Cited by 117Neurotransmitter Receptor Influence on BehaviorSubstance Abuse Treatment and OutcomesNeuroscience and Neuropharmacology Research

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Translating the neuroscience of alcoholism into clinical treatments: From blocking the buzz to curing the blues

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Heilig, Markus, Thorsell, Annika, Sommer, Wolfgang H., Hansson, Anita C., Ramchandani, Vijay A., George, David T., Hommer, Daniel, Barr, Christina S.·2010·Neuroscience & Biobehavioral Reviews

DOI 10.1016/j.neubiorev.2009.11.018PMC PMC2891917

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Abstract

Understanding the pathophysiology of addictive disorders is critical for development of new treatments. A major focus of addiction research has for a long time been on systems that mediate acute positively reinforcing effects of addictive drugs, most prominently the mesolimbic dopaminergic (DA) system and its connections. This research line has been successful in shedding light on the physiology of both natural and drug reward, but has not led to therapeutic breakthroughs. The role of classical reward systems is perhaps least clear in alcohol addiction. Here, recent work is summarized that points to some clinically important conclusions. First, important pharmacogenetic differences exist with regard to positively reinforcing effects of alcohol and the ability of this drug to activate classical reward pathways. This offers an opportunity for personalized treatment approaches in alcoholism. Second, brain stress and fear systems become pathologically activated in later stages of alcoholism and their activation is a major influence in escalation of alcohol intake, sensitization of stress responses, and susceptibility to relapse. These findings offer a new category of treatment mechanisms. Corticotropin-releasing hormone (CRH) signaling through CRH1 receptors is a major candidate target in this category, but recent data indicate that antagonists for substance P (SP) neurokinin 1 (NK1) receptors may have a similar potential.

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Thorsell A Schank JR Singley E Hunt SP Heilig M 2009 The neurokinin-1 receptor is required for alcohol reward and escalation of alcohol intake In press PNAS

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Authors: Heilig, M., Thorsell, A., Sommer, W. H., Hansson, A. C., Ramchandani, V. A., George, D. T., Hommer, D., & Barr, C. S.
Affiliations: National Institutes of Health (US)
Corresponding author: Heilig, Markus
ORCID: Heilig, Markus
Thorsell, Annika
Sommer, Wolfgang H.
Hansson, Anita C.
Ramchandani, Vijay A.
George, David T.
Barr, Christina S.
Venue: Neuroscience & Biobehavioral Reviews
Publisher: Elsevier BV
Published: 2010-11
Volume: 35
Issue: 2
Pages: 334-344
ISSN: 0149-7634 (ISSN-L)
DOI: 10.1016/j.neubiorev.2009.11.018
PMC: PMC2891917
OpenAlex: W2010733076
Cited by: 117
References: 144
Citations by year: 2026: 2 · 2025: 3 · 2024: 1 · 2023: 4 · 2022: 3 · 2021: 5 · 2020: 2 · 2019: 5 · 2018: 3 · 2017: 11 · 2016: 9 · 2015: 11 · 2014: 13 · 2013: 9 · 2012: 15
FWCI: 4.99
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience & Biobehavioral Reviews (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Institute on Alcohol Abuse and Alcoholism (ZIAAA000487)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: alcoholism, mesolimbic dopamine system, drug reward, pharmacogenetics, personalized treatment, relapse, corticotropin-releasing factor, substance P, NK1 receptor antagonists
MeSH terms: CRF Receptor, Type 1, Ethanol, Alcoholism, Animals, Brain, Corticotropin-Releasing Hormone, Humans, Models, Biological, Substance P, Drug Delivery Systems, Receptors, Corticotropin-Releasing Hormone, Translational Research, Biomedical, Neurokinin-1 Receptor Antagonists

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Translating the neuroscience of alcoholism into clinical treatments: From blocking the buzz to curing the blues

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