Cited by 99Neural and Behavioral Psychology StudiesNeuroscience and Neuropharmacology ResearchPrimate Behavior and Ecology

Von Economo neurons are present in the dorsolateral (dysgranular) prefrontal cortex of humans

Fajardo, C., Escobar, M.I., Buriticá, E., Arteaga, G., Umbarila, J., Casanova, M.F., Pimienta, H.·2008·Neuroscience Letters

Abstract

Von Economo neurons (VENs), also known as spindle cells, have been described in layer V of the anterior cingulate (BA 24) and frontoinsular cortex (FI) of humans and other great apes. In the present study we used immunohistochemistry against two specific neuronal markers (NeuN and MAP2) in order to establish the presence of these cell types in Brodmann area 9 (BA 9) of the human prefrontal cortex. We evaluated tissue samples of eight human postmortem brains (age range 26-50) from BAs 9, 24, 4, 46, 45, 10 and 17. We identified a group of cells with similar morphology to that previously described for VENs in all specimens of BA 9 examined, albeit less frequently than in BA 24. This is the first description of this cell type in a human brain area with well developed granular layers (BA 9).

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Crossref · 10.1016/j.neulet.2008.02.048

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  • Von Economo neurons are consistently affected in ASD and are present almost exclusively in the frontoinsular and anterior cingulate cortices.

    “a particular population of distinct neurons, the von Economo neurons (VENs), present almost exclusively in the frontoinsular (FI) and anterior cingulate cortices (ACC) have been found to be consistently affected in ASD [4, 104, 256, 258].”

    From Autism spectrum disorder: neuropathology and animal models (2017) · cites this paper as [104]

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Authors
Fajardo, C., Escobar, M. I., Buriticá, E., Arteaga, G., Umbarila, J., Casanova, M. F., & Pimienta, H.
Affiliations
  • Universidad del Valle (CO)
  • University of Louisville (US)
Venue
Neuroscience Letters
Publisher
Elsevier BV
Published
2008-04
Volume
435
Issue
3
Pages
215-218
ISSN
0304-3940 (ISSN-L)
OpenAlex
W1977735543
Cited by
99
References
22
Citations by year
2026: 1 · 2025: 4 · 2024: 4 · 2023: 7 · 2022: 6 · 2021: 3 · 2020: 3 · 2019: 6 · 2018: 5 · 2017: 7 · 2016: 5 · 2015: 7 · 2014: 7 · 2013: 5 · 2012: 9
FWCI
3.45
Type
journal article
Language
en
Open access
closed
Locations
  • Neuroscience Letters (publishedVersion)
  • PubMed (publishedVersion)
Funders
Universidad del Valle
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Social Sciences › Psychology › Social Psychology › Primate Behavior and Ecology
Keywords
von Economo neurons, spindle cells, dorsolateral prefrontal cortex, Brodmann area 9, human brain, granular layer, anterior cingulate cortex, frontoinsular cortex, NeuN, MAP2, postmortem brain
MeSH terms
Adult, Female, Humans, Male, Microtubule-Associated Proteins, Middle Aged, Neurons, Phosphopyruvate Hydratase, Prefrontal Cortex

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