Cross-frequency coupling between neuronal oscillations
Abstract
Electrophysiological recordings in animals, including humans, are modulated by oscillatory activities in several frequency bands. Little is known about how oscillations in various frequency bands interact. Recent findings from the human neocortex show that the power of fast gamma oscillations (30-150Hz) is modulated by the phase of slower theta oscillations (5-8Hz). Given that this coupling reflects a specific interplay between large ensembles of neurons, it is likely to have profound implications for neuronal processing.
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Different EEG frequency components are often coupled, with the magnitude of one frequency related to the magnitude or phase of another.
“Different frequency components are often related to each other such that the magnitude of one frequency is coupled to the magnitude or phase of another frequency (169).”
From Electrophysiological source imaging: A noninvasive window to brain dynamics (2018) · cites this paper as [169]
Cross-frequency coupling exists, with the amplitude, frequency or phase of high-frequency oscillations being modulated by slower oscillatory processes.
“This possibility is supported by the growing evidence on the existence of cross-frequency coupling, the amplitude, frequency or phase of high-frequency oscillations being modulated by slower oscillatory processes (Canolty et al., 2006”
From Neuronal Dynamics and Neuropsychiatric Disorders: Toward a Translational Paradigm for Dysfunctional Large-Scale Networks (2012) · cites this paper as Jensen and Colgin, 2007
Cites
Neuronal Oscillations in Cortical Networks
Buzsáki, G., & Draguhn, A. (2004) · Science · doi:10.1126/science.1099745 · Cited by 6,576 · see citing works
High Gamma Power Is Phase-Locked to Theta Oscillations in Human Neocortex
Canolty, R. T., Edwards, E., Dalal, S. S., Soltani, M., Nagarajan, S. S., Kirsch, H. E., Berger, M. S., Barbaro, N. M., & Knight, R. T. (2006) · Science · doi:10.1126/science.1128115 · Cited by 2,650 · see citing works
Phase relationship between hippocampal place units and the EEG theta rhythm
O'Keefe, J. M., & Recce, M. L. (1993) · Hippocampus · doi:10.1002/hipo.450030307 · Cited by 2,561 · see citing works
von Stein, A., & Sarnthein, J. (2000) · International Journal of Psychophysiology · doi:10.1016/s0167-8760(00)00172-0 · Cited by 1,553 · see citing works
Gamma (40-100 Hz) oscillation in the hippocampus of the behaving rat
Bragin, A., Jando, G., Nadasdy, Z., Hetke, J., Wise, K., & Buzsaki, G. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-01-00047.1995 · Cited by 1,527 · see citing works
Storage of 7 +/- 2 short-term memories in oscillatory subcycles
Lisman, J. E., & Idiart, M. A. P. (1995) · Science · doi:10.1126/science.7878473 · Cited by 1,471 · see citing works
Lakatos, P., Shah, A. S., Knuth, K. H., Ulbert, I., Karmos, G., & Schroeder, C. E. (2005) · Journal of Neurophysiology · doi:10.1152/jn.00263.2005 · Cited by 1,241 · see citing works
Phase Synchrony among Neuronal Oscillations in the Human Cortex
Palva, J. M., Palva, S., & Kaila, K. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.4250-04.2005 · Cited by 663 · see citing works
Soltész, I., & Deschênes, M. (1993) · Journal of Neurophysiology · doi:10.1152/jn.1993.70.1.97 · Cited by 410 · see citing works
Mormann, F., Fell, J., Axmacher, N., Weber, B., Lehnertz, K., Elger, C. E., & Fernández, G. (2005) · Hippocampus · doi:10.1002/hipo.20117 · Cited by 403 · see citing works
Jensen, O., & Lisman, J. E. (1996) · Learning & Memory · doi:10.1101/lm.3.2-3.279 · Cited by 383 · see citing works
Self-citationPhase-coupling of theta–gamma EEG rhythms during short-term memory processing
Schack, B., Vath, N., Petsche, H., Geissler, H.-G., & Möller, E. (2002) · International Journal of Psychophysiology · doi:10.1016/s0167-8760(01)00199-4 · Cited by 281 · see citing works
Bruns, A., & Eckhorn, R. (2003) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2003.07.001 · Cited by 225 · see citing works
White, J. A., Banks, M. I., Pearce, R. A., & Kopell, N. J. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.100124097 · Cited by 207 · see citing works
Maintenance of multiple working memory items by temporal segmentation
Jensen, O. B. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.06.004 · Cited by 98 · see citing works
Self-citationHippocampal Formation of Brain as Detector-Coder of Temporal Patterns of Information
McLardy, T. (1959) · Perspectives in biology and medicine · doi:10.1353/pbm.1959.0018 · Cited by 34 · see citing works
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Jensen, O., & Mazaheri, A. (2010) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2010.00186 · Cited by 3,237 · see citing works
Self-citationDynamic functional connectivity: Promise, issues, and interpretations
Hutchison, R. M., Womelsdorf, T., Allen, E. A., Bandettini, P. A., Calhoun, V. D., Corbetta, M., Della Penna, S., Duyn, J. H., Glover, G. H., Gonzalez-Castillo, J., et al. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2013.05.079 · Cited by 2,962 · see citing works
The role of phase synchronization in memory processes
Fell, J., & Axmacher, N. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn2979 · Cited by 1,620 · see citing works
Spectral fingerprints of large-scale neuronal interactions
Siegel, M., Donner, T. H., & Engel, A. K. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3137 · Cited by 1,295 · see citing works
Carhart-Harris, R. L., Leech, R., Hellyer, P. J., Shanahan, M., Feilding, A., Tagliazucchi, E., Chialvo, D. R., & Nutt, D. (2014) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2014.00020 · Cited by 1,252 · see citing works
Different Origins of Gamma Rhythm and High-Gamma Activity in Macaque Visual Cortex
Ray, S., & Maunsell, J. H. R. (2011) · PLoS Biology · doi:10.1371/journal.pbio.1000610 · Cited by 1,012 · see citing works
The pulvinar regulates information transmission between cortical areas based on attention demands
Saalmann, Y. B., Pinsk, M. A., Wang, L., Li, X., & Kastner, S. (2012) · Science · doi:10.1126/science.1223082 · Cited by 1,016 · see citing works
The Temporal Structures and Functional Significance of Scale-free Brain Activity
He, B. J., Zempel, J. M., Snyder, A. Z., & Raichle, M. E. (2010) · Neuron · doi:10.1016/j.neuron.2010.04.020 · Cited by 990 · see citing works
Investigating the electrophysiological basis of resting state networks using magnetoencephalography
Brookes, M. J., Woolrich, M., Luckhoo, H., Price, D., Hale, J. R., Stephenson, M. C., Barnes, G. R., Smith, S. M., & Morris, P. G. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1112685108 · Cited by 938 · see citing works
Network abnormalities and interneuron dysfunction in Alzheimer disease
Palop, J. J., & Mucke, L. (2016) · Nature reviews. Neuroscience · doi:10.1038/nrn.2016.141 · Cited by 1,022 · see citing works
Theta-gamma coupling increases during the learning of item-context associations
Tort, A. B. L., Komorowski, R. W., Manns, J. R., Kopell, N. J., & Eichenbaum, H. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911331106 · Cited by 919 · see citing works
EEG and MEG: Relevance to Neuroscience
Lopes da Silva, F. (2013) · Neuron · doi:10.1016/j.neuron.2013.10.017 · Cited by 900 · see citing works
Cross-Frequency Phase–Phase Coupling between Theta and Gamma Oscillations in the Hippocampus
Belluscio, M. A., Mizuseki, K., Schmidt, R., Kempter, R., & Buzsáki, G. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.4122-11.2012 · Cited by 784 · see citing works
Nasal Respiration Entrains Human Limbic Oscillations and Modulates Cognitive Function
Zelano, C., Jiang, H., Zhou, G., Arora, N., Schuele, S., Rosenow, J., & Gottfried, J. A. (2016) · The Journal of Neuroscience · doi:10.1523/jneurosci.2586-16.2016 · Cited by 599 · see citing works
Speech rhythms and multiplexed oscillatory sensory coding in the human brain
Gross, J., Hoogenboom, N., Thut, G., Schyns, P., Panzeri, S., Belin, P., & Garrod, S. (2013) · PLoS Biology · doi:10.1371/journal.pbio.1001752 · Cited by 643 · see citing works
Uhlhaas, P. J., Haenschel, C., Nikolic, D., & Singer, W. (2008) · Schizophrenia Bulletin · doi:10.1093/schbul/sbn062 · Cited by 629 · see citing works
Mechanisms and functions of theta rhythms
Colgin, L. L. (2013) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-062012-170330 · Cited by 559 · see citing works
Self-citationBuzsáki, G., & Watson, B. O. (2012) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2012.14.4/gbuzsaki · Cited by 579 · see citing works
A New Unifying Account of the Roles of Neuronal Entrainment
Lakatos, P., Gross, J., & Thut, G. (2019) · Current Biology · doi:10.1016/j.cub.2019.07.075 · Cited by 508 · see citing works
EEG oscillations: from correlation to causality
Herrmann, C. S., Strüber, D., Helfrich, R. F., & Engel, A. K. (2016) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2015.02.003 · Cited by 527 · see citing works
Uhlhaas, P. J., & Singer, W. (2012) · Neuron · doi:10.1016/j.neuron.2012.09.004 · Cited by 512 · see citing works
Theta power as a marker for cognitive interference
Nigbur, R., Ivanova, G., & Stürmer, B. (2011) · Clinical Neurophysiology · doi:10.1016/j.clinph.2011.03.030 · Cited by 482 · see citing works
Human hippocampal theta oscillations and the formation of episodic memories
Lega, B. C., Jacobs, J., & Kahana, M. (2012) · Hippocampus · doi:10.1002/hipo.20937 · Cited by 485 · see citing works
Intrinsic Coupling Modes: Multiscale Interactions in Ongoing Brain Activity
Engel, A. K., Gerloff, C., Hilgetag, C. C., & Nolte, G. (2013) · Neuron · doi:10.1016/j.neuron.2013.09.038 · Cited by 471 · see citing works
Wulff, P., Ponomarenko, A. A., Bartos, M., Korotkova, T. M., Fuchs, E. C., Bähner, F., Both, M., Tort, A. B. L., Kopell, N. J., Wisden, W., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0813176106 · Cited by 400 · see citing works
Burnett, S., Sebastian, C., Cohen Kadosh, K., & Blakemore, S.-J. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.10.011 · Cited by 391 · see citing works
Role of myelin plasticity in oscillations and synchrony of neuronal activity
Pajevic, S., Basser, P. J., & Fields, R. D. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2013.11.007 · Cited by 378 · see citing works
Oscillatory multiplexing of population codes for selective communication in the mammalian brain
Akam, T., & Kullmann, D. M. (2014) · Nature Reviews Neuroscience · doi:10.1038/nrn3668 · Cited by 327 · see citing works
A Dynamic Interplay within the Frontoparietal Network Underlies Rhythmic Spatial Attention
Fiebelkorn, I. C., Pinsk, M. A., & Kastner, S. (2018) · Neuron · doi:10.1016/j.neuron.2018.07.038 · Cited by 356 · see citing works
Oscillations and hippocampal-prefrontal synchrony
Colgin, L. L. (2011) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2011.04.006 · Cited by 299 · see citing works
Self-citationElectrophysiological source imaging: A noninvasive window to brain dynamics
He, B., Sohrabpour, A., Brown, E., & Liu, Z. (2018) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-062117-120853 · Cited by 297 · see citing works
Fast and Slow Oscillations in Human Primary Motor Cortex Predict Oncoming Behaviorally Relevant Cues
Saleh, M., Reimer, J., Penn, R., Ojakangas, C. L., & Hatsopoulos, N. G. (2010) · Neuron · doi:10.1016/j.neuron.2010.02.001 · Cited by 281 · see citing works
Assessing transient cross-frequency coupling in EEG data
Cohen, M. X. (2008) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2007.10.012 · Cited by 262 · see citing works
Oscillations and Filtering Networks Support Flexible Routing of Information
Akam, T., & Kullmann, D. M. (2010) · Neuron · doi:10.1016/j.neuron.2010.06.019 · Cited by 245 · see citing works
Theta dynamics reveal domain-specific control over stimulus and response conflict
Nigbur, R., Cohen, M. X., Ridderinkhof, K. R., & Stürmer, B. (2012) · Journal of Cognitive Neuroscience · doi:10.1162/jocn_a_00128 · Cited by 242 · see citing works
Left auditory cortex gamma synchronization and auditory hallucination symptoms in schizophrenia
Spencer, K. M., Niznikiewicz, M. A., Nestor, P. G., Shenton, M. E., & McCarley, R. W. (2009) · BMC Neuroscience · doi:10.1186/1471-2202-10-85 · Cited by 253 · see citing works
Friese, U., Köster, M., Hassler, U., Martens, U., Trujillo-Barreto, N., & Gruber, T. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2012.11.002 · Cited by 233 · see citing works
Uhlhaas, P. J., & Singer, W. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.11.019 · Cited by 243 · see citing works
Sharp edge artifacts and spurious coupling in EEG frequency comodulation measures
Kramer, M. A., Tort, A. B. L., & Kopell, N. J. (2008) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2008.01.020 · Cited by 195 · see citing works
Axmacher, N., Schmitz, D. P., Wagner, T., Elger, C. E., & Fell, J. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.1778-08.2008 · Cited by 204 · see citing works
Bezaire, M. J., Raikov, I., Burk, K., Vyas, D., & Soltesz, I. (2016) · eLife · doi:10.7554/elife.18566 · Cited by 198 · see citing works
Wang, J., Ethridge, L. E., Mosconi, M. W., White, S. P., Binder, D. K., Pedapati, E. V., Erickson, C. A., Byerly, M. J., & Sweeney, J. A. (2017) · Journal of Neurodevelopmental Disorders · doi:10.1186/s11689-017-9191-z · Cited by 176 · see citing works
Marshall, L., Kirov, R., Brade, J., Mölle, M., & Born, J. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016905 · Cited by 188 · see citing works
Florin, E., & Baillet, S. (2015) · NeuroImage · doi:10.1016/j.neuroimage.2015.01.054 · Cited by 184 · see citing works
Wang, L., Saalmann, Y. B., Pinsk, M. A., Arcaro, M. J., & Kastner, S. (2012) · Neuron · doi:10.1016/j.neuron.2012.09.033 · Cited by 158 · see citing works
Forward and backward connections in the brain: a DCM study of functional asymmetries
Chen, C. C., Henson, R. N., Stephan, K. E., Kilner, J. M., & Friston, K. J. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2008.12.041 · Cited by 109 · see citing works
Beta- and gamma-band activity reflect predictive coding in the processing of causal events
van Pelt, S., Heil, L., Kwisthout, J., Ondobaka, S., van Rooij, I., & Bekkering, H. (2016) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsw017 · Cited by 98 · see citing works
Classification of three anesthesia stages based on near-infrared spectroscopy signals
Liu, Z., Si, L., Shi, S., Li, J., Zhu, J., Lee, W. H., Lo, S.-L., Yan, X., Chen, B., Fu, F., et al. (2024) · IEEE Journal of Biomedical and Health Informatics · doi:10.1109/jbhi.2024.3409163 · Cited by 71 · see citing works
Wischnewski, M., Zerr, P., & Schutter, D. J. L. G. (2016) · Brain Stimulation · doi:10.1016/j.brs.2016.04.011 · Cited by 62 · see citing works
Sun, S., Yu, H., Yu, R., & Wang, S. (2023) · Translational Psychiatry · doi:10.1038/s41398-023-02625-w · Cited by 69 · see citing works
“A future study is needed to directly measure functional connectivity in these patients when they perform the same task.”
Herman, P. A., Lundqvist, M., & Lansner, A. (2013) · Brain Research · doi:10.1016/j.brainres.2013.08.002 · Cited by 47 · see citing works
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Jiang, H., He, B., Guo, X., Wang, X., Guo, M., Wang, Z., Xue, T., Li, H., Xu, T., Ye, S., et al. (2019) · Cerebral Cortex · doi:10.1093/cercor/bhz095 · Cited by 40 · see citing works
Jabbi, M., Kohn, P. D., Nash, T., Ianni, A., Coutlee, C., Holroyd, T., Carver, F. W., Chen, Q., Cropp, B., Kippenhan, J. S., et al. (2015) · Cerebral Cortex · doi:10.1093/cercor/bht427 · Cited by 39 · see citing works
Stamoulis, C., Vanderwert, R. E., Zeanah, C. H., Fox, N. A., & Nelson, C. A. (2015) · Journal of Cognitive Neuroscience · doi:10.1162/jocn_a_00877 · Cited by 39 · see citing works
Cohen, M. X., David, N., Vogeley, K., & Elger, C. E. (2009) · Psychophysiology · doi:10.1111/j.1469-8986.2008.00724.x · Cited by 31 · see citing works
Luo, Q., Cheng, X., Holroyd, T., Xu, D., Carver, F., & Blair, R. J. (2014) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2013.00940 · Cited by 31 · see citing works
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Winterer, G., & McCarley, R. W. (2010) · Schizophrenia · doi:10.1002/9781444327298.ch15 · Cited by 23 · see citing works
Kim, J. W., Lee, J., Kim, H.-J., Lee, Y. S., & Min, K. J. (2015) · Neuroscience Letters · doi:10.1016/j.neulet.2015.01.068 · Cited by 16 · see citing works
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Dash, M. B., Ajayi, S., Folsom, L., Gold, P. E., & Korol, D. L. (2018) · eneuro · doi:10.1523/eneuro.0403-17.2017 · Cited by 14 · see citing works
- Authors
- Jensen, O., & Colgin, L. L.
- Affiliations
- Donders Centre for Cognitive Neuroimaging (NL)
- Norwegian University of Science and Technology (NO)
- Corresponding author
- Jensen, Ole
- Venue
- Trends in Cognitive Sciences
- Publisher
- Elsevier BV
- Published
- 2007-07
- Volume
- 11
- Issue
- 7
- Pages
- 267-269
- ISSN
- 1364-6613 (ISSN-L)
- OpenAlex
- W1982695759
- Cited by
- 991
- References
- 17
- Citations by year
- 2026: 48 · 2025: 55 · 2024: 46 · 2023: 54 · 2022: 81 · 2021: 79 · 2020: 59 · 2019: 78 · 2018: 60 · 2017: 53 · 2016: 63 · 2015: 56 · 2014: 48 · 2013: 60 · 2012: 39
- FWCI
- 12.99
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Cognitive Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- cross-frequency coupling, neural oscillations, gamma oscillations, theta oscillations, phase modulation, neocortex, neuronal ensembles
- MeSH terms
- Animals, Biological Clocks, Cell Communication, Cortical Synchronization, Electroencephalography, Hippocampus, Humans, Mental Processes, Nerve Net, Synaptic Transmission, Neurons, Theta Rhythm, Neocortex, Rats
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