Anatomy and physiology of the basal ganglia: implications for DBS in psychiatry

Kopell, Brian Harris; Greenberg, Benjamin D.

doi:10.1016/j.neubiorev.2007.07.004

Cited by 156Neurological disorders and treatmentsObsessive-Compulsive Spectrum DisordersTranscranial Magnetic Stimulation Studies

Anatomy and physiology of the basal ganglia: implications for DBS in psychiatry

Kopell, Brian Harris, Greenberg, Benjamin D.·2008·Neuroscience & Biobehavioral Reviews

DOI 10.1016/j.neubiorev.2007.07.004

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Abstract

The basal ganglia have been a target for neuromodulation surgery since Russell Meyers' pioneering works in the late 1930s. Contemporary movement disorder surgery on the brain has evolved from empiric observations on movement behavior after neurological lesions. So too has the development of psychiatric surgical procedures followed the observation of lesions in the brain on cognitive and affective behavior. Just as deep brain stimulation (DBS) has revolutionized the practice of movement disorder surgery, its application to psychiatric illness has become the cutting edge of functional and restorative neurosurgery. The fundamental concept of the cortico-striatal-pallido-thalamocortical loop will be explored in the context of psychiatric disorders. DBS targeting this circuitry appears from initial evidence in obsessive-compulsive disorder (OCD) to be a promising option for patients with neuropsychiatric illness resistant to conventional therapies. Further exploring the anatomic interconnectivity of the physiologically relevant cortical and subcortical areas will inevitably lead to better applications of DBS for the treatment of OCD, major depression (MD) and potentially for other psychiatric disorders. Implementing such therapies optimally will require the creation of treatment centers with specialized expertise in the psychiatric, neurosurgical, and ethical issues that arise with these populations.

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ITP fibers continue rostrally through the ventral limb of the internal capsule and have modulatory connections to the DLPFC, OFC, ventromedial striatum, and intralaminar thalamus.
“ITP fibers continue rostrally through the ventral limb of the internal capsule, with modulatory connections to the DLPFC, OFC, ventromedial striatum, and intralaminar thalamus [74].”
From Deep brain stimulation for depression. (2022) · cites this paper as [74]

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Authors: Kopell, B. H., & Greenberg, B. D.
Affiliations: Medical College of Wisconsin (US)
Brown University (US)
Corresponding author: Kopell, Brian Harris
ORCID: Kopell, Brian Harris
Greenberg, Benjamin D.
Venue: Neuroscience & Biobehavioral Reviews
Publisher: Elsevier BV
Published: 2008-01
Volume: 32
Issue: 3
Pages: 408-422
ISSN: 0149-7634 (ISSN-L)
DOI: 10.1016/j.neubiorev.2007.07.004
OpenAlex: W2044486230
Cited by: 156
References: 79
Citations by year: 2026: 3 · 2025: 2 · 2024: 4 · 2023: 4 · 2022: 2 · 2021: 2 · 2020: 7 · 2019: 6 · 2018: 2 · 2017: 5 · 2016: 7 · 2015: 13 · 2014: 12 · 2013: 18 · 2012: 17
FWCI: 1.29
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience & Biobehavioral Reviews (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Neurology › Neurological disorders and treatments
Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
Keywords: deep brain stimulation, basal ganglia, obsessive-compulsive disorder, major depressive disorder, psychosurgery, neuropsychiatric disorders, therapeutic ethics
MeSH terms: Affective Disorders, Psychotic, Basal Ganglia, Mental Disorders, Cerebral Cortex, Depressive Disorder, Humans, Limbic System, Obsessive-Compulsive Disorder, Deep Brain Stimulation

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Anatomy and physiology of the basal ganglia: implications for DBS in psychiatry

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