Cited by 480Neurotransmitter Receptor Influence on BehaviorStress Responses and CortisolTreatment of Major Depression

Animal model of depression: Pharmacological sensitivity of a hedonic deficit

Open access
Katz, Richard J.·1982·Pharmacology Biochemistry and Behavior

Abstract

A reduction in sucrose and saccharine consumption following chronic stress is reported for the rat. This deficit may be related to consummatory deficits seen in endogenous depression. To further examine this state pharmacologically, stressed rats were treated with the antidepressant imipramine. Despite a general absence of appetitive effects (or in some cases mild anorexia) imipramine significantly restored saccharine consumption in a variety of tests. The pharmacological similarity of the deficit to the changes accompanying affective disorders further supports the potential applicability of the chronic stress model.

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  1. Katz, R. J., K. A. Roth, I. A. Mefford, B. J. Carroll and J. Barchas. The chronically stressed rat--a novel animal of endog- enomorphic depression. Proc. 3rd Int. Cong. Biol. Psychiat. Stockholm, Sweden, 1981.

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Authors
Katz, R. J.
Affiliations
University of Michigan (US)
Corresponding author
Katz, Richard J.
Venue
Pharmacology Biochemistry and Behavior
Publisher
Elsevier BV
Published
1982-06
Volume
16
Issue
6
Pages
965-968
ISSN
0091-3057 (ISSN-L)
OpenAlex
W2099660163
Cited by
480
References
7
Citations by year
2026: 8 · 2025: 18 · 2024: 21 · 2023: 22 · 2022: 16 · 2021: 20 · 2020: 22 · 2019: 20 · 2018: 20 · 2017: 17 · 2016: 16 · 2015: 11 · 2014: 26 · 2013: 15 · 2012: 18
FWCI
0.56
Type
journal article
Language
en
Open access
Locations
  • Pharmacology Biochemistry and Behavior (publishedVersion)
  • PubMed (publishedVersion)
  • Deep Blue (University of Michigan) (submittedVersion)
Funders
National Institute of Mental Health
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Keywords
animal models of depression, chronic stress, sucrose intake, imipramine, antidepressant sensitivity, anorexia, mood disorders
MeSH terms
Animals, Depressive Disorder, Disease Models, Animal, Drinking, Eating, Humans, Imipramine, Male, Motivation, Rats, Inbred Strains, Stress, Physiological, Rats

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