Role of genetic background in the effects of adolescent nicotine exposure on mesolimbic dopamine transmission
Abstract
Smoking during adolescence may increase the likelihood to develop nicotine dependence and to abuse other drugs such as cocaine. Despite great efforts to understand underlying neurobiological mechanisms of this progression, less attention has been paid to the role of genetic factors. Here, we investigated the influence of both genetic background and age at first nicotine exposure in the long‐lasting effects on mesolimbic dopamine transmission including the increased cocaine‐rewarding effect. Mid‐adolescent and adult rats of inbred strains Lewis (addiction prone) and Fischer 344 (addiction resistant) were administered nicotine (0.4 mg/kg) or vehicle once daily for 5 days. Changes in dopamine transmission were investigated by in vivo microdialysis and electrophysiology after 30 days of withdrawal, whereas changes in cocaine‐rewarding effect were assessed via conditioned place preference paradigm. Nicotine pre‐exposure differentially changed mesolimbic dopamine transmission depending on strain and age of pre‐exposure. A potentiation of dopamine response to nicotine was observed in nucleus accumbens (NAc) core of both strains and age groups, whereas dopamine response in NAc shell was enhanced exclusively in Lewis rats exposed to nicotine during adolescence. A similar response was observed following cocaine challenge at adulthood. Changes in VTA dopamine cell population and activity were observed only in adolescent nicotine‐pretreated Lewis rats, which also showed an increased cocaine‐rewarding effect at adulthood. These results highlight the influence of genetic background in the long‐lasting effects of nicotine exposure and suggest that exposure during adolescence might increase nicotine and cocaine‐rewarding properties in genetically vulnerable individuals, thereby facilitating progression toward dependence.
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Basal DA neuron firing rate is decreased in adult rats following mid-adolescent nicotine exposure (PND 38-42).
“another group reports that basal DA neuron firing rate was decreased in adult rats following mid-adolescent (PND 38–42) nicotine exposure [141].”
From Adolescent nicotine exposure and persistent neurocircuitry changes: unveiling lifelong psychiatric risks (2025) · cites this paper as [141]
Cites
The neural basis of drug craving: An incentive-sensitization theory of addiction
Robinson, T. (1993) · Brain Research Reviews · doi:10.1016/0165-0173(93)90013-p · Cited by 7,346 · see citing works
Dopamine in motivational control: rewarding, aversive, and alerting
Bromberg-Martin, E. S., Matsumoto, M., & Hikosaka, O. (2010) · Neuron · doi:10.1016/j.neuron.2010.11.022 · Cited by 2,396 · see citing works
Pan, L., Gurevich, E. V., & Gurevich, V. V. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m209532200 · Cited by 1,758 · see citing works
The incentive sensitization theory of addiction: some current issues
Robinson, T. E., & Berridge, K. C. (2008) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2008.0093 · Cited by 1,717 · see citing works
The control of firing pattern in nigral dopamine neurons: burst firing
Grace, A., & Bunney, B. (1984) · Journal of Neuroscience · doi:10.1523/jneurosci.04-11-02877.1984 · Cited by 1,346 · see citing works
Evidence for Addiction-like Behavior in the Rat
Deroche-Gamonet, V., Belin, D., & Piazza, P. V. (2004) · Science · doi:10.1126/science.1099020 · Cited by 1,135 · see citing works
Kandel, D. B., Yamaguchi, K., & Chen, K. (1992) · Journal of Studies on Alcohol · doi:10.15288/jsa.1992.53.447 · Cited by 1,039 · see citing works
Grace, A. A., & Bunney, B. S. (1983) · Neuroscience · doi:10.1016/0306-4522(83)90135-5 · Cited by 937 · see citing works
Dopamine and drug addiction: the nucleus accumbens shell connection
Di Chiara, G., Bassareo, V., Fenu, S., De Luca, M. A., Spina, L., Cadoni, C., Acquas, E., Carboni, E., Valentini, V., & Lecca, D. (2004) · Neuropharmacology · doi:10.1016/j.neuropharm.2004.06.032 · Cited by 935 · see citing works
Self-citationSpear, L. P. (2013) · Journal of Adolescent Health · doi:10.1016/j.jadohealth.2012.05.006 · Cited by 744 · see citing works
Tsuang, M. T., Lyons, M. J., Meyer, J. M., Doyle, T., Eisen, S. A., Goldberg, J., True, W., Lin, N., Toomey, R., & Eaves, L. (1998) · Archives of General Psychiatry · doi:10.1001/archpsyc.55.11.967 · Cited by 710 · see citing works
Kendler, K. S., Jacobson, K. C., Prescott, C. A., & Neale, M. C. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.4.687 · Cited by 693 · see citing works
Dopaminergic Network Differences in Human Impulsivity
Buckholtz, J. W., Treadway, M. T., Cowan, R. L., Woodward, N. D., Li, R., Ansari, M. S., Baldwin, R. M., Schwartzman, A. N., Shelby, E. S., Smith, C. E., et al. (2010) · Science · doi:10.1126/science.1185778 · Cited by 600 · see citing works
<scp>N</scp> icotine and the adolescent brain
Yuan, M., Cross, S. J., Loughlin, S. E., & Leslie, F. M. (2015) · The Journal of Physiology · doi:10.1113/jp270492 · Cited by 582 · see citing works
The dynamic effects of nicotine on the developing brain
Dwyer, J. B., McQuown, S. C., & Leslie, F. M. (2009) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2009.02.003 · Cited by 559 · see citing works
Slotkin, T. A. (2004) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2003.06.001 · Cited by 544 · see citing works
Early-onset drug use and risk for drug dependence problems
Chen, C.-Y., Storr, C. L., & Anthony, J. C. (2009) · Addictive Behaviors · doi:10.1016/j.addbeh.2008.10.021 · Cited by 466 · see citing works
Vanyukov, M. M., Tarter, R. E., Kirillova, G. P., Kirisci, L., Reynolds, M., Kreek, M. J., Conway, K. P., Maher, B. S., Iacono, W. G., Bierut, L. J., et al. (2012) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2011.12.018 · Cited by 438 · see citing works
Yang, H., de Jong, J. W., Tak, Y., Peck, J., Bateup, H. S., & Lammel, S. (2018) · Neuron · doi:10.1016/j.neuron.2017.12.022 · Cited by 407 · see citing works
Diversity of Transgenic Mouse Models for Selective Targeting of Midbrain Dopamine Neurons
Lammel, S., Steinberg, E. E., Földy, C., Wall, N. R., Beier, K. T., Luo, L., & Malenka, R. C. (2015) · Neuron · doi:10.1016/j.neuron.2014.12.036 · Cited by 345 · see citing works
Heritability of Smoking Initiation and Nicotine Dependence
Vink, J. M., Willemsen, G. A. H. M., & Boomsma, D. I. (2005) · Behavior Genetics · doi:10.1007/s10519-004-1327-8 · Cited by 342 · see citing works
Mesocorticolimbic Glutamatergic Pathway
Yamaguchi, T., Wang, H.-L., Li, X., Ng, T. H., & Morales, M. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.1598-11.2011 · Cited by 332 · see citing works
Levine, A., Huang, Y., Drisaldi, B., Griffin, E. A., Pollak, D. D., Xu, S., Yin, D., Schaffran, C., Kandel, D. B., & Kandel, E. R. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3003062 · Cited by 280 · see citing works
Neurobehavioral evidence for changes in dopamine system activity during adolescence
Wahlstrom, D., White, T., & Luciana, M. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.12.007 · Cited by 277 · see citing works
Degenhardt, L., Dierker, L., Chiu, W. T., Medina-Mora, M. E., Neumark, Y., Sampson, N., Alonso, J., Angermeyer, M., Anthony, J. C., Bruffaerts, R., et al. (2010) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2009.12.001 · Cited by 271 · see citing works
MAES, H. H. M., Sullivan, P. F., Bulik, C. M., Neale, M. C., Prescott, C. A., Eaves, L. J., & Kendler, K. S. (2004) · Psychological Medicine · doi:10.1017/s0033291704002405 · Cited by 254 · see citing works
The association between cigarette smoking and drug abuse in the United States
Lai, S., Lai, H., Page, J. B., & McCoy, C. B. (2000) · Journal of Addictive Diseases · doi:10.1300/j069v19n04_02 · Cited by 212 · see citing works
Liability to substance use disorders: 1. Common mechanisms and manifestations
Vanyukov, M. M., Tarter, R. E., Kirisci, L., Kirillova, G. P., Maher, B. S., & Clark, D. B. (2003) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2003.08.002 · Cited by 205 · see citing works
On the development of nicotine dependence in adolescence
Kandel, D. B., Hu, M., Griesler, P. C., & Schaffran, C. (2007) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2007.04.011 · Cited by 204 · see citing works
Cocaine use, abuse and dependence in a population-based sample of female twins
Kendler, K. S., & Prescott, C. A. (1998) · The British Journal of Psychiatry · doi:10.1192/bjp.173.4.345 · Cited by 202 · see citing works
Recent advances in the genetic epidemiology and molecular genetics of substance use disorders
Kendler, K. S., Chen, X., Dick, D., Maes, H., Gillespie, N., Neale, M. C., & Riley, B. (2012) · Nature Neuroscience · doi:10.1038/nn.3018 · Cited by 179 · see citing works
Luciana, M., Wahlstrom, D., Porter, J. N., & Collins, P. F. (2012) · Developmental Psychology · doi:10.1037/a0027432 · Cited by 156 · see citing works
Hanna, E. Z., Yi, H.-Y., Dufour, M. C., & Whitmore, C. C. (2001) · Journal of Substance Abuse · doi:10.1016/s0899-3289(01)00077-3 · Cited by 138 · see citing works
DiFranza, J. R., Savageau, J. A., Fletcher, K. E., Pbert, L. A., O’Loughlin, J. L., McNeill, A. D., Ockene, J. K., Friedman, K. E., Hazelton, J. K., Wood, C., et al. (2007) · PEDIATRICS · doi:10.1542/peds.2007-0027 · Cited by 138 · see citing works
The Impact of Cigarette Smoking on Stimulant Addiction
Weinberger, A. H., & Sofuoglu, M. (2009) · The American Journal of Drug and Alcohol Abuse · doi:10.1080/00952990802326280 · Cited by 122 · see citing works
Adolescent nicotine induces persisting changes in development of neural connectivity.
Smith, R. F., McDonald, C. G., Bergstrom, H. C., Ehlinger, D. G., & Brielmaier, J. M. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.05.019 · Cited by 120 · see citing works
Early Onset Cannabis Use and Progression to other Drug Use in a Sample of Dutch Twins
Lynskey, M. T., Vink, J. M., & Boomsma, D. I. (2006) · Behavior Genetics · doi:10.1007/s10519-005-9023-x · Cited by 120 · see citing works
Low dose nicotine treatment during early adolescence increases subsequent cocaine reward
McQuown, S. C., Belluzzi, J. D., & Leslie, F. M. (2007) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2006.10.012 · Cited by 117 · see citing works
Arpana Agrawal, A., Grant, J. D., Waldron, M., Duncan, A. E., Scherrer, J. F., Lynskey, M. T., Madden, P. A. F., Bucholz, K. K., & Heath, A. C. (2006) · Preventive Medicine · doi:10.1016/j.ypmed.2006.03.022 · Cited by 115 · see citing works
Rapid dopamine dynamics in the accumbens core and shell: Learning and action
Saddoris, M. P., Sugam, J. A., Cacciapaglia, F., & Carelli, R. (2013) · Frontiers in Bioscience · doi:10.2741/e615 · Cited by 114 · see citing works
Lenoir, M., & Ahmed, S. H. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301083 · Cited by 110 · see citing works
The transition from controlled to compulsive drug use is associated with a loss of sensitization
Ben‐Shahar, O., Ahmed, S. H., Koob, G. F., & Ettenberg, A. (2003) · Brain Research · doi:10.1016/j.brainres.2003.09.053 · Cited by 104 · see citing works
Spina, L., Fenu, S., Longoni, R., Rivas, E., & Di Chiara, G. (2006) · Psychopharmacology · doi:10.1007/s00213-005-0211-4 · Cited by 102 · see citing works
Self-citationThe Genetics of Smoking Related Behavior: A Brief Review
Li, M. D. (2003) · The American Journal of the Medical Sciences · doi:10.1097/00000441-200310000-00003 · Cited by 95 · see citing works
Sartor, C. E., Lessov-Schlaggar, C. N., Scherrer, J. F., Bucholz, K. K., Madden, P. A. F., Pergadia, M. L., Grant, J. D., Jacob, T., & Xian, H. (2010) · Addictive Behaviors · doi:10.1016/j.addbeh.2010.03.004 · Cited by 93 · see citing works
deBry, S., & Tiffany, S. (2008) · Nicotine & Tobacco Research · doi:10.1080/14622200701767811 · Cited by 92 · see citing works
Nicotine alters limbic function in adolescent rat by a 5-HT1A receptor mechanism
Dao, J. M., McQuown, S. C., Loughlin, S. E., Belluzzi, J. D., & Leslie, F. M. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.8 · Cited by 79 · see citing works
Neuroprotective and Neurotoxic Effects of Nicotine
Ferrea, S., & Winterer, G. (2009) · Pharmacopsychiatry · doi:10.1055/s-0029-1224138 · Cited by 76 · see citing works
Richmond‐Rakerd, L. S., Slutske, W. S., Lynskey, M. T., et al. (2016) · Journal of Abnormal Psychology · doi:10.1037/abn0000191 · Cited by 72 · see citing works
Hall, F. S., Drgonová, J., Jain, S., & Uhl, G. R. (2013) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2013.07.006 · Cited by 71 · see citing works
Elenkov, I. J., Květňanský, R., Hashiramoto, A., Bakalov, V. K., Link, A. A., Zachman, K., Crane, M., Ježová, D., Rovenský, J., Dimitrov, M. A., et al. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.3.1737 · Cited by 67 · see citing works
Edwards, A. C., MAES, H. H. M., Pedersen, N. L., & Kendler, K. S. (2010) · Psychological Medicine · doi:10.1017/s0033291710000589 · Cited by 66 · see citing works
Periadolescent nicotine exposure causes heterologous sensitization to cocaine reinforcement
McMillen, B. A., Davis, B. J., Williams, H. L., & Soderstrom, K. (2005) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2005.01.002 · Cited by 66 · see citing works
Gene-Gene Interactions Among CHRNA4, CHRNB2, BDNF, and NTRK2 in Nicotine Dependence
Li, M. D., Lou, X., Chen, G., Ma, J. Z., & Elston, R. C. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.04.026 · Cited by 65 · see citing works
Periadolescent Nicotine Exposure Reduces Cocaine Reward in Adult Mice
Kelley, B. M., & Middaugh, L. D. (1999) · Journal of Addictive Diseases · doi:10.1300/j069v18n03_04 · Cited by 65 · see citing works
Aberrant reward processing in Parkinson's disease is associated with dopamine cell loss
Aarts, E., Helmich, R. C. G., Janssen, M. J. R., Oyen, W. J. G., Bloem, B. R., & Cools, R. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.11.073 · Cited by 59 · see citing works
Kelley, B. M., & Rowan, J. D. (2004) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2004.04.002 · Cited by 59 · see citing works
Melis, M., Sagheddu, C., Felice, M. D., Casti, A., Madeddu, C., Spiga, S., Muntoni, A. L., Mackie, K., Marsicano, G., Colombo, G., et al. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.1844-14.2014 · Cited by 58 · see citing works
Self-citationCadoni, C., Simola, N., Espa, E., Fenu, S., & Chiara, G. D. (2013) · Addiction Biology · doi:10.1111/adb.12085 · Cited by 57 · see citing works
Self-citationPicetti, R., Caccavo, J. A., Ho, A., & Kreek, M. J. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2464-4 · Cited by 47 · see citing works
Picetti, R., Ho, A., Butelman, E. R., & Kreek, M. J. (2010) · Psychopharmacology · doi:10.1007/s00213-010-1899-3 · Cited by 45 · see citing works
Common liability to drug addictions: Theory, research, practice
Vanyukov, M. M., & Ridenour, T. A. (2012) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2012.01.005 · Cited by 42 · see citing works
Pharmacogenetics of Drug Dependence: Role of Gene Variations in Susceptibility and Treatment
Khokhar, J. Y., Ferguson, C. S., Zhu, A. Z. X., & Tyndale, R. F. (2010) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.010909.105826 · Cited by 42 · see citing works
Fischer 344 and Lewis Rat Strains as a Model of Genetic Vulnerability to Drug Addiction
Cadoni, C. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00013 · Cited by 41 · see citing works
Self-citationEarly adolescent nicotine exposure affects later-life cocaine reward in mice
Alajaji, M., Lazenka, M. F., Kota, D., Wise, L. E., Younis, R. M., Carroll, F. I., Levine, A., Selley, D. E., Sim-Selley, L. J., & Damaj, M. I. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.01.032 · Cited by 39 · see citing works
Birth Cohorts Analysis of Adolescent Cigarette Smoking and Subsequent Marijuana and Cocaine Use
Keyes, K. M., Hamilton, A. D., & Kandel, D. B. (2016) · American Journal of Public Health · doi:10.2105/ajph.2016.303128 · Cited by 36 · see citing works
Corongiu, S., Dessì, C., & Cadoni, C. (2020) · Addiction Biology · doi:10.1111/adb.12721 · Cited by 36 · see citing works
Self-citationDickson, P. E., Miller, M. M., Rogers, T. D., Blaha, C. D., & Mittleman, G. (2012) · Addiction Biology · doi:10.1111/j.1369-1600.2012.00496.x · Cited by 35 · see citing works
Genetic Factors Control Nicotine Self-Administration in Isogenic Adolescent Rat Strains
Chen, H., Hiler, K. A., Tolley, E. A., Matta, S. G., & Sharp, B. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0044234 · Cited by 35 · see citing works
Pomfrey, R. L., Bostwick, T. A., Wetzell, B., & Riley, A. L. (2015) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2015.08.004 · Cited by 34 · see citing works
Li, H., Bu, Q., Chen, B., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0087040 · Cited by 32 · see citing works
A Genetic Epidemiological Mega Analysis of Smoking Initiation in Adolescents
Maes, H. H., Prom-Wormley, E., Eaves, L. J., Rhee, S. H., Hewitt, J. K., Young, S., Corley, R., McGue, M., Iacono, W. G., Legrand, L., et al. (2016) · Nicotine & Tobacco Research · doi:10.1093/ntr/ntw294 · Cited by 32 · see citing works
Nicotine produces long-term increases in cocaine reinforcement in adolescent but not adult rats
Reed, S. C., & Izenwasser, S. (2017) · Brain Research · doi:10.1016/j.brainres.2016.07.044 · Cited by 23 · see citing works
Dickson, P. E., Rogers, T. D., Lester, D. B., Miller, M. M., Matta, S. G., Chesler, E. J., Goldowitz, D., Blaha, C. D., & Mittleman, G. (2011) · Psychopharmacology · doi:10.1007/s00213-010-2159-2 · Cited by 21 · see citing works
Cadoni, C., Muto, T., & Chiara, G. D. (2009) · Neuropharmacology · doi:10.1016/j.neuropharm.2009.07.033 · Cited by 21 · see citing works
Self-citationMaes, H., & Neale, M. (2017) · Nicotine & Tobacco Research · doi:10.1093/ntr/ntx086 · Cited by 16 · see citing works
Nicotine behavioral sensitization in Lewis and Fischer male rats.
Hamilton, K. R., Starosciak, A. K., Chwa, A., & Grunberg, N. E. (2012) · Experimental and Clinical Psychopharmacology · doi:10.1037/a0029088 · Cited by 10 · see citing works
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Unique, long-term effects of nicotine on adolescent brain.
Leslie, F. M. (2020) · Pharmacology, Biochemistry, and Behavior · doi:10.1016/j.pbb.2020.173010 · Cited by 178 · see citing works
“Animals treated with nicotine during early adolescence, but not late adolescence or adulthood, have been found to have enhanced rewarding effects of cocaine, methamphetamine and morphine, as measured by conditioned place preference later in adulthood (McMillen et al., 2005; Alajaji et al., 2016; Kota et al., 2018; Cad…”
BackgroundReynolds, L. M., Faure, P., & Barik, J. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-03110-0 · Cited by 26 · see citing works
- Authors
- Cadoni, C., De Felice, M., Corongiu, S., Dessì, C., Espa, E., Melis, M., & Fenu, S.
- Affiliations
- University of Cagliari (IT)
- Department of Biomedical Sciences, Division of Neuroscience and Clinical Pharmacology University of Cagliari Cagliari Italy
- National Research Council (IT)
- Corresponding author
- Cadoni, Cristina
- Venue
- Addiction Biology
- Publisher
- Wiley
- Published
- 2019-07-24
- Volume
- 25
- Issue
- 5
- Pages
- e12803-e12803
- ISSN
- 1355-6215 (ISSN-L)
- 1369-1600
- OpenAlex
- W2963239208
- Cited by
- 10
- References
- 77
- Citations by year
- 2025: 2 · 2023: 1 · 2022: 2 · 2021: 2 · 2020: 3
- FWCI
- 0.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Addiction Biology (publishedVersion)
- PubMed (publishedVersion)
- UNICA IRIS Institutional Research Information System (University of Cagliari) (submittedVersion)
- Funders
- Regione Autonoma della Sardegna (22/10/2011, Det. N.11200/1602, bando 2010, L.R. n. 7/2007)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Keywords
- adolescent nicotine exposure, genetic background, Lewis rats, F344 rats, nicotine dependence, cocaine reward, nucleus accumbens, ventral tegmental area, nicotine withdrawal, inbred rat strains
- MeSH terms
- Genetic Background, Age Factors, Animals, Disease Models, Animal, Dopamine, Male, Nicotine, Nucleus Accumbens, Rats, Inbred F344, Rats, Inbred Lew, Microdialysis, Cocaine-Related Disorders, Rats, Electrophysiological Phenomena
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