Cited by 16Attention Deficit Hyperactivity DisorderNeural dynamics and brain functionEEG and Brain-Computer Interfaces

Relationship between theta-phase gamma-amplitude coupling and attention-deficit/hyperactivity behavior in children

Kim, Jun Won, Lee, Jaewon, Kim, Hyun-Jin, Lee, Young Sik, Min, Kyung Joon·2015·Neuroscience Letters

Abstract

The Continuous Performance Test (CPT) is a valuable tool for assessing behavior in attention-deficit/hyperactivity disorder (ADHD). Quantitative electroencephalography (QEEG) is a promising tool for the diagnosis of ADHD. Recently, theta-phase gamma-amplitude coupling (TGC) measurement has received attention because it is a feasible method of assessing brain function. We investigated the relationship between CPT performance and EEG measures such as TGC and theta and gamma activity. EEGs were recorded from 68 volunteers from a camp for hyperactive children using a 19-electrode system. Their TGC, theta and 40 Hz gamma activity were estimated and compared with results obtained on the Korean ADHD Rating Scale (KARS) and the Intermediate Visual and Auditory (IVA) CPT. The results demonstrated significant negative partial correlations between TGC and the IVA CPT, such as the Response Control Quotient (RCQ) and Attention Quotient (AQ). TGC successfully identified the level of dysfunctional interaction of the attention/arousal system at a multi-scale large network level. It is thought that as the TGC increases, the efficacy of the system is very low or dysfunctional. Compensatory hyper-arousal patterns of the dysfunctional attention/arousal system may account for this effect. TGC is a promising neurophysiological marker for ADHD behavior in children.

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Crossref · 10.1016/j.neulet.2015.01.068

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Authors
Kim, J. W., Lee, J., Kim, H.-J., Lee, Y. S., & Min, K. J.
Affiliations
  • Seoul National University (KR)
  • Eulji University (KR)
  • Chung-Ang University (KR)
Corresponding author
Lee, Jaewon
Venue
Neuroscience Letters
Publisher
Elsevier BV
Published
2015-03
Volume
590
Pages
12-17
ISSN
0304-3940 (ISSN-L)
OpenAlex
W2009996119
Cited by
16
References
49
Citations by year
2025: 1 · 2024: 2 · 2022: 3 · 2021: 3 · 2020: 2 · 2019: 1 · 2017: 1 · 2016: 1 · 2015: 2
FWCI
1.08
Type
journal article
Language
en
Open access
closed
Locations
  • Neuroscience Letters (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Neuroscience › Cognitive Neuroscience › EEG and Brain-Computer Interfaces
Keywords
attention deficit hyperactivity disorder, hyperactivity in children, continuous performance test, quantitative EEG, theta activity, hyperarousal, neurophysiological markers
MeSH terms
Attention Deficit Disorder with Hyperactivity, Brain, Brain Mapping, Child, Female, Humans, Male, Theta Rhythm, Gamma Rhythm

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