Relationship between theta-phase gamma-amplitude coupling and attention-deficit/hyperactivity behavior in children
Abstract
The Continuous Performance Test (CPT) is a valuable tool for assessing behavior in attention-deficit/hyperactivity disorder (ADHD). Quantitative electroencephalography (QEEG) is a promising tool for the diagnosis of ADHD. Recently, theta-phase gamma-amplitude coupling (TGC) measurement has received attention because it is a feasible method of assessing brain function. We investigated the relationship between CPT performance and EEG measures such as TGC and theta and gamma activity. EEGs were recorded from 68 volunteers from a camp for hyperactive children using a 19-electrode system. Their TGC, theta and 40 Hz gamma activity were estimated and compared with results obtained on the Korean ADHD Rating Scale (KARS) and the Intermediate Visual and Auditory (IVA) CPT. The results demonstrated significant negative partial correlations between TGC and the IVA CPT, such as the Response Control Quotient (RCQ) and Attention Quotient (AQ). TGC successfully identified the level of dysfunctional interaction of the attention/arousal system at a multi-scale large network level. It is thought that as the TGC increases, the efficacy of the system is very low or dysfunctional. Compensatory hyper-arousal patterns of the dysfunctional attention/arousal system may account for this effect. TGC is a promising neurophysiological marker for ADHD behavior in children.
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Increased theta-gamma coupling has been associated with greater dysfunctional attention/arousal behaviors in ADHD children.
“Increased theta-gamma coupling has been associated with greater dysfunctional attention/arousal behaviors in ADHD children (59).”
From Perineuronal nets, inhibitory interneurons and anxiety-related ventral hippocampal neuronal oscillations are altered by early life adversity (2019) · cites this paper as [59]
Cites
Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing
Benjamini, Y., & Hochberg, Y. (1995) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1995.tb02031.x · Cited by 109,482 · see citing works
Delorme, A., & Makeig, S. (2004) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2003.10.009 · Cited by 24,371 · see citing works
A default mode of brain function
Raichle, M. E., MacLeod, A. M., Snyder, A. Z., Powers, W. J., Gusnard, D. A., & Shulman, G. L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.2.676 · Cited by 12,190 · see citing works
EEG alpha oscillations: The inhibition–timing hypothesis
Klimesch, W., Sauseng, P., & Hanslmayr, S. (2006) · Brain Research Reviews · doi:10.1016/j.brainresrev.2006.06.003 · Cited by 3,890 · see citing works
Kessler, R. C., Adler, L., Barkley, R., Biederman, J., Conners, C. K., Demler, O., Faraone, S. V., Greenhill, L. L., Howes, M. J., Secnik, K., et al. (2006) · American Journal of Psychiatry · doi:10.1176/ajp.2006.163.4.716 · Cited by 3,886 · see citing works
High Gamma Power Is Phase-Locked to Theta Oscillations in Human Neocortex
Canolty, R. T., Edwards, E., Dalal, S. S., Soltani, M., Nagarajan, S. S., Kirsch, H. E., Berger, M. S., Barbaro, N. M., & Knight, R. T. (2006) · Science · doi:10.1126/science.1128115 · Cited by 2,650 · see citing works
The functional role of cross-frequency coupling
Canolty, R. T., & Knight, R. T. (2010) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2010.09.001 · Cited by 2,101 · see citing works
Cross-frequency coupling between neuronal oscillations
Jensen, O., & Colgin, L. L. (2007) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2007.05.003 · Cited by 991 · see citing works
Cognitive functions of gamma-band activity: memory match and utilization
Herrmann, C. S., Munk, M. H. J., & Engel, A. K. (2004) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2004.06.006 · Cited by 755 · see citing works
Attention modulates synchronized neuronal firing in primate somatosensory cortex
Steinmetz, P. N., Roy, A., Fitzgerald, P. J., Hsiao, S. S., Johnson, K. O., & Niebur, E. (2000) · Nature · doi:10.1038/35004588 · Cited by 725 · see citing works
Dyslexia: a deficit in visuo-spatial attention, not in phonological processing
Vidyasagar, T. R., & Pammer, K. (2010) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2009.12.003 · Cited by 651 · see citing works
A Causal Link between Visual Spatial Attention and Reading Acquisition
Franceschini, S., Gori, S., Ruffino, M., Pedrolli, K., & Facoetti, A. (2012) · Current Biology · doi:10.1016/j.cub.2012.03.013 · Cited by 528 · see citing works
High-frequency gamma oscillations and human brain mapping with electrocorticography
Crone, N. E., Sinai, A., & Korzeniewska, A. (2006) · Progress in Brain Research · doi:10.1016/s0079-6123(06)59019-3 · Cited by 526 · see citing works
Relations Between Continuous Performance Test Performance Measures and ADHD Behaviors
Epstein, J. N., Erkanli, A., Conners, C. K., Klaric, J., Costello, J. E., & Angold, A. (2003) · Journal of Abnormal Child Psychology · doi:10.1023/a:1025405216339 · Cited by 520 · cited 1× · see citing works
“In the diagnosis of ADHD, the continuous performance task (CPT) has been recognized as a valuable tool that is capable of discriminating children with ADHD from normally developing peers [11,16,19,49].”
Neuropsychological Executive Functions and DSM-IV ADHD Subtypes
NIGG, J. T., BLASKEY, L. G., HUANG-POLLOCK, C. L., & RAPPLEY, M. D. (2002) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-200201000-00012 · Cited by 496 · see citing works
Daley, D., & Birchwood, J. (2010) · Child Care Health and Development · doi:10.1111/j.1365-2214.2009.01046.x · Cited by 490 · see citing works
Lee, K.-H., Williams, L. M., Breakspear, M. J., & Gordon, E. (2003) · Brain Research Reviews · doi:10.1016/s0165-0173(02)00220-5 · Cited by 479 · see citing works
The continuous performance test: a window on the neural substrates for attention?
Riccio, C. A., Reynolds, C. R., Lowe, P. A., & Moore, J. J. (2002) · Archives of Clinical Neuropsychology · doi:10.1093/arclin/17.3.235 · Cited by 446 · see citing works
Losier, B. J., McGrath, P. J., & Klein, R. M. (1996) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.1996.tb01494.x · Cited by 424 · see citing works
Corkum, P. V., & Siegel, L. S. (1993) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.1993.tb01784.x · Cited by 378 · see citing works
The Reliability and Validity of Korean Parent and Teacher ADHD Rating Scale
So, Y. K., Noh, J. S., Kim, Y. S., Ko, S. G., & Koh, Y. J. (2002) · Cited by 273 · see citing works
Anckarsäter, H., Stahlberg, O., Larson, T., Hakansson, C., Jutblad, S.-B., Niklasson, L., Nydén, A., Wentz, E., Westergren, S., Cloninger, C. R., et al. (2006) · American Journal of Psychiatry · doi:10.1176/appi.ajp.163.7.1239 · Cited by 271 · see citing works
Assessing transient cross-frequency coupling in EEG data
Cohen, M. X. (2008) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2007.10.012 · Cited by 262 · see citing works
Tonic, phasic, and transient EEG correlates of auditory awareness in drowsiness
Makeig, S., & Jung, T. (1996) · Cognitive Brain Research · doi:10.1016/0926-6410(95)00042-9 · Cited by 254 · see citing works
Top-down attentional processing enhances auditory evoked gamma band activity
Debener, S., Herrmann, C. S., Kranczioch, C., Gembris, D., & Engel, A. K. (2003) · Neuroreport · doi:10.1097/00001756-200304150-00005 · Cited by 212 · see citing works
Johnson, K. A., Robertson, I. H., Barry, E., Mulligan, A., Dáibhis, A., Daly, M., Watchorn, A., Gill, M., & Bellgrove, M. A. (2008) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2008.01936.x · Cited by 192 · see citing works
Ten years on: A follow-up review of ERP research in attention-deficit/hyperactivity disorder
Johnstone, S. J., Barry, R. J., & Clarke, A. R. (2012) · Clinical Neurophysiology · doi:10.1016/j.clinph.2012.09.006 · Cited by 184 · see citing works
The continuous performance test: a window on the neural substrates for attention?
Riccio, C. A. (2002) · Archives of Clinical Neuropsychology · doi:10.1016/s0887-6177(01)00111-1 · Cited by 178 · see citing works
"Gamma (40 Hz) phase synchronicity" and symptom dimensions in schizophrenia
Lee, K.-H., Williams, L. M., Haig, A. R., & Gordon, E. (2003) · Cognitive Neuropsychiatry · doi:10.1080/713752240 · Cited by 168 · see citing works
Chabot, R. J., Merkin, H., Wood, L. M., Davenport, T. L., & Serfontein, G. (1996) · Clinical Electroencephalography · doi:10.1177/155005949602700105 · Cited by 166 · see citing works
The Effects of QEEG-Informed Neurofeedback in ADHD: An Open-Label Pilot Study
Arns, M., Drinkenburg, W. H. I. M., & Kenemans, J. L. (2012) · Applied Psychophysiology and Biofeedback · doi:10.1007/s10484-012-9191-4 · Cited by 142 · see citing works
Yordanova, J., Banaschewski, T., Kolev, V., Woerner, W., & Rothenberger, A. (2001) · Clinical Neurophysiology · doi:10.1016/s1388-2457(01)00524-7 · Cited by 126 · see citing works
The Integrated Visual and Auditory Continuous Performance Test as a neuropsychological measure.
Tinius, T. P. (2003) · PubMed · Cited by 107 · see citing works
Atypical Frontal Brain Activation in ADHD: Preschool and Elementary School Boys and Girls
Baving, L., Laucht, M., & Schmidt, M. H. (1999) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199911000-00010 · Cited by 106 · see citing works
Gori, S., & Facoetti, A. (2013) · Vision Research · doi:10.1016/j.visres.2013.11.011 · Cited by 105 · see citing works
The Role of Frontal Dysfunction in Attention Deficit Hyperactivity Disorder
Benson, D. F. (1991) · Journal of Child Neurology · doi:10.1177/0883073891006001s02 · Cited by 101 · see citing works
Baeyens, D., Roeyers, H., & Walle, J. V. (2006) · Child Psychiatry & Human Development · doi:10.1007/s10578-006-0011-z · Cited by 101 · see citing works
Frontal lobe functioning in adolescents with attention deficit hyperactivity disorder.
Reeve, W. V., & Schandler, S. L. (2001) · PubMed · Cited by 69 · see citing works
Normative Data on the Korean ADHD Rating Scales(K-ARS) for Parents and Teacher
Kim, Y. S., So, Y. K., Noh, J. S., Choi, N. K., Kim, S. J., & Koh, Y. J. (2003) · Cited by 60 · see citing works
Theta–gamma coupling during a working memory task as compared to a simple vigilance task
Park, J. Y., Jhung, K., Lee, J., & An, S. K. (2012) · Neuroscience Letters · doi:10.1016/j.neulet.2012.10.061 · Cited by 52 · see citing works
Self-citationSpinelli, S., Vasa, R. A., Joel, S., Nelson, T. E., Pekar, J. J., & Mostofsky, S. H. (2010) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2010.02356.x · Cited by 47 · see citing works
Kim, J., Park, K.-H., Cheon, K.-A. A., Kim, B., Cho, S.-C., & Hong, K.-E. M. (2005) · The Canadian Journal of Psychiatry · doi:10.1177/070674370505001210 · Cited by 35 · see citing works
Self-citationThe Integrated Visual and Auditory Continuous Performance Test as a neuropsychological measure
Tinius, T. P. (2003) · Archives of Clinical Neuropsychology · doi:10.1016/s0887-6177(02)00144-0 · Cited by 34 · see citing works
Biological bases of ADHD--Neuroanatomy, genetics, and pathophysiology.
Swanson, J. M., & Castellanos, F. X. (2002) · Cited by 33 · see citing works
Integrated Visual and Auditory Continuous Performance Test
Sandford, J. A., & Turner, A. (1994) · PsycTESTS Dataset · doi:10.1037/t05189-000 · Cited by 33 · see citing works
The relationship between theta-gamma coupling and spatial memory ability in older adults
Park, J. Y., Lee, Y.-R., & Lee, J. (2011) · Neuroscience Letters · doi:10.1016/j.neulet.2011.04.056 · Cited by 28 · see citing works
Self-citationPaternal Autistic Traits are Predictive of Infants Visual Attention
Ronconi, L., Facoetti, A., Bulf, H., Franchin, L., Bettoni, R., & Valenza, E. (2013) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-013-2018-1 · Cited by 21 · see citing works
Natural rhythm: evidence for occult 40Hz gamma oscillation in resting motor cortex
Funk, A. P., & Epstein, C. M. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2004.08.066 · Cited by 19 · see citing works
Reiner, P. B. (2009) · Scientific American Mind · doi:10.1038/scientificamericanmind1109-64 · Cited by 3 · see citing works
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- Authors
- Kim, J. W., Lee, J., Kim, H.-J., Lee, Y. S., & Min, K. J.
- Affiliations
- Seoul National University (KR)
- Eulji University (KR)
- Chung-Ang University (KR)
- Corresponding author
- Lee, Jaewon
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 2015-03
- Volume
- 590
- Pages
- 12-17
- ISSN
- 0304-3940 (ISSN-L)
- OpenAlex
- W2009996119
- Cited by
- 16
- References
- 49
- Citations by year
- 2025: 1 · 2024: 2 · 2022: 3 · 2021: 3 · 2020: 2 · 2019: 1 · 2017: 1 · 2016: 1 · 2015: 2
- FWCI
- 1.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cognitive Neuroscience › EEG and Brain-Computer Interfaces
- Keywords
- attention deficit hyperactivity disorder, hyperactivity in children, continuous performance test, quantitative EEG, theta activity, hyperarousal, neurophysiological markers
- MeSH terms
- Attention Deficit Disorder with Hyperactivity, Brain, Brain Mapping, Child, Female, Humans, Male, Theta Rhythm, Gamma Rhythm
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