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Cited by 259Neurotransmitter Receptor Influence on BehaviorAnimal Vocal Communication and BehaviorNeuroscience and Neuropharmacology Research

The DOI matches its Crossref record; 100 of the 101 references it cites were found in a registry or an index.

Frequency-modulated 50 kHz ultrasonic vocalizations: a tool for uncovering the molecular substrates of positive affect

Burgdorf, Jeffrey, Panksepp, Jaak, Moskal, Joseph R.·2011·Neuroscience & Biobehavioral Reviews
DOI 10.1016/j.neubiorev.2010.11.011
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Abstract

The evidence that frequency modulated (FM) 50 kHz ultrasonic vocalizations (USVs) reflect a positive emotional state in rats is reviewed. Positive emotional states in humans are measured by facial-vocal displays (e.g., Duchenne smiling and laughter), approach behavior, and subjective self-report of feeling states. In laboratory animals, only facial-vocal displays, along with approach behavior can be measured. FM 50 kHz USVs are uniquely elevated by hedonic stimuli and suppressed by aversive stimuli. Rates of FM 50 kHz USVs are positively correlated to the rewarding value of the eliciting stimulus. Additionally, playbacks of these vocalizations are rewarding. The neural and pharmacological substrates of 50 kHz USVs are consistent with those of human positive affective states. By experimentally eliciting FM 50 kHz USVs, the novel molecular underpinning of positive affect can be elucidated and may be similar to those in humans. In humans, positive emotional states confer resilience to depression and anxiety, as well as promote overall health. Using rough-and-tumble play induced hedonic USVs, we have identified insulin like growth factor I and the NR2B subunit of the NMDA receptor as playing a functional role in positive affective states. From this research, we have developed a promising new class of antidepressants that is entering phase II clinical trials for the treatment of depression.

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Research works printed but not linked: 3

  1. Burgdorf, 2010, The antidepressant and anxiolytic properties of GLYX-13: a novel NMDA receptor glycine site functional partial agonist, Society for Neuroscience Abstract, 572.23
  2. Knutson, 2002, Anticipation of increasing monetary reward selectively recruits nucleus accumbens, J. Neurosci., 22, 3303
  3. Sheldon, K., Kashdan, T., Steger, M., (Eds.), in press. Designing the Future of Positive Psychology: Taking Stock and Moving Forward. Oxford University Press.

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Metadata

Authors
Burgdorf, J., Panksepp, J., & Moskal, J. R.
Affiliations
Northwestern University (US)
Corresponding author
Burgdorf, Jeffrey
ORCID
Venue
Neuroscience & Biobehavioral Reviews
Publisher
Elsevier BV
Published
2011-10
Volume
35
Issue
9
Pages
1831-1836
ISSN
0149-7634 (ISSN-L)
DOI
10.1016/j.neubiorev.2010.11.011
OpenAlex
W2052667603
Cited by
258
References
101
Citations by year
2026: 13 · 2025: 13 · 2024: 6 · 2023: 13 · 2022: 8 · 2021: 14 · 2020: 16 · 2019: 24 · 2018: 27 · 2017: 12 · 2016: 15 · 2015: 25 · 2014: 19 · 2013: 28 · 2012: 16
FWCI
1.52
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Neuroscience & Biobehavioral Reviews (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Animal Vocal Communication and Behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
ultrasonic vocalizations, 50-kHz vocalizations, positive affect, rats, rough-and-tumble play, insulin-like growth factor I, NR2B subunit, antidepressants, depression, reward, aversive stimuli, neural substrates of emotion
MeSH terms
Affect, Animals, Brain, Breeding, Humans, Male, Molecular Biology, Social Isolation, Ultrasonics, Vocalization, Animal, Rats, Long-Evans, Rats, Pleasure

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