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Gut microbiota‐derived short‐chain fatty acids and depression: deep insight into biological mechanisms and potential applications

Cheng, J., Hu, H., Ju, Y., Liu, J., Wang, M., Liu, B., & Zhang, Y. (2024) · General Psychiatry · doi:10.1136/gpsych-2023-101374 · Cited by 216 · see citing works

Epigenetics Control Microglia Plasticity

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The gut microbiome: a key player in the complexity of amyotrophic lateral sclerosis (ALS)

Boddy, S. L., Giovannelli, I., Sassani, M., Cooper-Knock, J., Snyder, M. P., Segal, E., Elinav, E., Barker, L. A., Shaw, P. J., & McDermott, C. J. (2021) · BMC Medicine · doi:10.1186/s12916-020-01885-3 · Cited by 127 · see citing works

Elucidating the specific mechanisms of the gut-brain axis: the short-chain fatty acids-microglia pathway

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<i>Akkermansia muciniphila</i> supplementation prevents cognitive impairment in sleep-deprived mice by modulating microglial engulfment of synapses

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Short-Chain Fatty Acids in the Microbiota–Gut–Brain Axis: Role in Neurodegenerative Disorders and Viral Infections

Majumdar, A., Venkatesh, I. P. S., & Basu, A. (2023) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.2c00803 · Cited by 85 · see citing works

Sodium butyrate alleviates lead-induced neuroinflammation and improves cognitive and memory impairment through the ACSS2/H3K9ac/BDNF pathway

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Gut microbiota-derived short chain fatty acids act as mediators of the gut–brain axis targeting age-related neurodegenerative disorders: a narrative review

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The functional roles of short chain fatty acids as postbiotics in human gut: future perspectives

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The Gut Microbiome as a Regulator of the Neuroimmune Landscape

Yu, L. W., Agirman, G., & Hsiao, E. Y. (2022) · Annual Review of Immunology · doi:10.1146/annurev-immunol-101320-014237 · Cited by 75 · see citing works

Serum short chain fatty acids mediate hippocampal BDNF and correlate with decreasing neuroinflammation following high pectin fiber diet in mice

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The Neuroprotective Effect of Short Chain Fatty Acids Against Sepsis-Associated Encephalopathy in Mice

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Short Term Intrarectal Administration of Sodium Propionate Induces Antidepressant-Like Effects in Rats Exposed to Chronic Unpredictable Mild Stress

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Major Depressive Disorder and Gut Microbiota: Role of Physical Exercise

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Lipopolysaccharide-Induced Depression-Like Behaviors Is Ameliorated by Sodium Butyrate via Inhibiting Neuroinflammation and Oxido-Nitrosative Stress

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The role of short-chain fatty acid in metabolic syndrome and its complications: focusing on immunity and inflammation

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Nutrition, gut microbiota, and alzheimer’s disease

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Classical HDACs in the regulation of neuroinflammation

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Gut Microbiota Metabolite Messengers in Brain Function and Pathology at a View of Cell Type-Based Receptor and Enzyme Reaction

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Connecting gut microbiomes and short chain fatty acids with the serotonergic system and behavior in Gallus gallus and other avian species

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Short‐chain fatty acids stimulate dendrite elongation in dendritic cells by inhibiting histone deacetylase

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Sodium Butyrate Protects N2a Cells against Aβ Toxicity In Vitro

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APOE genetics influence murine gut microbiome

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Brain-Gut-Microbiota Axis in Amyotrophic Lateral Sclerosis: A Historical Overview and Future Directions

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The role of short-chain fatty acids in central nervous system diseases: A bibliometric and visualized analysis with future directions

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Microbiota–gut–brain axis: Natural antidepressants molecular mechanism

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Overexpressed or hyperactivated Rac1 as a target to treat hepatocellular carcinoma

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Integrating Autism Spectrum Disorder Pathophysiology: Mitochondria, Vitamin A, CD38, Oxytocin, Serotonin and Melatonergic Alterations in the Placenta and Gut

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Epigenetics and Communication Mechanisms in Microglia Activation with a View on Technological Approaches

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Sodium butyrate reduces overnutrition-induced microglial activation and hypothalamic inflammation

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Effectiveness of probiotic/prebiotic/synbiotic treatments on anxiety: A systematic review and meta-analysis of randomized controlled trials

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Gut dysfunction may be the source of pathological aggregation of alpha-synuclein in the central nervous system through Paraquat exposure in mice

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Epidrugs in the Therapy of Central Nervous System Disorders: A Way to Drive on?

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Saponins isolated from Radix polygalae extent lifespan by modulating complement C3 and gut microbiota

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Dietary Fats and Cognitive Status in Italian Middle-Old Adults

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Microbial Reprogramming in Obsessive–Compulsive Disorders: A Review of Gut–Brain Communication and Emerging Evidence

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Dietary Fats and Depressive Symptoms in Italian Adults

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Pathogenesis from the microbial-gut-brain axis in white matter injury in preterm infants: A review

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Differentiation of human glioblastoma U87 cells into cholinergic neuron

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Identification of a pro-elongation effect of diallyl disulfide, a major organosulfur compound in garlic oil, on microglial process.

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Microbial Metabolomes in Alzheimer’s Disease: From Pathogenesis to Therapeutic Potential

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Acute Diallyl Disulfide Administration Prevents and Reveres Lipopolysaccharide-Induced Depression-Like Behaviors in Mice via Regulating Neuroinflammation and Oxido-Nitrosative Stress

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Microbial metabolites regulate social novelty via CaMKII neurons in the BNST

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Butyrate: a key mediator of gut-brain communication in Alzheimer’s disease

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Regulation of microglial process elongation, a featured characteristic of microglial plasticity

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A novel role of lactate: Promotion of Akt-dependent elongation of microglial process

Hong, H., Su, J., Zhang, Y., Xu, G., Huang, C., Bao, G., & Cui, Z. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.110136 · Cited by 17 · see citing works

The Role of Macronutrients and Gut Microbiota in Neuroinflammation Post-Traumatic Brain Injury: A Narrative Review

Cotoia, A., Charitos, I. A., Corriero, A., Tamburrano, S., & Cinnella, G. (2024) · Nutrients · doi:10.3390/nu16244359 · Cited by 17 · see citing works

Immune, blood-brain barrier, and metabolic biomarkers mediate gut-brain axis crosstalk in alzheimer’s disease

Li, J., Yuan, Z., Li, J., Liu, Z., Wang, Y., Cui, M., Suo, C., Li, J., Ding, D., Chen, X., et al. (2025) · Biomarker Research · doi:10.1186/s40364-025-00851-6 · Cited by 16 · see citing works

Prenatal inflammation exacerbates hyperoxia-induced neonatal brain injury

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Review of the Health Benefits of Cereals and Pseudocereals on Human Gut Microbiota

Zeyneb, H., Al‐Dalali, S., Pei, H., & Cao, X. (2023) · Food and Bioprocess Technology · doi:10.1007/s11947-023-03069-2 · Cited by 15 · see citing works

Sulforaphane triggers a functional elongation of microglial process via the Akt signal

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Trichostatin A relieves anxiety-and depression-like symptoms in APP/PS1 mice

Su, Q., Ren, Y.-H., Liu, G.-W., Gao, Y., Zhang, J. Y., Zhang, J.-N., Pei, X.-X., & Li, T. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1333235 · Cited by 13 · see citing works

Longitudinal Variations of CDC42 in Patients With Acute Ischemic Stroke During 3-Year Period: Correlation With CD4+ T Cells, Disease Severity, and Prognosis

Xiao, C., Ye, J., Zhang, X., & Meng, K. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2022.848933 · Cited by 13 · see citing works

KRIBB11: A Promising Drug that Promotes Microglial Process Elongation and Suppresses Neuroinflammation

Su, J., Dou, Z., Hong, H., Xu, F., Lu, X., Lu, Q., Ye, T., & Huang, C. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.857081 · Cited by 12 · see citing works

Bioinformatics Approach to Identify the Pathogenetic Link of Gut Microbiota-Derived Short-Chain Fatty Acids and Ischemic Stroke

Ding, L., Wang, J., Qiu, S., Ren, Z., Li, Y., & An, P. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04176-7 · Cited by 10 · see citing works

The Human Microbiome—A Physiologic Perspective

Yang, X. J., Louwies, T., Mars, R. A. T., & Kashyap, P. (2024) · Comprehensive physiology · doi:10.1002/j.2040-4603.2024.tb00299.x · Cited by 9 · see citing works

The Metabolomic Mind: Microbial Metabolite Programming of Microglia

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Microalgae-based Intestinal villi-targeting multistage biosystem for irritable bowel syndrome treatment

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Acupuncture modulates the microbiota-gut-brain axis: a new strategy for Parkinson’s disease treatment

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Positive impact of indicaxanthin from Opuntia ficus-indica fruit on high-fat diet–induced neuronal damage and gut microbiota dysbiosis

Terzo, S., Amato, A., Calvi, P., Giardina, M., Nuzzo, D., Picone, P., Piccionello, A. P., Amata, S., Giardina, I. C., Massaro, A. S., et al. (2024) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-23-02039 · Cited by 8 · see citing works

Metabolic Flexibility Assists Reprograming of Central and Peripheral Innate Immunity During Neurodevelopment

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Insights into host-microbe interaction: What can we do for the swine industry?

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Specialized, Pro-Resolving Mediators as Potential Therapeutic Agents for Alleviating Fibromyalgia Symptomatology

Livshits, G., & Kalinkovich, A. (2021) · Pain Medicine · doi:10.1093/pm/pnab060 · Cited by 8 · see citing works

The Gut Connection: A Narrative Review on the In-depth Analysis of Gut Microbiota and Metabolites in Depression

Sultana, A., Hussain, M. S., Maqbool, M., Agrawal, M., Bisht, A. S., Khurana, N., Singh, G., & Kumar, R. (2025) · Current Clinical Pharmacology · doi:10.2174/0127724328332998250118182255 · Cited by 7 · see citing works

Gut microbiome, a potential modulator of neuroepigenome

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Gut–brain axis and depression: focus on the amino acid and short-chain fatty acid metabolism

Chen, M., Lyu, Q., Huang, L., Lou, Y., & Wang, L. (2025) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000851 · Cited by 6 · see citing works

Microbiota-induced inflammation mediates the impacts of a Western diet on hippocampal-dependent memory

Crain, E., Minaya, D. M., & Serre, C. B. D. L. (2025) · Nutrition Research · doi:10.1016/j.nutres.2025.04.002 · Cited by 6 · see citing works

Differences in cognition, short-chain fatty acids and related metabolites in pregnant versus non-pregnant women: a cross-sectional study

Luo, H., Li, W., Wu, L., Zhong, S., Du, C., Liu, Y., Xu, Y., Huang, X., Bahru, A. H., Tang, X., et al. (2022) · BMC Pregnancy and Childbirth · doi:10.1186/s12884-022-04853-2 · Cited by 5 · see citing works

Short-chain fatty acids in mood and schizophrenia spectrum disorders: Evidence in the field and translational perspectives

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Gut Feelings: Linking Dysbiosis to Depression—A Narrative Literature Review

Bibolar, A. C., Nechita, V.-I., Lung, F. C., Crecan-Suciu, B. D., & Paunescu, R. (2025) · Medicina · doi:10.3390/medicina61081360 · Cited by 5 · see citing works

The Human Microbiome—A Physiologic Perspective

Yang, X. J., Louwies, T., Mars, R. A. T., & Kashyap, P. (2024) · Comprehensive physiology · doi:10.1002/cphy.c230013 · Cited by 12 · see citing works

Antenatal depressive symptoms impair offspring neurodevelopment by inducing maternal gut microbiota dysbiosis during pregnancy

Zhou, F., Wang, L., ZHAO, Y., Hu, C., Meng, Y., Fan, J., Fraser, W. D., Baillargeon, J., Ouyang, F., Lye, S. J., et al. (2026) · Gut Microbes · doi:10.1080/19490976.2026.2672188 · Cited by 3 · see citing works

Neurosteroids, Microbiota, and Neuroinflammation: Mechanistic Insights and Therapeutic Perspectives

Tahri, A., Niccolai, E., & Amedei, A. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26147023 · Cited by 3 · see citing works

Sterile soil mitigates the intergenerational loss of gut microbial diversity and anxiety-like behavior induced by antibiotics in mice

Li, N., Xiao, X., Zhang, H., Bai, Z., Li, M., Sun, J. Y., Dong, Y., Zhu, W., Fei, Z., Sun, X., et al. (2023) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2023.10.014 · Cited by 3 · see citing works

Gut–Brain Connection: Deciphering Causal Pathways Between Gut Microbiota and Neuroimaging Profiles Through Mendelian Randomization

Zeng, Y., Yang, L., Liu, H., Liao, H., Zhou, Y., & Liu, J. (2026) · Food Science & Nutrition · doi:10.1002/fsn3.71820 · Cited by 1 · see citing works

A relationship between intestinal microbiome and epilepsy: potential treatment options for drug-resistant epilepsy

Cherednichenko, A. S., Mozdor, P. V., Oleynikova, T. K., Khatam, P. A., Nastueva, F. M., Kovalenkov, K. O., Serdinova, A. S., Osmaeva, A. K., Rovchak, A. I., Esikova, Y. Y., et al. (2024) · Epilepsy and Paroxysmal Conditions · doi:10.17749/2077-8333/epi.par.con.2024.190 · Cited by 1 · see citing works

PREBIOTICS FOR ACUTE ISCHEMIC STROKE

Renamastika, S. N., Wahyuningrum, D. R., PUTRI, V. A., & Aisy, R. (2021) · International Journal of Pharmacy and Pharmaceutical Sciences · doi:10.22159/ijpps.2021v13i5.41110 · Cited by 1 · see citing works

Effect of diallyl disulfide on lipopolysaccharide-induced depression-like behavior in micePreprint

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The Effect of Polyunsaturated and Saturated Fatty Acids on Seizure Presence and Severity in a Cohort of Subjects in an Epilepsy Monitoring Unit

Wells, J. (2021) · DigitalCommons@UNMC

Rifaximin-Mediated Gut Microbiota Regulation Modulates the Polarization of Microglia During CUMS in RatPreprint

Li, H., Xiang, Y., Zhu, Z., Wang, W., Jiang, Z., Zhao, M., Cheng, S., Pan, F., Liu, D., Ho, R., et al. (2021) · Research Square · doi:10.21203/rs.3.rs-820698/v1

Modulation of gut-immune-brain axis by non-digestible oligosaccharides and omega-3 fatty acids in health and allergic disease

Szklany, K. (2023) · doi:10.33540/1717

Sterile Soil as Prebiotics Mitigate Intergenerational Loss of Gut Microbial Diversity and Anxiety-Like Behavior Induced by Antibiotics in micePreprint

Li, N., Xiao, X., Zhang, H., Bai, Z., Li, M., Sun, J. Y., Dong, Y., Zhu, W., Fei, Z., Sun, X., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.04.15.536315

Bioinformatics Approach to Identify the Pathogenetic Link of Gut Microbial Metabolites and StrokePreprint

Ding, L., Wang, J., Qiu, S., Ren, Z., Li, Y., & An, P. (2024) · Research Square · doi:10.21203/rs.3.rs-3848446/v1

Gut–brain communication through microbes

Green, M., & Foster, J. A. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-90144-4.00002-1

Nutritional significance of short-chain fatty acids

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The gut–brain–epigenetic axis in brain health

Louwies, T. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-15572-7.00057-7

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4-Phenylbutyrate Induces Functional Elongation of the Microglial Process Through Activation of Akt

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Anti-inflammatory mechanism of sodium butyrate in brain microglia

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The impact of the histone deacetylase inhibitor sodium butyrate on microglial polarization after oxygen and glucose deprivation

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A novel role of lactate: Promotion of Akt-dependent elongation of microglial process

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Regulation of microglial inflammatory response by sodium butyrate and short‐chain fatty acids

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