Destruction of ERP responses to deviance in an auditory oddball paradigm in amyloid infusion mice with memory deficits
Open accessAbstract
The amyloid-β (Aβ) oligomer is considered one of the major pathogens responsible for neuronal and synaptic loss in Alzheimer's disease (AD) brains. Although the neurotoxic mechanisms of Aβ have been widely investigated, experimental evidence for the direct linkage between neural signaling and cognitive impairments in association with peptide oligomers is lacking. Here, we conducted an auditory oddball paradigm utilizing an Aβ-infused Alzheimer's disease mouse model and interpreted the results based on Y-maze behavioral tests. We acutely injected Aβ oligomers into the intracerebroventricular brain region of normal mice to induce Aβ-associated cognitive impairments. During the auditory oddball paradigm, electroencephalograms (EEG) were recorded from frontal and parietal cortex of Aβ-infused and control mice. The event-related potentials (ERPs) elicited by auditory stimuli showed no significant difference in Aβ-infused mice compared to control mice. On the other hand, the differential ERP signature elicited by oddball sound stimuli was destructed in the Aβ-infused mice group. We noticed that ERP traces to standard and deviant tones were not significantly different in the Aβ group, while the control group showed differences in the amplitude of ERP components. In particular, the difference in the first negative component (N1) between standard and deviant tone, which indexes the sensory memory system, was significantly reduced in the parietal cortex of Aβ-infused mice. These findings demonstrate the direct influence of Aβ oligomers on the functional integrity of cortical areas in vivo. Furthermore, the N1 amplitude difference may provide a potential marker of sensory memory deficits in a mouse model of AD and yield additional targets for drug assessment in AD.
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The mismatch response is reduced by fibrillary Aβ in preclinical models.
“and is reduced by fibrillary Aβ in preclinical models. 38”
From Alzheimer's disease and its progression reduce pyramidal cell gain and connectivity (2025) · cites this paper as [38]
The Results (Peak amplitude of early components and MMN-like activity; page unavailable) report a significantly reduced MMN-like N1 difference in the parietal cortex of Aβ-infused mice. But the Discussion identifies the infused Aβ as soluble oligomeric, not fibrillary, so the claim names the wrong form of Aβ. (LLM, conf=0.90)
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Cites
Buzsáki, G. (2006) · doi:10.1093/acprof:oso/9780195301069.001.0001 · Cited by 4,873 · see citing works
Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid β-peptide
Haass, C., & Selkoe, D. J. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2101 · Cited by 4,744 · see citing works
A theory of cortical responses.
Friston, K. (2005) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2005.1622 · Cited by 4,578 · see citing works
Walsh, D. M., Klyubin, I., Fadeeva, J. V., Cullen, W. K., Anwyl, R., Wolfe, M. S., Rowan, M. J., & Selkoe, D. J. (2002) · Nature · doi:10.1038/416535a · Cited by 4,291 · see citing works
Näätänen, R., & Picton, T. (1987) · Psychophysiology · doi:10.1111/j.1469-8986.1987.tb00311.x · Cited by 3,321 · see citing works
The mismatch negativity (MMN) in basic research of central auditory processing: A review
Näätänen, R., Paavilainen, P., Rinne, T., & Alho, K. (2007) · Clinical Neurophysiology · doi:10.1016/j.clinph.2007.04.026 · Cited by 2,644 · see citing works
The Oxford Handbook of Event-Related Potential Components
(2011) · doi:10.1093/oxfordhb/9780195374148.001.0001 · Cited by 2,263 · see citing works
Karran, E., Mercken, M., & Strooper, B. D. (2011) · Nature Reviews Drug Discovery · doi:10.1038/nrd3505 · Cited by 2,188 · cited 1× · see citing works
“are released in the extracellular regions and begin to misfold into soluble oligomers and insoluble plaques [1].”
BackgroundAmyloid-β–induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks
Palop, J. J., & Mucke, L. (2010) · Nature Neuroscience · doi:10.1038/nn.2583 · Cited by 1,651 · see citing works
AMPAR Removal Underlies Aβ-Induced Synaptic Depression and Dendritic Spine Loss
Hsieh, H., Boehm, J., Sato, C., Iwatsubo, T., Tomita, T., Sisodia, S., & Malinow, R. (2006) · Neuron · doi:10.1016/j.neuron.2006.10.035 · Cited by 1,042 · see citing works
Jin, M., Shepardson, N., Yang, T., Chen, G., Walsh, D., & Selkoe, D. J. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1017033108 · Cited by 876 · see citing works
Soto, C. A., Sigurdsson, E. M., Morelli, L., Kumar, R., Castaño, E. M., & Frangione, B. (1998) · Nature Medicine · doi:10.1038/nm0798-822 · Cited by 874 · see citing works
‘Primitive intelligence’ in the auditory cortex
Näätänen, R., Tervaniemi, M. H., Sussman, E. S., Paavilainen, P., & Winkler, I. (2001) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01790-2 · Cited by 832 · see citing works
Memory‐based or afferent processes in mismatch negativity (MMN): A review of the evidence
Näätänen, R., Jacobsen, T., & Winkler, I. (2005) · Psychophysiology · doi:10.1111/j.1469-8986.2005.00256.x · Cited by 629 · see citing works
Ketamine-Induced Deficits in Auditory and Visual Context-Dependent Processing in Healthy Volunteers
Umbricht, D., Schmid, L., Koller, R., Vollenweider, F. X., Hell, D., & Javitt, D. C. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.12.1139 · Cited by 583 · see citing works
Mismatch negativity (MMN), the deviance-elicited auditory deflection, explained
May, P. J. C., & Tiitinen, H. (2010) · Psychophysiology · doi:10.1111/j.1469-8986.2009.00856.x · Cited by 549 · see citing works
An in vivo model for the neurodegenerative effects of beta amyloid and protection by substance P.
Kowall, N. W., Beal, M. F., Busciglio, J. A., Duffy, L. K., & Yankner, B. A. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.16.7247 · Cited by 525 · see citing works
MPTP Mouse Models of Parkinson’s Disease: An Update
Meredith, G. E., & Rademacher, D. J. (2011) · Journal of Parkinson's Disease · doi:10.3233/jpd-2011-11023 · Cited by 471 · see citing works
Näätänen, R., Kujala, T., Escera, C., Baldeweg, T., Kreegipuu, K., Carlson, S., & Ponton, C. W. (2011) · Clinical Neurophysiology · doi:10.1016/j.clinph.2011.09.020 · Cited by 426 · see citing works
Sensory Processing Dysfunction in the Personal Experience and Neuronal Machinery of Schizophrenia
Javitt, D. C., & Freedman, R. (2015) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2014.13121691 · Cited by 403 · see citing works
Glutathione Precursor, N-Acetyl-Cysteine, Improves Mismatch Negativity in Schizophrenia Patients
Lavoie, S., Murray, M. M., Deppen, P., Knyazeva, M. G., Berk, M., Boulat, O., Bovet, P., Bush, A. I., Conus, P., Copolov, D., et al. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301624 · Cited by 371 · see citing works
Protection against β‐amyloid peptide toxicity in vivo with long‐term administration of ferulic acid
Yan, J.-J., Cho, J., Kim, H., Kim, K., Jung, J., Huh, S., Suh, H., Kim, Y., & Song, D. (2001) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704047 · Cited by 364 · see citing works
Self-citationAuditory dysfunction in schizophrenia: integrating clinical and basic features
Javitt, D. C., & Sweet, R. A. (2015) · Nature reviews. Neuroscience · doi:10.1038/nrn4002 · Cited by 363 · see citing works
Transgenic mouse models of Alzheimer’s disease.
Elder, G. A., Gama Sosa, M. A., & De Gasperi, R. (2010) · Mount Sinai Journal of Medicine A Journal of Translational and Personalized Medicine · doi:10.1002/msj.20159 · Cited by 336 · see citing works
Mismatch negativity and late auditory evoked potentials in comatose patients
Fischer, C., Morlet, D., Bouchet, P., Luauté, J., Jourdan, C., & Salord, F. (1999) · Clinical Neurophysiology · doi:10.1016/s1388-2457(99)00131-5 · Cited by 267 · see citing works
β-Amyloid protein-induced Alzheimer's disease animal model
Nitta, A., Itoh, A., Hasegawa, T., & Nabeshima, T. (1994) · Neuroscience Letters · doi:10.1016/0304-3940(94)90239-9 · Cited by 266 · see citing works
Umbricht, D., Koller, R., Vollenweider, F. X., & Schmid, L. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01242-2 · Cited by 258 · see citing works
Yamada, K., Tanaka, T., Han, D., Senzaki, K., Kameyama, T., & Nabeshima, T. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00408.x · Cited by 238 · see citing works
Behavioral assays with mouse models of Alzheimer's disease: Practical considerations and guidelines
Puzzo, D., Lee, L. S., Palmeri, A., Calabrese, G., & Arancio, O. (2014) · Biochemical Pharmacology · doi:10.1016/j.bcp.2014.01.011 · Cited by 214 · see citing works
Two separate mechanisms underlie auditory change detection and involuntary control of attention
Rinne, T., Särkkä, A., Degerman, A., Schröger, E., & Alho, K. (2006) · Brain Research · doi:10.1016/j.brainres.2006.01.043 · Cited by 207 · see citing works
Alzheimers Disease and P300: Review and Evaluation of Task and Modality
Polich, J. M., & Corey‐Bloom, J. (2005) · Current Alzheimer Research · doi:10.2174/156720505774932214 · Cited by 192 · see citing works
Mouse behavioral endophenotypes for schizophrenia
Amann, L. C., Gandal, M. J., Halene, T. B., Ehrlichman, R. S., White, S., McCarren, H. S., & Siegel, S. J. (2010) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2010.04.008 · Cited by 180 · see citing works
Behavioral and EEG changes in male 5xFAD mice
Schneider, F., Baldauf, K., Wetzel, W., & Reymann, K. G. (2014) · Physiology & Behavior · doi:10.1016/j.physbeh.2014.05.041 · Cited by 176 · see citing works
Deviance-elicited Changes in Event-related Potentials are Attenuated by Ketamine in Mice
Ehrlichman, R. S., Maxwell, C. R., Majumdar, S., & Siegel, S. J. (2008) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2008.20097 · Cited by 154 · see citing works
Ali, T., Yoon, G. H., Shah, S. A., Lee, H. Y., & Kim, M. O. (2015) · Scientific Reports · doi:10.1038/srep11708 · Cited by 146 · see citing works
Abnormal Cognition, Sleep, EEG and Brain Metabolism in a Novel Knock-In Alzheimer Mouse, PLB1
Platt, B., Drever, B. D., Koss, D. J., Stoppelkamp, S., Jyoti, A., Plano, A., Utan, A., Merrick, G., Ryan, D., Melis, V., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027068 · Cited by 141 · see citing works
Ehrlichman, R. S., Luminais, S. N., White, S., Rudnick, N. D., Ma, N., Dow, H. C., Kreibich, A. S., Abel, T. G., Brodkin, E. S., Hahn, C.-G., et al. (2009) · Brain Research · doi:10.1016/j.brainres.2009.07.065 · Cited by 134 · see citing works
Auditory sensory memory impairment in Alzheimerʼs disease
Pekkonen, E., Jousmäki, V., Könönen, M., Reinikainen, K., & Partanen, J. (1994) · Neuroreport · doi:10.1097/00001756-199412000-00033 · Cited by 133 · see citing works
Kim, H. Y., Lee, D. K., Chung, B.-R., Kim, H. V., & Kim, Y. S. (2016) · Journal of Visualized Experiments · doi:10.3791/53308 · Cited by 133 · see citing works
Self-citationScopolamine effects on functional brain connectivity: a pharmacological model of Alzheimer’s disease
Bajo, R., Pusil, S. A., López, M. E., Canuet, L., Pereda, E., Osipova, D. V., Maestú, F., & Pekkonen, E. (2015) · Scientific Reports · doi:10.1038/srep09748 · Cited by 119 · see citing works
Amnesia induced by β-amyloid fragments is counteracted by cannabinoid CB1 receptor blockade
Mazzola, C., Micale, V., & Drago, F. (2003) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2003.08.026 · Cited by 118 · see citing works
β‐Amyloid is transmitted via neuronal connections along axonal membranes
Song, H., Shim, S., Kim, D., Won, S., Joo, S., Kim, S., Jeon, N. L., & Yoon, S. (2013) · Annals of Neurology · doi:10.1002/ana.24029 · Cited by 115 · see citing works
Deviance-related electrophysiological activity in mice: is there mismatch negativity in mice?
Umbricht, D., Vyssotki, D., Латанов, А. В., Nitsch, R. M., & Lipp, H. (2004) · Clinical Neurophysiology · doi:10.1016/j.clinph.2004.08.015 · Cited by 112 · see citing works
Cortical event-related potentials in preclinical familial Alzheimer disease
Golob, E. J., Ringman, J. M., Irimajiri, R., Bright, S., Schaffer, B., Medina, L. D., & Starr, A. (2009) · Neurology · doi:10.1212/wnl.0b013e3181c1de77 · Cited by 108 · see citing works
Amyloid‐β oligomers impair fear conditioned memory in a calcineurin‐dependent fashion in mice
Dineley, K. T., Kayed, R., Neugebauer, V., Fu, Y., Zhang, W., Reese, L. C., & Taglialatela, G. (2010) · Journal of Neuroscience Research · doi:10.1002/jnr.22445 · Cited by 106 · see citing works
Effects of Strain, Novelty, and NMDA Blockade on Auditory-Evoked Potentials in Mice
Siegel, S. J., Connolly, P. M., Liang, Y., Lenox, R. H., Gur, R. E., Bilker, W. B., Kanes, S. J., & Turetsky, B. I. (2002) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300087 · Cited by 104 · see citing works
EEG, Activity, and Sleep Architecture in a Transgenic AβPPswe/PSEN1A246E Alzheimer's Disease Mouse
Jyoti, A., Plano, A., Riedel, G., & Platt, B. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-100879 · Cited by 100 · see citing works
Tomé, D., Barbosa, F., Nowak, K., & Teixeira, J. M. (2014) · Journal of Neural Transmission · doi:10.1007/s00702-014-1258-3 · Cited by 100 · see citing works
Harkany, T., Hortobágyi, T., Sasvári, M., Kónya, C., Penke, B., Luiten, P. G. M., & Nyakas, C. J. (1999) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(99)00058-5 · Cited by 97 · see citing works
Aminopyridazines inhibit β-amyloid-induced glial activation and neuronal damage in vivo
Craft, J. M., Watterson, D. M., Frautschy, S. A., & Eldik, L. J. V. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2004.01.006 · Cited by 91 · see citing works
Improvement by nefiracetam of β‐amyloid‐(1‐42)‐induced learning and memory impairments in rats
Yamada, K., Tanaka, T., Mamiya, T., Shiotani, T., Kameyama, T., & Nabeshima, T. (1999) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0702309 · Cited by 90 · see citing works
Criteria for determining whether mismatch responses exist in animal models: Focus on rodents
Harms, L. R., Michie, P. T., & Näätänen, R. (2015) · Biological Psychology · doi:10.1016/j.biopsycho.2015.07.006 · Cited by 74 · see citing works
Diminished N1 Auditory Evoked Potentials to Oddball Stimuli in Misophonia Patients
Schröder, A., van Diepen, R. M., Mazaheri, A., Petalas, D. P., Soto, V., Vulink, N. C. C., & Denys, D. A. J. P. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00123 · Cited by 73 · see citing works
Cecchi, M., Moore, D. K., Sadowsky, C., Solomon, P. R., Doraiswamy, P. M., Smith, C. D., Jicha, G. A., Budson, A. E., Arnold, S. E., & Fadem, K. C. (2015) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1016/j.dadm.2015.08.004 · Cited by 69 · see citing works
Mismatch negativity during attend and ignore conditions in Alzheimer's disease
Kazmerski, V. A., Friedman, D., & Ritter, W. (1997) · Biological Psychiatry · doi:10.1016/s0006-3223(96)00344-7 · Cited by 69 · see citing works
Umbricht, D., Vyssotki, D., Латанов, А. В., Nitsch, R. M., Brambilla, R., D’Adamo, P., & Lipp, H.-P. (2004) · Brain Research · doi:10.1016/j.brainres.2004.05.097 · Cited by 62 · see citing works
Campbell, T. A., Winkler, I., & Kujala, T. (2007) · Psychophysiology · doi:10.1111/j.1469-8986.2007.00529.x · Cited by 54 · see citing works
The neurobiology of MMN and implications for schizophrenia
Michie, P. T., Malmierca, M. S., Harms, L. R., & Todd, J. (2016) · Biological Psychology · doi:10.1016/j.biopsycho.2016.01.011 · Cited by 52 · see citing works
Event-related potential markers of brain changes in preclinical familial Alzheimer disease
Quiroz, Y. T., Ally, B. A., Celone, K., McKeever, J. D., Ruiz‐Rizzo, A. L., Lopera, F. J., Stern, C. E., & Budson, A. E. (2011) · Neurology · doi:10.1212/wnl.0b013e318227b1b0 · Cited by 50 · see citing works
NR2B Antagonist CP-101,606 Abolishes Pitch-Mediated Deviance Detection in Awake Rats
Sivarao, D. V., Chen, P., Yang, Y., Li, Y.-W., Pieschl, R. L., & Ahlijanian, M. K. (2014) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2014.00096 · Cited by 49 · see citing works
Harms, L. R. (2015) · Biological Psychology · doi:10.1016/j.biopsycho.2015.06.015 · Cited by 42 · see citing works
Jiang, S., Yan, C., Qiao, Z., Yao, H., Jiang, S., Qiu, X., Yang, X., Fang, D., Yang, Y., Zhang, L., et al. (2017) · Neuroscience Letters · doi:10.1016/j.neulet.2017.03.032 · Cited by 37 · see citing works
Ruzzoli, M., Pirulli, C., Mazza, V., Miniussi, C., & Brignani, D. (2016) · Scientific Reports · doi:10.1038/srep33167 · Cited by 33 · see citing works
Moessnang, C., Habel, U., Schneider, F. W., & Siegel, S. J. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.156 · Cited by 13 · see citing works
Alzheimer disease detection and analysis using P3 component of ERP in Alzheimer type dementia
Park, E. H., Cho, S.-H., Kim, J. W., et al. (2005) · Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society · doi:10.1109/iembs.2001.1019109 · Cited by 5 · see citing works
Alzheimer Disease Detection and Analysis Using P3 Componenet of ERP in Alzheimer Type Dementia
Park, E. H., Cho, S. Y., Kim, J. W., et al. (2001) · Defense Technical Information Center (DTIC) · Cited by 1 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
- [39]Bennys K, Portet F, Martin K, Nargeot CG, Touchon J, Rondouin G. Interest of event related evoked potentials (N2 and P3) in neurodegenerative disease: Comparison between mild cognitive impairment, Alzheimer disease, amyotrophic lateral sclerosis and controls. Neurobiology of aging. 2002; 23(1): S157– S8.
- [48]Paxinos G, Franklin KB. Paxinos and Franklin’s the mouse brain in stereotaxic coordinates: Academic press; 2019.
Cited by
Sorted by citations
Alzheimer's disease and its progression reduce pyramidal cell gain and connectivity
Lanskey, J. H., Jafarian, A., Karadag, M., Kocagoncu, E., Williams, R. S., Yadav, P., Quinn, A. J., Pitt, J., Thayanandan, T., Lowe, S., et al. (2025) · Alzheimer's & Dementia · doi:10.1002/alz.70805 · Cited by 2 · see citing works
“38 The mismatch paradigm has important advantages as a potential platform in translational studies and for drug development.”
- Authors
- Kim, B., Shin, J., Kim, Y., & Choi, J. H.
- Affiliations
- Korea Institute of Science and Technology (KR)
- Yonsei University (KR)
- Corresponding author
- Choi, Jee Hyun
- Venue
- PLOS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2020-03-11
- Volume
- 15
- Issue
- 3
- Pages
- e0230277
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC7065782
- OpenAlex
- W3011325433
- Cited by
- 11
- References
- 66
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 3 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 1
- FWCI
- 0.75
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS ONE (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Funders
- National Research Foundation of Korea (2017R1A2B3012659)
- National Research Council of Science and Technology (CRC-15-04-KIST)
- Korea Health Industry Development Institute (HI18C0836010018)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- amyloid-beta oligomers, Alzheimer's disease, auditory oddball paradigm, event-related potentials, N1 component, intracerebroventricular administration, parietal cortex, cognitive impairment
- MeSH terms
- Alzheimer Disease, Animals, Evoked Potentials, Auditory, Frontal Lobe, Male, Mice, Inbred ICR, Parietal Lobe, Mice, Spatial Memory
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