Cited by 10Neurotransmitter Receptor Influence on BehaviorSmoking Behavior and CessationNicotinic Acetylcholine Receptors Study

Role of genetic background in the effects of adolescent nicotine exposure on mesolimbic dopamine transmission

Cadoni, Cristina, De Felice, Marta, Corongiu, Silvia, Dessì, Christian, Espa, Elena, Melis, Miriam, Fenu, Sandro·2020·Addiction Biology

Abstract

Smoking during adolescence may increase the likelihood to develop nicotine dependence and to abuse other drugs such as cocaine. Despite great efforts to understand underlying neurobiological mechanisms of this progression, less attention has been paid to the role of genetic factors. Here, we investigated the influence of both genetic background and age at first nicotine exposure in the long‐lasting effects on mesolimbic dopamine transmission including the increased cocaine‐rewarding effect. Mid‐adolescent and adult rats of inbred strains Lewis (addiction prone) and Fischer 344 (addiction resistant) were administered nicotine (0.4 mg/kg) or vehicle once daily for 5 days. Changes in dopamine transmission were investigated by in vivo microdialysis and electrophysiology after 30 days of withdrawal, whereas changes in cocaine‐rewarding effect were assessed via conditioned place preference paradigm. Nicotine pre‐exposure differentially changed mesolimbic dopamine transmission depending on strain and age of pre‐exposure. A potentiation of dopamine response to nicotine was observed in nucleus accumbens (NAc) core of both strains and age groups, whereas dopamine response in NAc shell was enhanced exclusively in Lewis rats exposed to nicotine during adolescence. A similar response was observed following cocaine challenge at adulthood. Changes in VTA dopamine cell population and activity were observed only in adolescent nicotine‐pretreated Lewis rats, which also showed an increased cocaine‐rewarding effect at adulthood. These results highlight the influence of genetic background in the long‐lasting effects of nicotine exposure and suggest that exposure during adolescence might increase nicotine and cocaine‐rewarding properties in genetically vulnerable individuals, thereby facilitating progression toward dependence.

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Crossref · 10.1111/adb.12803

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Authors
Cadoni, C., De Felice, M., Corongiu, S., Dessì, C., Espa, E., Melis, M., & Fenu, S.
Affiliations
  • University of Cagliari (IT)
  • Department of Biomedical Sciences, Division of Neuroscience and Clinical Pharmacology University of Cagliari Cagliari Italy
  • National Research Council (IT)
Corresponding author
Cadoni, Cristina
Venue
Addiction Biology
Publisher
Wiley
Published
2019-07-24
Volume
25
Issue
5
Pages
e12803-e12803
ISSN
  • 1355-6215 (ISSN-L)
  • 1369-1600
OpenAlex
W2963239208
Cited by
10
References
77
Citations by year
2025: 2 · 2023: 1 · 2022: 2 · 2021: 2 · 2020: 3
FWCI
0.84
Type
journal article
Language
en
Open access
closed
Locations
  • Addiction Biology (publishedVersion)
  • PubMed (publishedVersion)
  • UNICA IRIS Institutional Research Information System (University of Cagliari) (submittedVersion)
Funders
Regione Autonoma della Sardegna (22/10/2011, Det. N.11200/1602, bando 2010, L.R. n. 7/2007)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
Keywords
adolescent nicotine exposure, genetic background, Lewis rats, F344 rats, nicotine dependence, cocaine reward, nucleus accumbens, ventral tegmental area, nicotine withdrawal, inbred rat strains
MeSH terms
Genetic Background, Age Factors, Animals, Disease Models, Animal, Dopamine, Male, Nicotine, Nucleus Accumbens, Rats, Inbred F344, Rats, Inbred Lew, Microdialysis, Cocaine-Related Disorders, Rats, Electrophysiological Phenomena

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