DYRK1A (Dual-Specificity Tyrosine-Phosphorylated and -Regulated Kinase 1A): A Gene with Dosage Effect During Development and Neurogenesis

Proline-directed and non-proline-directed phosphorylation of PHF-tau

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A genome-wide Drosophila RNAi screen identifies DYRK-family kinases as regulators of NFAT

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Neurodevelopmental delay, motor abnormalities and cognitive deficits in transgenic mice overexpressing Dyrk1A (minibrain), a murine model of Down's syndrome

Altafaj, X. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.18.1915 · Cited by 396 · see citing works

minibrain: A new protein kinase family involved in postembryonic neurogenesis in Drosophila

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The kinase DYRK phosphorylates protein-synthesis initiation factor eIF2Bɛ at Ser539 and the microtubule-associated protein tau at Thr212: potential role for DYRK as a glycogen synthase kinase 3-priming kinase

Woods, Y. L., Cohen, P., Becker, W. B., Jakes, R., Goedert, M., Wang, X., & Proud, C. G. (2001) · Biochemical Journal · doi:10.1042/bj3550609 · Cited by 343 · see citing works

Dyrk1A Haploinsufficiency Affects Viability and Causes Developmental Delay and Abnormal Brain Morphology in Mice

Fotaki, V., Dierssen, M., Alcántara, S., Martı́nez, S., Martı́, E., Casas, C., Visa, J., Soriano, E., Estivill, X., & Arbonés, M. L. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.18.6636-6647.2002 · Cited by 330 · see citing works

Activation-Loop Autophosphorylation Is Mediated by a Novel Transitional Intermediate Form of DYRKs

Lochhead, P. A., Sibbet, G. J., MORRICE, N. A., & Cleghon, V. (2005) · Cell · doi:10.1016/j.cell.2005.03.034 · Cited by 323 · see citing works

Functional screening of 2 Mb of human chromosome 21q22.2 in transgenic mice implicates minibrain in learning defects associated with Down syndrome

Smith, D., Stevens, M. E., Sudanagunta, S. P., Bronson, R. T., Makhinson, M., Watabe, A. M., O’Dell, T. J., Fung, J., Weier, H. G., Cheng, J., et al. (1997) · Nature Genetics · doi:10.1038/ng0597-28 · Cited by 321 · see citing works

Altered Cortical Synaptic Morphology and Impaired Memory Consolidation in Forebrain- Specific Dominant-Negative PAK Transgenic Mice

Hayashi, M. L., Choi, S.-Y., Rao, B. S. S., Jung, H.-Y., Lee, H.-K., Zhang, D., Chattarji, S., Kirkwood, A., & Tonegawa, S. (2004) · Neuron · doi:10.1016/j.neuron.2004.05.003 · Cited by 280 · see citing works

The kinase DYRK1A phosphorylates the transcription factor FKHR at Ser329 in vitro, a novel in vivo phosphorylation site

Woods, Y. L., Rena, G., MORRICE, N. A., Barthel, A., Becker, W. B., Guo, S., Unterman, T. G., & Cohen, P. (2001) · Biochemical Journal · doi:10.1042/bj3550597 · Cited by 265 · see citing works

Dyrk, a Dual Specificity Protein Kinase with Unique Structural Features Whose Activity Is Dependent on Tyrosine Residues between Subdomains VII and VIII

Kentrup, H., Becker, W. B., Heukelbach, J., Wilmes, A., Schürmann, A., Huppertz, C., Kainulainen, H., & Joost, H. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.7.3488 · Cited by 259 · see citing works

Structural and Functional Characteristics of Dyrk, a Novel Subfamily of Protein Kinases with Dual Specificity

Becker, W. B., & Joost, H. (1998) · Progress in nucleic acid research and molecular biology · doi:10.1016/s0079-6603(08)60503-6 · Cited by 226 · see citing works

DYRK1A BAC transgenic mice show altered synaptic plasticity with learning and memory defects

Ahn, K.-J., Jeong, H. K., Choi, H.-S., Ryoo, S.-R., Kim, Y. J., Goo, J.-S., Choi, S.-Y., Han, J.-S., Ha, I., & Song, W.-J. (2006) · Neurobiology of Disease · doi:10.1016/j.nbd.2005.12.006 · Cited by 220 · see citing works

A human homologue of Drosophila minibrain (MNB) is expressed in the neuronal regions affected in Down syndrome and maps to the critical region

Guimerá, J. (1996) · Human Molecular Genetics · doi:10.1093/hmg/5.9.1305 · Cited by 217 · see citing works

Identification of the autophosphorylation sites and characterization of their effects in the protein kinase DYRK1A

Himpel, S., PANZER, P., EIRMBTER, K., Czajkowska, H., Sayed, M., Packman, L. C., Blundell, T. L., Kentrup, H., Grötzinger, J., Joost, H., et al. (2001) · Biochemical Journal · doi:10.1042/bj3590497 · Cited by 209 · see citing works

Regulation of Gli1 Transcriptional Activity in the Nucleus by Dyrk1

Mao, J., Maye, P. F., Kogerman, P., Tejedor, F. J., Toftgård, R., Xie, W., Wu, G., & Wu, D. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m206743200 · Cited by 190 · see citing works

Phosphorylation of spliceosomal protein SAP 155 coupled with splicing catalysisPreprint

Wang, C., Chua, K. F., Seghezzi, W., Lees, E. M., Gozani, O., & Reed, R. (1998) · Genes & Development · doi:10.1101/gad.12.10.1409 · Cited by 187 · see citing works

HumanMinibrainHomologue (MNBH/DYRK1): Characterization, Alternative Splicing, Differential Tissue Expression, and Overexpression in Down Syndrome

Guimera, J., Casas, C., Estivill, X., & Pritchard, M. (1999) · Genomics · doi:10.1006/geno.1999.5775 · Cited by 186 · see citing works

Constitutive Dyrk1A is abnormally expressed in Alzheimer disease, Down syndrome, Pick disease, and related transgenic models

Ferrer, I., Barrachina, M., Puig, B., de Lagrán, M. M., Martı́, E., Ávila, J., & Dierssen, M. (2005) · Neurobiology of Disease · doi:10.1016/j.nbd.2005.03.020 · Cited by 181 · see citing works

Isolation of Human and Murine Homologues of theDrosophilaMinibrain Gene: Human Homologue Maps to 21q22.2 in the Down Syndrome “Critical Region”

Song, W., Sternberg, L. R., Kasten-Sportès, C., Keuren, M. L. V., Chung, S.-H., Slack, A. C., Miller, D. E., Glover, T. W., Chiang, P.-W., Lou, L., et al. (1996) · Genomics · doi:10.1006/geno.1996.0636 · Cited by 177 · see citing works

Protein kinase Dyrk1 activates cAMP response element-binding protein during neuronal differentiation in hippocampal progenitor cells

Yang, E. J., Ahn, Y. S., & Chung, K. C. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104091200 · Cited by 172 · see citing works

Evolutionary constraints associated with functional specificity of the CMGC protein kinases MAPK, CDK, GSK, SRPK, DYRK, and CK2α

Kannan, N., & Neuwald, A. F. (2004) · Protein Science · doi:10.1110/ps.04637904 · Cited by 167 · see citing works

DYRK1A accumulates in splicing speckles through a novel targeting signal and induces speckle disassembly

Álvarez‐Fernández, M., Estivill, X., & de la Luna, S. (2003) · Journal of Cell Science · doi:10.1242/jcs.00618 · Cited by 161 · see citing works

Dyrk1A expression pattern supports specific roles of this kinase in the adult central nervous system

Martı́, E., Altafaj, X., Dierssen, M., de la Luna, S., Fotaki, V., Alvarez, M., Pérez-Riba, M., Ferrer, I., & Estivill, X. (2003) · Brain Research · doi:10.1016/s0006-8993(02)04069-6 · Cited by 136 · see citing works

YakA, a protein kinase required for the transition from growth to development in Dictyostelium

Souza, G. M., Lu, S., & Kuspa, A. (1998) · Development · doi:10.1242/dev.125.12.2291 · Cited by 129 · see citing works

On dendrites in Down syndrome and DS murine models: a spiny way to learn

Benavides‐Piccione, R. (2004) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2004.08.001 · Cited by 124 · see citing works

Characterization of Cyclin L2, a Novel Cyclin with an Arginine/Serine-rich Domain

de Graaf, K., Hekerman, P., Spelten, O., Herrmann, A., Packman, L. C., Büssow, K., Müller-Newen, G., & Becker, W. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m310794200 · Cited by 124 · see citing works

Cloning of a Human Homolog of theDrosophila Minibrain/Rat Dyrk Gene from “the Down Syndrome Critical Region” of Chromosome 21

Shindoh, N., Kudoh, J., Maeda, H., Yamaki, A., Minoshima, S., Shimizu, Y., & Shimizu, N. (1996) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1996.1135 · Cited by 120 · see citing works

Phosphorylation of Ser640 in Muscle Glycogen Synthase by DYRK Family Protein Kinases

Skurat, A. V., & Dietrich, A. D. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m301769200 · Cited by 110 · see citing works

The protein kinase DYRK1A phosphorylates the splicing factor SF3b1/SAP155 at Thr434, a novel in vivo phosphorylation site

de Graaf, K., Czajkowska, H., Rottmann, S., Packman, L. C., Lilischkis, R., Lüscher, B., & Becker, W. B. (2006) · BMC Biochemistry · doi:10.1186/1471-2091-7-7 · Cited by 109 · see citing works

Dynamin is a minibrain kinase/dual specificity Yak1-related kinase 1A substrate

Chen-Hwang, M.-C., Chen, H.-R., Elzinga, M., & Hwang, Y.-W. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111101200 · Cited by 106 · see citing works

Expression patterns and subcellular localization of the Down syndrome candidate protein MNB/DYRK1A suggest a role in late neuronal differentiation

Hämmerle, B., Carnicero, A., Elizalde, C., Cerón, J., Martı́nez, S., & Tejedor, F. J. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02665.x · Cited by 103 · see citing works

Mnb/Dyrk1A Is Transiently Expressed and Asymmetrically Segregated in Neural Progenitor Cells at the Transition to Neurogenic Divisions

Hämmerle, B., Vera-Samper, E., Speicher, S. A., Arencibia, R., Martı́nez, S., & Tejedor, F. J. (2002) · Developmental Biology · doi:10.1006/dbio.2002.0675 · Cited by 96 · see citing works

Transgenic Mouse In Vivo Library of Human Down Syndrome Critical Region 1

Branchi, I., Bichler, Z., Minghetti, L., Delabar, J. M., Malchiodi‐Albedi, F., Gonzalez, M.-C., Chettouh, Z., Nicolini, A., Chabert, C., Smith, D., et al. (2004) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/63.5.429 · Cited by 95 · see citing works

Alterations in the phenotype of neocortical pyramidal cells in the Dyrk1A+/− mouse

Benavides‐Piccione, R., Dierssen, M., Ballesteros‐Yáñez, I., de Lagrán, M. M., Arbonés, M. L., Fotaki, V., DeFelipe, J., & Elston, G. N. (2005) · Neurobiology of Disease · doi:10.1016/j.nbd.2005.02.004 · Cited by 92 · see citing works

High-Level Expression of the Mnb/Dyrk1A Gene in Brain and Heart during Rat Early Development

Okui, M., Ide, T., Morita, K., Funakoshi, E., Ito, F., Ogita, K., Yoneda, Y., Kudoh, J., & Shimizu, N. (1999) · Genomics · doi:10.1006/geno.1999.5998 · Cited by 86 · see citing works

DYRK1A enhances the mitogen-activated protein kinase cascade in PC12 cells by forming a complex with Ras, B-Raf, and MEK1

Kelly, P. A., & Rahmani, Z. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e04-12-1085 · Cited by 86 · cited 1× · see citing works

Dynamin 1 antisense oligonucleotide treatment prevents neurite formation in cultured hippocampal neurons.

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The MNB/DYRK1A protein kinase: Neurobiological functions and Down syndrome implications

Hämmerle, B., Elizalde, C., Galcerán, J., Becker, W. B., & Tejedor, F. J. (2003) · Journal of neural transmission. Supplementum · doi:10.1007/978-3-7091-6721-2_11 · Cited by 81 · see citing works

Cell type- and brain structure-specific patterns of distribution of minibrain kinase in human brain

Węgiel, J., Kuchna, I., Nowicki, K., Frackowiak, J., Dowjat, K., Silverman, W. P., Reisberg, ‌., de Leon, M. J., Wısnıewskı, T., Adayev, T., et al. (2004) · Brain Research · doi:10.1016/j.brainres.2004.03.008 · Cited by 80 · see citing works

Phosphorylation-dependent Interaction between the Splicing Factors SAP155 and NIPP1

Boudrez, A., Beullens, M., Waelkens, E., Stalmans, W., & Bollen, M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m204427200 · Cited by 79 · see citing works

Motor phenotypic alterations in TgDyrk1a transgenic mice implicate DYRK1A in Down syndrome motor dysfunction

de Lagrán, M. M., Altafaj, X., Gallego, X., Martı́, E., Estivill, X., Sahún, I., Fillat, C., & Dierssen, M. (2003) · Neurobiology of Disease · doi:10.1016/j.nbd.2003.10.002 · Cited by 77 · see citing works

The minibrain kinase homolog, mbk-2, is required for spindle positioning and asymmetric cell division in early C. elegans embryos

Pang, K. M., Ishidate, T., Nakamura, K., Shirayama, M., Trzepacz, C., Schubert, C., Priess, J. R., & Mello, C. C. (2003) · Developmental Biology · doi:10.1016/j.ydbio.2003.09.024 · Cited by 75 · see citing works

The MNB/DYRK1A protein kinase: Genetic and biochemical properties

Galcerán, J., de Graaf, K., Tejedor, F. J., & Becker, W. B. (2003) · Journal of neural transmission. Supplementum · doi:10.1007/978-3-7091-6721-2_12 · Cited by 74 · see citing works

A new expression cloning strategy for isolation of substrate-specific kinases by using phosphorylation site-specific antibody

Matsuo, R., Ochiai, W., Nakashima, K., & Taga, T. (2001) · Journal of Immunological Methods · doi:10.1016/s0022-1759(00)00313-6 · Cited by 72 · see citing works

Haploinsufficiency of Dyrk1A in Mice Leads to Specific Alterations in the Development and Regulation of Motor Activity.

Fotaki, V., de Lagrán, M. M., Estivill, X., Arbonés, M. L., & Dierssen, M. (2004) · Behavioral Neuroscience · doi:10.1037/0735-7044.118.4.815 · Cited by 68 · see citing works

Reversible blockage of neurite development and growth cone formation in neuronal cultures of a temperature-sensitive mutant of Drosophila

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Dyrk1A Potentiates Steroid Hormone-Induced Transcription via the Chromatin Remodeling Factor Arip4

Sitz, J. H., Tigges, M., Baumgärtel, K., Хаспеков, Л. Г., & Lutz, B. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.13.5821-5834.2004 · Cited by 64 · see citing works

Transcriptional Dysregulation in Down Syndrome: Predictions for Altered Protein Complex Stoichiometries and Post-translational Modifications, and Consequences for Learning/Behavior Genes ELK, CREB, and the Estrogen and Glucocorticoid Receptors

Gardiner, K. (2006) · Behavior Genetics · doi:10.1007/s10519-006-9051-1 · Cited by 63 · see citing works

Characterization of Caenorhabditis elegans Homologs of the Down Syndrome Candidate Gene DYRK1A

Raich, W. B., Moorman, C., Lacefield, C., Lehrer, J., Bartsch, D., Plasterk, R. H. A., Kandel, E. R., & Hobert, O. (2003) · Genetics · doi:10.1093/genetics/163.2.571 · Cited by 61 · see citing works

Interaction of the E1A Oncoprotein with Yak1p, a Novel Regulator of Yeast Pseudohyphal Differentiation, and Related Mammalian Kinases

Zhang, Z., Smith, M. M., & Mymryk, J. S. (2001) · Molecular Biology of the Cell · doi:10.1091/mbc.12.3.699 · Cited by 54 · see citing works

DYRK1 is a co-activator of FKHR (FOXO1a)-dependent glucose-6-phosphatase gene expression

von Groote-Bidlingmaier, F., Schmoll, D., Orth, H., Joost, H., Becker, W. B., & Barthel, A. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)02914-5 · Cited by 53 · see citing works

Mnb/Dyrk1A Phosphorylation Regulates the Interaction of Dynamin 1 with SH3 Domain-Containing Proteins

Huang, Y. Q., Chen‐Hwang, M., Dolios, G., Murakami, N., Padovan, J. C., Wang, R., & Hwang, Y. (2004) · Biochemistry · doi:10.1021/bi036060+ · Cited by 51 · see citing works

Saccharomyces cerevisiae Yak1p protein kinase autophosphorylates on tyrosine residues and phosphorylates myelin basic protein on a C-terminal serine residue

Kassis, S., Melhuish, T. A., Annan, R. S., Chen, S. L., Lee, J. C., Livi, G. P., & Creasy, C. L. (2000) · Biochemical Journal · doi:10.1042/bj3480263 · Cited by 47 · see citing works

Regulation of the proapoptotic activity of huntingtin interacting protein 1 by Dyrk1 and caspase-3 in hippocampal neuroprogenitor cells

Kang, J. E., Choi, S. A., Park, J. B., & Chung, K. C. (2005) · Journal of Neuroscience Research · doi:10.1002/jnr.20534 · Cited by 45 · see citing works

Expression of the Mnb (dyrk) Protein in Adult and Embryonic Mouse Tissues

Rahmani, Z., Lopes, C., Rachidi, M., & Delabar, J. M. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.9803 · Cited by 44 · see citing works

Regulation of Dyrk1A kinase activity by 14-3-3

Kim, D., Won, J., Shin, D. W., Kang, J., Kim, Y. J., Choi, S. Y., Hwang, M.-K., Jeong, B.-W., Kim, G. S., Joe, C. O., et al. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.08.102 · Cited by 41 · see citing works

DYRK gene structure and erythroid-restricted features of DYRK3 gene expression

Zhang, D., Li, K., Erickson‐Miller, C. L., Weiss, M. J., & Wojchowski, D. M. (2004) · Genomics · doi:10.1016/j.ygeno.2004.08.021 · Cited by 29 · see citing works

Dual-specificity tyrosine-phosphorylated and regulated kinase 1A (DYRK1A) interacts with the phytanoyl-CoA α-hydroxylase associated protein 1 (PAHX-AP1), a brain specific protein

Bescond, M., & Rahmani, Z. (2005) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2004.12.006 · Cited by 23 · see citing works

Identification of a novel putative mitogen-activated kinase cascade on human chromosome 21 by computational approaches

Pellegrini-Calace, M., & Tramontano, A. (2006) · Bioinform. · doi:10.1093/bioinformatics/btl006 · Cited by 22 · see citing works

1DYRK1A (Dual-Specificity Tyrosine-Phosphorylated and -Regulated Kinase 1A): A Gene with Dosage Effect During Development and Neurogenesis

Dierssen, M., & de Lagrán, M. M. (2006) · TSW Development & Embryology · doi:10.1100/tswde.2006.120 · Cited by 3 · see citing works

Down syndrome

Antonarakis, S. E., Skotko, B. G., Rafii, M. S., Strydom, A., Pape, S. E., Bianchi, D. W., Sherman, S. L., & Reeves, R. H. (2020) · Nature Reviews Disease Primers · doi:10.1038/s41572-019-0143-7 · Cited by 964 · see citing works

Cognitive deficits and associated neurological complications in individuals with Down's syndrome

Lott, I. T., & Dierssen, M. (2010) · The Lancet Neurology · doi:10.1016/s1474-4422(10)70112-5 · Cited by 484 · see citing works

The dendritic tree and brain disorders

Kulkarni, V. A., & Firestein, B. L. (2012) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2012.03.005 · Cited by 390 · see citing works

Harmine specifically inhibits protein kinase DYRK1A and interferes with neurite formation

Göckler, N., Jofré, G., Papadopoulos, C., Soppa, U., Tejedor, F., & Becker, W. (2009) · The FEBS Journal · doi:10.1111/j.1742-4658.2009.07346.x · Cited by 266 · see citing works

Down syndrome: the brain in trisomic mode

Dierssen, M. (2012) · Nature reviews. Neuroscience · doi:10.1038/nrn3314 · Cited by 273 · see citing works

Neurological phenotypes for Down syndrome across the life span

Lott, I. T. (2012) · Progress in Brain Research · doi:10.1016/b978-0-444-54299-1.00006-6 · Cited by 225 · see citing works

Activation, regulation, and inhibition of DYRK1A

Becker, W. B., & Sippl, W. (2010) · FEBS Journal · doi:10.1111/j.1742-4658.2010.07956.x · Cited by 225 · see citing works

MNB/DYRK1A as a multiple regulator of neuronal development

Tejedor, F. J., & Hämmerle, B. (2011) · The FEBS Journal · doi:10.1111/j.1742-4658.2010.07954.x · Cited by 214 · see citing works

Disruptive de novo mutations of DYRK1A lead to a syndromic form of autism and ID

van Bon, B. W. M., Coe, B. P., Bernier, R., Green, C., Gerdts, J., Witherspoon, K., Kleefstra, T., Willemsen, M. H., Kumar, R., Bosco, P., et al. (2016) · Molecular Psychiatry · doi:10.1038/mp.2015.5 · Cited by 204 · see citing works

Rodent models in Down syndrome research: impact and future opportunities

Hérault, Y., Delabar, J. M., Fisher, E., Tybulewicz, V. L. J., Yu, E. Y., & Brault, V. (2017) · Disease Models & Mechanisms · doi:10.1242/dmm.029728 · Cited by 191 · see citing works

Trisomy 21 and early brain development

Haydar, T. F., & Reeves, R. H. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2011.11.001 · Cited by 200 · see citing works

DYRK1A, a dosage-sensitive gene involved in neurodevelopmental disorders, is a target for drug development in down syndrome

Duchon, A., & Herault, Y. (2016) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2016.00104 · Cited by 181 · see citing works

DYRK1A haploinsufficiency causes a new recognizable syndrome with microcephaly, intellectual disability, speech impairment, and distinct facies

Ji, J., Lee, H., Argiropoulos, B., Dorrani, N., Mann, J., Martinez-Agosto, J. A., Gomez-Ospina, N., Gallant, N., Bernstein, J. A., Hudgins, L., et al. (2015) · European Journal of Human Genetics · doi:10.1038/ejhg.2015.71 · Cited by 145 · see citing works

Recent Advances in the Design, Synthesis, and Biological Evaluation of Selective DYRK1A Inhibitors: A New Avenue for a Disease Modifying Treatment of Alzheimer’s?

Smith, B. E., Medda, F., Gokhale, V. M., Dunckley, T. L., & Hulme, C. (2012) · ACS Chemical Neuroscience · doi:10.1021/cn300094k · Cited by 146 · see citing works

Transient expression of <i>Mnb/Dyrk1a</i> couples cell cycle exit and differentiation of neuronal precursors by inducing <i>p27KIP1</i> expression and suppressing NOTCH signaling

Hämmerle, B., Ulin, E., Guimera, J., Becker, W., Guillemot, F., & Tejedor, F. J. (2011) · Development · doi:10.1242/dev.066167 · Cited by 137 · see citing works

The protein kinase DYRK1A regulates caspase-9-mediated apoptosis during retina development.

Laguna, A., Aranda, S., Barallobre, M., Barhoum, R., Fernández, E., Fotaki, V., Delabar, J., de la Luna, S., de la Villa, P., & Arbonés, M. (2008) · Developmental Cell · doi:10.1016/j.devcel.2008.10.014 · Cited by 131 · see citing works

Aneuploidy: From a Physiological Mechanism of Variance to Down Syndrome

Dierssen, M., Hérault, Y., & Estivill, X. (2009) · Physiological Reviews · doi:10.1152/physrev.00032.2007 · Cited by 132 · see citing works

Meta-analysis of heterogeneous Down Syndrome data reveals consistent genome-wide dosage effects related to neurological processes

Vilardell, M., Rasche, A., Thormann, A., Maschke-Dutz, E., Jurado, L. A. P., Lehrach, H., & Herwig, R. (2011) · BMC Genomics · doi:10.1186/1471-2164-12-229 · Cited by 126 · see citing works

The polyphenols resveratrol and epigallocatechin-3-gallate restore the severe impairment of mitochondria in hippocampal progenitor cells from a Down syndrome mouse model

Valenti, D., Lidia de, B. A. R. I., Rasmo, D. D., Signorile, A., Henrion‐Caude, A., Contestabile, A., & Vacca, R. A. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2016.03.003 · Cited by 128 · see citing works

Zebrafish knockout of Down syndrome gene, DYRK1A, shows social impairments relevant to autism

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Intragenic deletion in DYRK1A leads to mental retardation and primary microcephaly

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A chemical with proven clinical safety restores Down syndrome-related phenotypes via DYRK1A inhibition

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DYRK1A: the double-edged kinase as a protagonist in cell growth and tumorigenesis

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Dyrk1A Influences Neuronal Morphogenesis Through Regulation of Cytoskeletal Dynamics in Mammalian Cortical Neurons

de Lagrán, M. M., Benavides‐Piccione, R., Ballesteros‐Yáñez, I., Calvo, M., Morales, M., Fillat, C., DeFelipe, J., Ramakers, G. J. A., & Dierssen, M. (2012) · Cerebral Cortex · doi:10.1093/cercor/bhr362 · Cited by 90 · see citing works

Dyrk1A Inhibition as Potential Treatment for Alzheimer’S Disease

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Sprouty2-Mediated Inhibition of Fibroblast Growth Factor Signaling Is Modulated by the Protein Kinase DYRK1A

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Environmental enrichment rescues DYRK1A activity and hippocampal adult neurogenesis in TgDyrk1A

Pons‐Espinal, M., de Lagrán, M. M., & Dierssen, M. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2013.08.008 · Cited by 70 · see citing works

CK2 Is a Novel Negative Regulator of NADPH Oxidase and a Neuroprotectant in Mice after Cerebral Ischemia

Kim, G. S., Jung, J. E., Niizuma, K., & Chan, P. H. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.4161-09.2009 · Cited by 72 · see citing works

Truncation and Activation of Dual Specificity Tyrosine Phosphorylation-regulated Kinase 1A by Calpain I

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Targeting Dyrk1A with AAVshRNA Attenuates Motor Alterations in TgDyrk1A, a Mouse Model of Down Syndrome

Ortiz-Abalia, J., Sahún, I., Altafaj, X., Andreu, N., Estivill, X., Dierssen, M., & Fillat, C. (2008) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2008.09.010 · Cited by 70 · see citing works

DYRK1A regulates the recruitment of 53BP1 to the sites of DNA damage in part through interaction with RNF169

Menon, V., Ananthapadmanabhan, V., Swanson, S. K., Saini, S., Sesay, F. F., Yakovlev, V. A., Florens, L. A., DeCaprio, J. A., Washburn, M. P., Dozmorov, M. G., et al. (2019) · Cell Cycle · doi:10.1080/15384101.2019.1577525 · Cited by 53 · see citing works

Engineering DYRK1A overdosage yields Down syndrome-characteristic cortical splicing aberrations

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Using C. elegans to Decipher the Cellular and Molecular Mechanisms Underlying Neurodevelopmental Disorders

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Identification of harmine and β-carboline analogs from a high-throughput screen of an approved drug collection; profiling as differential inhibitors of DYRK1A and monoamine oxidase A and for in vitro and in vivo anti-cancer studies

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Evidence that increased Kcnj6 gene dose is necessary for deficits in behavior and dentate gyrus synaptic plasticity in the Ts65Dn mouse model of Down syndrome

Kleschevnikov, A. M., Yu, J., Kim, J., Lysenko, L. V., Zeng, Z., Yu, Y. E., & Mobley, W. C. (2017) · Neurobiology of Disease · doi:10.1016/j.nbd.2017.03.009 · Cited by 46 · see citing works

Therapeutic Effects of Catechins in Less Common Neurological and Neurodegenerative Disorders

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Neurodevelopmental disorder risk gene DYRK1A is required for ciliogenesis and brain size in Xenopus embryos

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Protein Kinases: Starting a Molecular Systems View of Endocytosis

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Effect of DYRK1A activity inhibition on development of neuronal progenitors isolated from Ts65Dn mice

Mazur‐Kolecka, B., Golabek, A. A., Kida, E., Rabe, A., Hwang, Y., Adayev, T., Węgiel, J., Flory, M. J., Kaczmarski, W., Marchi, E. J., et al. (2012) · Journal of Neuroscience Research · doi:10.1002/jnr.23007 · Cited by 38 · see citing works

The DCR Protein TTC3 Affects Differentiation and Golgi Compactness in Neurons through Specific Actin-Regulating Pathways

Berto, G. E., Iobbi, C., Camera, P., Scarpa, E., Iampietro, C., Bianchi, F. T., Gai, M., Sgrò, F., Cristofani, F., Gärtner, A., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0093721 · Cited by 38 · see citing works

Green tea extracts containing epigallocatechin-3-gallate modulate facial development in Down syndrome

Starbuck, J. M., Llambrich, S., González, R., Albaigès, J., Sarlé, A., Wouters, J., González, A., Sevillano, X., Sharpe, J. A., de la Torre, R., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-83757-1 · Cited by 38 · see citing works

DYRK1A stabilizes HPV16E7 oncoprotein through phosphorylation of the threonine 5 and threonine 7 residues

Liang, Y., Chang, H., Wang, C.-Y., & Yu, W. (2008) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2008.04.003 · Cited by 38 · see citing works

Genome-Wide Association Study Identifies Single Nucleotide Polymorphism in DYRK1A Associated with Replication of HIV-1 in Monocyte-Derived Macrophages

Bol, S. M., Moerland, P., Limou, S., van Remmerden, Y., Coulonges, C., van Manen, D., Herbeck, J., Fellay, J., Síeberer, M., Sietzema, J. G., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017190 · Cited by 44 · see citing works

DYRK1A mutations in two unrelated patients

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Microdeletion of the Down syndrome critical region at 21q22

Fujita, H., Torii, C., Kosaki, R., Yamaguchi, S., Kudoh, J., Hayashi, K., Takahashi, T., & Kosaki, K. (2010) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.33228 · Cited by 33 · see citing works

Dyrk1A Positively Stimulates ASK1-JNK Signaling Pathway during Apoptotic Cell Death

Choi, H., & Chung, K. (2011) · Experimental Neurobiology · doi:10.5607/en.2011.20.1.35 · Cited by 30 · see citing works

DYRK1A BAC Transgenic Mouse: A New Model of Thyroid Dysgenesis in Down Syndrome

Kariyawasam, D., Rachdi, L., Carré, A., Martin, M., Houlier, M., Janel, N., Delabar, J.-M., Scharfmann, R., & Polak, M. (2015) · Endocrinology · doi:10.1210/en.2014-1329 · Cited by 30 · see citing works

Inhibition of Dyrk1A Attenuates LPS-Induced Neuroinflammation via the TLR4/NF-κB P65 Signaling Pathway

Ju, C., Wang, Y., Zang, C., Liu, H., Yuan, F., Ning, J., Shang, M., Ma, J., Li, G., Yang, Y., et al. (2022) · Inflammation · doi:10.1007/s10753-022-01699-w · Cited by 30 · see citing works

Deciphering the Link Between Hyperhomocysteinemia and Ceramide Metabolism in Alzheimer-Type Neurodegeneration

Stunff, H. L., Véret, J., Kassis, N., Denom, J., Meneyrol, K., Paul, J., Cruciani‐Guglielmacci, C., Magnan, C., & Janel, N. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.00807 · Cited by 30 · see citing works

Discoveries in Down syndrome

Kleschevnikov, A. M., Belichenko, P. V., Salehi, A., & Wu, C. (2012) · Progress in brain research · doi:10.1016/b978-0-444-54299-1.00010-8 · Cited by 29 · see citing works

DYRK1A Controls HIV-1 Replication at a Transcriptional Level in an NFAT Dependent Manner

Booiman, T., Loukachov, V., van Dort, K. V., Wout, A. V. V. '., & Kootstra, N. (2015) · PLoS ONE · doi:10.1371/journal.pone.0144229 · Cited by 27 · see citing works

Dopaminergic deficiency in mice with reduced levels of the dual‐specificity tyrosine‐phosphorylated and regulated kinase 1A, Dyrk1A+/−

de Lagrán, M. M., Bortolozzi, A. A., Millán, O., Gispert, J. D., Gonzalez, J. R., Arbonés, M. L., Artigas, F., & Dierssen, M. (2006) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2006.00285.x · Cited by 26 · see citing works

Age-associated motor and visuo-spatial learning phenotype in Dyrk1A heterozygous mutant mice

Arqué, G., de Lagrán, M. M., Arbonés, M. L., & Dierssen, M. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.07.027 · Cited by 24 · see citing works

Novel DYRK1A Inhibitor Rescues Learning and Memory Deficits in a Mouse Model of Down Syndrome

Stensen, W., Rothweiler, U., Engh, R. A., Stasko, M. R., Bederman, I. R., Costa, A. C. S., Fugelli, A., & Svendsen, J. S. M. (2021) · Pharmaceuticals · doi:10.3390/ph14111170 · Cited by 22 · see citing works

BDNF and DYRK1A Are Variable and Inversely Correlated in Lymphoblastoid Cell Lines from Down Syndrome Patients

Tlili, A., Hoischen, A., Ripoll, C., Benabou, E., Badel, A., Ronan, A., Touraine, R. L., Grattau, Y., Stora, S., van Bon, B. W. M., et al. (2012) · Molecular Neurobiology · doi:10.1007/s12035-012-8284-7 · Cited by 22 · see citing works

Distinct selective forces and Neanderthal introgression shaped genetic diversity at genes involved in neurodevelopmental disorders

Mozzi, A., Forni, D., Cagliani, R., Pozzoli, U., Clerici, M., & Sironi, M. (2017) · Scientific Reports · doi:10.1038/s41598-017-06440-4 · Cited by 19 · see citing works

E3 Ligase SCFβTrCP-induced DYRK1A Protein Degradation Is Essential for Cell Cycle Progression in HEK293 Cells*

Liu, Q., Tang, Y., Chen, L., Liu, N., Lang, F., Liu, H., Wang, P., & Sun, X.-L. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.717553 · Cited by 18 · see citing works

Functional implications of hippocampal adult neurogenesis in intellectual disabilities

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Dyrk1a activates antioxidant NQO1 expression through an ERK1/2-Nrf2 dependent mechanism.

Noll, C., Tlili, A., Ripoll, C., Mallet, L., Paul, J., Delabar, J., & Janel, N. (2012) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2011.11.194 · Cited by 20 · see citing works

Acridine: A Scaffold for the Development of Drugs for Alzheimer's Disease

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Plasticity as a therapeutic target for improving cognition and behavior in Down syndrome

Martínez‐Cué, C., & Dierssen, M. (2019) · Progress in brain research · doi:10.1016/bs.pbr.2019.11.001 · Cited by 15 · see citing works

Further investigation of Paprotrain: Towards the conception of selective and multi-targeted CNS kinase inhibitors

Labrière, C., Lozach, O., Blairvacq, M., Meijer, L., & Guillou, C. (2016) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2016.08.069 · Cited by 15 · see citing works

Overexpression of DYRK1A, a Down Syndrome Candidate gene, Impairs Primordial Germ Cells Maintenance and Migration in zebrafish

Liu, Y., Lin, Z., Liu, M., Wang, H., & Sun, H. (2017) · Scientific Reports · doi:10.1038/s41598-017-15730-w · Cited by 14 · see citing works

Overexpression of DYRK1A inhibits choline acetyltransferase induction by oleic acid in cellular models of Down syndrome

Hijazi, M., Fillat, C., Medina, J. M., & Velasco, A. L. (2012) · Experimental Neurology · doi:10.1016/j.expneurol.2012.10.016 · Cited by 10 · see citing works

Identification of Plant Homologues of Dual Specificity Yak1-Related Kinases

Karpov, P. A., Раевский, А., Korablyov, M., & Blume, Y. B. (2014) · Computational Biology Journal · doi:10.1155/2014/909268 · Cited by 9 · see citing works

Development of a sensitive non-radioactive protein kinase assay and its application for detecting DYRK activity in Xenopus laevis oocytes

Lilienthal, E., Kolanowski, K., & Becker, W. B. (2010) · BMC Biochemistry · doi:10.1186/1471-2091-11-20 · Cited by 9 · see citing works

Green Tea Catechins Modulate Skeletal Development with Effects Dependent on Dose, Time, and Structure in a down Syndrome Mouse Model

Llambrich, S., González, R., Wouters, J., Muñoz, J. R., Salassa, S., Wouters, K., Bulck, V. V., Sharpe, J. A., Callaerts‐Vegh, Z., Velde, G. V., et al. (2022) · Nutrients · doi:10.3390/nu14194167 · Cited by 8 · see citing works

Generation of improved human cerebral organoids from single copy DYRK1A knockout induced pluripotent stem cells in trisomy 21: hypothetical solutions for neurodevelopmental models and therapeutic alternatives in down syndrome

Çağlayan, E. (2016) · Cell Biology International · doi:10.1002/cbin.10694 · Cited by 7 · see citing works

The role of Goldilocks protein kinase DYRK1A in embryonic development

Johnson, H. K., Litovchick, L., & DICKINSON, A. J. G. (2025) · Developmental Biology · doi:10.1016/j.ydbio.2025.06.009 · Cited by 5 · see citing works

Pleiotropic effects of trisomy and pharmacologic modulation on structural, functional, molecular, and genetic systems in a Down syndrome mouse model

Llambrich, S., Tielemans, B., Saliën, E., Atzori, M., Wouters, K., Bulck, V. V., Platt, M., Vanherp, L., Fernandez, N. G., de la Fuente, L. G., et al. (2024) · eLife · doi:10.7554/elife.89763.3 · Cited by 5 · see citing works

Ethanol-Induced Changes in Brain of Transgenic Mice Overexpressing DYRK1A

Fructuoso, M., Gu, Y. C., Kassis, N., de Lagrán, M. M., Dierssen, M., & Janel, N. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-01967-6 · Cited by 5 · see citing works

Applications of piperazine scaffold in drug design

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Epigallocatechin-3-Gallate Improves Facial Dysmorphology Associated with Down SyndromePreprint

Starbuck, J. M., Llambrich, S., González, R., Albaigès, J., Sarlé, A., Wouters, J., González, A., Sevillano, X., Sharpe, J. A., de la Torre, R., et al. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/276493 · Cited by 3 · see citing works

Ageing in Down Syndrome: DYRK1A As a Candidate Gene for Cognitive Decline

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Growth charts in DYRK1A syndrome

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Pleiotropic effects of trisomy and pharmacologic modulation on structural, functional, molecular, and genetic systems in a Down syndrome mouse model

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Mechanisms regulating the p120-catenin/Kaiso pathway

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Efecto del factor neurotrófico ácido oleico en modelos celulares de síndrome de Down

Vega, M. H. (2014) · doi:10.14201/gredos.124163

El envejecimiento en el síndrome de Down: Dyrk1A como gen candidato para el declive cognitivo

de Lagrán, M. M., Bortolozzi, A. A., Gispert, J., Millán, O., Artigas, F., Fillat, C., & Dierssen, M. (2008) · Revista Médica Internacional sobre el Síndrome de Down · doi:10.1016/s1138-2074(08)70024-1

A commentary on: Overexpression of Dyrk1A inhibits choline acetyltransferase induction by oleic acid in cellular models of Down syndrome

Dierssen, M. (2013) · Experimental Neurology · doi:10.1016/j.expneurol.2013.03.024

Social dysfunction and mental retardation

Pietropaolo, S., Sluyter, F., & Crusio, W. E. (2014) · Cambridge University Press eBooks · doi:10.1017/cbo9781107360556.010

DigitalCommons@Th e Texas Medical Center

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EFFECTS OF HSA21 GENE EXPRESSION ON EARLY VERTEBRATE DEVELOPMENT

Edie, S. (2014)

Impact of DYRK1A Haploinsufficiency on Facial Morphology using Three-Dimensional Morphometric Analysis

Hammond, S. (2020) · Journal of International Crisis and Risk Communication Research

Pleiotropic effects of trisomy and pharmacologic modulation on structural, functional, molecular, and genetic systems in a Down syndrome mouse modelPreprint

Llambrich, S., Tielemans, B., Saliën, E., Atzori, M., Wouters, K., Bulck, V. V., Platt, M., Vanherp, L., Fernandez, N. G., de la Fuente, L. G., et al. (2023) · eLife · doi:10.7554/elife.89763.1

Pleiotropic effects of trisomy and pharmacologic modulation on structural, functional, molecular, and genetic systems in a Down syndrome mouse modelPreprint

Llambrich, S., Tielemans, B., Saliën, E., Atzori, M., Wouters, K., Bulck, V. V., Platt, M., Vanherp, L., Fernandez, N. G., de la Fuente, L. G., et al. (2024) · eLife · doi:10.7554/elife.89763.2

A Comprehensive Investigation on the Role of Bioactives on DYRK1A to Avert Alzheimer’s Disease

Sharma, M., Mazumder, R., Padhi, S., & Shivangi, K. (2025) · Journal of Natural Remedies · doi:10.18311/jnr/2025/49903

Loss of DYRK1A ortholog mbk-1 impairs locomotor behavior in Caenorhabditis elegansPreprint

Otte, E. D., Bratch, E., Robbins, A., Roper, R. J., & Goodlett, C. R. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.11.04.686526

Unveiling Lipid Signaling in Leishmania: Mechanisms and Implications for Therapeutics

Paul, M., & Ghosh, M. (2025) · Current Biotechnology · doi:10.2174/0122115501405284251117045640

Rôle de XDSCR6 et de ses partenaires au cours du développement embryonnaire précoce de Xenopus laevis

Loreti, M. (2017) · doi:10.70675/57e0f3d3z704dz4113z974bz4e76939b1c8c

Recherches de biomarqueurs impliqués dans la maladie d’Alzheimer et associés à la protéine DYRK1A dans le syndrome de Down pour valider des traitements potentiels

Gu, Y. (2020) · theses.fr (ABES) · doi:10.70675/ac74aea3z1c11z4272z8737z57c293c54614

Caractérisation des mécanismes moléculaires impliqués dans la mise en place des altérations cérébrales dans un modèle préclinique de diabète de type 2

Hamzé, R. (2023) · theses.fr (ABES) · doi:10.70675/3ac7f72cz196fz4796z99a3z89271cd76677

Genes and Their Role in Intellectual Disabilities and Brain Development

Bourin, M. (2025) · Archives of Biomedical Research · doi:10.33696/biomedicalresearch.1.004

Integrative Insights Into DYRK1A From Molecular Function to Therapeutic Advancement

Paul, S., Dubey, S., & Tiwari, P. (2026) · Chemical Biology and Drug Design · doi:10.1111/cbdd.70366

Evidence for functional convergence between LZTS2 and DYRK1A during craniofacial development

Cheng, N., Lima, S., Litovchick, L., & DICKINSON, A. J. G. (2026) · Developmental Dynamics · doi:10.1002/dvdy.70192

BindingDB Entry 50048220: Further investigation of Paprotrain: Towards the conception of selective and multi-targeted CNS kinase inhibitors.

BindingDB (2018) · UC San Diego · doi:10.7270/q24x59s3

Recent insights into the function of DYRK1A

Becker, W. B. (2010) · FEBS Journal · doi:10.1111/j.1742-4658.2010.07953.x · Cited by 10 · see citing works

DYRK1A Signaling in the Brain: Molecular Mechanisms and Neurotransmitter Regulation

Paul, S., Dubey, S., & Tiwari, P. K. (2026) · Current Neurovascular Research · doi:10.2174/0115672026453723260618053839

MNB/DYRK1A as a multiple regulator of neuronal development

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Dyrk1A Haploinsufficiency Affects Viability and Causes Developmental Delay and Abnormal Brain Morphology in Mice

Fotaki, V., Dierssen, M., Alcántara, S., Martı́nez, S., Martı́, E., Casas, C., Visa, J., Soriano, E., Estivill, X., & Arbonés, M. L. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.18.6636-6647.2002 · Cited by 330 · see citing works

1DYRK1A (Dual-Specificity Tyrosine-Phosphorylated and -Regulated Kinase 1A): A Gene with Dosage Effect During Development and Neurogenesis

Dierssen, M., & de Lagrán, M. M. (2006) · TSW Development & Embryology · doi:10.1100/tswde.2006.120 · Cited by 3 · see citing works