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Hippocampal subregion-specific microRNA expression during epileptogenesis in experimental temporal lobe epilepsy

Gorter, Jan A., Iyer, Anand, White, Ian, Colzi, Anna, van Vliet, Erwin A., Sisodiya, Sanjay, Aronica, Eleonora·2014·Neurobiology of Disease
DOI 10.1016/j.nbd.2013.10.026
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Abstract

Since aberrant miRNA expression has been implicated in numerous brain diseases, we studied miRNA expression and miRNA regulation of important signaling pathways during temporal lobe epileptogenesis in order to identify possible targets for epilepsy therapy. The temporal profile of miRNA expression was analyzed in three brain regions (CA1; dentate gyrus, DG; parahippocampal cortex, PHC) associated with epileptogenesis in a rat model for temporal lobe epilepsy. Tissue was obtained after electrically-induced status epilepticus (SE) at 1day (n=5), 1week (n=5) and 3-4months (n=5), and compared with control tissue (n=10) using the Exiqon microRNA arrays which contain capture probes targeting all miRNAs for rat (p<0.01, and a 1.5 fold up- or downregulation). Expression of three blood plasma miRNAs from the same group of rats was also investigated in rats in order to determine whether plasma miRNAs could serve as potential biomarkers of the epileptogenic process. Molecular pathways potentially altered by the expression of multiple miRNAs were identified using a web-based algorithm, DIANA. In CA1 and DG, more upregulated than downregulated miRNAs were present during each stage after SE. The highest numbers of upregulated miRNAs were encountered during the chronic stage in the DG. In PHC, a high number of downregulated miRNAs were detected. Key pathways involved, based upon quantitatively altered miRNA expression were: axon guidance, MAPK signaling pathway, focal adhesion, TGFβ, ErbB-,…

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Research works printed but not linked: 76

  1. Aronica, 2011, Inflammation in epilepsy: clinical observations, Epilepsia, 52, 26, 10.1111/j.1528-1167.2011.03033.x · DOI · Paper page
  2. Aronica, 2007, Gene expression profile in temporal lobe epilepsy, Neuroscientist, 13, 1, 10.1177/1073858406295832 · DOI
  3. Aronica, 2003, Expression and cell distribution of group I and group II metabotropic glutamate receptor subtypes in Taylor-type focal cortical dysplasia, Epilepsia, 44, 785, 10.1046/j.1528-1157.2003.54802.x · DOI
  4. Aronica, 2010, Expression pattern of miR-146a, an inflammation-associated microRNA, in experimental and human temporal lobe epilepsy, Eur. J. Neurosci., 31, 1100, 10.1111/j.1460-9568.2010.07122.x · DOI
  5. Artmann, 2012, Detection of simultaneous group effects in microRNA expression and related target gene sets, PLoS ONE, 7, e38365, 10.1371/journal.pone.0038365 · DOI
  6. Becker, 2003, Correlated stage- and subfield-associated hippocampal gene expression patterns in experimental and human temporal lobe epilepsy, Eur. J. Neurosci., 18, 2792, 10.1111/j.1460-9568.2003.02993.x · DOI
  7. Benjamini, 2001, Controlling the false discovery rate in behavior genetics research, Behav. Brain Res., 125, 279, 10.1016/S0166-4328(01)00297-2 · DOI · Paper page
  8. Bhalala, 2012, microRNA-21 regulates astrocytic response following spinal cord injury, J. Neurosci., 32, 17935, 10.1523/JNEUROSCI.3860-12.2012 · DOI · Paper page
  9. Bian, 2011, Functions of noncoding RNAs in neural development and neurological diseases, Mol. Neurobiol., 44, 359, 10.1007/s12035-011-8211-3 · DOI
  10. Bienvenu, 2013, Refining the phenotype associated with MEF2C point mutations, Neurogenetics, 14, 71, 10.1007/s10048-012-0344-7 · DOI
  11. Blondal, 2013, Assessing sample and miRNA profile quality in serum and plasma or other biofluids, Methods, 59, S1, 10.1016/j.ymeth.2012.09.015 · DOI
  12. Boison, 2010, Inhibitory RNA in epilepsy: research tools and therapeutic perspectives, Epilepsia, 51, 1659, 10.1111/j.1528-1167.2010.02672.x · DOI
  13. Busceti, 2007, Induction of the Wnt inhibitor, Dickkopf-1, is associated with neurodegeneration related to temporal lobe epilepsy, Epilepsia, 48, 694, 10.1111/j.1528-1167.2007.01055.x · DOI
  14. Cacheaux, 2009, Transcriptome profiling reveals TGF-beta signaling involvement in epileptogenesis, J. Neurosci., 29, 8927, 10.1523/JNEUROSCI.0430-09.2009 · DOI
  15. Cleveland, 1979, Robust locally weighted regression and smoothing scatter plots, J. Am. Stat. Assoc., 74, 829, 10.1080/01621459.1979.10481038 · DOI · Paper page
  16. Cohen, 2011, MicroRNA regulation of homeostatic synaptic plasticity, Proc. Natl. Acad. Sci. U. S. A., 108, 11650, 10.1073/pnas.1017576108 · DOI · Paper page
  17. Danger, 2013, Expression of miR-142-5p in peripheral blood mononuclear cells from renal transplant patients with chronic antibody-mediated rejection, PLoS ONE, 8, e60702, 10.1371/journal.pone.0060702 · DOI
  18. Davidson-Moncada, 2010, MicroRNAs of the immune system: roles in inflammation and cancer, Proc. Natl. Acad. Sci. U. S. A., 1183, 183, 10.1111/j.1749-6632.2009.05121.x · DOI
  19. Dweep, 2011, miRWalk-database: prediction of possible miRNA binding sites by “walking” the genes of three genomes, J. Biomed. Inform., 44, 839, 10.1016/j.jbi.2011.05.002 · DOI
  20. Friedman, 2009, Blood–brain barrier breakdown-inducing astrocytic transformation: novel targets for the prevention of epilepsy, Epilepsy Res., 85, 142, 10.1016/j.eplepsyres.2009.03.005 · DOI
  21. Gallego, 2012, In vivo microRNA detection and quantitation in cerebrospinal fluid, J. Mol. Neurosci., 47, 243, 10.1007/s12031-012-9731-7 · DOI
  22. Gantier, 2010, New perspectives in MicroRNA regulation of innate immunity, J. Interf. Cytokine Res., 30, 283, 10.1089/jir.2010.0037 · DOI · Paper page
  23. Gorter, 2001, Progression of spontaneous seizures after status epilepticus is related with extensive bilateral loss of hilar parvalbumin and somatostatin immunoreactive neurons, Eur. J. Neurosci., 13, 657, 10.1046/j.1460-9568.2001.01428.x · DOI
  24. Gorter, 2002, Long-lasting increased excitability differs in dentate gyrus vs. CA1 in freely moving chronic epileptic rats after electrically induced status epilepticus, Hippocampus, 12, 311, 10.1002/hipo.1100 · DOI
  25. Gorter, 2003, Neuronal cell death in a rat model for mesial temporal lobe epilepsy is induced by the initial status epilepticus and not by later repeated spontaneous seizures, Epilepsia, 44, 647, 10.1046/j.1528-1157.2003.53902.x · DOI
  26. Gorter, 2006, Potential new antiepileptogenic targets indicated by microarray analysis in a rat model for temporal lobe epilepsy, J. Neurosci., 26, 11083, 10.1523/JNEUROSCI.2766-06.2006 · DOI · Paper page
  27. Griffiths-Jones, 2008, miRBase: tools for microRNA genomics, Nucleic Acids Res., 36, D154, 10.1093/nar/gkm952 · DOI
  28. Harraz, 2012, MicroRNA-223 is neuroprotective by targeting glutamate receptors, Proc. Natl. Acad. Sci. U. S. A., 109, 18962, 10.1073/pnas.1121288109 · DOI · Paper page
  29. He, 2007, Cloning and identification of novel microRNAs from rat hippocampus, Acta Biochim. Biophys. Sin., 39, 708, 10.1111/j.1745-7270.2007.00324.x · DOI
  30. Holtmaat, 2003, Transient downregulation of Sema3A mRNA in a rat model for temporal lobe epilepsy. A novel molecular event potentially contributing to mossy fiber sprouting, Exp. Neurol., 182, 142, 10.1016/S0014-4886(03)00035-9 · DOI
  31. Hu, 2012, MicroRNA expression profile of the hippocampus in a rat model of temporal lobe epilepsy and miR-34a-targeted neuroprotection against hippocampal neurone cell apoptosis post-status epilepticus, BMC Neurosci., 13, 115, 10.1186/1471-2202-13-115 · DOI
  32. Ilhan-Mutlu, 2012, Plasma MicroRNA-21 concentration may be a useful biomarker in glioblastoma patients, Cancer Invest., 30, 615, 10.3109/07357907.2012.708071 · DOI
  33. Jimenez-Mateos, 2011, miRNA Expression profile after status epilepticus and hippocampal neuroprotection by targeting miR-132, Am. J. Pathol., 179, 2519, 10.1016/j.ajpath.2011.07.036 · DOI
  34. Jimenez-Mateos, 2012, Silencing microRNA-134 produces neuroprotective and prolonged seizure-suppressive effects, Nat. Med., 18, 1087, 10.1038/nm.2834 · DOI
  35. Jin, 2013, Circulating microRNAs: a novel class of potential biomarkers for diagnosing and prognosing central nervous system diseases, Cell. Mol. Neurobiol., 33, 601, 10.1007/s10571-013-9940-9 · DOI
  36. Kan, 2012, Genome-wide microRNA profiling of human temporal lobe epilepsy identifies modulators of the immune response, Cell. Mol. Life Sci., 69, 3127, 10.1007/s00018-012-0992-7 · DOI
  37. Kumar, 2006, Hyperexcitability, interneurons, and loss of GABAergic synapses in entorhinal cortex in a model of temporal lobe epilepsy, J. Neurosci., 26, 4613, 10.1523/JNEUROSCI.0064-06.2006 · DOI
  38. Kumar, 2007, Recurrent circuits in layer II of medial entorhinal cortex in a model of temporal lobe epilepsy, J. Neurosci., 27, 1239, 10.1523/JNEUROSCI.3182-06.2007 · DOI
  39. Kumarswamy, 2011, Regulation and function of miRNA-21 in health and disease, RNA Biol., 8, 706, 10.4161/rna.8.5.16154 · DOI
  40. Lehmann, 2012, An unconventional role for miRNA: let-7 activates Toll-like receptor 7 and causes neurodegeneration, Nat. Neurosci., 15, 827, 10.1038/nn.3113 · DOI · Paper page
  41. Li, 2012, Neuregulin 1 regulates excitability of fast-spiking neurons through Kv1.1 and acts in epilepsy, Nat. Neurosci., 15, 267, 10.1038/nn.3006 · DOI · Paper page
  42. Liu, 2010, Brain and blood microRNA expression profiling of ischemic stroke, intracerebral hemorrhage, and kainate seizures, J. Cereb. Blood Flow Metab., 30, 92, 10.1038/jcbfm.2009.186 · DOI
  43. Lukasiuk, 2006, Epileptogenesis-related genes revisited, Prog. Brain Res., 158, 223, 10.1016/S0079-6123(06)58011-2 · DOI
  44. Lukasiuk, 2011, Extracellular proteases in epilepsy, Epilepsy Res., 96, 191, 10.1016/j.eplepsyres.2011.08.002 · DOI
  45. Maroso, 2011, Interleukin-1 type 1 receptor/Toll-like receptor signalling in epilepsy: the importance of IL-1beta and high-mobility group box 1, J. Int. Med., 270, 319, 10.1111/j.1365-2796.2011.02431.x · DOI
  46. Mitchell, 2008, Circulating microRNAs as stable blood-based markers for cancer detection, Proc. Natl. Acad. Sci. U. S. A., 105, 10513, 10.1073/pnas.0804549105 · DOI · Paper page
  47. Nateri, 2007, ERK activation causes epilepsy by stimulating NMDA receptor activity, EMBO J., 26, 4891, 10.1038/sj.emboj.7601911 · DOI
  48. Nowakowska, 2010, Severe mental retardation, seizures, and hypotonia due to deletions of MEF2C, Am. J. Med. Genet. B Neuropsychiatr. Genet., 153B, 1042, 10.1002/ajmg.b.31071 · DOI
  49. O'Connell, 2012, microRNA regulation of inflammatory responses, Annu. Rev. Immunol., 30, 295, 10.1146/annurev-immunol-020711-075013 · DOI · Paper page
  50. Olsen, 2009, MicroRNAs show mutually exclusive expression patterns in the brain of adult male rats, PLoS ONE, 4, e7225, 10.1371/journal.pone.0007225 · DOI
  51. Omran, 2012, Interleukin-1beta and microRNA-146a in an immature rat model and children with mesial temporal lobe epilepsy, Epilepsia, 53, 1215, 10.1111/j.1528-1167.2012.03540.x · DOI · Paper page
  52. Pitkanen, 2011, Mechanisms of epileptogenesis and potential treatment targets, Lancet Neurol., 10, 173, 10.1016/S1474-4422(10)70310-0 · DOI
  53. Quinn, 2011, A trio of microRNAs that control Toll-like receptor signalling, Int. Immunol., 23, 421, 10.1093/intimm/dxr034 · DOI · Paper page
  54. Ramakers, 2003, Assumption-free analysis of quantitative real-time polymerase chain reaction (PCR) data, Neurosci. Lett., 339, 62, 10.1016/S0304-3940(02)01423-4 · DOI
  55. Risbud, 2011, Neurotrophin-3 mRNA a putative target of miR21 following status epilepticus, Brain Res., 1424, 53, 10.1016/j.brainres.2011.09.039 · DOI
  56. Ruijter, 2009, Amplification efficiency: linking baseline and bias in the analysis of quantitative PCR data, Nucleic Acid Res., 37, e45, 10.1093/nar/gkp045 · DOI · Paper page
  57. Russo, 2013, mTOR inhibition modulates epileptogenesis, seizures and depressive behavior in a genetic rat model of absence epilepsy, Neuropharmacology, 69, 25, 10.1016/j.neuropharm.2012.09.019 · DOI
  58. Sheedy, 2010, Negative regulation of TLR4 via targeting of the proinflammatory tumor suppressor PDCD4 by the microRNA miR-21, Nat. Immunol., 11, 141, 10.1038/ni.1828 · DOI · Paper page
  59. Sheinerman, 2012, Plasma microRNA biomarkers for detection of mild cognitive impairment, Aging, 4, 590, 10.18632/aging.100486 · DOI · Paper page
  60. Song, 2011, Temporal lobe epilepsy induces differential expression of hippocampal miRNAs including let-7e and miR-23a/b, Brain Res., 1387, 134, 10.1016/j.brainres.2011.02.073 · DOI · Paper page
  61. Tan, 2012, Neuregulin 1 represses limbic epileptogenesis through ErbB4 in parvalbumin-expressing interneurons, Nat. Neurosci., 15, 258, 10.1038/nn.3005 · DOI
  62. Tolner, 2005, Presubiculum stimulation in vivo evokes distinct oscillations in superficial and deep entorhinal cortex layers in chronic epileptic rats, J. Neurosci., 25, 8755, 10.1523/JNEUROSCI.1165-05.2005 · DOI
  63. Tolner, 2007, Synaptic responses in superficial layers of medial entorhinal cortex from rats with kainate-induced epilepsy, Neurobiol. Dis., 26, 419, 10.1016/j.nbd.2007.01.009 · DOI
  64. van Vliet, 2004, Progression of temporal lobe epilepsy in the rat is associated with immunocytochemical changes in inhibitory interneurons in specific regions of the hippocampal formation, Exp. Neurol., 187, 367, 10.1016/j.expneurol.2004.01.016 · DOI
  65. van Vliet, 2009, Decreased expression of synaptic vesicle protein 2A, the binding site for levetiracetam, during epileptogenesis and chronic epilepsy, Epilepsia, 50, 422, 10.1111/j.1528-1167.2008.01727.x · DOI
  66. van Vliet, 2012, Inhibition of mammalian target of rapamycin reduces epileptogenesis and blood–brain barrier leakage but not microglia activation, Epilepsia, 53, 1254, 10.1111/j.1528-1167.2012.03513.x · DOI
  67. Vezzani, 2010, ICE/caspase 1 inhibitors and IL-1beta receptor antagonists as potential therapeutics in epilepsy, Curr. Opin. Investig. Drugs, 11, 43
  68. Vezzani, 2011, IL-1 receptor/Toll-like receptor signaling in infection, inflammation, stress and neurodegeneration couples hyperexcitability and seizures, Brain Behav. Immun., 25, 1281, 10.1016/j.bbi.2011.03.018 · DOI
  69. Vezzani, 2013, Epilepsy and brain inflammation, Exp. Neurol., 244, 11, 10.1016/j.expneurol.2011.09.033 · DOI · Paper page
  70. Xu, 2003, EphA/ephrin-A interactions regulate epileptogenesis and activity-dependent axonal sprouting in adult rats, Mol. Cell. Neurosci., 24, 984, 10.1016/j.mcn.2003.08.003 · DOI
  71. Xu, 2013, MicroRNA-21 with therapeutic potential in autoimmune diseases, Expert Opin. Ther. Targets, 17, 659, 10.1517/14728222.2013.773311 · DOI
  72. Yelamanchili, 2010, MicroRNA-21 dysregulates the expression of MEF2C in neurons in monkey and human SIV/HIV neurological disease, Cell Death Dis., 1, e77, 10.1038/cddis.2010.56 · DOI
  73. Zeng, 2008, Rapamycin prevents epilepsy in a mouse model of tuberous sclerosis complex, Ann. Neurol., 63, 444, 10.1002/ana.21331 · DOI · Paper page
  74. Zhang, 2012, miR-21 represses FasL in microglia and protects against microglia-mediated neuronal cell death following hypoxia/ischemia, Glia, 60, 1888, 10.1002/glia.22404 · DOI · Paper page
  75. Zhang, 2013, Selective secretion of microRNA in CNS system, Protein Cell, 4, 243, 10.1007/s13238-013-3006-0 · DOI
  76. Ziu, 2011, Temporal differences in microRNA expression patterns in astrocytes and neurons after ischemic injury, PLoS ONE, 6, e14724, 10.1371/journal.pone.0014724 · DOI

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Metadata

Authors
Gorter, J. A., Iyer, A., White, I., Colzi, A., van Vliet, E. A., Sisodiya, S., & Aronica, E.
Venue
Neurobiology of Disease
Publisher
Elsevier BV
Published
2014-02
Volume
62
Pages
508-520
ISSN
0969-9961
DOI
10.1016/j.nbd.2013.10.026
Cited by
172
References
6
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Funders
  • National Epilepsy Fund — “Power of the Small”
  • Hersenstichting Nederland (NEF 13-01)
  • UCB Pharma
  • National Institute for Health Research University College London Hospitals Biomedical Research Centre

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