Von Economo neurons are present in the dorsolateral (dysgranular) prefrontal cortex of humans
Abstract
Von Economo neurons (VENs), also known as spindle cells, have been described in layer V of the anterior cingulate (BA 24) and frontoinsular cortex (FI) of humans and other great apes. In the present study we used immunohistochemistry against two specific neuronal markers (NeuN and MAP2) in order to establish the presence of these cell types in Brodmann area 9 (BA 9) of the human prefrontal cortex. We evaluated tissue samples of eight human postmortem brains (age range 26-50) from BAs 9, 24, 4, 46, 45, 10 and 17. We identified a group of cells with similar morphology to that previously described for VENs in all specimens of BA 9 examined, albeit less frequently than in BA 24. This is the first description of this cell type in a human brain area with well developed granular layers (BA 9).
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Von Economo neurons are consistently affected in ASD and are present almost exclusively in the frontoinsular and anterior cingulate cortices.
“a particular population of distinct neurons, the von Economo neurons (VENs), present almost exclusively in the frontoinsular (FI) and anterior cingulate cortices (ACC) have been found to be consistently affected in ASD [4, 104, 256, 258].”
From Autism spectrum disorder: neuropathology and animal models (2017) · cites this paper as [104]
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Self-citation
- Authors
- Fajardo, C., Escobar, M. I., Buriticá, E., Arteaga, G., Umbarila, J., Casanova, M. F., & Pimienta, H.
- Affiliations
- Universidad del Valle (CO)
- University of Louisville (US)
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 2008-04
- Volume
- 435
- Issue
- 3
- Pages
- 215-218
- ISSN
- 0304-3940 (ISSN-L)
- OpenAlex
- W1977735543
- Cited by
- 99
- References
- 22
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 4 · 2023: 7 · 2022: 6 · 2021: 3 · 2020: 3 · 2019: 6 · 2018: 5 · 2017: 7 · 2016: 5 · 2015: 7 · 2014: 7 · 2013: 5 · 2012: 9
- FWCI
- 3.45
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience Letters (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Universidad del Valle
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Social Sciences › Psychology › Social Psychology › Primate Behavior and Ecology
- Keywords
- von Economo neurons, spindle cells, dorsolateral prefrontal cortex, Brodmann area 9, human brain, granular layer, anterior cingulate cortex, frontoinsular cortex, NeuN, MAP2, postmortem brain
- MeSH terms
- Adult, Female, Humans, Male, Microtubule-Associated Proteins, Middle Aged, Neurons, Phosphopyruvate Hydratase, Prefrontal Cortex
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