ADHD and the Prefrontal Cortex
Open accessAbstract
Attention deficit/hyperactivity disorder (ADHD) is characterized by symptoms of inattention, impulsivity, and locomotor hyperactivity. Recent advances in neurobiology, imaging, and genetics have led to a greater understanding of the etiology and treatment of ADHD. Studies have found that ADHD is associated with weaker function and structure of prefrontal cortex (PFC) circuits, especially in the right hemisphere. The prefrontal association cortex plays a crucial role in regulating attention, behavior, and emotion, with the right hemisphere specialized for behavioral inhibition. The PFC is highly dependent on the correct neurochemical environment for proper function: noradrenergic stimulation of postsynaptic alpha-2A adrenoceptors and dopaminergic stimulation of D1 receptors is necessary for optimal prefrontal function. ADHD is associated with genetic changes that weaken catecholamine signaling and, in some patients, with slowed PFC maturation. Effective pharmacologic treatments for ADHD all enhance catecholamine signaling in the PFC and strengthen its regulation of attention and behavior. Recent animal studies show that therapeutic doses of stimulant medications preferentially increase norepinephrine and, to a lesser extent, dopamine, in the PFC. These doses reduce locomotor activity and improve PFC regulation of attention and behavior through enhanced catecholamine stimulation of alpha-2A and D1 receptors. These findings in animals are consistent with improved PFC function in normal human subjects and, more prominently, in patients with ADHD. Thus, a highly cohesive story is emerging regarding the etiology and treatment of ADHD.
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Loss of catecholaminergic innervation underlies the most important ADHD symptoms.
“Loss of catecholaminergic innervation underlies the most important ADHD symptoms [381].”
From Development of prefrontal cortex (2022) · cites this paper as [381]
In “Imaging Studies Show Changes in Catecholamine Transmission” (page not provided), the paper suggests that loss of catecholamines in the prefrontal cortex is most important for ADHD symptoms. It describes reduced release or signaling, not loss of catecholaminergic innervation, and presents the link as a suggestion rather than an established cause. (LLM, conf=0.86)
Experimental — accuracy not yet measuredAlteration of glutamate/GABA equilibrium has been related to a diminished capability to focus on demanding tasks and to result in DA dysregulation, causing inhibition of defective pyramidal neurons and a decrease shift in excitation towards tasks regulated in the PFC.
“Alteration of glutamate/GABA equilibrium has been related to a diminished capability to focus on demanding tasks [98] and to result in DA dysregulation, causing inhibition of defective pyramidal neurons and a decrease shift in excitation towards tasks regulated in the PFC [99, 100].”
From Molecular Characterisation of the Mechanism of Action of Stimulant Drugs Lisdexamfetamine and Methylphenidate on ADHD Neurobiology: A Review (2022) · cites this paper as [99]
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Cites
Parallel organization of functionally segregated circuits linking basal ganglia and cortex
Alexander, G. E., DeLong, M. R., & Strick, P. L. (1986) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.09.030186.002041 · Cited by 8,527 · see citing works
Inhibition and the right inferior frontal cortex
Aron, A. R., Robbins, T. W., & Poldrack, R. A. (2004) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2004.02.010 · Cited by 3,197 · see citing works
Mesulam, M. (1998) · Brain · doi:10.1093/brain/121.6.1013 · Cited by 3,072 · see citing works
Cellular basis of working memory
Goldman-Rakic, P. S. (1995) · Neuron · doi:10.1016/0896-6273(95)90304-6 · Cited by 2,663 · see citing works
A cortical network for directed attention and unilateral neglect
Mesulam, M. ‐. (1981) · Annals of Neurology · doi:10.1002/ana.410100402 · Cited by 2,498 · see citing works
Top-Down Versus Bottom-Up Control of Attention in the Prefrontal and Posterior Parietal Cortices
Buschman, T. J., & Miller, E. K. (2007) · Science · doi:10.1126/science.1138071 · Cited by 2,380 · see citing works
Molecular genetics of attention-deficit/hyperactivity disorder
Faraone, S. V., Perlis, R. H., Doyle, A. E., Smoller, J. W., Goralnick, J. J., Holmgren, M. A., & Sklar, P. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.11.024 · Cited by 2,357 · see citing works
Effects of parietal injury on covert orienting of attention
Posner, M., Walker, J., Friedrich, F., & Rafal, R. (1984) · The Journal of Neuroscience · doi:10.1523/jneurosci.04-07-01863.1984 · Cited by 2,191 · see citing works
Tol, H. H. M. V., Bunzow, J. R., Guan, H., Sunahara, R. K., Seeman, P. M., Niznik, H. B., & Civelli, O. (1991) · Nature · doi:10.1038/350610a0 · Cited by 2,015 · see citing works
Basal ganglia and cerebellar loops: motor and cognitive circuits
Middleton, F. (2000) · Brain Research Reviews · doi:10.1016/s0165-0173(99)00040-5 · Cited by 1,940 · see citing works
Dysfunction in the neural circuitry of emotion regulation–a possible prelude to violence
Davidson, R. J., Putnam, K. M., & Larson, C. L. (2000) · Science · doi:10.1126/science.289.5479.591 · Cited by 1,894 · see citing works
Attention-deficit/hyperactivity disorder is characterized by a delay in cortical maturation
Shaw, P., Eckstrand, K., Sharp, W., Blumenthal, J., Lerch, J. P., Greenstein, D., Clasen, L., Evans, A., Giedd, J., & Rapoport, J. L. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707741104 · Cited by 1,819 · see citing works
Castellanos, F. X. (2002) · JAMA · doi:10.1001/jama.288.14.1740 · Cited by 1,646 · see citing works
Impairment of social and moral behavior related to early damage in human prefrontal cortex
Anderson, S. W., Bechara, A., Damasio, H., Tranel, D., & Damasio, A. R. (1999) · Nature Neuroscience · doi:10.1038/14833 · Cited by 1,539 · see citing works
Dissociation in prefrontal cortex of affective and attentional shifts
Dias, R., Robbins, T. W., & Roberts, A. C. (1996) · Nature · doi:10.1038/380069a0 · Cited by 1,527 · see citing works
Cognitive Deficit Caused by Regional Depletion of Dopamine in Prefrontal Cortex of Rhesus Monkey
Brozoski, T. J., Brown, R. M., Rosvold, H. E., & Goldman, P. S. (1979) · Science · doi:10.1126/science.112679 · Cited by 1,500 · see citing works
Stimulus-selective properties of inferior temporal neurons in the macaque
Desimone, R., Albright, T. D., Gross, C. G., & Bruce, C. J. (1984) · Journal of Neuroscience · doi:10.1523/jneurosci.04-08-02051.1984 · Cited by 1,424 · see citing works
D1 Dopamine Receptors in Prefrontal Cortex: Involvement in Working Memory
Sawaguchi, T., & Goldman-Rakic, P. S. (1991) · Science · doi:10.1126/science.1825731 · Cited by 1,364 · see citing works
Coull, J. T., & Nobre, A. C. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-18-07426.1998 · Cited by 1,254 · see citing works
Selective gating of visual signals by microstimulation of frontal cortex
Moore, T., & Armstrong, K. M. (2003) · Nature · doi:10.1038/nature01341 · Cited by 1,156 · see citing works
Bymaster, F. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(02)00346-9 · Cited by 1,123 · see citing works
Fundamental Components of Attention
Knudsen, E. I. (2007) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.30.051606.094256 · Cited by 1,020 · see citing works
Inverted-U dopamine D1 receptor actions on prefrontal neurons engaged in working memory
Vijayraghavan, S., Wang, M., Birnbaum, S. G., Williams, G. V., & Arnsten, A. F. T. (2007) · Nature Neuroscience · doi:10.1038/nn1846 · Cited by 1,013 · see citing works
Self-citationRubia, K., Overmeyer, S., Taylor, E., Brammer, M., Williams, S. C. R., Simmons, A., & Bullmore, E. T. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.6.891 · Cited by 1,010 · see citing works
Rubia, K., Russell, T., Overmeyer, S., Brammer, M. J., Bullmore, E. T., Sharma, T., Simmons, A., Williams, S. C. R., Giampietro, V., Andrew, C. M., et al. (2001) · NeuroImage · doi:10.1006/nimg.2000.0685 · Cited by 999 · see citing works
Development of Cortical Circuitry and Cognitive Function
Goldman‐Rakic, P. S. (1987) · Child Development · doi:10.2307/1130201 · Cited by 817 · see citing works
CASEY, B. J., CASTELLANOS, F. X., GIEDD, J. N., MARSH, W. L., HAMBURGER, S. D., SCHUBERT, A. B., VAUSS, Y. C., VAITUZIS, A. C., DICKSTEIN, D. P., SARFATTI, S. E., et al. (1997) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199703000-00016 · Cited by 800 · see citing works
Decision-making processes following damage to the prefrontal cortex
Manes, F., Sahakian, B., Clark, L., Rogers, R., Antoun, N., Aitken, M., & Robbins, T. (2002) · Brain · doi:10.1093/brain/awf049 · Cited by 799 · see citing works
Ghashghaei, H. T., & Barbas, H. (2002) · Neuroscience · doi:10.1016/s0306-4522(02)00446-3 · Cited by 785 · see citing works
Bush, G., Valera, E. M., & Seidman, L. J. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.01.034 · Cited by 714 · see citing works
Catecholamine receptors on locus coeruleus neurons: Pharmacological characterization
Cedarbaum, J. M., & Aghajanian, G. K. (1977) · European Journal of Pharmacology · doi:10.1016/0014-2999(77)90312-0 · Cited by 714 · see citing works
Visual attention mediated by biased competition in extrastriate visual cortex
Desimone, R. (1998) · Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences · doi:10.1098/rstb.1998.0280 · Cited by 696 · see citing works
Wang, M., Ramos, B. P., Paspalas, C. D., Shu, Y., Simen, A., Duque, A., Vijayraghavan, S., Brennan, A., Dudley, A., Nou, E., et al. (2007) · Cell · doi:10.1016/j.cell.2007.03.015 · Cited by 672 · see citing works
Self-citationBerridge, C. W., Devilbiss, D. M., Andrzejewski, M. E., Arnsten, A. F. T., Kelley, A. E., Schmeichel, B., Hamilton, C., & Spencer, R. C. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.04.022 · Cited by 617 · see citing works
Self-citationMehta, M. A., Owen, A. M., Sahakian, B. J., Mavaddat, N., Pickard, J. D., & Robbins, T. W. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-06-j0004.2000 · Cited by 608 · see citing works
Sesack, S. R., Hawrylak, V. A., Matus, C., Guido, M. A., & Levey, A. I. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-07-02697.1998 · Cited by 582 · see citing works
Neurochemical Modulation of Response Inhibition and Probabilistic Learning in Humans
Chamberlain, S. R., Müller, U., Blackwell, A. D., Clark, L., Robbins, T. W., & Sahakian, B. J. (2006) · Science · doi:10.1126/science.1121218 · Cited by 573 · see citing works
Cortical abnormalities in children and adolescents with attention-deficit hyperactivity disorder
Sowell, E. R., Thompson, P. M., Welcome, S. E., Henkenius, A. L., Toga, A. W., & Peterson, B. S. (2003) · The Lancet · doi:10.1016/s0140-6736(03)14842-8 · Cited by 567 · see citing works
Arnsten, A. F. T., & Goldman-Rakic, P. S. (1985) · Science · doi:10.1126/science.2999977 · Cited by 549 · see citing works
Self-citationExecutive "Brake Failure" following Deactivation of Human Frontal Lobe
Chambers, C. D., Bellgrove, M. A., Stokes, M. G., Henderson, T. R., Garavan, H., Robertson, I. H., Morris, A. P., & Mattingley, J. B. (2006) · Journal of Cognitive Neuroscience · doi:10.1162/089892906775990606 · Cited by 544 · see citing works
Prefrontal regions involved in keeping information in and out of mind
Bunge, S. A. (2001) · Brain · doi:10.1093/brain/124.10.2074 · Cited by 528 · see citing works
Separate body- and world-referenced representations of visual space in parietal cortex
Snyder, L. H., Grieve, K. L., Brotchie, P., & Andersen, R. A. (1998) · Nature · doi:10.1038/29777 · Cited by 502 · see citing works
Prefrontal cortex regulates inhibition and excitation in distributed neural networks
Knight, R. T., Richard Staines, W., Swick, D., & Chao, L. L. (1999) · Acta Psychologica · doi:10.1016/s0001-6918(99)00004-9 · Cited by 498 · see citing works
Localization of dopamine D4 receptors in GABAergic neurons of the primate brain
Mrzljak, L., Bergson, C., Pappy, M., Huff, R., Levenson, R., & Goldman-Rakic, P. S. (1996) · Nature · doi:10.1038/381245a0 · Cited by 494 · see citing works
Makris, N., Biederman, J., Valera, E. M., Bush, G., Kaiser, J., Kennedy, D. N., Caviness, V. S., Faraone, S. V., & Seidman, L. J. (2007) · Cerebral Cortex · doi:10.1093/cercor/bhl047 · Cited by 450 · see citing works
Frontal lesions and sustained attention
Wilkins, A. J., Shallice, T., & McCarthy, R. (1987) · Neuropsychologia · doi:10.1016/0028-3932(87)90024-8 · Cited by 450 · see citing works
Daly, G., Hawi, Z., Fitzgerald, M., & Gill, M. (1999) · Molecular Psychiatry · doi:10.1038/sj.mp.4000510 · Cited by 414 · see citing works
Robbins, T. W. (2007) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2007.2097 · Cited by 413 · see citing works
Molecular Genetics of Attention Deficit Hyperactivity Disorder
Faraone, S. V., & Mick, E. (2010) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2009.12.004 · Cited by 411 · see citing works
Lidow, M. S., Goldman-Rakic, P. S., Gallager, D. W., & Rakic, P. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90003-7 · Cited by 394 · see citing works
Methylphenidate improves response inhibition in adults with attention-deficit/hyperactivity disorder
Aron, A. R., Dowson, J. H., Sahakian, B. J., & Robbins, T. W. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00609-7 · Cited by 392 · see citing works
Arnsten, A., Cai, J., & Goldman-Rakic, P. (1988) · The Journal of Neuroscience · doi:10.1523/jneurosci.08-11-04287.1988 · Cited by 391 · see citing works
Self-citationLewis, D. (1997) · Neuropsychopharmacology · doi:10.1016/s0893-133x(96)00277-1 · Cited by 388 · see citing works
U’PRICHARD, D. C., BECHTEL, W. D., ROUOT, B. M., & SNYDER, S. H. (1979) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)11406-5 · Cited by 384 · see citing works
Smiley, J. F., Levey, A. I., Ciliax, B. J., & Goldman‐Rakic, P. S. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.12.5720 · Cited by 383 · see citing works
Seidman, L. J., Valera, E. M., Makris, N., Monuteaux, M. C., Boriel, D., Kelkar, K., Kennedy, D. N., Caviness, V. S., Bush, G., Aleardi, M., et al. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.04.031 · Cited by 378 · see citing works
Arnsten, A. F., & Dudley, A. G. (2005) · Behavioral and Brain Functions · doi:10.1186/1744-9081-1-2 · Cited by 363 · see citing works
Self-citationNeural Circuits Subserving the Retrieval and Maintenance of Abstract Rules
Bunge, S. A., Kahn, I., Wallis, J. D., Miller, E. K., & Wagner, A. D. (2003) · Journal of Neurophysiology · doi:10.1152/jn.00910.2002 · Cited by 361 · see citing works
Arnsten, A. F. T. (1998) · Science · doi:10.1126/science.280.5370.1711 · Cited by 341 · see citing works
Self-citationArnsten, A. F. T., & Goldman-Rakic, P. S. (1984) · Brain Research · doi:10.1016/0006-8993(84)90351-2 · Cited by 333 · see citing works
Self-citationVolkow, N. D., Wang, G.-J., Newcorn, J., Telang, F., Solanto, M. V., Fowler, J. S., Logan, J., Ma, Y., Schulz, K., Pradhan, K., et al. (2007) · Archives of General Psychiatry · doi:10.1001/archpsyc.64.8.932 · Cited by 331 · see citing works
Lewis, D., Campbell, M., Foote, S., Goldstein, M., & Morrison, J. (1987) · The Journal of Neuroscience · doi:10.1523/jneurosci.07-01-00279.1987 · Cited by 325 · see citing works
Ernst, M., Zametkin, A. J., Matochik, J. A., Jons, P. H., & Cohen, R. M. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-15-05901.1998 · Cited by 320 · see citing works
Selective D2 receptor actions on the functional circuitry of working memory
Wang, M., Vijayraghavan, S., & Goldman-Rakic, P. S. (2004) · Science · doi:10.1126/science.1091162 · Cited by 319 · see citing works
Protein kinase C overactivity impairs prefrontal cortical regulation of working memory
Birnbaum, S. G., Yuan, P. X., Wang, M., Vijayraghavan, S., Bloom, A. K., Davis, D. J., Gobeske, K. T., Sweatt, J. D., Manji, H. K., & Arnsten, A. F. T. (2004) · Science · doi:10.1126/science.1100021 · Cited by 318 · see citing works
Self-citationBiederman, J., Melmed, R. D., Patel, A., McBurnett, K., Konow, J., Lyne, A., Scherer, N., & for the SPD503 Study Group (2008) · Pediatrics · doi:10.1542/peds.2006-3695 · Cited by 317 · see citing works
Kuczenski, R., & Segal, D. S. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-16-07264.2002 · Cited by 316 · see citing works
Hunt, R. D., Minderaa, R. B., & Cohen, D. J. (1985) · Journal of the American Academy of Child Psychiatry · doi:10.1016/s0002-7138(09)60065-0 · Cited by 313 · see citing works
A Double-Blind Placebo Controlled Study of Desipramine in the Treatment of ADD: I. Efficacy
Biederman, J., Baldessarini, R. J., WRIGHT, V., Knee, D., & Harmatz, J. S. (1989) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-198909000-00022 · Cited by 310 · see citing works
Gene targeting — homing in on α2-adrenoceptor-subtype function
MacDonald, E., Kobilka, B. K., & Scheinin, M. (1997) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(97)01063-8 · Cited by 310 · see citing works
Atomoxetine improved response inhibition in adults with attention deficit/hyperactivity disorder
Chamberlain, S. R., del Campo, N., Dowson, J., Müller, U., Clark, L., Robbins, T. W., & Sahakian, B. J. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.03.003 · Cited by 288 · see citing works
Gazzaley, A., Rissman, J., Cooney, J., Rutman, A., Seibert, T., Clapp, W., & D'Esposito, M. (2007) · Cerebral Cortex · doi:10.1093/cercor/bhm113 · Cited by 287 · see citing works
Birnbaum, S., Gobeske, K. T., Auerbach, J., Taylor, J. R., & Arnsten, A. F. T. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00138-9 · Cited by 281 · see citing works
Self-citationHuman prefrontal lesions increase distractibility to irrelevant sensory inputs
Chao, L. L., & Knight, R. T. (1995) · Neuroreport · doi:10.1097/00001756-199508000-00005 · Cited by 265 · see citing works
Frontostriatal connectivity and its role in cognitive control in parent-child dyads with ADHD
Casey, B. J., Epstein, J. N., Buhle, J., Liston, C., Davidson, M. C., Tonev, S. T., Spicer, J., Niogi, S., Millner, A. J., Reiss, A., et al. (2007) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2007.06101754 · Cited by 258 · see citing works
Mehta, M. A., Goodyer, I. M., & Sahakian, B. J. (2004) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2004.00221.x · Cited by 257 · see citing works
Prefrontal cortex gating of auditory transmission in humans
Knight, R. T., Scabini, D., & Woods, D. L. (1989) · Brain Research · doi:10.1016/0006-8993(89)91381-4 · Cited by 256 · see citing works
Brain dopamine transporter levels in treatment and drug naive adults with ADHD
Volkow, N. D., Wang, G.-J., Newcorn, J., Fowler, J. S., Telang, F., Solanto, M. V., Logan, J., Wong, C., Ma, Y., Swanson, J. M., et al. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2006.10.014 · Cited by 249 · see citing works
Role of human prefrontal cortex in attention control.
Knight, R. T., Grabowecky, M., & Scabini, D. (1995) · PubMed · Cited by 242 · see citing works
Manji, H. K., & Lenox, R. H. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00235-8 · Cited by 241 · see citing works
Makris, N., Buka, S. L., Biederman, J., Papadimitriou, G. M., Hodge, S. M., Valera, E. M., Brown, A. B., Bush, G., Monuteaux, M. C., Caviness, V. S., et al. (2008) · Cerebral Cortex · doi:10.1093/cercor/bhm156 · Cited by 239 · see citing works
"No longer gage": Frontal lobe dysfunction and emotional changes.
Stuss, D. T., Gow, C. A., & Hetherington, C. R. (1992) · Journal of Consulting and Clinical Psychology · doi:10.1037//0022-006x.60.3.349 · Cited by 238 · see citing works
Through the looking glass: Differential noradenergic modulation of prefrontal cortical function
Arnsten, A. F. T. (2000) · Neural Plasticity · doi:10.1155/np.2000.133 · Cited by 229 · see citing works
Self-citationSupport for association between ADHD and two candidate genes: NET1 and DRD1
Bobb, A. J., Addington, A. M., Sidransky, E., Gornick, M. C., Lerch, J. P., GREENSTEIN, D. K., CLASEN, L. S., Sharp, W. S., Inoff‐Germain, G., Vrièze, F. W., et al. (2005) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30142 · Cited by 223 · see citing works
Electrophysiologic evidence of increased distractibility after dorsolateral prefrontal lesions
Woods, D. L., & Knight, R. T. (1986) · Neurology · doi:10.1212/wnl.36.2.212 · Cited by 218 · see citing works
Durston, S., Fossella, J., Casey, B. J., Pol, H. E. H., Galván, A., Schnack, H. G., Steenhuis, M., Minderaa, R. B., Buitelaar, J. K., Kahn, R. S., et al. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001649 · Cited by 216 · see citing works
Rubia, K., Smith, A. B., & Taylor, E. (2006) · Child Neuropsychology · doi:10.1080/09297040600770761 · Cited by 212 · see citing works
Bush, G., Spencer, T. J., Holmes, J., Shin, L. M., Valera, E. M., Seidman, L. J., Makris, N., Surman, C., Aleardi, M., Mick, E., et al. (2008) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2007.16 · Cited by 201 · see citing works
Arnsten, A. F. T. (2007) · Cerebral Cortex · doi:10.1093/cercor/bhm033 · Cited by 200 · see citing works
Self-citationLevitt, P., RAKIC, P. T., & Goldman‐Rakic, P. S. (1984) · The Journal of Comparative Neurology · doi:10.1002/cne.902270105 · Cited by 191 · see citing works
Guanfacine, But Not Clonidine, Improves Planning and Working Memory Performance in Humans
Jäkälä, P. (1999) · Neuropsychopharmacology · doi:10.1016/s0893-133x(98)00127-4 · Cited by 189 · see citing works
Taylor, F. B., & Russo, J. (2001) · Journal of Clinical Psychopharmacology · doi:10.1097/00004714-200104000-00015 · Cited by 189 · see citing works
Clark, L., Blackwell, A. D., Aron, A. R., Turner, D. C., Dowson, J. H., Robbins, T. W., & Sahakian, B. J. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.07.020 · Cited by 188 · see citing works
Cheon, K.-A. A., Ryu, Y. H., Kim, Y.-K., Namkoong, K., Kim, C., & Lee, J. E. (2003) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-002-1047-3 · Cited by 187 · see citing works
Li, B.-M., & Mei, Z.-T. (1994) · Behavioral and Neural Biology · doi:10.1016/s0163-1047(05)80034-2 · Cited by 186 · see citing works
Franowicz, J. S., Kessler, L. E., Borja, C. M. D., Kobilka, B. K., Limbird, L. E., & Arnsten, A. F. T. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-19-08771.2002 · Cited by 185 · see citing works
Self-citationPetrides, M. (1986) · Journal of Neuroscience · doi:10.1523/jneurosci.06-07-02054.1986 · Cited by 172 · see citing works
Arnsten, A. F. T., & Contant, T. A. (1992) · Psychopharmacology · doi:10.1007/bf02245302 · Cited by 168 · see citing works
Self-citationRudolph, K. K. (1999) · Cerebral Cortex · doi:10.1093/cercor/9.1.90 · Cited by 163 · see citing works
Tahir, E., Yazgan, Y., Çırakoğlu, B., Ozbay, F., Waldman, I. D., & Asherson, P. J. (2000) · Molecular Psychiatry · doi:10.1038/sj.mp.4000744 · Cited by 156 · see citing works
Mao, Z.-M., Arnsten, A. F. T., & Li, B.-M. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00139-0 · Cited by 156 · see citing works
Self-citationWang, X., Zhong, P., & Yan, Z. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-21-09185.2002 · Cited by 155 · see citing works
Spencer, T. J., Biederman, J., Madras, B. K., Dougherty, D. D., Bonab, A. A., Livni, E., Meltzer, P. C., Martin, J., Rauch, S., & Fischman, A. J. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.12.008 · Cited by 150 · see citing works
The beta-1 adrenergic antagonist, betaxolol, improves working memory performance in rats and monkeys
Ramos, B. P., Colgan, L., Nou, E., Ovadia, S., Wilson, S. R., & Arnsten, A. F. T. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.05.022 · Cited by 147 · see citing works
Self-citationAvery, R. A. (2000) · Neuropsychopharmacology · doi:10.1016/s0893-133x(00)00111-1 · Cited by 142 · see citing works
Uhlén, S., & Wikberg, J. E. S. (1991) · European Journal of Pharmacology · doi:10.1016/0014-2999(91)90299-6 · Cited by 141 · see citing works
Lewis, D. A., & Morrison, J. H. (1989) · The Journal of Comparative Neurology · doi:10.1002/cne.902820302 · Cited by 131 · see citing works
Neurocognitive effects of methylphenidate in adult attention-deficit/hyperactivity disorder
Turner, D. C., Blackwell, A. D., Dowson, J. H., McLean, A., & Sahakian, B. J. (2005) · Psychopharmacology · doi:10.1007/s00213-004-1993-5 · Cited by 127 · see citing works
Ramos, B. P., Stark, D., Verduzco, L., van Dyck, C. H., & Arnsten, A. F. T. (2006) · Learning & Memory · doi:10.1101/lm.298006 · Cited by 124 · see citing works
Self-citationRomán, T., Schmitz, M., Polanczyk, G., Eizirik, M., Rohde, L., & Hutz, M. (2002) · American journal of medical genetics · doi:10.1002/ajmg.10194 · Cited by 123 · see citing works
Noradrenergic Control of Thalamic Oscillation: the Role of α‐2 Receptors
Buzsáki, G., Kennedy, B., Solt, V. B., & Ziegler, M. (1991) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1991.tb00083.x · Cited by 123 · see citing works
Cai, J. X., Ma, Y.-Y., Xu, L., & Hu, X.-T. (1993) · Brain Research · doi:10.1016/0006-8993(93)91034-p · Cited by 122 · see citing works
Franowicz, J. S., & Arnsten, A. F. T. (1998) · Psychopharmacology · doi:10.1007/s002130050533 · Cited by 118 · see citing works
Self-citationKustanovich, V., Ishii, J., Crawford, L., Yang, M. H., McGough, J., McCracken, J. T., Smalley, S., & Nelson, S. F. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001466 · Cited by 114 · see citing works
Barbas, H., Medalla, M., Alade, O., Suski, J., Zikopoulos, B., & Lera, P. (2005) · Cerebral Cortex · doi:10.1093/cercor/bhi018 · Cited by 112 · see citing works
Uhlén, S., Porter, A. C., & Neubig, R. R. (1994) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)24043-5 · Cited by 111 · see citing works
Linkage of the Dopamine D4 Receptor Gene and Attention-Deficit/Hyperactivity Disorder
Sunohara, G., Roberts, W., MALONE, M. A., Schachar, R. J., Tannock, R., Basile, V. S., Wigal, T. L., Wigal, S. B., Schuck, S. E. B., Moriarty, J., et al. (2000) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-200012000-00017 · Cited by 108 · see citing works
Mill, J. S., Caspi, A., Williams, B. S., Craig, I., Taylor, A., Polo-Tomás, M., Berridge, C. W., Poulton, R., & Moffitt, T. E. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.4.462 · Cited by 102 · see citing works
Donnelly, M., Zametkin, A. J., Rapoport, J. L., Ismond, D. R., Weingartner, H., Lane, E., Oliver, J., Linnoila, M., & Potter, W. Z. (1986) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.1986.13 · Cited by 100 · see citing works
Divided and Focused Attention in Patients with Lesion of the Prefrontal Cortex
Godefroy, O., & Rousseaux, M. (1996) · Brain and Cognition · doi:10.1006/brcg.1996.0010 · Cited by 98 · see citing works
Bellgrove, M. A., Hawi, Z., Gill, M., & Robertson, I. H. (2006) · Cortex · doi:10.1016/s0010-9452(08)70426-x · Cited by 97 · see citing works
Locomotor hyperactivity induced by blockade of prefrontal cortical α2-adrenoceptors in monkeys
Ma, C.-L., Arnsten, A. F. T., & Li, B.-M. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.11.004 · Cited by 96 · see citing works
Self-citationThe prefrontal cortex and internally generated motor acts
Goldman, P. S., Bates, J. F., & Chafee, M. V. (1992) · Current Opinion in Neurobiology · doi:10.1016/0959-4388(92)90141-7 · Cited by 96 · see citing works
Román, T., Schmitz, M., Polanczyk, G. V., Eizirik, M., Rohde, L., & Hutz, M. (2003) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.20018 · Cited by 94 · see citing works
Steere, J. C., & Arnsten, A. F. T. (1997) · Behavioral Neuroscience · doi:10.1037//0735-7044.111.5.883 · Cited by 94 · see citing works
Self-citationSHERIDAN, M. A., HINSHAW, S., & D'ESPOSITO, M. (2007) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/chi.0b013e31812eecf7 · Cited by 90 · see citing works
Frontal decortication in rhesus monkeys: A test of the interference hypothesis
Bartus, R. T., & LeVere, T. E. (1977) · Brain Research · doi:10.1016/0006-8993(77)90103-2 · Cited by 88 · see citing works
Medetomidine, atipamezole, and guanfacine in delayed response performance of aged monkeys
Pia Rämä, A., Linnankoski, I., Tanila, H., Pertovaara, A., & Carlson, S. (1996) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(96)00111-6 · Cited by 76 · see citing works
Rapoport, J. L., & Inoff‐Germain, G. (2002) · Journal of Attention Disorders · doi:10.1177/070674370200601s07 · Cited by 72 · see citing works
[Dopaminergic A10 neurons and frontal system (author's transl)].
Simon, H. (1981) · PubMed · Cited by 69 · see citing works
Ma, C.-L., Qi, X.-L., Peng, J.-Y., & Li, B.-M. (2003) · NeuroReport · doi:10.1097/01.wnr.0000070831.57864.7b · Cited by 69 · see citing works
Executive Functioning Among Finnish Adolescents With Attention-Deficit/Hyperactivity Disorder
LOO, S. K., HUMPHREY, L. A., TAPIO, T., MOILANEN, I. K., McGOUGH, J. J., McCRACKEN, J. T., YANG, M. H., DANG, J., TAANILA, A., EBELING, H., et al. (2007) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/chi.0b013e3181575014 · Cited by 67 · see citing works
Kieling, C., Genro, J. P., Hutz, M. H., & Rohde, L. A. (2008) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30636 · Cited by 65 · see citing works
Xu, C., Schachar, R., Tannock, R., Roberts, W., Malone, M., Kennedy, J., & Barr, C. (2001) · American journal of medical genetics · doi:10.1002/1096-8628(2001)9999:9999 · Cited by 63 · see citing works
Neural Activity in Primate Parietal Area 7a Related to Spatial Analysis of Visual Mazes
Crowe, D. A. (2003) · Cerebral Cortex · doi:10.1093/cercor/bhg088 · Cited by 63 · see citing works
la Fougère, C., Krause, J., Krause, K.-H., Josef Gildehaus, F., Hacker, M., Koch, W., Hahn, K., Tatsch, K., & Dresel, S. (2006) · Nuclear Medicine Communications · doi:10.1097/01.mnm.0000230077.48480.68 · Cited by 57 · see citing works
Perseveration induced by methylphenidate in children: preliminary findings
Dyme, I. Z., Sahakian, B. J., Golinko, B. E., & Rabe, E. F. (1982) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(82)80177-2 · Cited by 56 · see citing works
Segal, D. S., & Kuczenski, R. T. (1999) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)35066-9 · Cited by 48 · see citing works
Dissociation of neglect subtypes with transcranial magnetic stimulation
Ghacibeh, G. A., Shenker, J. I., Winter, K. H., Triggs, W. J., & Heilman, K. M. (2007) · Neurology · doi:10.1212/01.wnl.0000276950.77470.50 · Cited by 48 · see citing works
van Zwieten, P. A., & Chalmers, J. P. (1994) · Cardiovascular Drugs and Therapy · doi:10.1007/bf00877397 · Cited by 43 · see citing works
Locomotor activity following lateral frontal lesions in Rhesus monkeys.
Gross, C. G. (1963) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0048041 · Cited by 41 · see citing works
Locomotor effects of regional ablations of frontal cortex in rhesus monkeys.
French, G. M. (1959) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0042491 · Cited by 41 · see citing works
Makanjuola, R. O. A., & Ashcroft, G. W. (1982) · Psychopharmacology · doi:10.1007/bf00449121 · Cited by 39 · see citing works
Effects of guanfacine on three forms of distraction in the aging macaque
O'Neill, J., Fitten, L. J., Siembieda, D. W., Ortiz, F., & Halgren, E. (2000) · Life Sciences · doi:10.1016/s0024-3205(00)00681-0 · Cited by 32 · see citing works
The development of the frontal lobe. A view from the rear of the brain.
RAKIC, P. T. (1995) · PubMed · Cited by 28 · see citing works
Different Affinities of α2-Agonists for Imidazoline and α2-Adrenergic Receptors
Coupry, I., Lachaud, V., Podevin, R., et al. (1989) · American Journal of Hypertension · doi:10.1093/ajh/2.6.468 · Cited by 26 · see citing works
The α2A-Adrenergic Agonist Guanfacine Improves Visuomotor Associative Learning in Monkeys
Wang, M., Ji, J., & Li, B. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300278 · Cited by 19 · see citing works
Polymorphisms of Dopamine-β-Hydroxylase in ADHD Children
Kopečková, M., Paclt, I., & Goetz, P. (2006) · Folia Biologica · doi:10.14712/fb2006052060194 · Cited by 9 · see citing works
Shammah-Lagnado (2000) · doi:10.1002/1096-9861(20000710)422:4
Flagged first, then by citations
Research works printed but not linked: 11
- [1]Solanto MV Solanto MV Arnsten AFT Castellanos FX Attention-Deficit/Hyperactivity Disorder: Clinical features Stimulant Drugs and ADHD: Basic and Clinical Neuroscience 2001 New York Oxford University Press 3 30
- [3]Stuss DT Knight RT Principles of Frontal Lobe Function 2002 New York Oxford University Press
- [26]DSM I. Diagnostic and statistical manual of mental disorders 4th edition American Psychiatric Association
- [82]Arnsten AFT Manji HK Mania: A rational neurobiology Future Neurology 2008 3 in press.
- [90]Arnsten AFT Steere JC Hunt RD The contribution of alpha-2 noradrenergic mechanisms to prefrontal cortical cognitive function: potential significance to Attention Deficit Hyperactivity Disorder Arch Gen Psychiatry 1996 53 448 455 8624188
- [95]Seidman LJ Valera EM Makris N Structural brain imaging of attention-deficit/hyperactivity disorder Biol Psychiatry 2005 57 1263 1272 15949998
- [112]Comings DE Clinical and molecular genetics of ADHD and Tourette syndrome. Two related polygenic disorders Ann N Y Acad Sci 2001 931 50 83 11462757
- [122]van Dyck CH Quinlan DM Cretella L Staley JK Malison RT Baldwin RM Striatal dopamine transporter availability with [123I]β-CIT SPECT is unaltered in adult Attention Deficit Hyperactivity Disorder Am. J. Psychiatry 2002 159 309 312 11823278
- [149]Engberg G Eriksson E Effects of alpha-2-adrenoceptor agonists on locus coeruleus firing rate and brain noradrenaline turnover in EEDQ-treated rats Naunyn-Schmiedebergs Arch. Pharmacol 1991 343 472 477 1652697
- [150]Scahill L Chappell PB Kim YS Schultz RT Katsovich L Shepherd E Guanfacine in the treatment of children with tic disorders and ADHD: A placebo-controlled study Amer. J. Psychiatry 2001 158 1067 1074 11431228
- [156]Group TTsSS Treatment of ADHD in children with tics: a randomized controlled trial Neurology 2002 58 527 536 11865128
Cited by
Sorted by citations
Arnsten, A. F. T., & Rubia, K. (2012) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2012.01.008 · Cited by 568 · see citing works
Self-citationRubia, K. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.09.023 · Cited by 440 · see citing works
Development of prefrontal cortex
Kolk, S. M., & Rakic, P. (2022) · Neuropsychopharmacology · doi:10.1038/s41386-021-01137-9 · Cited by 378 · see citing works
“Attention deficit/hyperactivity disorder (ADHD) is a NDD characterized by signs of inattention, impulsivity, and hyperactivity [380, 381].”
BackgroundPharmacotherapy of obesity: available medications and drugs under investigation.
Pilitsi, E., Farr, O. M., Polyzos, S. A., Perakakis, N., Nolen-Doerr, E., Papathanasiou, A.-E., & Mantzoros, C. S. (2019) · Metabolism · doi:10.1016/j.metabol.2018.10.010 · Cited by 248 · see citing works
Choi, W.-S., Woo, Y. S., Wang, S.-M., Lim, H. K., & Bahk, W.-M. (2022) · PLOS ONE · doi:10.1371/journal.pone.0277175 · Cited by 221 · see citing works
Perry, J. L., Joseph, J. E., Jiang, Y., Zimmerman, R. S., Kelly, T. H., Darna, M., Huettl, P., Dwoskin, L. P., & Bardo, M. T. (2011) · Brain Research Reviews · doi:10.1016/j.brainresrev.2010.09.001 · Cited by 180 · see citing works
Hodgkins, P., Shaw, M., Coghill, D., & Hechtman, L. (2012) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-012-0286-5 · Cited by 147 · see citing works
Neurobiology of Attention Deficit/Hyperactivity Disorder
Purper‐Ouakil, D., Ramoz, N., Lepagnol-Bestel, A.-M., Gorwood, P. A. P. M., & Simonneau, M. (2011) · Pediatric Research · doi:10.1203/pdr.0b013e318212b40f · Cited by 146 · see citing works
Sonuga-Barke, E. J. S., Wiersema, J. R., van der Meere, J. J., & Roeyers, H. (2010) · Neuropsychology Review · doi:10.1007/s11065-009-9115-0 · Cited by 142 · see citing works
Hulvershorn, L. A., Mennes, M., Castellanos, F. X., Di Martino, A., Milham, M. P., Hummer, T. A., & Roy, A. K. (2014) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2013.11.012 · Cited by 138 · see citing works
Liao, C., Laporte, A. D., Spiegelman, D., Akçimen, F., Joober, R., Dion, P. A., & Rouleau, G. A. (2019) · Nature Communications · doi:10.1038/s41467-019-12450-9 · Cited by 128 · see citing works
Zheng, F., Gao, P., He, M., Li, M., Wang, C., Zeng, Q., Zhou, Z., Yu, Z., & Zhang, L. (2014) · BMC Public Health · doi:10.1186/1471-2458-14-1022 · Cited by 113 · see citing works
Cerebellar-Subcortical-Cortical Systems as Modulators of Cognitive Functions
Clark, S., Semmel, E. S., Aleksonis, H. A., Steinberg, S. N., & King, T. Z. (2021) · Neuropsychology Review · doi:10.1007/s11065-020-09465-1 · Cited by 115 · see citing works
Karalunas, S. L., Gustafsson, H. C., Dieckmann, N. F., Tipsord, J., Mitchell, S. H., & Nigg, J. T. (2017) · Journal of Abnormal Psychology · doi:10.1037/abn0000292 · Cited by 104 · see citing works
Dougherty, C. C., Evans, D. W., Myers, S. M., Moore, G. J., & Michael, A. M. (2016) · Neuropsychology Review · doi:10.1007/s11065-015-9300-2 · Cited by 104 · see citing works
The role of prefrontal catecholamines in attention and working memory
Clark, K., & Noudoost, B. (2014) · Frontiers in Neural Circuits · doi:10.3389/fncir.2014.00033 · Cited by 101 · see citing works
Yu, C., Garcia-Olivares, J., Candler, S., Schwabe, S., & Maletic, V. (2020) · Journal of Experimental Pharmacology · doi:10.2147/jep.s256586 · Cited by 96 · see citing works
New onset executive function difficulties at menopause: a possible role for lisdexamfetamine
Epperson, C. N., Shanmugan, S., Kim, D. R., Mathews, S., Czarkowski, K. A., Bradley, J., Appleby, D. H., Iannelli, C., Sammel, M. D., & Brown, T. E. (2015) · Psychopharmacology · doi:10.1007/s00213-015-3953-7 · Cited by 90 · see citing works
Artificial food dyes and attention deficit hyperactivity disorder
Kanarek, R. B. (2011) · Nutrition Reviews · doi:10.1111/j.1753-4887.2011.00385.x · Cited by 80 · see citing works
An, L., Cao, X.-H., Cao, Q.-J., Sun, L., Yang, L., Zou, Q.-H., Katya, R., Zang, Y.-F., & Wang, Y.-F. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.27 · Cited by 88 · see citing works
Heart Rate Variability in Children with Attention-Deficit/Hyperactivity Disorder: A Pilot Study
Rukmani, M. R., Seshadri, S. P., Thennarasu, K., Raju, T. R., & Sathyaprabha, T. N. (2016) · Annals of Neurosciences · doi:10.1159/000443574 · Cited by 69 · see citing works
Quintero, J., Gutiérrez-Casares, J. R., & Álamo, C. (2022) · Neurology and Therapy · doi:10.1007/s40120-022-00392-2 · Cited by 70 · see citing works
“However, the MPH effects on these signalling pathways were totally inhibited using ADRD1B blockers, showing that ADRD1B mediates the phosphorylation of PKA signalling through MPH in the PFC [143].”
BackgroundInfluentialReducing substance use during adolescence: a translational framework for prevention
Stanis, J. J., & Andersen, S. L. (2014) · Psychopharmacology · doi:10.1007/s00213-013-3393-1 · Cited by 69 · see citing works
Adult ADHD: Underdiagnosis of a Treatable Condition
Rivas-Vazquez, R. A., Diaz, S. G., Visser, M. M., & Rivas-Vazquez, A. A. (2023) · Journal of Health Service Psychology · doi:10.1007/s42843-023-00077-w · Cited by 68 · see citing works
Oh, S., Choi, J., Han, D. H., & Kim, E. (2024) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-023-02174-z · Cited by 63 · see citing works
Kozłowska, A., Wojtacha, P., Równiak, M., Kolenkiewicz, M., & Huang, A. C. W. (2019) · Psychopharmacology · doi:10.1007/s00213-019-5180-0 · Cited by 63 · see citing works
Knecht, C., de Alvaro, R., Martı́nez-Raga, J., & Balanzá‐Martínez, V. (2014) · International Journal of Adolescent Medicine and Health · doi:10.1515/ijamh-2015-5007 · Cited by 65 · see citing works
Boczek, T., Mackiewicz, J., Sobolczyk, M., Wawrzyniak, J., Lisek, M., Ferenc, B., Guo, F., & Żylińska, L. (2021) · Cells · doi:10.3390/cells10051228 · Cited by 61 · see citing works
Abu‐Elfotuh, K., Abdel-Sattar, S. A., Abbas, A. N., Mahran, Y. F., Alshanwani, A. R., Hamdan, A. M., Atwa, A. M., Reda, E., Ahmed, Y. M., Zaghlool, S. S., et al. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113799 · Cited by 62 · see citing works
Working for the future: parentally deprived Nigerian Children have enhanced working memory ability
Nweze, T., Nwoke, M. B., Nwufo, J. I., Aniekwu, R. I., & Lange, F. (2020) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.13241 · Cited by 58 · see citing works
Guanfacine Extended Release: A New Pharmacological Treatment Option in Europe
Huß, M., Chen, W., & Ludolph, A. G. (2015) · Clinical Drug Investigation · doi:10.1007/s40261-015-0336-0 · Cited by 56 · see citing works
Viloxazine in the Management of CNS Disorders: A Historical Overview and Current Status
Findling, R. L., Candler, S. A., Nasser, A. F., Schwabe, S., Yu, C., Garcia-Olivares, J., O’Neal, W., & Newcorn, J. H. (2021) · CNS Drugs · doi:10.1007/s40263-021-00825-w · Cited by 55 · see citing works
Beaudin, S. A., Strupp, B. J., Strawderman, M. S., & Smith, D. R. (2016) · Environmental Health Perspectives · doi:10.1289/ehp258 · Cited by 53 · see citing works
Kollins, S. H., López, F. A., Vince, B. D., Turnbow, J. M., Farrand, K., Lyne, A., Wigal, S. B., & Roth, T. (2011) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2010.0064 · Cited by 53 · see citing works
Gillett, G., Watson, G., Saunders, K. E. A., & McGowan, N. M. (2021) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2021.09.043 · Cited by 50 · see citing works
Genesis and Maintenance of Attentional Biases: The Role of the Locus Coeruleus-Noradrenaline System
Ehlers, M. R., & Todd, R. M. (2017) · Neural Plasticity · doi:10.1155/2017/6817349 · Cited by 47 · see citing works
Novel pharmacological targets for GABAergic dysfunction in ADHD
Ferranti, A. S., Luessen, D. J., & Niswender, C. M. (2024) · Neuropharmacology · doi:10.1016/j.neuropharm.2024.109897 · Cited by 43 · see citing works
The impact of acute tryptophan depletion on attentional performance in adult patients with ADHD
Mette, C., Zimmermann, M., Grabemann, M., Abdel‐Hamid, M., UEKERMANN, J., Biskup, C. S., Wiltfang, J., Zepf, F. D., & Kis, B. (2013) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12090 · Cited by 43 · see citing works
Who says this is a modern disorder? The early history of attention deficit hyperactivity disorder.
Martinez-Badía, J., & Martínez-Raga, J. (2015) · World Journal of Psychiatry · doi:10.5498/wjp.v5.i4.379 · Cited by 33 · see citing works
Spatial Attention, Feature-Based Attention, and Saccades: Three Sides of One Coin?
Mazer, J. A. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.03.014 · Cited by 40 · see citing works
Loh, H. W., Ooi, C. P., Oh, S. L., Barua, P. D., Tan, Y. R., Acharya, U. R., & Fung, D. S. S. (2023) · Cognitive Neurodynamics · doi:10.1007/s11571-023-10028-2 · Cited by 44 · see citing works
Schmeichel, B. E., Zemlan, F. P., & Berridge, C. W. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.07.005 · Cited by 39 · see citing works
Risk of ADHD After Multiple Exposures to General Anesthesia: A Nationwide Retrospective Cohort Study
Tsai, C.-J., Lee, C. T., Liang, S. H., Tsai, P.-J., Chen, V. C., & Gossop, M. (2015) · Journal of Attention Disorders · doi:10.1177/1087054715587094 · Cited by 38 · see citing works
Umehara, M., Ago, Y., Fujita, K., Hiramatsu, N., Takuma, K., & Matsuda, T. (2013) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2013.01.033 · Cited by 37 · see citing works
Morris, L. S., To, B., Baek, K., Chang-Webb, Y. C., Mitchell, S., Strelchuk, D., Mikheenko, Y., Phillips, W., Zandi, M. S., Jenaway, A., et al. (2017) · NeuroImage Clinical · doi:10.1016/j.nicl.2017.08.007 · Cited by 37 · see citing works
Conley, T. E., Beaudin, S. A., Lasley, S. M., Fornal, C. A., Hartman, J., Uribe, W., Khan, T., Strupp, B. J., & Smith, D. R. (2019) · Journal of Neurochemistry · doi:10.1111/jnc.14934 · Cited by 36 · see citing works
Bubenzer‐Busch, S., Herpertz‐Dahlmann, B., Kuzmanovic, B., Gaber, T. J., Helmbold, K., Ullisch, M. G., Baurmann, D., Eickhoff, S. B., Fink, G. R., & Zepf, F. D. (2016) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12475 · Cited by 35 · see citing works
Corominas, M., Ramos‐Quiroga, J. A., Ferrer, M., Sáez‐Francàs, N., Gloria Palomar, A., Bosch, R., & Casas, M. (2012) · ADHD Attention Deficit and Hyperactivity Disorders · doi:10.1007/s12402-012-0075-5 · Cited by 35 · see citing works
Bayless, D. W., Darling, J. S., & Daniel, J. M. (2013) · Hormones and Behavior · doi:10.1016/j.yhbeh.2013.10.003 · Cited by 34 · see citing works
Lasley, S. M., Fornal, C. A., Mandal, S., Strupp, B. J., Beaudin, S. A., & Smith, D. R. (2019) · Toxicological Sciences · doi:10.1093/toxsci/kfz208 · Cited by 32 · see citing works
ADHD Identification using Convolutional Neural Network with Seed-based Approach for fMRI Data
Ariyarathne, G., Silva, S. D., Dayarathna, S., Meedeniya, D., & Jayarathne, S. (2020) · International Conference on Software and Computer Applications (ICSCA) · doi:10.1145/3384544.3384552 · Cited by 33 · see citing works
Albayrak, Ö., Albrecht, B., Scherag, S., Barth, N., Hinney, A., & Hebebrand, J. (2011) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2010.12.023 · Cited by 31 · see citing works
Neurobiology of Attention Deficit Hyperactivity Disorder
Faraone, S. V., & Radonjić, N. V. (2023) · Springer eBooks · doi:10.1007/978-3-030-42825-9_33-1 · Cited by 31 · see citing works
Challenges in the Transition of Care for Adolescents With Attention-Deficit/Hyperactivity Disorder
Robb, A. S., & Findling, R. L. (2013) · Postgraduate Medicine · doi:10.3810/pgm.2013.07.2685 · Cited by 29 · see citing works
Kawaura, K., Karasawa, J.-I., Chaki, S., & Hikichi, H. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.05.044 · Cited by 29 · see citing works
Smith, D. R., & Strupp, B. J. (2023) · Neurotherapeutics · doi:10.1007/s13311-023-01345-9 · Cited by 27 · see citing works
Lisdexamfetamine: A pharmacokinetic review
Comiran, E., Kessler, F. H., Fröehlich, P. E., & Limberger, R. P. (2016) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2016.04.026 · Cited by 31 · see citing works
Song, I. G., Kim, H., Cho, Y.-M., Lim, Y., Moon, D.-S., Shin, S. H., Kim, E., Park, J., Shin, J. E., Han, J. H., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-06094-x · Cited by 27 · see citing works
Matsuo, Y., Watanabe, M., Taniike, M., Mohri, I., Kobashi, S., Tachibana, M., Kobayashi, Y., & Kitamura, Y. (2015) · PLoS ONE · doi:10.1371/journal.pone.0125573 · Cited by 26 · see citing works
Dimitrov, L. V., Kaminski, J. W., Holbrook, J. R., Bitsko, R. H., Yeh, M., Courtney, J. G., O’Masta, B., Maher, B. S., Cerles, A. A., McGowan, K., et al. (2023) · Prevention Science · doi:10.1007/s11121-023-01601-6 · Cited by 26 · see citing works
Fikke, L. T., Melinder, A. M. D., & Landrø, N. I. (2013) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.2283 · Cited by 25 · see citing works
Andrzejewski, M. E., Spencer, R. C., Harris, R. L., Feit, E. C., McKee, B. L., & Berridge, C. W. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.01.018 · Cited by 24 · see citing works
Caballero-Puntiverio, M., Lerdrup, L., Arvastson, L., Aznar, S., & Andreasen, J. T. (2019) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2019.109823 · Cited by 24 · see citing works
Johnstone, S. J., Parrish, L., Jiang, H., Zhang, D., Williams, V., & Sun, L. (2021) · Biological Psychology · doi:10.1016/j.biopsycho.2021.108080 · Cited by 23 · see citing works
Amengual, J. L., Bello, F. D., Hamed, S. B., & Hamed, S. B. (2022) · Nature Communications · doi:10.1038/s41467-022-32385-y · Cited by 20 · see citing works
Hayton, S. J., Olmstead, M. C., & Dumont, É. C. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023885 · Cited by 21 · see citing works
Attention Networks in ADHD Adults after Working Memory Training with a Dual n-Back Task
Dotare, M., Bader, M., Mesrobian, S. K., Asai, Y., Villa, A. E. P., & Lintas, A. (2020) · Brain Sciences · doi:10.3390/brainsci10100715 · Cited by 21 · see citing works
Sears, C. G., Sears, L. L., & Zierold, K. M. (2020) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2020.106855 · Cited by 21 · see citing works
Romero-García, R., Hook, R. W., Tiego, J., Bethlehem, R. A. I., Goodyer, I. M., Jones, P. B., Dolan, R. J., Grant, J. E., Bullmore, E. T., Yücel, M., et al. (2020) · Neuropsychopharmacology · doi:10.1038/s41386-020-00848-9 · Cited by 19 · see citing works
Korte, S. M., Prins, J., van den Bergh, F. S., Oosting, R. S., Dupree, R., Korte-Bouws, G. A. H., Westphal, K. G. C., Olivier, B., Denys, D. A. J. P., Garland, A., et al. (2016) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2016.11.024 · Cited by 19 · see citing works
Pongpitakdamrong, A., Chirdkiatgumchai, V., Ruangdaraganon, N., Roongpraiwan, R., Sirachainan, N., Soongprasit, M., & Udomsubpayakul, U. (2021) · Journal of Developmental & Behavioral Pediatrics · doi:10.1097/dbp.0000000000000993 · Cited by 19 · see citing works
Zepf, F. D., Bubenzer‐Busch, S., Runions, K., Rao, P., Wong, J. W. Y., Mahfouda, S., Morandini, H. A. E., Stewart, R. M., Moore, J. K., Biskup, C. S., et al. (2017) · Brain and Cognition · doi:10.1016/j.bandc.2017.10.005 · Cited by 20 · see citing works
Batten, S. R., Hartle, A. E., Barbosa, L. S., Hadj-Amar, B., Bang, D., Melville, N., Twomey, T., White, J. P., Torres, A. S., Celaya, X., et al. (2025) · Cell Reports · doi:10.1016/j.celrep.2024.115162 · Cited by 20 · see citing works
Stimulant medications affect arousal and reward, not attention networks
Kay, B. P., Wheelock, M. D., Siegel, J. S., Raut, R. V., Chauvin, R. J., Metoki, A., Rajesh, A., Eck, A., Pollaro, J., Wang, A., et al. (2025) · Cell · doi:10.1016/j.cell.2025.11.039 · Cited by 19 · see citing works
Peña, I. D., Shen, G., & Shi, W. (2020) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2020.173826 · Cited by 18 · see citing works
Behavioral and Psychiatric Disorders in Syndromic Autism
Genovese, A., & Butler, M. G. (2024) · Brain Sciences · doi:10.3390/brainsci14040343 · Cited by 19 · see citing works
Methylphenidate alleviates manganese-induced impulsivity but not distractibility
Beaudin, S. A., Strupp, B. J., Uribe, W., Ysais, L., Strawderman, M. S., & Smith, D. R. (2017) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2017.03.005 · Cited by 16 · see citing works
Martínez-Raga, J., Knecht, C., & de Alvaro, R. (2015) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s65735 · Cited by 15 · see citing works
NR4A2: Effects of an “Orphan” Receptor on Sustained Attention in a Schizophrenic Population
Ancín, I., Cabranes, J. A., Vázquez-Álvarez, B., Santos, J. L., Sánchez‐Morla, E. M., Alaerts, M., Del‐Favero, J., & Barabash, A. (2012) · Schizophrenia Bulletin · doi:10.1093/schbul/sbr176 · Cited by 17 · see citing works
Hawkins, R. D. (2013) · Learning & Memory · doi:10.1101/lm.031237.113 · Cited by 17 · see citing works
The use of attention-deficit hyperactivity disorder medications in cardiac disease
Topriceanu, C., Moon, J., Captur, G., & Perera, B. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.1020961 · Cited by 15 · see citing works
Agoalikum, E., Klugah‐Brown, B., Wu, H., Hu, P., Jing, J., & Biswal, B. B. (2023) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2023.1076873 · Cited by 17 · see citing works
Luking, K. R., Jirsaraie, R. J., Tillman, R., Luby, J. L., Barch, D. M., & Sotiras, A. (2021) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2021.06.013 · Cited by 16 · see citing works
Umehara, M., Ago, Y., Kawanai, T., Fujita, K., Hiramatsu, N., Takuma, K., & Matsuda, T. (2013) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e3283633648 · Cited by 15 · see citing works
Kubas, H. A., Backenson, E. M., Wilcox, G., Piercy, J. C., & Hale, J. B. (2012) · Postgraduate Medicine · doi:10.3810/pgm.2012.09.2592 · Cited by 14 · see citing works
Salehzadeh, S. A., Mohammadian, A., & Salimi, F. (2019) · Asian Journal of Psychiatry · doi:10.1016/j.ajp.2019.101884 · Cited by 14 · see citing works
Reduced prefrontal cortex and sympathetic nervous system activity correlate with fatigue after aHSCT
Boberg, E., Iacobaeus, E., Greenfield, M. S., Wang, Y., Msghina, M., & Blanc, K. L. (2021) · Bone Marrow Transplantation · doi:10.1038/s41409-021-01539-9 · Cited by 14 · see citing works
Díaz, F. C., Kramar, C. P., Hernandez, M. A., & Medina, J. H. (2017) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2017.00209 · Cited by 14 · see citing works
Hermes, G., Hyman, S. M., Fogelman, N., Kosten, T. R., & Sinha, R. (2019) · American Journal on Addictions · doi:10.1111/ajad.12942 · Cited by 14 · see citing works
An, D., You, Y., Ma, Q., Xu, Z., Liu, Z., Liao, R., Chen, H., Wang, Y., Wang, Y., Dai, H., et al. (2025) · Neuron · doi:10.1016/j.neuron.2024.12.002 · Cited by 13 · see citing works
Schildroth, S., Friedman, A., White, R. F., Kordas, K., Placidi, D., Bauer, J. A., Webster, T. F., Coull, B. A., Cagna, G., Wright, R. O., et al. (2023) · Environmental Research · doi:10.1016/j.envres.2023.115457 · Cited by 13 · see citing works
Meisinger, C., & Freuer, D. (2023) · BMJ Mental Health · doi:10.1136/bmjment-2022-300642 · Cited by 13 · see citing works
Chai, Y., Chimelis-Santiago, J. R., Bixler, K., Aalsma, M. C., Yu, M., & Hulvershorn, L. A. (2021) · NeuroImage Clinical · doi:10.1016/j.nicl.2021.102789 · Cited by 12 · see citing works
Single cell spatial biology over developmental time can decipher pediatric brain pathologies
Nussinov, R., Yavuz, B. R., & Jang, H. (2024) · Neurobiology of Disease · doi:10.1016/j.nbd.2024.106597 · Cited by 11 · see citing works
Ryan, J. E., Fruchtman, M., Sparr‐Jaswa, A., Knehans, A. C., & Worster, B. K. (2024) · Developmental Psychobiology · doi:10.1002/dev.22540 · Cited by 11 · see citing works
Huang, H.-C., Wu, L. S., Yu, S.-C., Wu, B., Lua, A. C., Lee, S.-M., & Liu, C. (2018) · Psychiatry Investigation · doi:10.30773/pi.2017.07.24 · Cited by 11 · see citing works
Frankowska, M., Miszkiel, J., Pomierny-Chamioło, L., Pomierny, B., Giannotti, G., Suder, A., & Filip, M. (2019) · Journal of Psychopharmacology · doi:10.1177/0269881118821113 · Cited by 11 · see citing works
BrainNET: Inference of Brain Network Topology Using Machine Learning
Murugesan, G. K., Yogananda, C. G. B., Nalawade, S. S., Davenport, E. M., Wagner, B. C., Kim, W. H., & Maldjian, J. A. (2020) · Brain Connectivity · doi:10.1089/brain.2020.0745 · Cited by 11 · see citing works
Schneider, H., Riederle, J., & Seuss, S. (2021) · Artificial intelligence · doi:10.5772/intechopen.97938 · Cited by 11 · see citing works
Faraone, S. V., Ward, C. L., Boucher, M., Elbekai, R., & Brunner, E. (2025) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2025.106275 · Cited by 10 · see citing works
- Authors
- Arnsten, A. F. T.
- Affiliations
- Yale University (US)
- Corresponding author
- Arnsten, Amy F.T.
- ORCID
- Arnsten, Amy F.T.
- Venue
- The Journal of Pediatrics
- Publisher
- Elsevier BV
- Published
- 2009-05
- Volume
- 154
- Issue
- 5
- Pages
- I-S43
- ISSN
- 0022-3476 (ISSN-L)
- PMC
- PMC2894421
- OpenAlex
- W11706560
- Cited by
- 220
- References
- 5
- Citations by year
- 2026: 30 · 2025: 31 · 2024: 23 · 2023: 23 · 2022: 12 · 2021: 13 · 2020: 11 · 2019: 10 · 2018: 3 · 2017: 7 · 2016: 5 · 2015: 10 · 2014: 9 · 2013: 11 · 2012: 10
- FWCI
- 4.54
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The Journal of Pediatrics (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (R37AG006036)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- attention deficit hyperactivity disorder, prefrontal cortex, right hemisphere, behavioral inhibition, catecholamine signaling, dopamine D1 receptor, prefrontal cortex maturation, stimulant medication, norepinephrine, dopamine, ADHD etiology, ADHD treatment
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