silica nanoparticle-encapsulated Bifidobacterium attenuates brain Aβ burden and improves olfactory dysfunction of APP/PS1 mice by nasal delivery

Liu, N., Yang, C., Liang, X., Cao, K., Xie, J., Luo, Q., & Luo, H. (2022) · Journal of Nanobiotechnology · doi:10.1186/s12951-022-01642-z · Cited by 45 · see citing works

Intranasal Therapeutics for Neurodegenerative Disorders: Overcoming the Blood–Brain Barrier with Smart Formulations and Devices

Kumar, S., Yadav, A., Verma, R. K., Kumar, A., Gupta, P. K., & Shukla, R. (2025) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.5c00386 · Cited by 14 · see citing works

Factors of carrier affecting the adhesion of microspheres via intranasal administration

Sun, M. (2012) · Journal of Guangdong Pharmaceutical University

Preparation and Physicochemical Properties of Solid Lipid Nanoparticles Containing Praziquantel

Jinsong, Y. (2007) · Zhongguo yaofang

Solid lipid nanoparticles as delivery systems for Gambogenic acid

Huang, X., Chen, Y., Peng, D., Li, Q., Wang, X., Wang, D., & Chen, W. (2012) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2012.08.058 · Cited by 64 · see citing works

DEVELOPMENT AND EVALUATION OF TIZANIDINE HYDROCHLORIDE LOADED SOLID LIPID NANOPARTICLES

PAVITHRA, K., ST, B., & Manjunath, K. (2019) · Asian Journal of Pharmaceutical and Clinical Research · doi:10.22159/ajpcr.2019.v12i10.34545 · Cited by 3 · see citing works

Solid lipid nanoparticle (SLN) formulations as a potential tool for the reduction of cytotoxicity of saponins

de Ven, H. V., Vermeersch, M., Shunmugaperumal, T., et al. (2009) · Die Pharmazie · doi:10.31083/ph.2009.8222 · Cited by 11 · see citing works