Mismatch negativity as a potential neurobiological marker of early-stage Alzheimer disease and vascular dementia
Abstract
Alzheimer's disease (AD) and vascular dementia (VD) are serious, irreversible forms of cognitive impairment, which means that an early diagnosis is essential to slow down their progression. One potential neurophysiological biomarker of these diseases is the mismatch negativity (MMN) event-related potentials (ERP) component, which reflects an automatic detection mechanism at the pre-attentive stages of information processing. We evaluated the auditory MMN response in individuals from two patient groups: those in the prodromal stages of AD (P-AD) and those in the prodromal stages of VD (P-VD). Thirty patients (15 P-AD patients and 15 P-VD patients) and 30 age-matched controls were recruited to undergo electrophysiological recordings during the presentation of an auditory deviant-standard-reverse oddball paradigm that was used to elicit genuine MMN responses. We show that over the frontal-central area, the mean amplitude of the MMN was significantly reduced in both the P-AD (p=0.017) and P-VD groups (p=0.013) compared with controls. The MMN peak latency in P-VD patients was significantly shorter than in controls (p=0.027). No MMN response differences between the P-AD and P-VD were found in either the frontal-central or the temporal areas. These results indicate that P-AD and P-VD patients exhibit impaired pre-attentive information processing mechanisms as revealed by the frontal-central area MMN response, which is associated with sensory memory and cognitive deficits.
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Abnormal MMN in patients with neurocognitive disorders (Alzheimer's disease and vascular dementia) may be predictive of the course of the disorder itself.
“abnormal MMN in patients with neurocognitive disorders (i.e., Alzheimer ' s disease and vascular dementia) may be predictive of the course of the disorder itself (Jiang et al., 2017)”
From Predictive coding in neuropsychiatric disorders: a systematic transdiagnostic review. (2025) · cites this paper as Jiang et al., 2017
Previous mismatch negativity studies have shown differences between people with AD and controls.
“Previous mismatch negativity studies have shown differences between people with AD and controls. 34 , 35”
From Alzheimer's disease and its progression reduce pyramidal cell gain and connectivity (2025) · cites this paper as [35]
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Predictive coding in neuropsychiatric disorders: a systematic transdiagnostic review.
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“The literature also suggests that abnormal MMN in patients with neurocognitive disorders (i.e., Alzheimer ’ s disease and vascular dementia) may be predictive of the course of the disorder itself (Jiang et al., 2017), and thus may be used for preventive intervention.”
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Alzheimer's disease and its progression reduce pyramidal cell gain and connectivity
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“34,35 Although the mismatch response does not directly probe episodic memory, it is correlated with episodic memory in people at risk of AD 36,37 and is reduced by fibrillary A β in preclinical models.”
- Authors
- Jiang, S., Yan, C., Qiao, Z., Yao, H., Jiang, S., Qiu, X., Yang, X., Fang, D., Yang, Y., Zhang, L., Wang, L., & Zhang, L.
- Affiliations
- Harbin Medical University (CN)
- Second Affiliated Hospital of Harbin Medical University (CN)
- Northwestern University (US)
- Corresponding author
- Yang, Yanjie
- Zhang, Limei
- Wang, Lina
- Zhang, Liming
- ORCID
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 2017-04
- Volume
- 647
- Pages
- 26-31
- ISSN
- 0304-3940 (ISSN-L)
- OpenAlex
- W2603668426
- Cited by
- 37
- References
- 42
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 3 · 2023: 4 · 2022: 9 · 2021: 8 · 2020: 1 · 2018: 3
- FWCI
- 0.90
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience Letters (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (31271093)
- Postdoctoral foundation of Heilongjiang Province (LBH-Z16102)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neurobiology of Language and Bilingualism
- Life Sciences › Neuroscience › Cognitive Neuroscience › Hearing Loss and Rehabilitation
- Keywords
- mismatch negativity, Alzheimer's disease, vascular dementia, prodromal Alzheimer's disease, early diagnosis, neurobiological biomarkers, auditory oddball paradigm, MMN amplitude, MMN latency, sensory memory
- MeSH terms
- Aged, Alzheimer Disease, Electroencephalography, Evoked Potentials, Humans, Magnetic Resonance Imaging, Middle Aged, Dementia, Vascular, Case-Control Studies
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