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mRNA up-regulation of MHC II and pivotal pro-inflammatory genes in normal brain aging
Abstract
In normal brain aging, CNS resident macrophages exhibit increased expression of major histocompatibility complex (MHC) II expression. However, the transcriptional basis for this observation has not been clarified nor have age-related alterations in pivotal pro-inflammatory genes been characterized. Age-related mRNA alterations in MHC II, MHC II accessory molecules and several pro-inflammatory mediators were measured in older (24 months) and younger (3 months) male F344xBN F1 rats. Real time RT-PCR was utilized to measure steady state mRNA levels in hippocampus. Older as compared to younger animals exhibited increased mRNA levels of MHC II, CD86, CIITA and IFN-gamma. Furthermore, IL-10 and CD200 mRNA, molecules that down-regulate macrophage activation, was decreased in older animals. The present results indicate that normal brain aging is characterized by a shift towards a pro-inflammatory microenvironment in the CNS.
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“Associated with these morphological alterations are biochemical changes, such as elevated expression of antigen presentation molecules (MHCII), Toll-like receptors, pro-inflammatory cytokines (IL-1β), reduced expression of regulatory molecules (CX3CR1 and CD200R) (Frank et al, 2006;Maher et al, 2004), DNA methylation changes and telomere shortening (Flanary and Streit, 2003;Zannas et al, 2015).”
From Microglia Priming with Aging and Stress (2017) · cites this paper as Frank et al, 2006
In the citing paper
“Microglia under normal aging (ie, aging in absence of neurodegeneration) showed upregulation of genes associated with antigen presentation, such as MHCII, CD86, and CIITA (Frank et al, 2006;Godbout et al, 2005;VanGuilder et al, 2011), and suppression of anti-inflammatory genes, such as IL-10 and CD200 (Frank et al, 2006).”
From Microglia Priming with Aging and Stress (2017) · cites this paper as Frank et al, 2006
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Cites
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
Livak, K. J., & Schmittgen, T. D. (2001) · Methods · doi:10.1006/meth.2001.1262 · Cited by 180,860
Gapped BLAST and PSI-BLAST: a new generation of protein database search programs
Altschul, S. (1997) · Nucleic Acids Research · doi:10.1093/nar/25.17.3389 · Cited by 73,302
Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction
Chomczynski, P., & Sacchi, N. (1987) · Analytical Biochemistry · doi:10.1006/abio.1987.9999 · Cited by 65,515
A new mathematical model for relative quantification in real-time RT-PCR
Pfaffl, M. W. (2001) · Nucleic Acids Research · doi:10.1093/nar/29.9.e45 · Cited by 34,610
Microglia: a sensor for pathological events in the CNS
Kreutzberg, G. W. (1996) · Trends in Neurosciences · doi:10.1016/0166-2236(96)10049-7 · Cited by 4,396
The Immunological Synapse: A Molecular Machine Controlling T Cell Activation
Grakoui, A., Bromley, S. K., Sumen, C., Davis, M. M., Shaw, A. S., Allen, P. M., & Dustin, M. L. (1999) · Science · doi:10.1126/science.285.5425.221 · Cited by 3,110
Gene regulation and DNA damage in the ageing human brain
Lu, T., Pan, Y., Kao, S.-Y., Li, C., Kohane, I., Chan, J., & Yankner, B. A. (2004) · Nature · doi:10.1038/nature02661 · Cited by 1,874
Dong, Y., & Benveniste, E. N. (2001) · Glia · doi:10.1002/glia.1107 · Cited by 1,325
Aloisi, F. (2001) · Glia · doi:10.1002/glia.1106 · Cited by 1,310
Streit, W. J., Walter, S. A., & Pennell, N. A. (1999) · Progress in Neurobiology · doi:10.1016/s0301-0082(98)00069-0 · Cited by 1,096
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Zhao, W., Zhang, J., Davis, E. G., & Rebeck, G. W. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00210 · Cited by 24
Perkins, A. E., Piazza, M. K., Vore, A. S., Deak, M. M., Varlinskaya, E. I., & Deak, T. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.11.013 · Cited by 26
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Gruel, R., Bijnens, B., Daele, J. V. D., Thys, S., Willems, R., Wuyts, D., Dam, D. V., Verstraelen, P., Verboven, R., Roels, J., et al. (2024) · Aging Cell · doi:10.1111/acel.14120 · Cited by 24
Terrence Deak, B. (2007) · International Journal of Comparative Psychology · doi:10.46867/ijcp.2007.20.02.14 · Cited by 25
Chromosomal and gonadal factors regulate microglial sex effects in the aging brain
Ocañas, S. R., Ansere, V. A., Kellogg, C. M., Isola, J. V. V., Chucair‐Elliott, A. J., & Freeman, W. M. (2023) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2023.02.008 · Cited by 25
Zahedi, A. S., DANESHPOUR, M. S., Akbarzadeh, M., Hedayati, M., Azizi, F., & Zarkesh, M. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e19911 · Cited by 24
Progesterone and Vitamin D Hormone as a Biologic Treatment of Traumatic Brain Injury in the Aged
Stein, D. G., & Cekic, M. M. (2011) · PM&R · doi:10.1016/j.pmrj.2011.03.010 · Cited by 25
Differential response to intrahippocampal interleukin-4/interleukin-13 in aged and exercise mice
Littlefield, A. M., & Kohman, R. A. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.11.027 · Cited by 24
Siemsen, B. M., Landin, J. D., McFaddin, J. A., Hooker, K. N., Chandler, L. J., & Scofield, M. D. (2020) · Journal of Neuroscience Research · doi:10.1002/jnr.24683 · Cited by 26
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Kohman, R. A. (2012) · Methods in molecular biology · doi:10.1007/978-1-62703-071-7_11 · Cited by 25
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Hein, A. M., & O’Banion, M. K. (2012) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-011-9340-1 · Cited by 22
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Taetzsch, T., Benusa, S. D., Levesque, S., Mumaw, C. L., & Block, M. L. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1446-z · Cited by 21
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Self-citationShen, Z.-B., Meng, H.-W., Meng, X.-S., Lv, Z.-K., Fang, M., Zhang, L.-L., Lv, Z.-L., Li, M.-S., Liu, A., Han, J.-H., et al. (2023) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2023.115417 · Cited by 21
Age and sex differences in primary microglia culture: A comparative study
Ngwa, C., Qi, S., Mamun, A. A., Xu, Y., Sharmeen, R., & Liu, F. (2021) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2021.109359 · Cited by 22
Muscat, S. M., Butler, M. J., Bettes, M. N., DeMarsh, J. W., Scaria, E. A., Deems, N. P., & Barrientos, R. M. (2023) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2023.12.028 · Cited by 20
Self-citationZhao, L., Wang, F., Gui, B., Hua, F., & Qian, Y. (2011) · Experimental Gerontology · doi:10.1016/j.exger.2011.09.002 · Cited by 20
Wlodarek, L., Cao, F., Alibhai, F. J., Fekete, Á., Noyan, N., Tobin, S. W., Marvasti, T. B., Wu, J., Li, S., Weisel, R. D., et al. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1681-3 · Cited by 20
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Yuan, M., Wang, Y., Wang, S., Huang, Z., Jin, F., Zou, Q., Li, J., Pu, Y., & Cai, Z. (2021) · Aging and Disease · doi:10.14336/ad.2021.04017 · Cited by 20
Satyam, S. M., & Bairy, L. K. (2022) · Nutrients · doi:10.3390/nu14153029 · Cited by 21
Exercise alters LPS-induced glial activation in the mouse brain
Mota, B. C., & Kelly, Á. M. (2020) · Neuronal Signaling · doi:10.1042/ns20200003 · Cited by 21
Navarro, E., Norden, D. M., Trojanowski, P. J., Godbout, J. P., & López, M. G. (2021) · Molecules · doi:10.3390/molecules26082107 · Cited by 20
Epigenetic and 3D genome reprogramming during the aging of the human hippocampus
Zemke, N. R., Lee, S. Y., Mamde, S., Yang, B., Berchtold, N. C., Garduño, B. M., Indralingam, H. S., Bartosik, W. M., Lau, P. K., Dong, K., et al. (2026) · Science · doi:10.1126/science.adt8307 · Cited by 32
Hoogland, I. C. M., Yik, J., Westhoff, D., Engelen-Lee, J.-Y., Seron, M. V., Man, W. K., Houben-Weerts, J. H. P. M., Tanck, M. W. T., van Westerloo, D. J., van der Poll, T., et al. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02452-8 · Cited by 18
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González, G. M., Hart, B. A. ‘., Bugiani, M., Plemel, J. R., Schenk, G. J., Kooij, G., & Luchicchi, A. (2025) · Acta Neuropathologica · doi:10.1007/s00401-025-02923-1 · Cited by 20
Cárdenas‐Tueme, M., Trujillo-Villarreal, L. A., Ramírez-Amaya, V., Garza‐Villarreal, E. A., Camacho‐Morales, A., & Reséndez‐Pérez, D. (2022) · NeuroImage · doi:10.1016/j.neuroimage.2022.119039 · Cited by 18
Butler, M. J., Mackey-Alfonso, S. E., Massa, N., Baskin, K. K., & Barrientos, R. M. (2023) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2023.1227241 · Cited by 18
Self-citationChamniansawat, S., & Sawatdiyaphanon, C. (2018) · International Journal of Toxicology · doi:10.1177/1091581818761653 · Cited by 16
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Tennakoon, A., Katharesan, V., Musgrave, I., Koblar, S. A., Faull, R. L. M., Curtis, M. A., & Johnson, I. (2021) · Journal of Neuroscience Research · doi:10.1002/jnr.24996 · Cited by 17
McGuiness, J., Scheinert, R. B., Asokan, A., Stadler, V.-C., Lee, C. S., Rani, A., Kumar, A., Foster, T. C., & Ormerod, B. K. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00280 · Cited by 15
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Nheu, D., Ellen, O., Ye, S., Öztürk, E., Pagnin, M., Kertadjaja, S., Theotokis, P., Grigoriadis, N., McLean, C., & Petratos, S. (2022) · Cells · doi:10.3390/cells11233768 · Cited by 16
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Johnson, R. W., & Godbout, J. P. (2007) · Elsevier eBooks · doi:10.1016/b978-012088576-3/50022-8 · Cited by 15
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Sanchez-Molina, P., Almolda, B., Benseny‐Cases, N., González, B., Perálvarez‐Marín, A., & Castellano, B. (2021) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2021.03.015 · Cited by 14
Ball, J. B., McNulty, C. J., Green‐Fulgham, S. M., Dragavon, J. M., Rocha, I. R. C., Finch, M. R., Prévost, E. D., Siddique, I. I., Woodall, B. J., Watkins, L. R., et al. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2023.1225847 · Cited by 13
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Soares, N. L., & Vieira, H. L. A. (2021) · Neurochemical Research · doi:10.1007/s11064-021-03456-1 · Cited by 14
Jensen, S. K., & Yong, V. W. (2014) · Clinical and Experimental Neuroimmunology · doi:10.1111/cen3.12093 · Cited by 14
Bakhtogarimov, I. R., Kudryavtseva, A. V., Krasnov, G. S., Gladysh, N. S., Volodin, V. V., Kudryavtsev, A. A., Bulavkina, E. V., Goncharova, M. A., Ledyaeva, V. S., Сергеевич, П. И., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23052491 · Cited by 11
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Li, Y., Khandia, R., Papadakis, M., Alexiou, A. T., Simonov, A. N., & Khan, A. A. (2022) · BMC Genomic Data · doi:10.1186/s12863-022-01089-z · Cited by 11
Toedebusch, C. M., Garcia, V. B., Snyder, J. C., Jones, M. R., Schulz, D. J., Johnson, G. C., Villalón, E., Coates, J. R., & Garcia, M. L. (2019) · GeroScience · doi:10.1007/s11357-019-00133-8 · Cited by 13
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Sil, S., Thangaraj, A., Oladapo, A., Hu, G., Kutchy, N. A., Liao, K., Buch, S. J., & Periyasamy, P. (2022) · Viruses · doi:10.3390/v15010044 · Cited by 10
Yang, W., Xu, S., Zhou, M., & Chan, P. (2024) · Aging · doi:10.18632/aging.205954 · Cited by 10
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Rommy von Bernhardi, M., & Eugenín, J. L. (2024) · Neuropharmacology · doi:10.1016/j.neuropharm.2024.110241 · Cited by 10
López‐González, I., Cordomí, C. T., & Ferrer, I. (2017) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlw117 · Cited by 10
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Comella-Bolla, A., Valente, T., Miguez, A., Brito, V., Ginés, S., Solà, C., Straccia, M., & Canals, J. M. (2019) · PLoS ONE · doi:10.1371/journal.pone.0224901 · Cited by 10
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Lu, H., Gong, L., Xu, H., Zhou, Q., Zhao, H., Wu, S., Hu, R. H., & Li, X. (2022) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-022-01192-w · Cited by 8
Lee, J. M., Lee, J. H., Kim, S., Sim, T. H., & Kim, Y. (2023) · Scientific Reports · doi:10.1038/s41598-023-35833-x · Cited by 10
Davis, D. S., & Carson, M. J. (2012) · Springer eBooks · doi:10.1007/978-1-4614-4729-0_1 · Cited by 8
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Barrientos, R. M., Thompson, V. M., Arnold, T. H., Frank, M. G., Watkins, L. R., & Maier, S. F. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.07.004 · Cited by 8
Self-citationSiemsen, B., Landin, J., McFaddin, J., Hooker, K., Chandler, L., & Scofield, M. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/566034 · Cited by 8
Wang, S., Wang, J., Hu, Z., Wu, L., & Huang, L. (2026) · Experimental Neurology · doi:10.1016/j.expneurol.2026.115663 · Cited by 7
Deakin, I. H., Godlewska, B. R., Walker, M. A., Huang, G., Schwab, M. H., Nave, K., Law, A. J., & Harrison, P. J. (2018) · Translational Psychiatry · doi:10.1038/s41398-018-0288-2 · Cited by 8
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Salmani, H., Hosseini, M., Nabi, M. M., Noshahr, Z. S., Baghcheghi, Y., & Sadeghi, M. (2022) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2022.04.013 · Cited by 6
Neuroinflammation and oxidative injury in developmental neurotoxicity
Milatović, D., Zaja‐Milatovic, S., Brockett, M. M., BREYER, R. M., Aschner, M., & Montine, T. J. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-89773-0.00056-4 · Cited by 7
Kohman, R. A., Crowell, B., Urbach‐Ross, D., & Kusnecov, A. W. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06921.x · Cited by 7
Martin, D. S. D., Walsh, M., Miller, A., Skerrett, H. E., Byrne, P., Mandel, A., Bolton, A. E., & Lynch, M. A. (2009) · NeuroImmunoModulation · doi:10.1159/000228915 · Cited by 8
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Farooqui, A. A. (2016) · Springer eBooks · doi:10.1007/978-3-319-15889-1_7 · Cited by 6
Lin, S., He, L., Shen, R., Fang, F., Pan, H., Zhu, X., Wang, M., Zhou, Z., Liu, Z., Wang, X., et al. (2020) · European Journal of Neurology · doi:10.1111/ene.14224 · Cited by 5
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Jalloh, A., Flowers, A., Hudson, C., Chaput, D., Guergues, J., Stevens, S. M., & Bickford, P. C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22126373 · Cited by 5
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Self-citationAge-Dependent Microglial Response to Systemic Infection
Cyr, B. S., & Vaccari, J. P. D. R. (2021) · Cells · doi:10.3390/cells10051037 · Cited by 5
Jimenez-Harrison, D., Butler, M. J., Ijaz, H., Alsabbagh, R., Bettes, M. N., DeMarsh, J. W., Mackey-Alfonso, S. E., Muscat, S. M., Alvarez, B. D., Blackwell, J. A., et al. (2025) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2025.100969 · Cited by 4
Self-citationCo-signaling Molecules in Neurological Diseases
Kivisäkk, P., & Khoury, S. J. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-981-32-9717-3_9 · Cited by 4
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Huang, H., Wu, J., Chang, Y., Wang, H., Tian, Y., Chen, Z., Feng, J., & Wang, H. (2023) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.3c00010 · Cited by 5
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Bruszt, N., Bali, Z. K., Nagy, L. V., Bodó, K., Engelmann, P., & Hernádi, I. (2025) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyaf014 · Cited by 4
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Deak, T., Burzynski, H. E., Nunes, P. T., Day, S. M., & Savage, L. M. (2025) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-81908-7_12 · Cited by 3
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Kezic, J. M., Chrysostomou, V., McMenamin, P. G., & Crowston, J. G. (2020) · Experimental Eye Research · doi:10.1016/j.exer.2020.107995 · Cited by 3
Hu, Y., Xie, A.-M., & Cheng, Q. (2019) · Inflammation Research · doi:10.1007/s00011-019-01290-4 · Cited by 4
Couch, C., Alawieh, A. M., Toutonji, A., Atkinson, C., & Tomlinson, S. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1161051 · Cited by 3
Ghosh, S., & Sarma, J. D. (2025) · Biogerontology · doi:10.1007/s10522-025-10252-9 · Cited by 3
An integrated transcriptomic analysis of brain aging and strategies for healthy aging
Liu, H., Nie, X., Wang, F., Chen, D., Zeng, Z., Shu, P., & Huang, J. (2024) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2024.1450337 · Cited by 5
Martínez-Membrives, E. (2012) · TDX (Tesis Doctorals en Xarxa) · Cited by 3
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Payton, A., Dawes, P., Platt, H., Morton, C. C., Moore, D. R., Massey, J., Horan, M. A., Ollier, W., Munro, K. J., & Pendleton, N. (2015) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32393 · Cited by 2
Barkhordarian, A., Chiappelli, F., & Demerjian, G. G. (2018) · Springer eBooks · doi:10.1007/978-3-319-76367-5_3 · Cited by 2
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Yu, L., Liu, M., Guan, M.-Q., Wang, R., Yang, X., Zhang, X., Wei, J., Wu, S.-F., Gu, H., Fu, Q., et al. (2024) · Immunity & Ageing · doi:10.1186/s12979-024-00486-5 · Cited by 1
Li, H., Wu, F., Zheng, F., Li, X., Yuan, P., Xu, M., & Wu, W. (2025) · Aging Research · doi:10.26599/agr.2025.9340062 · Cited by 1
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Sheng, W., Wang, Q., Huang, Y., Gu, J., Ding, C., Cui, Z., Tang, S., Xia, X., & Chen, J. (2026) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.67.1.32 · Cited by 1
Zheng, H., Guan, A., Li, X., Zhang, X., Zheng, L., & Zhao, Y. (2026) · CytoJournal · doi:10.25259/cytojournal_127_2025 · Cited by 1
Nadjar, A., Leyrolle, Q., Joffre, C., & Layé, S. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-811959-4.00024-9 · Cited by 3
Microglial Cell Dysregulation in the Aged Brain and Neurodegeneration
Triolo-Mieses, M., Fadić, R., & Rommy von Bernhardi, M. (2021) · Springer eBooks · doi:10.1007/978-3-030-71519-9_180-1 · Cited by 1
Malik, S., Xavier, S., Soch, A., Younesi, S., Yip, J. L. K., Slayo, M., Barrientos, R. M., Sominsky, L., & Spencer, S. J. (2024) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2024.04.010 · Cited by 1
Self-citationMicroglial Cell Dysregulation in the Aged Brain and Neurodegeneration
Triolo-Mieses, M., Fadić, R., & Rommy von Bernhardi, M. (2022) · Springer eBooks · doi:10.1007/978-3-031-15080-7_180 · Cited by 1
Fenn, A. M., Norden, D. M., & Godbout, J. P. (2015) · Wiley eBooks · doi:10.1002/9781118732748.ch6 · Cited by 1
Role of microglia in myelin turnover
Safaiyan, S. (2016) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-5727
Cleland, A. (2010) · The Knowledge Bank (The Ohio State University)
Microglial Cells and Inflammatory Cytokines in the Aged Brain
Richwine, A. F., & Johnson, R. W. (2008) · Springer eBooks · doi:10.1007/978-0-387-84851-8_19
MOLECULAR MECHANISMS OF AGING IN THE PERIPHERAL NOCICEPTIVE SYSTEM
Wang, S. (2007) · D-Scholarship@Pitt (University of Pittsburgh)
Parkinson’s Disease and the Immune System
Roberta, J., Crichton, R. R., & Dexter, D. T. (2012) · InTech eBooks · doi:10.5772/16868
Manig, A. (2015) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-4994
Luteolin Inhibits Microglia and Alters Hippocampal-Dependent Spatial Working
Jang, S., Dilger, R. N., & Johnson, R. W. (2010)
Knuesel, I. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-800228-5.00004-2
Defining microglial phenotypic diversity and the impact of ageing
Grabert, K. (2015) · ERA
Metadata
- Authors
- Frank, M. G., Barrientos, R. M., Biedenkapp, J. C., Rudy, J. W., Watkins, L. R., & Maier, S. F.
- Affiliations
- University of Colorado Boulder (US)
- Corresponding author
- Frank, Matthew G.
- ORCID
- Venue
- Neurobiology of Aging
- Publisher
- Elsevier BV
- Published
- 2006-05
- Volume
- 27
- Issue
- 5
- Pages
- 717-722
- ISSN
- 0197-4580 (ISSN-L)
- OpenAlex
- W2078514181
- Cited by
- 327
- References
- 51
- Citations by year
- 2026: 7 · 2025: 7 · 2024: 12 · 2023: 15 · 2022: 20 · 2021: 24 · 2020: 21 · 2019: 17 · 2018: 19 · 2017: 13 · 2016: 24 · 2015: 18 · 2014: 17 · 2013: 13 · 2012: 18
- FWCI
- 6.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurobiology of Aging (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5f32mh064339-03)
- National Institute of Mental Health (5 F32 MH064339-03)
- National Institute on Drug Abuse (F32DA015591)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
- Keywords
- brain aging, MHC class II, microglia, pro-inflammatory genes, hippocampus, CD86, CIITA, interferon-gamma, IL-10, CD200, macrophage activation, neuroinflammation, gene expression
- MeSH terms
- Aging, Animals, Brain, Genes, MHC Class II, Inflammation, Male, Neurons, Rats, Inbred F344, Receptors, Immunologic, RNA, Messenger, Antigens, CD, Up-Regulation, DNA Primers, DNA, Complementary, Gene Expression Regulation, Developmental, Reverse Transcriptase Polymerase Chain Reaction, Rats
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