Overexpression of Dyrk1A is implicated in several cognitive, electrophysiological and Neuromorphological alterations found in a mouse model of down syndrome
Open accessAbstract
Down syndrome (DS) phenotypes result from the overexpression of several dosage-sensitive genes. The DYRK1A (dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A) gene, which has been implicated in the behavioral and neuronal alterations that are characteristic of DS, plays a role in neuronal progenitor proliferation, neuronal differentiation and long-term potentiation (LTP) mechanisms that contribute to the cognitive deficits found in DS. The purpose of this study was to evaluate the effect of Dyrk1A overexpression on the behavioral and cognitive alterations in the Ts65Dn (TS) mouse model, which is the most commonly utilized mouse model of DS, as well as on several neuromorphological and electrophysiological properties proposed to underlie these deficits. In this study, we analyzed the phenotypic differences in the progeny obtained from crosses of TS females and heterozygous Dyrk1A (+/-) male mice. Our results revealed that normalization of the Dyrk1A copy number in TS mice improved working and reference memory based on the Morris water maze and contextual conditioning based on the fear conditioning test and rescued hippocampal LTP. Concomitant with these functional improvements, normalization of the Dyrk1A expression level in TS mice restored the proliferation and differentiation of hippocampal cells in the adult dentate gyrus (DG) and the density of GABAergic and glutamatergic synapse markers in the molecular layer of the hippocampus. However, normalization of the Dyrk1A gene dosage did not affect other structural (e.g., the density of mature hippocampal granule cells, the DG volume and the subgranular zone area) or behavioral (i.e., hyperactivity/attention) alterations found in the TS mouse. These results suggest that Dyrk1A overexpression is involved in some of the cognitive, electrophysiological and neuromorphological alterations, but not in the structural alterations found in DS, and suggest that pharmacological strategies targeting this gene may improve the treatment of DS-associated learning disabilities.
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Subtracting one copy of Dyrk1a at conception from otherwise trisomic mice improved cognitive, neurological and Alzheimer disease-like phenotypes.
“Subtracting one copy of Dyrk1a at conception from otherwise trisomic mice improved cognitive, neurological and Alzheimer disease-like phenotypes (Garcia-Cerro et al., 2014; Garcia-Cerro et al., 2017) and improved T-maze and contextual fear conditioning tests (Jiang et al., 2015).”
From Sex-specific developmental alterations in DYRK1A expression in the brain of a Down syndrome mouse model (2024) · cites this paper as Garcia-Cerro et al., 2014
The Experimental Animals section describes trisomic offspring with one fewer Dyrk1A copy, and Results I reports improved working and reference memory; the Discussion also reports rescued hippocampal LTP and improved neuromorphological measures. The paper does not report improvement in Alzheimer disease-like phenotypes. Results II says motor coordination and other tested motor functions were unaffected, so the broad claim of neurological improvement needs qualification. Page numbers are unavailable in our copy. (LLM, conf=0.88)
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PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT
Lowry, O. H., Rosebrough, N., Farr, A. L., & Randall, R. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52451-6 · Cited by 315,771 · see citing works
Shrestha, S., & Offer, S. M. (2016) · Medical Epigenetics · doi:10.1159/000444713 · Cited by 8,949 · see citing works
Developments of a water-maze procedure for studying spatial learning in the rat
Morris, R. (1984) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(84)90007-4 · Cited by 7,180 · see citing works
Neurogenesis in the adult is involved in the formation of trace memories
Shors, T. J., Miesegaes, G. R., Beylin, A. V., Zhao, M., Rydel, T. A., & Gould, E. (2001) · Nature · doi:10.1038/35066584 · Cited by 2,014 · see citing works
GABA regulates synaptic integration of newly generated neurons in the adult brain
Ge, S., Goh, E. L. K., Sailor, K. A., Kitabatake, Y., Ming, G., & Song, H. (2005) · Nature · doi:10.1038/nature04404 · Cited by 1,261 · see citing works
Roles of continuous neurogenesis in the structural and functional integrity of the adult forebrain
Imayoshi, I., Sakamoto, M., Ohtsuka, T., Takao, K., Miyakawa, T., Yamaguchi, M., Mori, K., Ikeda, T., Itohara, S., & Kageyama, R. (2008) · Nature Neuroscience · doi:10.1038/nn.2185 · Cited by 1,054 · see citing works
Spatial memory and hippocampal function
Olton, D. S., & Paras, B. C. (1979) · Neuropsychologia · doi:10.1016/0028-3932(79)90042-3 · Cited by 927 · see citing works
Neurogenesis may relate to some but not all types of hippocampal‐dependent learning
Shors, T. J., Townsend, D. A., Zhao, M., Kozorovitskiy, Y., & Gould, E. (2002) · Hippocampus · doi:10.1002/hipo.10103 · Cited by 853 · see citing works
GABAergic Excitation Promotes Neuronal Differentiation in Adult Hippocampal Progenitor Cells
Tozuka, Y., Fukuda, S., Namba, T., Seki, T., & Hisatsune, T. (2005) · Neuron · doi:10.1016/j.neuron.2005.08.023 · Cited by 741 · see citing works
A learning deficit related to age and β-amyloid plaques in a mouse model of Alzheimer's disease
Chen, G., Chen, K. S., Knox, J., Inglis, J., Bernard, A., Martin, S. J., Justice, A., McConlogue, L., Games, D., Freedman, S. B., et al. (2000) · Nature · doi:10.1038/35050103 · Cited by 740 · see citing works
Unusual spectral energy distribution of a galaxy previously reported to be at redshift 6.68
Chen, H., Lanzetta, K. M., Pascarelle, S. M., & Yahata, N. (2000) · RePEc: Research Papers in Economics · Cited by 680 · see citing works
Pharmacotherapy for cognitive impairment in a mouse model of Down syndrome
Fernandez, F., Morishita, W., Zuniga, E., Nguyen, J., Blank, M., Malenka, R. C., & Garner, C. C. (2007) · Nature Neuroscience · doi:10.1038/nn1860 · Cited by 509 · see citing works
Kleschevnikov, A. M., Belichenko, P. V., Villar, A. J., Epstein, C. J., Malenka, R. C., & Mobley, W. C. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.1766-04.2004 · Cited by 459 · see citing works
Goosens, K. A., & Maren, S. (2001) · Learning & Memory · doi:10.1101/lm.37601 · Cited by 451 · see citing works
Unusual spectral energy distribution of a galaxy previously reported to be at redshift 6.68
Chen, H., Lanzetta, K. M., Pascarelle, S., & Yahata, N. (2000) · Nature · doi:10.1038/35046031 · Cited by 447 · see citing works
Goldman‐Rakic, P. S. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00130-4 · Cited by 416 · see citing works
Savonenko, A. V., Xu, G. M., Melnikova, T., Morton, J. L., Gonzales, V., Wong, M. P., Price, D. L., Tang, F., Markowska, A. L., & Borchelt, D. (2005) · Neurobiology of Disease · doi:10.1016/j.nbd.2004.10.022 · Cited by 396 · see citing works
Altafaj, X. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.18.1915 · Cited by 396 · see citing works
Bortone, D., & Polleux, F. (2009) · Neuron · doi:10.1016/j.neuron.2009.01.034 · Cited by 387 · see citing works
Campeau, S., & Davis, M. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-03-02312.1995 · Cited by 379 · see citing works
Seamans, J. K., Floresco, S., & Phillips, A. G. (1995) · Behavioral Neuroscience · doi:10.1037//0735-7044.109.6.1063 · Cited by 370 · see citing works
Fotaki, V., Dierssen, M., Alcántara, S., Martı́nez, S., Martı́, E., Casas, C., Visa, J., Soriano, E., Estivill, X., & Arbonés, M. L. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.18.6636-6647.2002 · Cited by 330 · see citing works
Self-citationSmith, D., Stevens, M. E., Sudanagunta, S. P., Bronson, R. T., Makhinson, M., Watabe, A. M., O’Dell, T. J., Fung, J., Weier, H. G., Cheng, J., et al. (1997) · Nature Genetics · doi:10.1038/ng0597-28 · Cited by 321 · see citing works
Goto, Y., Yang, C. R., & Otani, S. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.08.026 · Cited by 305 · see citing works
de la Torre, R., Sola, S. D., Pons‐Espinal, M., Duchon, A., de Lagrán, M. M., Farré, M., Fitó, M., Benejam, B., Langohr, K., Rodríguez, J. C., et al. (2013) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201300325 · Cited by 283 · see citing works
Discovery and genetic localization of down syndrome cerebellar phenotypes using the Ts65Dn mouse
Baxter, L. L. (2000) · Human Molecular Genetics · doi:10.1093/hmg/9.2.195 · Cited by 275 · see citing works
Olig1 and Olig2 triplication causes developmental brain defects in down syndrome.
Chakrabarti, L., Best, T. K., Cramer, N. P., Carney, R. S. E., Isaac, J. T. R., Galdzicki, Z., & Haydar, T. F. (2010) · Nature Neuroscience · doi:10.1038/nn.2600 · Cited by 258 · see citing works
DYRK1A and DYRK3 Promote Cell Survival through Phosphorylation and Activation of SIRT1
Guo, X., Williams, J. G., Schug, T. T., & Li, X. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.102574 · Cited by 237 · see citing works
A behavioral assessment of Ts65Dn mice: a putative Down syndrome model
Escorihuela, R. M., Fernández‐Teruel, A., Vallina, I. F., Baamonde, C., Lumbreras, M., Dierssen, M., Tobeña, A., & Flórez, J. (1995) · Neuroscience Letters · doi:10.1016/0304-3940(95)12052-6 · Cited by 234 · see citing works
Self-citationCerebellar role in fear-conditioning consolidation
Sacchetti, B., Baldi, E., Lorenzini, C. A., & Bucherelli, C. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.112660399 · Cited by 233 · see citing works
Activation, regulation, and inhibition of DYRK1A
Becker, W. B., & Sippl, W. (2010) · FEBS Journal · doi:10.1111/j.1742-4658.2010.07956.x · Cited by 225 · see citing works
Duchon, A., Raveau, M., Chevalier, C., Nalesso, V., Sharp, A. J., & Herault, Y. (2011) · Mammalian Genome · doi:10.1007/s00335-011-9356-0 · Cited by 224 · see citing works
Garthe, A., & Kempermann, G. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00063 · Cited by 222 · see citing works
DYRK1A BAC transgenic mice show altered synaptic plasticity with learning and memory defects
Ahn, K.-J., Jeong, H. K., Choi, H.-S., Ryoo, S.-R., Kim, Y. J., Goo, J.-S., Choi, S.-Y., Han, J.-S., Ha, I., & Song, W.-J. (2006) · Neurobiology of Disease · doi:10.1016/j.nbd.2005.12.006 · Cited by 220 · see citing works
Rickman, C. B., Li, T., Frankel, W. N., Danciger, M., Coffin, J. M., Applebury, M. L., & Farber, D. B. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.7.2955 · Cited by 216 · see citing works
Green Tea Polyphenols Rescue of Brain Defects Induced by Overexpression of DYRK1A
Guedj, F., Sebrié, C., Rivals, I., Ledru, A., Paly, E., Bizot, J. C., Smith, D., Rubin, E. M., Gillet, B., Arbonés, M. L., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004606 · Cited by 216 · see citing works
Self-citationMNB/DYRK1A as a multiple regulator of neuronal development
Tejedor, F. J., & Hämmerle, B. (2011) · The FEBS Journal · doi:10.1111/j.1742-4658.2010.07954.x · Cited by 214 · see citing works
Wang, G.-W., & Cai, J. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.09.002 · Cited by 205 · see citing works
Earnheart, J. C., Schweizer, C., Crestani, F., Iwasato, T., Itohara, S., Mohler, H., & Lüscher, B. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.3609-06.2007 · Cited by 203 · see citing works
Retrograde amnesia after hippocampal damage: Recent vs. remote memories in two tasks
Sutherland, R. J., Weisend, M. P., Mumby, D. G., Astur, R. S., Hanlon, F. M., Koerner, A., Thomas, M. J., Wu, Y., Moses, S. N., Cole, C., et al. (2001) · Hippocampus · doi:10.1002/1098-1063(2001)11:1 · Cited by 190 · see citing works
Bianchi, P., Ciani, E., Guidi, S., Trazzi, S., Felice, D., Grossi, G., Fernandez, M., Giuliani, A., Calza, L., & Bartesaghi, R. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.0534-10.2010 · Cited by 188 · see citing works
Mouse models of Down syndrome as a tool to unravel the causes of mental disabilities
Rueda, N., Flórez, J., & Martínez-Cué, C. (2012) · Neural Plasticity · doi:10.1155/2012/584071 · Cited by 171 · see citing works
Self-citationHibaoui, Y., Grad, I., Letourneau, A., Sailani, M. R., Dahoun, S., Santoni, F. A., Gimelli, S., Guipponi, M., Pelte, M. F., Béna, F., et al. (2014) · EMBO Molecular Medicine · doi:10.1002/emmm.201302848 · Cited by 170 · see citing works
Braudeau, J., Delatour, B., Duchon, A., Pereira, P. L., Dauphinot, L., de Chaumont, F., Olivo‐Marín, J., Dodd, R. H., Hérault, Y., & Potier, M. (2011) · Journal of Psychopharmacology · doi:10.1177/0269881111405366 · Cited by 163 · see citing works
Motor dysfunction in a mouse model for Down syndrome
Costa, A. C. S., WALSH, K., & Davisson, M. T. (1999) · Physiology & Behavior · doi:10.1016/s0031-9384(99)00178-x · Cited by 161 · see citing works
Restoration of Norepinephrine-Modulated Contextual Memory in a Mouse Model of Down Syndrome
Salehi, A., Faizi, M., Colas, D., Valletta, J. S., Laguna, J., Takimoto‐Kimura, R., Kleschevnikov, A. M., Wagner, S. L., Aisen, P. S. S., Shamloo, M., et al. (2009) · Science Translational Medicine · doi:10.1126/scitranslmed.3000258 · Cited by 159 · see citing works
Lithium rescues synaptic plasticity and memory in Down syndrome mice
Contestabile, A., Greco, B., Ghezzi, D., Tucci, V., Benfenati, F., & Gasparini, L. (2012) · Journal of Clinical Investigation · doi:10.1172/jci64650 · Cited by 157 · see citing works
DYRK1A: A master regulatory protein controlling brain growth
Guedj, F., Pereira, P. L., Najas, S., Barallobre, M. J., Chabert, C., Souchet, B., Sebrié, C., Verney, C., Hérault, Y., Arbonés, M. L., et al. (2012) · Neurobiology of Disease · doi:10.1016/j.nbd.2012.01.007 · Cited by 155 · see citing works
Self-citationMartínez‐Cué, C., Martinez, P. M., Rueda, N., Vidal, R., García-Cerro, S., Vidal, V., Corrales, A., Montero, J. A., Pazos, Á., Flórez, J., et al. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.1203-12.2013 · Cited by 154 · see citing works
Self-citationYabut, O., Domogauer, J., & D’Arcangelo, G. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.4711-09.2010 · Cited by 154 · see citing works
Excitatory-inhibitory relationship in the fascia dentata in the Ts65Dn mouse model of down syndrome.
Belichenko, P. V., Kleschevnikov, A. M., Masliah, E., Wu, C., Takimoto‐Kimura, R., Salehi, A., & Mobley, W. C. (2009) · Journal of Comparative Neurology · doi:10.1002/cne.21895 · Cited by 141 · see citing works
Dyrk1A phosphorylates p53 and inhibits proliferation of embryonic neuronal cells
Park, J., Oh, Y., Yoo, L., Jung, M.-S., Song, W.-J., Lee, S.-H., Seo, H., & Chung, K. C. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.147520 · Cited by 134 · see citing works
The protein kinase DYRK1A regulates caspase-9-mediated apoptosis during retina development.
Laguna, A., Aranda, S., Barallobre, M., Barhoum, R., Fernández, E., Fotaki, V., Delabar, J., de la Luna, S., de la Villa, P., & Arbonés, M. (2008) · Developmental Cell · doi:10.1016/j.devcel.2008.10.014 · Cited by 131 · see citing works
Self-citationTranscript catalogs of human chromosome 21 and orthologous chimpanzee and mouse regions
Sturgeon, X., & Gardiner, K. J. (2011) · Mammalian Genome · doi:10.1007/s00335-011-9321-y · Cited by 117 · cited 1× · see citing works
“This mouse bears a partial trisomy of a segment of Mmu16, containing approximately 92 genes orthologous to Hsa21 genes [48]; in addition, the Ts65Dn mouse also carries a trisomy of ,10 Mb of Mmu17 containing 60 genes that are not homologous to Hsa21 [49].”
BackgroundExcitation/inhibition balance and learning are modified by Dyrk1a gene dosage
Souchet, B., Guedj, F., Sahún, I., Duchon, A., Daubigney, F., Badel, A., Yanagawa, Y., Barallobre, M. J., Dierssen, M., Yu, E. Y., et al. (2014) · Neurobiology of Disease · doi:10.1016/j.nbd.2014.04.016 · Cited by 112 · see citing works
Self-citationLlorens-Martı́n, M., Torres‐Alemán, I., & Trejo, J. L. (2006) · Hippocampus · doi:10.1002/hipo.20175 · Cited by 98 · see citing works
Transgenic Mouse In Vivo Library of Human Down Syndrome Critical Region 1
Branchi, I., Bichler, Z., Minghetti, L., Delabar, J. M., Malchiodi‐Albedi, F., Gonzalez, M.-C., Chettouh, Z., Nicolini, A., Chabert, C., Smith, D., et al. (2004) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/63.5.429 · Cited by 95 · see citing works
Prefrontal Deficits in a Murine Model Overexpressing the Down Syndrome Candidate GeneDyrk1a
Thomazeau, A., Lassalle, O., Iafrati, J., Souchet, B., Guedj, F., Janel, N., Chavis, P., Delabar, J. M., & Manzoni, O. J. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.2852-13.2014 · Cited by 93 · see citing works
Biedenkapp, J. C., & Rudy, J. W. (2008) · Learning & Memory · doi:10.1101/lm.1099109 · Cited by 89 · see citing works
Infants with Down syndrome: Percentage and age for acquisition of gross motor skills
Pereira, K., Basso, R. P., Lindquist, A. R. R., da Silva, L. G. P., & Tudella, E. (2013) · Research in Developmental Disabilities · doi:10.1016/j.ridd.2012.11.021 · Cited by 87 · see citing works
Pérez-Cremades, D., Hernández, S., Blasco-Ibáñez, J. M., Crespo, C., Nacher, J., & Varea, E. (2010) · Journal of Neural Transmission · doi:10.1007/s00702-010-0376-9 · Cited by 85 · see citing works
Quantitative PCR genotyping assay for the Ts65Dn mouse model of Down syndrome
Liu, D. P., Schmidt, C., Billings, T., & Davisson, M. T. (2003) · BioTechniques · doi:10.2144/03356st02 · Cited by 84 · see citing works
Altafaj, X., Martín, E. D., Ortiz-Abalia, J., Valderrama, A., Lao-Peregrín, C., Dierssen, M., & Fillat, C. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2012.11.017 · Cited by 75 · see citing works
Is it possible to improve neurodevelopmental abnormalities in Down syndrome?
Bartesaghi, R., Guidi, S., & Ciani, E. (2011) · Reviews in the Neurosciences · doi:10.1515/rns.2011.037 · Cited by 74 · see citing works
Fear conditioning to discontinuous auditory cues requires perirhinal cortical function.
Kholodar-Smith, D. B., Allen, T. A., & Brown, T. H. (2008) · Behavioral Neuroscience · doi:10.1037/a0012902 · Cited by 72 · see citing works
Ortiz-Abalia, J., Sahún, I., Altafaj, X., Andreu, N., Estivill, X., Dierssen, M., & Fillat, C. (2008) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2008.09.010 · Cited by 70 · see citing works
Colas, D., Chuluun, B., Warrier, D. R., Blank, M., Wetmore, D. Z., Buckmaster, P. S., Garner, C. C., & Heller, H. C. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12169 · Cited by 63 · see citing works
Treating enhanced GABAergic inhibition in Down syndrome: Use of GABA α5-selective inverse agonists
Martínez-Cué, C., Delatour, B., & Potier, M.-C. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.12.008 · Cited by 58 · see citing works
Self-citationTriplication of DYRK1A causes retinal structural and functional alterations in Down syndrome
Laguna, A., Barallobre, M. J., Marchena, M., Mateus, C., Ramírez, E., Martínez‐Cué, C., Delabar, J. M., Castelo-Branco, M. S., de la Villa, P., & Arbonés, M. L. (2013) · Human Molecular Genetics · doi:10.1093/hmg/ddt125 · Cited by 54 · see citing works
Self-citationPromotion of Neuronal Plasticity by (−)-Epigallocatechin-3-Gallate
Xie, W. Q., Ramakrishna, N., Wieraszko, A., & Hwang, Y. (2007) · Neurochemical Research · doi:10.1007/s11064-007-9494-7 · Cited by 50 · see citing works
McKay, S. M., & Angulo-Kinzler, R. M. (2005) · Infant Behavior and Development · doi:10.1016/j.infbeh.2005.09.004 · Cited by 50 · see citing works
Schebesta, M., & Serluca, F. C. (2009) · Developmental Dynamics · doi:10.1002/dvdy.21909 · Cited by 47 · see citing works
Statistical and theoretical considerations for the platform re-location water maze
Saab, B. J., Saab, A. M. P., & Roder, J. (2011) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2011.03.008 · Cited by 38 · see citing works
Erratum: correction: Neurogenesis in the adult is involved in the formation of trace memories
Shors, T. J., Miesegaes, G. R., Beylin, A. V., Zhao, M., Rydel, T. A., & Gould, E. (2001) · Nature · doi:10.1038/414938a · Cited by 35 · see citing works
Anxiety and panic responses to a predator in male and female Ts65Dn mice, a model for Down syndrome
Martínez‐Cué, C., Rueda, N., García, E., & Flórez, J. (2005) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2005.00175.x · Cited by 29 · see citing works
Self-citationApoptosis in Down’s syndrome: lessons from studies of human and mouse models
Rueda, N., Flórez, J., & Martínez-Cué, C. (2013) · Apoptosis · doi:10.1007/s10495-012-0785-3 · Cited by 25 · see citing works
Self-citationIncreased Dosage of DYRK1A and Brain Volumetric Alterations in a YAC Model of Partial Trisomy 21
Sebrié, C., Chabert, C., Ledru, A., Guedj, F., Po, C., Smith, D., Rubin, E. M., Rivals, I., Belœil, J., Gillet, B., et al. (2008) · The Anatomical Record · doi:10.1002/ar.20640 · Cited by 23 · see citing works
Pérez‐Domper, P., Gradari, S., & Trejo, J. L. (2013) · Ageing Research Reviews · doi:10.1016/j.arr.2013.06.001 · Cited by 15 · see citing works
Differential expression and regulation of olig genes in zebrafish
Tiso, N., Filippi, A., Benato, F., Negrisolo, E., Modena, N., Vaccari, E., Driever, W., & Argenton, F. (2009) · The Journal of comparative neurology · doi:10.1002/cne.22054 · Cited by 14 · see citing works
Rueda, N., Flórez, J., & Martínez‐Cué, C. (2011) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2011.06.001 · Cited by 12 · see citing works
Self-citationNishizawà, Y., Fujita, T., MATSUOKA, K., & Nakagawa, H. (2006) · Pediatrics International · doi:10.1111/j.1442-200x.2006.02258.x · Cited by 8 · see citing works
Guedj, F., Pereira, P. L., Najas, S., Barallobre, M. J., Chabert, C., Souchet, B., Sebrié, C., Verney, C., Hérault, Y., Arbonés, M. L., et al. (2012) · Neurobiology of Disease · doi:10.1016/j.nbd.2012.03.034 · Cited by 1 · see citing works
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Hérault, Y., Delabar, J. M., Fisher, E., Tybulewicz, V. L. J., Yu, E. Y., & Brault, V. (2017) · Disease Models & Mechanisms · doi:10.1242/dmm.029728 · Cited by 191 · see citing works
Xu, R., Brawner, A. T., Li, S., Liu, J.-J., Kim, H., Xue, H., Pang, Z. P., Kim, W.-Y., Hart, R. P., Liu, Y., et al. (2019) · Cell Stem Cell · doi:10.1016/j.stem.2019.04.014 · Cited by 193 · see citing works
Duchon, A., & Herault, Y. (2016) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2016.00104 · Cited by 181 · see citing works
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Gupta, M., Dhanasekaran, A. R., & Gardiner, K. (2016) · Mammalian Genome · doi:10.1007/s00335-016-9661-8 · Cited by 167 · see citing works
DYRK1A and cognition: A lifelong relationship
Arbonés, M. L., Thomazeau, A., Nakano-Kobayashi, A., Hagiwara, M., & Delabar, J. M. (2018) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2018.09.010 · Cited by 165 · see citing works
Self-citationThe GABAergic Hypothesis for Cognitive Disabilities in Down Syndrome
Contestabile, A., Magara, S., & Cancedda, L. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00054 · Cited by 141 · see citing works
Lindberg, M. F., & Meijer, L. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22116047 · Cited by 123 · see citing works
Down syndrome: Neurobiological alterations and therapeutic targets
Vacca, R. A., Bawari, S., Valenti, D., Tewari, D., Nabavi, S. F., Shirooie, S., Sah, A. N., Volpicella, M., Braidy, N., & Nabavi, S. M. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.01.001 · Cited by 90 · see citing works
Genetic dissection of the down syndrome critical region
Jiang, X., Liu, C., Yu, T., Zhang, L., Meng, K., Xing, Z., Belichenko, P. V., Kleschevnikov, A. M., Pao, A., Peresie, J., et al. (2015) · Human Molecular Genetics · doi:10.1093/hmg/ddv364 · Cited by 88 · see citing works
Nguyen, T. L., Duchon, A., Manousopoulou, A., Loaëc, N., Villiers, B., Pani, G., Karatas, M., Mechling, A. E., Harsan, L. A., Limanton, E., et al. (2018) · Disease Models & Mechanisms · doi:10.1242/dmm.035634 · Cited by 87 · see citing works
Stagni, F., Giacomini, A., Emili, M., Trazzi, S., Guidi, S., Sassi, M., Ciani, E., Rimondini, R., & Bartesaghi, R. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.07.031 · Cited by 76 · see citing works
DYRK1A Protein, A Promising Therapeutic Target to Improve Cognitive Deficits in Down Syndrome
Féki, A., & Hibaoui, Y. (2018) · Brain Sciences · doi:10.3390/brainsci8100187 · Cited by 71 · see citing works
Pharmacological correction of excitation/inhibition imbalance in Down syndrome mouse models
Souchet, B., Guedj, F., Penke-Verdier, Z., Daubigney, F., Duchon, A., Hérault, Y., Bizot, J., Janel, N., Créau, N., Delatour, B., et al. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00267 · Cited by 74 · see citing works
Parrini, M., Ghezzi, D., Deidda, G., Medrihan, L., Castroflorio, E., Alberti, M., Baldelli, P., Cancedda, L., & Contestabile, A. (2017) · Scientific Reports · doi:10.1038/s41598-017-17201-8 · Cited by 73 · see citing works
Patkee, P. A., Baburamani, A. A., Kyriakopoulou, V., Davidson, A., Avini, E., Dimitrova, R., Allsop, J. M., Hughes, E., Kangas, J., McAlonan, G. M., et al. (2019) · NeuroImage Clinical · doi:10.1016/j.nicl.2019.102139 · Cited by 73 · see citing works
Down Syndrome Cognitive Phenotypes Modeled in Mice Trisomic for All HSA 21 Homologues
Belichenko, P. V., Kleschevnikov, A. M., Becker, A., Wagner, G. E., Lysenko, L. V., Yu, Y. E., & Mobley, W. C. (2015) · PLoS ONE · doi:10.1371/journal.pone.0134861 · Cited by 70 · see citing works
Alemany-González, M., Gener, T., Nebot, P., Vilademunt, M., Dierssen, M., & Puig, M. V. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1921314117 · Cited by 62 · see citing works
Absence of Prenatal Forebrain Defects in the Dp(16)1Yey/+ Mouse Model of down Syndrome.
Goodliffe, J. W., Olmos-Serrano, J. L., Aziz, N. M., Pennings, J. L. A., Guedj, F., Bianchi, D. W., & Haydar, T. F. (2016) · The Journal of Neuroscience · doi:10.1523/jneurosci.2513-15.2016 · Cited by 65 · see citing works
Rüben, K., Wurzlbauer, A., Walte, A., Sippl, W., Bracher, F., & Becker, W. B. (2015) · PLoS ONE · doi:10.1371/journal.pone.0132453 · Cited by 65 · see citing works
Souchet, B., Duchon, A., Gu, Y., Dairou, J., Chevalier, C., Daubigney, F., Nalesso, V., Créau, N., Yu, Y., Janel, N., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-40328-9 · Cited by 54 · see citing works
Blazek, J. D., Abeysekera, I., Li, J., & Roper, R. J. (2015) · Human Molecular Genetics · doi:10.1093/hmg/ddv284 · Cited by 54 · see citing works
Maréchal, D., Brault, V., Léon, A., Martin, D., Pereira, P. L., Loaëc, N., Birling, M., Friocourt, G., Blondel, M., & Hérault, Y. (2019) · Human Molecular Genetics · doi:10.1093/hmg/ddy447 · Cited by 56 · see citing works
Chen, X., Salehi, A., Pearn, M. L., Overk, C., Nguyen, P. D., Kleschevnikov, A. M., Maccecchini, M. L., & Mobley, W. C. (2020) · Alzheimer s & Dementia · doi:10.1002/alz.12185 · Cited by 54 · see citing works
Cognitive Impairment, Neuroimaging, and Alzheimer Neuropathology in Mouse Models of Down Syndrome
Hamlett, E. D., Boger, H. A., Ledreux, A., Kelley, C. M., Mufson, E. J., Falangola, M. F., Guilfoyle, D. N., Nixon, R. A., Patterson, D., Duval, N., et al. (2015) · Current Alzheimer Research · doi:10.2174/1567205012666150921095505 · Cited by 51 · see citing works
Roewenstrunk, J., Vona, C. D., Chen, J., Borràs, E., Dong, C., Arató, K., Sabidó, E., Huen, M. S. Y., & de la Luna, S. (2019) · Scientific Reports · doi:10.1038/s41598-019-42445-x · Cited by 48 · see citing works
ACE2 in chronic disease and COVID-19: gene regulation and post-translational modification
Wang, C., Chuang, H., & Tan, T. (2023) · Journal of Biomedical Science · doi:10.1186/s12929-023-00965-9 · Cited by 44 · see citing works
Ahmed, M. M., Dhanasekaran, A. R., Block, A., Tong, S., Costa, A. C. S., Stasko, M. R., & Gardiner, K. (2015) · PLoS ONE · doi:10.1371/journal.pone.0119491 · Cited by 45 · see citing works
Targeting trisomic treatments: optimizing Dyrk1a inhibition to improve Down syndrome deficits
Stringer, M., Goodlett, C. R., & Roper, R. J. (2017) · Molecular Genetics & Genomic Medicine · doi:10.1002/mgg3.334 · Cited by 44 · see citing works
Stringer, M., Abeysekera, I., Dria, K. J., Roper, R. J., & Goodlett, C. R. (2015) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2015.09.002 · Cited by 45 · see citing works
Brault, V., Nguyen, T. L., Gutiérrez, J. F., Iacono, G. L., Birling, M., Lalanne, V., Méziane, H., Manousopoulou, A., Pavlovic, G., Lindner, L., et al. (2021) · PLoS Genetics · doi:10.1371/journal.pgen.1009777 · Cited by 41 · see citing works
Stem and progenitor cell dysfunction in human trisomies
Liu, B., Filippi, S. L., Roy, A., & Roberts, I. A. G. (2014) · EMBO Reports · doi:10.15252/embr.201439583 · Cited by 42 · see citing works
Deau, E., Lindberg, M. F., Miege, F., Roche, D., George, N. S., George, P. G., Krämer, A., Knapp, S., & Meijer, L. (2023) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.3c00884 · Cited by 42 · see citing works
Olmos-Serrano, J. L., Tyler, W. A., Cabral, H., & Haydar, T. F. (2016) · Experimental Neurology · doi:10.1016/j.expneurol.2016.02.005 · Cited by 42 · see citing works
Duchon, A., Moreno, M. D. M. M., Lorenzo, S. M., de Souza, M. P. S., Chevalier, C., Nalesso, V., Méziane, H., de Sousa, P. L., Noblet, V., Armspach, J., et al. (2021) · Human Molecular Genetics · doi:10.1093/hmg/ddab012 · Cited by 38 · see citing works
Modeling Down syndrome in animals from the early stage to the 4.0 models and next
Moreno, M. D. M. M., Brault, V., Birling, M., Pavlovic, G., & Hérault, Y. (2020) · Progress in brain research · doi:10.1016/bs.pbr.2019.08.001 · Cited by 32 · see citing works
Navarro-Romero, A., Vázquez‐Oliver, A., Gomis‐González, M., Garzón-Montesinos, C., Falcón‐Moya, R., Pastor, A., Martín‐García, E., Pizarro, N., Busquets-García, A., Revest, J., et al. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.01.014 · Cited by 35 · see citing works
Alldred, M. J., Chao, H. M., Lee, S. H., Beilin, J., Powers, B. E., Petkova, E., Strupp, B. J., & Ginsberg, S. D. (2018) · Hippocampus · doi:10.1002/hipo.22832 · Cited by 35 · see citing works
Parrini, M., Naskar, S., Alberti, M., Colombi, I., Morelli, G., Rocchi, A., Nanni, M., Piccardi, F., Charles, S., Ronzitti, G., et al. (2021) · Molecular Therapy · doi:10.1016/j.ymthe.2021.05.023 · Cited by 33 · see citing works
DYRK1A mutations in two unrelated patients
Ruaud, L., Mignot, C., Guët, A., Ohl, C., Nava, C., Héron, D., Keren, B., Depienne, C., Benoît, V., Maystadt, I., et al. (2015) · European Journal of Medical Genetics · doi:10.1016/j.ejmg.2014.12.014 · Cited by 33 · see citing works
Translational validity and implications of pharmacotherapies in preclinical models of Down syndrome
Rueda, N., Flórez, J., Dierssen, M., & Martínez‐Cué, C. (2019) · Progress in brain research · doi:10.1016/bs.pbr.2019.10.001 · Cited by 29 · see citing works
Self-citationDYRK1A promotes viral entry of highly pathogenic human coronaviruses in a kinase-independent manner
Strine, M. S., Cai, W. L., Wei, J., Alfajaro, M. M., Filler, R. B., Biering, S. B., Sarnik, S. A., Chow, R. D.-W., Patil, A., Cervantes, K. S., et al. (2023) · PLoS Biology · doi:10.1371/journal.pbio.3002097 · Cited by 29 · see citing works
Meijer, L., Chrétien, E., & Ravel, D. (2024) · Journal of Alzheimer s Disease · doi:10.3233/jad-240078 · Cited by 30 · see citing works
New Perspectives for the Rescue of Cognitive Disability in Down Syndrome
Bartesaghi, R., Haydar, T. F., Delabar, J. M., Dierssen, M., Martínez‐Cué, C., & Bianchi, D. W. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.2775-15.2015 · Cited by 32 · see citing works
Self-citationMouse-based genetic modeling and analysis of Down syndrome
Xing, Z., Li, Y., Pao, A., Bennett, A. S., Tycko, B., Mobley, W. C., & Yu, Y. E. (2016) · British Medical Bulletin · doi:10.1093/bmb/ldw040 · Cited by 30 · see citing works
Down syndrome and DYRK1A overexpression: relationships and future therapeutic directions
Murphy, A. J., Wilton, S. D., Aung-Htut, M. T., & McIntosh, C. S. (2024) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2024.1391564 · Cited by 27 · see citing works
Martínez‐Cué, C., & Rueda, N. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186906 · Cited by 26 · see citing works
Self-citationBrain circuit pathology in Down syndrome: from neurons to neural networks
Bartesaghi, R. (2023) · Reviews in the Neurosciences · doi:10.1515/revneuro-2022-0067 · Cited by 25 · see citing works
García-Cerro, S., Rueda, N., Vidal, V., Puente, A., Campa, V. M., Lantigua, S., Narcís, J. O., Velasco, A. L., Bartesaghi, R., & Martínez‐Cué, C. (2020) · Journal of Nutrition · doi:10.1093/jn/nxaa074 · Cited by 23 · see citing works
Self-citationRescue of deficits by Brwd1 copy number restoration in the Ts65Dn mouse model of Down syndrome
Fulton, S. L., Wenderski, W., Lepack, A. E., Eagle, A. L., Fanutza, T., Bastle, R. M., Ramakrishnan, A., Hays, E. C., Neal, A., Bendl, J. M., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-34200-0 · Cited by 21 · see citing works
Cerebellar alterations in a model of Down syndrome: The role of the Dyrk1A gene
García-Cerro, S., Vidal, V., Lantigua, S., Berciano, M. T., Lafarga, M., Ramos‐Cabrer, P., Padró, D., Rueda, N., & Martínez‐Cué, C. (2017) · Neurobiology of Disease · doi:10.1016/j.nbd.2017.12.002 · Cited by 20 · see citing works
Self-citationEGCG-like non-competitive inhibitor of DYRK1A rescues cognitive defect in a down syndrome model
Delabar, J. M., Gomes, M. A. G. B., Fructuoso, M., Sarrazin, N., George, N. S., Fleary‐Roberts, N., Sun, H., Bui, L. C., Rodrigues‐Lima, F., Janel, N., et al. (2024) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2023.116098 · Cited by 19 · see citing works
Rueda, N., Vidal, V., García-Cerro, S., Puente, A., Campa, V. M., Lantigua, S., Narcís, J. O., Bartesaghi, R., & Martínez‐Cué, C. (2020) · Journal of Nutrition · doi:10.1093/jn/nxaa207 · Cited by 17 · see citing works
Self-citationPrioritizing the development of mouse models for childhood brain disorders
Ogden, K. K., Ozkan, E. D., & Rumbaugh, G. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.07.029 · Cited by 20 · see citing works
Zhu, B., Parsons, T., Stensen, W., Svendsen, J. S. M., Fugelli, A., & Hodge, J. J. L. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.881385 · Cited by 18 · see citing works
Vidal, V., García-Cerro, S., Martinez, P. M., Corrales, A., Lantigua, S., Vidal, R., Rueda, N., Ozmen, L., Hernandez, M., & Martínez‐Cué, C. (2017) · Molecular Neurobiology · doi:10.1007/s12035-017-0675-3 · Cited by 17 · see citing works
Self-citationCorrales, A., Parisotto, E. B., Vidal, V., García-Cerro, S., Lantigua, S., Diego, M., Filho, D. W., Sánchez‐Barceló, E. J., Martínez‐Cué, C., & Rueda, N. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.07.022 · Cited by 18 · see citing works
Self-citationPlasticity as a therapeutic target for improving cognition and behavior in Down syndrome
Martínez‐Cué, C., & Dierssen, M. (2019) · Progress in brain research · doi:10.1016/bs.pbr.2019.11.001 · Cited by 15 · see citing works
Self-citationBartesaghi, R., Vicari, S., & Mobley, W. C. (2022) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-041521-103641 · Cited by 15 · see citing works
Translating molecular advances in Down syndrome and Fragile X syndrome into therapies
Faúndez, V., Toma, I. D., Bardoni, B., Bartesaghi, R., Nižetić, D., de la Torre, R., Kadosh, R. C., Hérault, Y., Dierssen, M., Potier, M., et al. (2018) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2018.03.006 · Cited by 13 · see citing works
Self-citationLowe, S. A., Usowicz, M. M., & Hodge, J. J. L. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.01.017 · Cited by 13 · see citing works
Long, R., Drawbaugh, M. L., Davis, C., Goodlett, C. R., Williams, J., & Roper, R. J. (2019) · Complementary Therapies in Medicine · doi:10.1016/j.ctim.2019.07.002 · Cited by 13 · see citing works
Hawley, L. E., Prochaska, F., Stringer, M., Goodlett, C. R., & Roper, R. J. (2022) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2022.173404 · Cited by 11 · see citing works
Anderson, M. P. (2018) · Wiley eBooks · doi:10.1002/9781119013112.ch40 · Cited by 11 · see citing works
Hawley, L. E., Stringer, M., Deal, A. J., Folz, A., Goodlett, C. R., & Roper, R. J. (2024) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106359 · Cited by 10 · see citing works
Influence of allelic differences in Down syndrome
Roper, R. J., Hawley, L. E., & Goodlett, C. R. (2020) · Progress in brain research · doi:10.1016/bs.pbr.2019.09.001 · Cited by 9 · see citing works
Vieiros, M., Almeida-Toledano, L., Serra-Delgado, M., Navarro‐Tapia, E., Ramos-Triguero, A., Muñoz, C., Martínez, L., Marchei, E., Gómez‐Roig, M. D., García‐Algar, Ó., et al. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.118138 · Cited by 8 · see citing works
Llambrich, S., González, R., Wouters, J., Muñoz, J. R., Salassa, S., Wouters, K., Bulck, V. V., Sharpe, J. A., Callaerts‐Vegh, Z., Velde, G. V., et al. (2022) · Nutrients · doi:10.3390/nu14194167 · Cited by 8 · see citing works
Çağlayan, E. (2016) · Cell Biology International · doi:10.1002/cbin.10694 · Cited by 7 · see citing works
DYRK1A in the physiology and pathology of the neuron-astrocyte axis
Cisternas, P., Kim, J.-Y., Ashfeld, B. L., & Zartman, J. J. (2025) · Frontiers in Neuroscience · doi:10.3389/fnins.2025.1626062 · Cited by 7 · see citing works
Huizar, F. J., Hill, H. M., Bacher, E. P., Eckert, K. E., Gulotty, E. M., Rodriguez, K. X., Tucker, Z. D., Banerjee, M., Liu, H., Wiest, O., et al. (2022) · ChemMedChem · doi:10.1002/cmdc.202100512 · Cited by 7 · see citing works
William, C. M., Saqran, L., Stern, M. A., Chiang, C. L., Herrick, S. P., Rangwala, A., Albers, M. W., Frosch, M. P., & Hyman, B. T. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.1045-17.2017 · Cited by 6 · see citing works
The Hallmarks of Aneuploidy in Cancer and Congenital Syndromes
Cheng, P., Singh, K., Reeves, R. H., & Davoli, T. (2025) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev-genom-111723-103557 · Cited by 5 · see citing works
The role of Goldilocks protein kinase DYRK1A in embryonic development
Johnson, H. K., Litovchick, L., & DICKINSON, A. J. G. (2025) · Developmental Biology · doi:10.1016/j.ydbio.2025.06.009 · Cited by 5 · see citing works
Conan, P., Léon, A., Caroff, N., Rollet, C., Chaïr, L., Martin, J., Bihel, F. J. ‐., Mignen, O., Voisset, C., & Friocourt, G. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.1110163 · Cited by 5 · see citing works
Llambrich, S., Tielemans, B., Saliën, E., Atzori, M., Wouters, K., Bulck, V. V., Platt, M., Vanherp, L., Fernandez, N. G., de la Fuente, L. G., et al. (2024) · eLife · doi:10.7554/elife.89763.3 · Cited by 5 · see citing works
Can Green Tea Polyphenols Improve Phenotypes Associated With Down Syndrome?
Roper, R. J., & Goodlett, C. R. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-813008-7.00035-7 · Cited by 5 · see citing works
Synaptic Plasticity in the Hippocampus
Bliss, T., Collingridge, G. L., Cooke, S. F., Georgiou, J., & Morris, R. (2025) · Oxford University Press eBooks · doi:10.1093/med/9780190065324.003.0010 · Cited by 4 · see citing works
DYRK1A Up-Regulation Specifically Impairs a Presynaptic Form of Long-Term Potentiation
Lepagnol-Bestel, A.-M., Haziza, S., Viard, J., Salin, P. A., Duchon, A., Hérault, Y., & Simonneau, M. (2025) · Life · doi:10.3390/life15020149 · Cited by 2 · see citing works
Down syndrome: a model for chromosome abnormalities
Overk, C., & Mobley, W. C. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-85654-6.00007-1 · Cited by 2 · see citing works
García-Cerro, S., Mas, S., Gortat, A., Sindreu, C., Martínez-Pinteño, A., Mármol, F., Boloc, D., Rodríguez, N., Gassó, P., & Lafuente, A. (2018) · Neuropsychiatry · doi:10.4172/neuropsychiatry.1000436 · Cited by 2 · see citing works
Self-citationGenetic Mechanisms of Memory Disorders (Excluding Alzheimer's Disease)
Kaas, G. A., Hawkins, K. E., & Sweatt, J. D. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809324-5.21125-5 · Cited by 2 · see citing works
Colt, M., Gordon, A., Peng, Y.-J., Wu, Y., Martin, K., & Chang, K. T. (2026) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.2517506123 · Cited by 1 · see citing works
Rachidi, M. (2018) · Medical Journal of Clinical Trials & Case Studies · doi:10.23880/mjccs-16000150 · Cited by 1 · see citing works
Savardi, A., Ziogas, I., Bolla, M., & Cancedda, L. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-815318-5.00021-2 · Cited by 1 · see citing works
Regulation of Drosophila brain development and organ growth by the Minibrain/Rala signaling network
Brown, M., Sciascia, E., Ning, K., Adam, W., & Veraksa, A. N. (2024) · G3 Genes Genomes Genetics · doi:10.1093/g3journal/jkae219 · Cited by 1 · see citing works
Ts65Dn synaptic proteome partially recapitulates AD biochemical signaturePreprint
de Salazar, M. G. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.04.25.538253 · Cited by 1 · see citing works
Llambrich, S., Tielemans, B., Saliën, E., Atzori, M., Wouters, K., Bulck, V. V., Platt, M., Vanherp, L., Fernandez, N. G., de la Fuente, L. G., et al. (2023) · eLife · doi:10.1101/2023.07.31.551282 · Cited by 6 · see citing works
Bartholomew, S. K., Turk, J., Winslow, W., Foley, C., Shaw, A. Y., Rokey, S., Tallino, S., Judd, J. M., Beach, T. G., Serrano, G. E., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.01.20.700091 · Cited by 1 · see citing works
Cognitive function in mice with segmental trisomy of human chromosome 21 Down Syndrome genes
Canonica, T. (2019) · ORCA Online Research @Cardiff (Cardiff University)
Reeves, R. H. (2020) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.736421494.793563938
Kinase-independent activity of DYRK1A promotes viral entry of highly pathogenic human coronavirusesPreprint
Strine, M. S., Cai, W. L., Wei, J., Alfajaro, M. M., Filler, R., Biering, S. B., Sarnik, S. A., Patil, A., Cervantes, K. S., Collings, C. K., et al. (2022) · bioRxiv · doi:10.1101/2022.09.13.507833
Llambrich, S., Tielemans, B., Saliën, E., Atzori, M., Wouters, K., Bulck, V. V., Platt, M., Vanherp, L., Fernandez, N. G., de la Fuente, L. G., et al. (2023) · eLife · doi:10.7554/elife.89763.1
Llambrich, S., Tielemans, B., Saliën, E., Atzori, M., Wouters, K., Bulck, V. V., Platt, M., Vanherp, L., Fernandez, N. G., de la Fuente, L. G., et al. (2024) · eLife · doi:10.7554/elife.89763.2
Folz, A., Sloan, K., & Roper, R. J. (2025) · Springer eBooks · doi:10.1007/978-3-031-78611-2_1
Impact of Cre/LoxP-Mediated Chromosome Engineering Technology on Down Syndrome Research
Xing, Z., Douglas, A., Pao, A., Glass, T. J., Connor, N. P., & Yu, Y. E. (2025) · Springer eBooks · doi:10.1007/978-3-031-78611-2_2
DYRK1A modulates fear memory formation via epigenetic modification
Kang, D.-S., & Koo, J. W. (2025) · Molecular Brain · doi:10.1186/s13041-025-01216-8
DYRK1A Expression and Thyroid Dysfunction in Subjects With Down Syndrome
Khatri, A., Dutta, S., Mukhopadhyay, A., Deshpande, A., Ghosh, S., Bhattacharyya, N. P., Mukhopadhyay, P., & Ghosh, S. K. (2026) · Clinical Endocrinology · doi:10.1111/cen.70099
Orchestrating mitochondrial protein import: The emerging role of DYRK1A in health and disease
Shankar, S., & Meisinger, C. (2026) · Protein Science · doi:10.1002/pro.70631
- Authors
- García-Cerro, S., Martínez, P., Vidal, V., Corrales, A., Flórez, J., Vidal, R., Rueda, N., Arbonés, M. L., & Martínez-Cué, C.
- Affiliations
- Universidad de Cantabria (ES)
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2014-09-04
- Volume
- 9
- Issue
- 9
- Pages
- e106572
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC4154723
- OpenAlex
- W2018237527
- Cited by
- 104
- References
- 83
- Citations by year
- 2026: 5 · 2025: 10 · 2024: 7 · 2023: 9 · 2022: 9 · 2021: 4 · 2020: 9 · 2019: 13 · 2018: 9 · 2017: 10 · 2016: 7 · 2015: 11 · 2014: 1
- FWCI
- 9.62
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, cc-by)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- UCrea (University of Cantabria) (submittedVersion, cc-by)
- Zenodo (CERN European Organization for Nuclear Research) (submittedVersion, cc-by)
- Funders
- Ministerio de Economía y Competitividad
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Down syndrome and intellectual disability research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Developmental Neuroscience › Williams Syndrome Research
- Keywords
- Down syndrome, DYRK1A, Ts65Dn mouse model, gene dosage, cognitive impairment, working memory, reference memory, fear conditioning, hippocampal long-term potentiation, neuronal differentiation, learning disabilities
- MeSH terms
- Dyrk Kinases, Animals, Cognition, Disease Models, Animal, Down Syndrome, Female, Male, Memory, Mice, Transgenic, Protein-Tyrosine Kinases, Protein Serine-Threonine Kinases, Long-Term Potentiation, Mice
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