Cited by 220Down syndrome and intellectual disability researchGenetics and Neurodevelopmental DisordersAlzheimer's disease research and treatments

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DYRK1A BAC transgenic mice show altered synaptic plasticity with learning and memory defects

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Ahn, Kyoung-Jin, Jeong, Hey Kyeong, Choi, Han-Saem, Ryoo, Soo-Ryoon, Kim, Yeon Ju, Goo, Jun-Seo, Choi, Se-Young, Han, Jung-Soo, Ha, Ilho, Song, Woo-Joo·2006·Neurobiology of Disease

DOI 10.1016/j.nbd.2005.12.006

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Abstract

Among the various phenotypes seen in Down syndrome (DS), mental retardation is the most common and most debilitating condition suffered by individuals with DS. The DYRK1A gene on human chromosome 21q22.2 encodes a subfamily of protein kinases that displays dual substrate specificities and is known to play a critical role in neurodevelopment. To study DS mental retardation, we have generated transgenic mice that contain only one copy of the complete human DYRK1A gene in a bacterial artificial chromosome. The transgenic mice showed significant impairment in hippocampal-dependent memory tasks in a Morris water maze. Interestingly, we observed shifts in both long-term potentiation and long-term depression, which suggests a role for DYRK1A in bidirectional synaptic plasticity. These mice represent the most clinically relevant DYRK1A mouse model to date and provide us a valuable tool for the in vivo study of mechanisms that underlie the learning and memory deficit in DS.

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Authors: Ahn, K.-J., Jeong, H. K., Choi, H.-S., Ryoo, S.-R., Kim, Y. J., Goo, J.-S., Choi, S.-Y., Han, J.-S., Ha, I., & Song, W.-J.
Affiliations: Inje University (KR)
Seoul National University (KR)
Corresponding author: Ha, Ilho
Song, Woo-Joo
ORCID: Ryoo, Soo-Ryoon
Choi, Se-Young
Han, Jung-Soo
Venue: Neurobiology of Disease
Publisher: Elsevier BV
Published: 2006-06
Volume: 22
Issue: 3
Pages: 463-472
ISSN: 0969-9961 (ISSN-L)
DOI: 10.1016/j.nbd.2005.12.006
OpenAlex: W2110646442
Cited by: 220
References: 54
Citations by year: 2026: 1 · 2025: 4 · 2024: 5 · 2023: 7 · 2022: 11 · 2021: 6 · 2020: 7 · 2019: 10 · 2018: 8 · 2017: 17 · 2016: 9 · 2015: 6 · 2014: 15 · 2013: 15 · 2012: 27
FWCI: 14.00
Type: journal article
Language: en
Open access: green
doaj.org
Licence: cc-by-sa
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neurobiology of Disease (publishedVersion)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Seoul National University Open Repository (Seoul National University) (submittedVersion)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Down syndrome and intellectual disability research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Keywords: DYRK1A, Down syndrome, intellectual disability, transgenic mouse model, bacterial artificial chromosome, synaptic plasticity, long-term potentiation, long-term depression, hippocampal-dependent memory, learning and memory impairment, protein kinases
MeSH terms: Dyrk Kinases, Animals, Disease Models, Animal, Down Syndrome, Humans, Immunohistochemistry, Learning Disabilities, Memory Disorders, Mice, Transgenic, Neuronal Plasticity, Protein-Tyrosine Kinases, Polymerase Chain Reaction, Protein Serine-Threonine Kinases, In Situ Hybridization, Fluorescence, Chromosomes, Artificial, Bacterial, Mice

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DYRK1A BAC transgenic mice show altered synaptic plasticity with learning and memory defects

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