Genetic and environmental influences on the covariation between hyperactivity and conduct disturbance in juvenile twins
Abstract
Structural equation models were applied to the maternal ratings of 265 MZ and 163 DZ male-male, 347 MZ and 160 DZ female-female, and 262 male-female twin pairs, aged 8-16 years, who participated in the Virginia Twin Study of Adolescent Behavioral Development (VTSABD). Substantial additive genetic influences and contrast effects were found for hyperactivity, and additive genetic and shared environmental effects or positive comparison effects (particularly for the girls) for oppositional/ conduct disturbance. Bivariate model fitting showed that the covariation between hyperactivity and oppositional/conduct problems in both younger and older boys and girls is almost entirely attributable to genetic factors. However, whereas in the younger males and females the same set of genes explain all the variation in hyperactivity and conduct disturbance, in the older cohort at least some of the genetic effects are behavior- and gender-specific.
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The presence of distinct genes in ADHD, ODD, and CD suggests that the comorbidity found in childhood does not explain the continuity of the disorders in adolescence.
“the presence of distinct genes in those disorders suggests that the comorbidity found in childhood does not explain the continuity of the disorders in adolescence”
From ADHD, CD, and ODD: Systematic review of genetic and environmental risk factors (2018) · cites this paper as Silberg et al., 1996
At younger ages, comorbidity between ADHD and ODD or CD is noticeable and seems to share a behavioral dimension originating in a common genetic mechanism.
“at younger ages, the comorbidity between ADHD and ODD or CD is noticeable, and it seems to share a behavioral dimension, originating in a common genetic mechanism”
From ADHD, CD, and ODD: Systematic review of genetic and environmental risk factors (2018) · cites this paper as Silberg et al., 1996
Early onset of behavioral comorbidities of ADHD, CD, and ODD may be primarily attributed to shared genetic influences.
“the early onset of behavioral comorbidities of ADHD, CD, and ODD may be primarily attributed to shared genetic in fl uences”
From ADHD, CD, and ODD: Systematic review of genetic and environmental risk factors (2018) · cites this paper as Silberg et al., 1996
Cites
Methodology for Genetic Studies of Twins and Families
Neale, M. C., & Cardon, L. R. (1992) · doi:10.1007/978-94-015-8018-2 · Cited by 4,005 · see citing works
Comorbidity in Child Psychopathology: Concepts, Issues and Research Strategies
Caron, C., & Rutter, M. (1991) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.1991.tb00350.x · Cited by 1,051 · see citing works
Self-citationHyperactive Boys Almost Grown Up: I. Psychiatric Status
Gittelman, R. (1985) · Archives of General Psychiatry · doi:10.1001/archpsyc.1985.01790330017002 · Cited by 977 · see citing works
WEISS, G., HECHTMAN, L., MILROY, T., & PERLMAN, T. (1985) · Journal of the American Academy of Child Psychiatry · doi:10.1016/s0002-7138(09)60450-7 · Cited by 753 · see citing works
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Molecular genetics of attention-deficit/hyperactivity disorder
Faraone, S. V., Perlis, R. H., Doyle, A. E., Smoller, J. W., Goralnick, J. J., Holmgren, M. A., & Sklar, P. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.11.024 · Cited by 2,357 · see citing works
Rhee, S. H., & Waldman, I. D. (2002) · Psychological Bulletin · doi:10.1037/0033-2909.128.3.490 · Cited by 1,266 · see citing works
Neurobiology of attention-deficit hyperactivity disorder
Faraone, S. V., & Biederman, J. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00240-6 · Cited by 811 · see citing works
Waldman, I. D., Rowe, D. C., Abramowitz, A., Kozel, S. T., Mohr, J. H., Sherman, S. L., Cleveland, H. H., Sanders, M. L., Gard, J. M. C., & Stever, C. (1998) · The American Journal of Human Genetics · doi:10.1086/302132 · Cited by 462 · see citing works
Structure and Etiology of Co-Occurring Internalizing and Externalizing Disorders in Adolescents
Cosgrove, V. E., Rhee, S. H., Gelhorn, H. L., Boeldt, D., Corley, R. C., Ehringer, M. A., Young, S. E., & Hewitt, J. K. (2011) · Journal of Abnormal Child Psychology · doi:10.1007/s10802-010-9444-8 · Cited by 296 · see citing works
Self-citationSkirrow, C., McLoughlin, G., Kuntsi, J., & Asherson, P. (2009) · Expert Review of Neurotherapeutics · doi:10.1586/ern.09.2 · Cited by 217 · see citing works
Liability to substance use disorders: 1. Common mechanisms and manifestations
Vanyukov, M. M., Tarter, R. E., Kirisci, L., Kirillova, G. P., Maher, B. S., & Clark, D. B. (2003) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2003.08.002 · Cited by 205 · see citing works
Deficient Response Inhibition as a Cognitive Endophenotype of ADHD
SLAATS-WILLEMSE, D., SWAAB-BARNEVELD, H., de SONNEVILLE, L., van der MEULEN, E., & BUITELAAR, J. (2003) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-200310000-00016 · Cited by 185 · see citing works
Personality traits among ADHD adults: implications of late-onset and subthreshold diagnoses
Faraone, S. V., Kunwar, A., Adamson, J., & Biederman, J. (2009) · Psychological Medicine · doi:10.1017/s0033291708003917 · Cited by 150 · see citing works
High Loading of Polygenic Risk for ADHD in Children With Comorbid Aggression
Hamshere, M. L., Langley, K., Martin, J., Agha, S. S., Stergiakouli, E., Anney, R. J. L., Buitelaar, J., Faraone, S. V., Lesch, K.-P., Neale, B. M., et al. (2013) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2013.12081129 · Cited by 144 · see citing works
Self-citationTuvblad, C., Zheng, M., Raine, A., & Baker, L. A. (2009) · Journal of Abnormal Child Psychology · doi:10.1007/s10802-008-9278-9 · Cited by 134 · see citing works
Faraone, S. V., Biederman, J., Feighner, J. A., & Monuteaux, M. C. (2000) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.68.5.830 · Cited by 111 · see citing works
Biederman, J., Kim, J. W., Doyle, A. E., Mick, E., Fagerness, J., Smoller, J. W., & Faraone, S. V. (2008) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30874 · Cited by 100 · see citing works
Timing of menarche and the origins of conduct disorder
Burt, S. A., McGue, M., DeMarte, J. A., Krueger, R. F., & Iacono, W. G. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.8.890 · Cited by 86 · see citing works
Christiansen, H., Chen, W., Oades, R. D., Asherson, P., Taylor, E. A., Lasky-Su, J., Zhou, K., Banaschewski, T., Buschgens, C., Franke, B., et al. (2008) · Journal of Neural Transmission · doi:10.1007/s00702-007-0837-y · Cited by 79 · see citing works
Genetics of Childhood Disorders: XX. ADHD, Part 4: Is ADHD Genetically Heterogeneous?
FARAONE, S. V. (2000) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-200011000-00022 · Cited by 76 · see citing works
The etiology of associations between negative emotionality and childhood externalizing disorders.
Singh, A. L., & Waldman, I. D. (2010) · Journal of Abnormal Psychology · doi:10.1037/a0019342 · Cited by 78 · see citing works
Genetic and cultural transmission of antisocial behavior: An extended twin parent model
Maes, H. H., Silberg, J. L., Neale, M. C., & Eaves, L. J. (2007) · Twin Research and Human Genetics · doi:10.1375/twin.10.1.136 · Cited by 76 · see citing works
Self-citationADHD, CD, and ODD: Systematic review of genetic and environmental risk factors
Azeredo, A., Moreira, D., & Barbosa, F. (2018) · Research in Developmental Disabilities · doi:10.1016/j.ridd.2017.12.010 · Cited by 75 · see citing works
Harvey, E. A., Breaux, R. P., & Lugo-Candelas, C. I. (2016) · Journal of Abnormal Psychology · doi:10.1037/abn0000090 · Cited by 84 · see citing works
“This notion is supported by twin studies suggesting that comorbidity between ADHD and ODD/CD is largely due to shared genetics (Eaves et al., 2000; Silberg et al., 1996).”
ResultMoruzzi, S., Rijsdijk, F., & Battaglia, M. (2014) · Journal of Abnormal Child Psychology · doi:10.1007/s10802-013-9725-0 · Cited by 67 · see citing works
Taylor, J., McGue, M., & Iacono, W. G. (2000) · Journal of Child Psychology and Psychiatry · doi:10.1111/1469-7610.00628 · Cited by 67 · see citing works
The etiology of criminal onset: The enduring salience of nature and nurture
DeLisi, M., Beaver, K. M., Wright, J. P., & Vaughn, M. G. (2008) · Journal of Criminal Justice · doi:10.1016/j.jcrimjus.2008.04.001 · Cited by 64 · see citing works
Andersson, A., Tuvblad, C., Chen, Q., Du Rietz, E., Cortese, S., Kuja‐Halkola, R., & Larsson, H. (2020) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.13233 · Cited by 56 · see citing works
Doyle, A. E., & Faraone, S. V. (2002) · Current Psychiatry Reports · doi:10.1007/s11920-002-0049-y · Cited by 38 · see citing works
Vierikko, E., Pulkkinen, L., Kaprio, J., & Rose, R. J. (2004) · Twin Research · doi:10.1375/136905204774200541 · Cited by 38 · see citing works
Pennington, B. F., Willcutt, E., & Rhee, S. H. (2005) · Advances in Child Development and Behavior · doi:10.1016/s0065-2407(05)80010-2 · Cited by 31 · see citing works
- Authors
- Silberg, J., Rutter, M., Meyer, J., Maes, H., Hewitt, J., Simonoff, E., Pickles, A., Loeber, R., & Eaves, L.
- Affiliations
- Virginia Commonwealth University (US)
- University of Pittsburgh (US)
- Corresponding author
- Silberg, Judy
- Venue
- Journal of Child Psychology and Psychiatry
- Publisher
- Wiley
- Published
- 1996-10
- Volume
- 37
- Issue
- 7
- Pages
- 803-816
- ISSN
- 0021-9630 (ISSN-L)
- 1469-7610
- OpenAlex
- W2156091071
- Cited by
- 237
- References
- 4
- Citations by year
- 2026: 1 · 2021: 2 · 2020: 2 · 2019: 1 · 2018: 2 · 2016: 3 · 2015: 6 · 2014: 5 · 2013: 7 · 2012: 9
- FWCI
- 11.05
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Child Psychology and Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- John D. and Catherine T. MacArthur Foundation
- National Institutes of Health (1r01mh048604-01, 5r21mh052584-03)
- National Institute of Mental Health (MH48604, MH45268, MH52584, R01MH045268)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Social Sciences › Psychology › Clinical Psychology › Psychopathy, Forensic Psychiatry, Sexual Offending
- Keywords
- hyperactivity, oppositional behavior, genetic factors, shared environment, additive genetic effects, contrast effects, twin studies, sex differences, age differences
- MeSH terms
- Adolescent, Age Factors, Analysis of Variance, Child, Child Behavior Disorders, Diseases in Twins, Environment, Factor Analysis, Statistical, Female, Humans, Hyperkinesis, Male, Phenotype, Sex Factors, Twins, Dizygotic, Twins, Monozygotic, Virginia, Comorbidity, Prevalence, Likelihood Functions
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