Cited by 56Gut microbiota and healthAlzheimer's disease research and treatmentsProbiotics and Fermented Foods

Nutrition, gut microbiota, and alzheimer’s disease

Open access
Romanenko, Mariana, Kholin, Victor, Koliada, Alexander, Vaiserman, Alexander·2021·Frontiers in Psychiatry

Abstract

Nutrition is known to play an important role in the pathogenesis of Alzheimer's disease. Evidence is obtained that the gut microbiota is a key player in these processes. Dietary changes (both adverse and beneficial) may influence the microbiome composition, thereby affecting the gut-brain axis and the subsequent risk for Alzheimer's disease progression. In this review, the research findings that support the role of intestinal microbiota in connection between nutritional factors and the risk for Alzheimer's disease onset and progression are summarized. The mechanisms potentially involved in these processes as well as the potential of probiotics and prebiotics in therapeutic modulation of contributed pathways are discussed.

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Crossref · 10.3389/fpsyt.2021.712673

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  • The positive effects of a GM-favorable diet are likely due to the availability of prebiotics, probiotics, SCFAs, and polyphenols.

    “This is likely due to the availability of prebiotics, probiotics, SCFAs, and polyphenols.”
  • A significant body of evidence demonstrates that consuming a GM-favorable diet can positively influence the GM, improve health status, and enhance cognitive function.

    “A comprehensive review of this topic is beyond the scope of this review, however, a significant body of evidence demonstrates that consuming a GM-favorable diet can positively influence the GM, improve health status, and enhance cognitive function (506–510).”

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Authors
Romanenko, M., Kholin, V., Koliada, A., & Vaiserman, A.
Affiliations
D. F. Chebotarev State Institute of Gerontology of the National Academy of Medical Sciences of Ukraine (UA)
Corresponding author
Romanenko, Mariana
Venue
Frontiers in Psychiatry
Published
2021-08-05
Volume
12
Pages
712673-712673
ISSN
1664-0640 (ISSN-L)
OpenAlex
W3188826759
Cited by
56
References
137
Citations by year
2026: 7 · 2025: 7 · 2024: 20 · 2023: 12 · 2022: 7 · 2021: 3
FWCI
1.10
Type
journal article
Language
en
Open access
Locations
  • Frontiers in Psychiatry (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Keywords
Alzheimer's disease, gut microbiota, nutrition, gut-brain axis, dietary factors, microbiota composition, probiotics, prebiotics, disease progression, neurodegeneration

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