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Involvement of Disabled-2 protein in the central nervous system inflammation following experimental cryoinjury of rat brains
Abstract
Disabled-2 (Dab-2) functions in the mitogenic signal transduction pathway, and is expressed in a variety of tissues. We investigated the roles of Dab-2 expression in the rat brain following experimental cryoinjury in relation to central nervous system (CNS) inflammation. Western blot analysis showed that Dab-2 expression increased significantly (p < 0.001) in the frontal cortex 4-14 days after cryoinjury, and declined slightly thereafter. Immunohistochemistry showed that Dab-2 immunostaining occurred in most of the vessels in the control cerebral cortex. After cryoinjury, Dab-2 was localized in the majority of inflammatory cells (especially in ED1-positive macrophages) in the core and periphery, as well as in vessels. These findings suggest that Dab-2 is involved in the inflammation that follows CNS injury through the migration of activated inflammatory cells in the rat brain.
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The lack of Dab2 protein expression in microglia persists throughout development (E12.5-14.5 onwards), in adult CNS microglia at rest, and even under traumatic injury.
“The lack of Dab2 protein expression in microglia (Iba1+/Dab2-) which persists throughout development (E12.5-14.5 onwards in this study), in adult CNS microglia at rest (this study), and even under traumatic injury [57]”
From Dynamic expression of Dab2 in the mouse embryonic central nervous system (2008) · cites this paper as [57]
In response to CNS injury, Dab2 expression is primarily located to macrophages accumulating at the site of injury, but absent from neurons, neuroglia and microglia.
“in response to CNS injury [57] where Dab2 expression is primarily located to macrophages accumulating at the site of injury, but absent from neurons, neuroglia and microglia.”
From Dynamic expression of Dab2 in the mouse embryonic central nervous system (2008) · cites this paper as [57]
These findings are consistent with the expression pattern of Dab2 observed in the adult nervous system (this study and [57]).
“These findings are consistent with its expression pattern observed in the adult nervous system (this study and [57])”
From Dynamic expression of Dab2 in the mouse embryonic central nervous system (2008) · cites this paper as [57]
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Research works printed but not linked: 15
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Cited by
Sorted by citations
Endocytosis and Physiology: Insights from Disabled-2 Deficient Mice
Tao, W., Moore, R., Smith, E. R., & Xu, X.-X. (2016) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2016.00129 · Cited by 43
Dynamic expression of Dab2 in the mouse embryonic central nervous system
Cheung, K.-K., Mok, S. C., Rezaie, P., & Chan, W. Y. (2008) · BMC Developmental Biology · doi:10.1186/1471-213x-8-76 · Cited by 23
Metadata
- Authors
- Moon, C., Lee, J., Ahn, M., & Shin, T.
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 2005-04
- Volume
- 378
- Issue
- 2
- Pages
- 88-91
- ISSN
- 0304-3940
- Cited by
- 14
- References
- 0
- Language
- en
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