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Caffeine prevents d-galactose-induced cognitive deficits, oxidative stress, neuroinflammation and neurodegeneration in the adult rat brain
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“By reversing oxidative processes and reducing neuroinflammation, caffeine may indirectly inhibit ageing of the brain [95]”
From Health Benefits and Chemical Composition of Matcha Green Tea: A Review (2020) · cites this paper as [95]
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Cites
Memory deficits associated with senescence: A neurophysiological and behavioral study in the rat.
Barnes, C. A. (1979) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0077579 · Cited by 2,088
Apoptosis in neurodegenerative disorders
Mattson, M. P. (2000) · Nature Reviews Molecular Cell Biology · doi:10.1038/35040009 · Cited by 1,605
Fluoro-Jade B: a high affinity fluorescent marker for the localization of neuronal degeneration
Schmued, L. C., & Hopkins, K. J. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02513-0 · Cited by 1,218
Lyras, L., Cairns, N. J., Jenner, A., Jenner, P., & Halliwell, B. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.68052061.x · Cited by 531 · cited 2×
“Many studies have explained the role of oxidative stress in neuronal degeneration and have demonstrated that several mechanisms related to oxidative stress and free-radical reactions may play an important role in the pathogenesis of age related neurodegenerative disorders such as AD and PD (Smith et al., 1996; Lyras e…”
Advanced glycation endproducts and their receptor RAGE in Alzheimer's disease
Srikanth, V., Maczurek, A., Phan, T., Steele, M., Westcott, B., Juskiw, D., & Münch, G. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.04.016 · Cited by 524 · cited 1×
“AGE level increases with aging and pathologically has been implicated in various age-associated disorders such as atheriosclerosis, nephropathy, diabetes and AD (Bayens, 2001; Srikanth et al., 2009).”
The neuroprotective effects of caffeine: A prospective population study (the Three City Study)
Ritchie, K., Carrière, I., de Mendonça, A., Portet, F., Dartigues, J. F., Rouaud, O., Barberger-Gateau, P., & Ancelin, M. L. (2007) · Neurology · doi:10.1212/01.wnl.0000266670.35219.0c · Cited by 347
Caffeine as an Antioxidant: Inhibition of Lipid Peroxidation Induced by Reactive Oxygen Species
Devasagayam, T. P. A., Kamat, J. P., Mohan, H., & Kesavan, P. C. (1996) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(96)00040-5 · Cited by 331 · cited 1×
“It has been studied that caffeine prevents lipid peroxidation which inhibits the ROS-induced oxidative stress (Devasagayam et al., 1996).”
A focus on the synapse for neuroprotection in Alzheimer disease and other dementias
Coleman, P., Federoff, H., & Kurlan, R. (2004) · Neurology · doi:10.1212/01.wnl.0000140626.48118.0a · Cited by 314
van Gelder, B. M., Buijsse, B., Tijhuis, M., Kalmijn, S., Giampaoli, S., Nissinen, A., & Kromhout, D. (2007) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602495 · Cited by 228
Research works printed but not linked: 63
- Abreu, 2011, Chronic coffee and caffeine ingestion effects on the cognitive function and antioxidant system of rat brains, Pharmacol. Biochem. Behav., 99, 659, 10.1016/j.pbb.2011.06.010 · DOI
- Ali, 2015, Melatonin ameliorates amyloid beta-induced memory deficits, tau hyperphosphorylation and neurodegeneration via PI3/Akt/GSk3β pathway in the mouse hippocampus, J. Pineal Res., 10.1111/jpi.12238 · DOI · Paper page
- Ali, 2015, Melatonin attenuates D-galactose-induced memory impairment, neuroinflammation and neurodegeneration via RAGE/NF-KB/JNK signaling pathway in aging mouse model, J. Pineal Res., 58, 71, 10.1111/jpi.12194 · DOI · Paper page
- Alzoubi, 2013, Caffeine prevents cognitive impairment induced by chronic psychosocial stress and/or high fat–high carbohydrate diet, Behav. Brain Res., 237, 7, 10.1016/j.bbr.2012.09.018 · DOI
- Azad, 2010, Role of oxidative/nitrosative stress-mediated Bcl-2 regulation in apoptosis and malignant transformation, Ann. N. Y. Acad. Sci., 1203, 1, 10.1111/j.1749-6632.2010.05608.x · DOI
- Badshah, 2014, Apomorphine attenuates ethanol-induced neurodegeneration in the adult cortex, Neurochem. Int., 74, 8, 10.1016/j.neuint.2014.04.009 · DOI
- Badshah, 2015, Protective effects of anthocyanins against amyloid beta-induced neurotoxicity in vivo and in vitro, Neurochem. Int., 80, 51, 10.1016/j.neuint.2014.10.009 · DOI
- Barcelos, 2014, Caffeine supplementation modulates oxidative stress markers in the liver of trained rats, Life Sci., 96, 40, 10.1016/j.lfs.2013.12.002 · DOI
- Bayens, 2001, The role of AGEs in aging: causation or correlation, Exp. Gerontol., 36, 1527, 10.1016/S0531-5565(01)00138-3 · DOI · Paper page
- Bernardi, 2006, The mitochondrial permeability transition from in vitro artifact to disease target, FEBS J., 273, 2077, 10.1111/j.1742-4658.2006.05213.x · DOI · Paper page
- Bretteville, 2012, Hypothermia-induced hyperphosphorylation: a new model to study tau kinase inhibitors, Sci. Rep., 1038, 00480, 10.1038/srep00480 · DOI
- Bruunsgaard, 1999, A high plasma concentration of TNF-alpha is associated with dementia in centenarians, J. Gerontol. A Biol. Sci. Med. Sci., 54, 357, 10.1093/gerona/54.7.M357 · DOI · Paper page
- Cao, 2004, Distinct requirements for p38alpha and c-Jun N-terminal kinase stress-activated protein kinases in different forms of apoptotic neuronal death, J. Biol. Chem., 279, 35903, 10.1074/jbc.M402353200 · DOI
- Castegna, 2002, Proteomic identification of oxidatively modified proteins in Alzheimer's disease brain. Part I: creatine kinase BB, glutamine synthase, and ubiquitin carboxy-terminal hydrolase L-1, Free Radic. Biol. Med., 33, 562, 10.1016/S0891-5849(02)00914-0 · DOI · Paper page
- Costa, 2008, Caffeine improves adult mice performance in the object recognition task and increases BDNF and TrkB independent on phospho-CREB immunocontent in the hippocampus, Neurochem. Int., 53, 89, 10.1016/j.neuint.2008.06.006 · DOI
- Cui, 2006, Chronic systemic D-galactose exposure induces memory loss, neurodegeneration, and oxidative damage in mice: protective effects of R-alpha-lipoic acid, J. Neurosci. Res., 83, 1584, 10.1002/jnr.20845 · DOI · Paper page
- Finkel, 2000, Oxidants, oxidative stress and the biology of ageing, Nature, 408, 239, 10.1038/35041687 · DOI · Paper page
- Garcia, 1992, Prevention of programmed cell death of sympathetic neurons by the bcl-2 proto-oncogene, Science, 258, 302, 10.1126/science.1411528 · DOI · Paper page
- Gemma, 2010, Neuron-microglia dialogue and hippocampal neurogenesis in the aged brain, Aging Dis., 1, 232
- Haider, 2015, A high dose of short term exogenous d-galactose administration in young male rats produces symptoms simulating the natural aging process, Life Sci., 124, 110, 10.1016/j.lfs.2015.01.016 · DOI
- Hamilton, 2012, The effect of ageing on neurogenesis and oxidative stress in the APPswe/PS1deltaE9 mouse model of Alzheimer's disease, Brain Res., 1449, 83, 10.1016/j.brainres.2012.02.015 · DOI
- Harman, 1956, Aging: a theory based on free radical and radiation chemistry, J. Gerontol., 11, 298, 10.1093/geronj/11.3.298 · DOI · Paper page
- He, 2009, Neuroprotective effects of (-)-epigallocatechin-3-gallate on aging mice induced by D-galactose, Biol. Pharm. Bull., 32, 55, 10.1248/bpb.32.55 · DOI
- Hu, 2015, The positive effects of Ginsenoside Rg1 upon the hematopoietic microenvironment in a D-galactose-induced aged rat model, BMC Complement. Altern. Med., 15, 119, 10.1186/s12906-015-0642-3 · DOI
- Iida, 2002, Expression of 8-oxoguanine DNA gly-cosylase is reduced and associated with neurofibrillary tangles in Alzheimer's disease brain, Acta Neuropathol., 103, 20, 10.1007/s004010100418 · DOI
- Jeong, 2011, Ethanol extract of Scutellaria baicalensis Georgi prevents oxidative damage and neuroinflammation and memorial impairments in artificial senescence mice, J. Biomed. Sci., 18, 1423, 10.1186/1423-0127-18-14 · DOI
- Joshi, 2014, Silibinin ameliorates LPS-induced memory deficits in experimental animals, Neurobiol. Learn. Mem., 116, 117, 10.1016/j.nlm.2014.09.006 · DOI
- Kumar, 2010, Centella asiatica attenuates D-galactose induced cognitive impairment, oxidative and mitochondrial dysfunction in mice, Int. J. Alzheimers Dis., 347569
- Lan, 2012, Danggui-Shaoyao-San ameliorates cognition deficits and attenuates oxidative stress-related neuronal apoptosis in d-galactose-induced senescent mice, J. Ethnopharmacol, 141, 386, 10.1016/j.jep.2012.02.050 · DOI
- Leite, 2014, Caffeine and diphenyl diselenide improve long-term memory impaired in middle-aged rats, Exp. Gerontol., 53, 67, 10.1016/j.exger.2014.03.008 · DOI
- Li, 1997, Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade, Cell, 91, 479, 10.1016/S0092-8674(00)80434-1 · DOI · Paper page
- Liu, 2005, Role of JNK activation in apoptosis: a double-edged sword, Cell Res., 15, 36, 10.1038/sj.cr.7290262 · DOI · Paper page
- Lu, 2007, Ursolic acid ameliorates cognition deficits and attenuates oxidative damage in the brain of senescent mice induced by D-galactose, Biochem. Pharmacol., 74, 1078, 10.1016/j.bcp.2007.07.007 · DOI · Paper page
- Lu, 2010, Purple sweet Potato color alleviates D-galactose-induced brain aging in old mice by promoting survival of neurons via PI3K pathway and inhibiting cytochrome C-mediated apoptosis, Brain Pathol., 20, 598, 10.1111/j.1750-3639.2009.00339.x · DOI
- Lu, 2010, Ursolic acid attenuates D-Galactose-induced inflammatory response in mouse prefrontal cortex through inhibiting AGEs/RAGE/NF-kB pathway activation, Cereb. Cortex, 20, 2540, 10.1093/cercor/bhq002 · DOI
- Mandir, 2000, NMDA but not non- NMDA excitotoxicity is mediated by Poly (ADP-ribose) polymerase, J. Neurosci., 20, 8005, 10.1523/JNEUROSCI.20-21-08005.2000 · DOI
- Manning, 2003, Target JNK for therapeutic benefit: from Junk to gold?, Nat. Rev. Drug Discov., 2554
- Moy, 2013, Caffeine prevents weight gain and cognitive impairment caused by a high-fat diet while elevating hippocampal BDNF, Physiol. Behave., 109, 69, 10.1016/j.physbeh.2012.11.008 · DOI
- Olanow, 1993, A radical hypothesis for neurodegeneration, Trends Neurosci., 16, 439, 10.1016/0166-2236(93)90070-3 · DOI · Paper page
- Panchal, 2012, Caffeine attenuates metabolic syndrome in diet-induced obese rats, Nutrition, 28, 1055, 10.1016/j.nut.2012.02.013 · DOI
- Prasanthi, 2010, Caffeine protects against oxidative stress and Alzheimer's disease-like pathology in rabbit hippocampus induced by cholesterol-enriched diet, Free Radic. Biol. Med., 49, 1212, 10.1016/j.freeradbiomed.2010.07.007 · DOI
- Qian, 2008, Aqueous extract of the Chinese medicine, Danggui-Shaoyao-San, inhibits apoptosis in hydrogen peroxide induced PC12 cells by preventing cytochrome c release and inactivating of caspase cascade, Cell Biol. Int., 32, 304, 10.1016/j.cellbi.2007.10.004 · DOI
- Riedel, 1996, Cognition enhancers in age-related cognitive decline, Drugs Aging, 8, 245, 10.2165/00002512-199608040-00003 · DOI
- Rosenzweig, 2003, Impact of aging on hippocampal function: plasticity, network dynamics, and cognition, Prog. Neurobiol., 69, 143, 10.1016/S0301-0082(02)00126-0 · DOI · Paper page
- Rosso, 2008, Caffeine: neuroprotective functions in cognition and Alzheimer's disease, Am. J. Alzheimers Dis. Other Dement., 23, 417, 10.1177/1533317508320083 · DOI
- Sallaberry, 2013, Chronic caffeine prevents changes in inhibitory avoidance memory and hippocampal BDNF immunocontent in middle-aged rats, Neuropharmacology, 64, 153, 10.1016/j.neuropharm.2012.07.010 · DOI
- Sayre, 1997, 4-Hydroxynonenal-derived advanced lipid peroxidation end products are increased in Alzheimer's disease, J. Neurochem., 68, 2092, 10.1046/j.1471-4159.1997.68052092.x · DOI · Paper page
- Schon, 2003, Neuronal degeneration and mitochondrial dysfunction, J. Clin. Investig., 111, 303, 10.1172/JCI200317741 · DOI
- Shi, 1991, Antioxidant behaviour of caffeine: efficient scavenging of hydroxyl radicals, Food Chem. Toxicol., 29, 1, 10.1016/0278-6915(91)90056-D · DOI · Paper page
- Smith, 1996, Oxidative posttranslational modifications in Alzheimer disease. A possible pathogenic role in the formation of senile plaques and neurofibrillary tangles, Mol. Chem. Neuropathol., 28, 41, 10.1007/BF02815203 · DOI
- Souza, 2013, Antioxidant activity elicited by low dose of caffeine attenuates pentylenetetrazol-induced seizures and oxidative damage in rats, Neurochem. Int., 62, 821, 10.1016/j.neuint.2013.02.021 · DOI
- Thornberry, 1998, Caspases: enemies within, Science, 281, 1312, 10.1126/science.281.5381.1312 · DOI · Paper page
- Tian, 2005, Advanced glycation end product-induced aging of the retinal pigment epithelium and choroid: a comprehensive transcriptional response, Proc. Natl. Acad. Sci., 102, 11846, 10.1073/pnas.0504759102 · DOI
- Uddin, 2010, Toxic effects of d-galactose on thymus and spleen that resemble aging, J. Immunotoxicol., 7, 165, 10.3109/15476910903510806 · DOI
- Vander, 1999, Bcl-2 proteins: regulators of apoptosis or of mitochondrial homeostasis?, Nat. Cell Biol., 1, 209, 10.1038/70237 · DOI · Paper page
- Wang, 2015, Saponins from Panax japonicus attenuate D-galactose-induced cognitive impairment through its anti-oxidative and anti-apoptotic effects in rats, J. Pharm. Pharmacol., 10.1111/jphp.12413 · DOI
- Wei, 2005, Behavioral study of the D-galactose induced aging model in C57BL/6J mice, Behav. Brain Res., 157, 245, 10.1016/j.bbr.2004.07.003 · DOI · Paper page
- Wu, 2008, Purple sweet potato color repairs d-galactose-induced spatial learning and memory impairment by regulating the expression of synaptic proteins, Neurobiol. Learn. Mem., 90, 19, 10.1016/j.nlm.2008.01.010 · DOI
- Xian, 2014, Isorhynchophylline improves learning and memory impairments induced by D-galactose in mice, Neurochem. Int., 76, 42, 10.1016/j.neuint.2014.06.011 · DOI
- Zhang, 1994, Nitric oxide activation of poly (ADP-ribose) synthetase in neurotoxicity, Science, 263, 687, 10.1126/science.8080500 · DOI · Paper page
- Zhang, 2007, Catalpol ameliorates cognition deficits and attenuates oxidative damage in the brain of senescent mice induced by D-galactose, Pharmacol. Biochem. Behav., 88, 64, 10.1016/j.pbb.2007.07.004 · DOI
- Zhang, 2011, Chronic administration of Liu Wei Dihuang protects rat's brain against D-galactose-induced impairment of cholinergic system, Acta Physiol. Sin., 63, 245
- Zhu, 2014, Ginsenoside Rg1 prevents cognitive impairment and hippocampus senescence in a rat model of D-galactose-induced aging, PLoS One, 9, e101291, 10.1371/journal.pone.0101291 · DOI
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“As a result, neurodegeneration and brain aging were observed [23,37,38].”
Background
Metadata
- Authors
- Ullah, F., Ali, T., Ullah, N., & Kim, M. O.
- Venue
- Neurochemistry International
- Publisher
- Elsevier BV
- Published
- 2015-11
- Volume
- 90
- Pages
- 114-124
- ISSN
- 0197-0186
- Cited by
- 190
- References
- 9
- Language
- en
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- Funders
- Ministry of Science, ICT & Future Planning (2012-0009521)
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- Ullah, F., Ali, T., Ullah, N., & Kim, M. O. (2015). Caffeine prevents d-galactose-induced cognitive deficits, oxidative stress, neuroinflammation and neurodegeneration in the adult rat brain. Neurochemistry International. https://doi.org/10.1016/j.neuint.2015.07.001
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