Cited by 157Neurogenesis and neuroplasticity mechanismsMultiple Sclerosis Research StudiesMesenchymal stem cell research

PDGF and FGF2 pathways regulate distinct oligodendrocyte lineage responses in experimental demyelination with spontaneous remyelination

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Murtie, Joshua C., Zhou, Yong-Xing, Le, Tuan Q., Vana, Adam C., Armstrong, Regina C.·2005·Neurobiology of Disease

Abstract

Repair of myelin damage in the adult CNS requires oligodendrocyte progenitor (OP) proliferation and subsequent differentiation into remyelinating oligodendrocytes. Platelet-derived growth factor (PDGF) and fibroblast growth factor-2 (FGF2) have been predicted to act individually and/or cooperatively to generate remyelinating oligodendrocytes. Analysis of PDGF alpha receptor (PDGF alpha R) heterozygous (+/-) mice indicates that PDGF alpha R expression modulates oligodendrocyte density in non-lesioned adult CNS. Analysis of cuprizone demyelination and recovery in PDGF alpha R+/- mice, FGF2 knockout (-/-) mice, and PDGF alpha R+/- FGF2-/- mice demonstrated that: (1) OP proliferation and oligodendrocyte regeneration is impaired in PDGF alpha R heterozygotes, (2) PDGF alpha R+/- and FGF2-/- deletions do not act cooperatively to impair OP amplification, (3) oligodendrocyte differentiation is more frequent in FGF2-/- mice, and (4) FGF2 deletion in combination with the PDGF alpha R+/- genotype rescues impaired oligodendrocyte regeneration of PDGF alpha R heterozygotes. These findings demonstrate distinct roles for PDGF and FGF2 in vivo in the context of a demyelinating disease with spontaneous remyelination.

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Crossref · 10.1016/j.nbd.2004.12.006

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Authors
Murtie, J. C., Zhou, Y.-X., Le, T. Q., Vana, A. C., & Armstrong, R. C.
Affiliations
Uniformed Services University of the Health Sciences (US)
Corresponding author
Armstrong, Regina C.
Venue
Neurobiology of Disease
Publisher
Elsevier BV
Published
2005-06
Volume
19
Issue
1-2
Pages
171-182
ISSN
0969-9961 (ISSN-L)
OpenAlex
W2021786345
Cited by
157
References
50
Citations by year
2026: 3 · 2025: 5 · 2024: 9 · 2023: 5 · 2022: 4 · 2021: 5 · 2020: 6 · 2019: 9 · 2018: 7 · 2017: 3 · 2016: 10 · 2015: 11 · 2014: 14 · 2013: 12 · 2012: 8
FWCI
2.29
Type
journal article
Language
en
Open access
Locations
  • Neurobiology of Disease (publishedVersion)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
National Institute of Neurological Disorders and Stroke (R01NS039293, NS39293)
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
  • Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
Keywords
platelet-derived growth factor, fibroblast growth factor 2, PDGF receptor alpha, oligodendrocyte precursor cells, remyelination, demyelination, cuprizone, oligodendrocyte differentiation, oligodendrocyte proliferation
MeSH terms
Animals, Corpus Callosum, Demyelinating Diseases, Male, Mice, Inbred C57BL, Nerve Fibers, Myelinated, Oligodendroglia, Signal Transduction, Fibroblast Growth Factor 2, Mice, Knockout, Cell Lineage, Receptor, Platelet-Derived Growth Factor alpha, NIH 3T3 Cells, Mice

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