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The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.

Disabled-2 is transcriptionally regulated by ICSBP and augments macrophage spreading and adhesion

Rosenbauer, Frank, Kallies, Axel, Scheller, Marina, Knobeloch, Klaus‐Peter, Rock, Charles O., Schwieger, Maike, Stocking, Carol, Horak, Ivan·2002·The EMBO Journal
DOI 10.1093/emboj/21.3.211
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Abstract

Mice lacking transcription factor interferon consensus sequence binding protein (ICSBP) develop a syndrome similar to human chronic myeloid leukemia and are immunodeficient. In order to define the molecular mechanisms responsible for the cellular defects of ICSBP(-/-) mice, we used bone marrow-derived macrophages (BMM) to identify genes deregulated in the absence of ICSBP. Here, we report that disabled-2 (Dab2), a signal phosphoprotein, is transcriptionally up-regulated and accumulates in the cytoskeleton/membrane fraction of ICSBP(-/-) BMM. Moreover, our results revealed Dab2 as a novel IFN-gamma-response gene. Both ICSBP and the Ets-transcription factor PU.1 bind to the Dab2 promoter, whereby ICSBP represses PU.1-induced Dab2 promoter transactivation in vitro. Notably, repression of Dab2 expression by ICSBP is also found in myeloid progenitors. Overexpression of Dab2 leads to accelerated cell adhesion and spreading, accompanied by enhanced actin fiber formation. Furthermore, cell adhesion induces transient Dab2 phosphorylation and its translocation to the cytoskeletal/membrane fraction. Our results identify a novel role of Dab2 as an inducer of cell adhesion and spreading, and strongly suggest that the up-regulation of Dab2 contributes to the hematopoietic defect seen in ICSBP(-/-) mice.

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Crossref · 10.1093/emboj/21.3.211

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7 of 7 references verified0 citation errors · 0 not checkable

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  • Studies of cultured cells suggested that Dab2 acts in macrophage spreading and adhesion.

    “Studies of cultured cells suggested that Dab2 acts in macrophage spreading and adhesion (Rosenbauer et al., 2002).”

    From Endocytosis and Physiology: Insights from Disabled-2 Deficient Mice (2016) · cites this paper as Rosenbauer et al., 2002

  • ICSBP represses the PU.1-induced transactivation, thereby suppressing Dab2 expression.

    “Significantly, ICSBP represses the PU.1-induced transactivation, thereby suppressing Dab2 expression.”

    From Dynamic expression of Dab2 in the mouse embryonic central nervous system (2008) · cites this paper as [52]

  • Both ICSBP and PU.1 bind to the Dab2 promoter; ICSBP represses Dab2 promoter transactivation while PU.1 induces it.

    “Both of these transcription factors bind to the Dab2 promoter, but whereas ICSBP represses Dab2 promoter transactivation, PU.1 induces it [52].”

    From Dynamic expression of Dab2 in the mouse embryonic central nervous system (2008) · cites this paper as [52]

  • ICSBP and PU.1 are haematopoietic-restricted transcription factors critical for the development of haematopoietic cells.

    “and the Ets transcription factor PU.1, are haematopoietic-restricted transcription factors critical for the development of haematopoietic cells [52].”

    From Dynamic expression of Dab2 in the mouse embryonic central nervous system (2008) · cites this paper as [52]

  • Cross-talk between PU.1 and ICSBP may be crucial in regulating genes related to myeloid cell differentiation and cell functions.

    “These data indicate that cross-talk between PU.1 and ICSBP may be crucial in regulating genes related to myeloid cell differentiation and cell functions.”

    From Dynamic expression of Dab2 in the mouse embryonic central nervous system (2008) · cites this paper as [52]

Citations

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Metadata

Authors
Rosenbauer, F., Kallies, A., Scheller, M., Knobeloch, K., Rock, C. O., Schwieger, M., Stocking, C., & Horak, I.
Venue
The EMBO Journal
Publisher
Springer Science and Business Media LLC
Published
2002-02-01
Volume
21
Issue
3
Pages
211-220
ISSN
  • 0261-4189
  • 1460-2075
DOI
10.1093/emboj/21.3.211
Cited by
59
References
7
Language
en
Licence

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