Cited by 327Neuroinflammation and Neurodegeneration MechanismsGenetics, Aging, and Longevity in Model OrganismsPhagocytosis and Immune Regulation

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mRNA up-regulation of MHC II and pivotal pro-inflammatory genes in normal brain aging

Frank, Matthew G., Barrientos, Ruth M., Biedenkapp, Joseph C., Rudy, Jerry W., Watkins, Linda R., Maier, Steven F.·2006·Neurobiology of Aging

DOI 10.1016/j.neurobiolaging.2005.03.013

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Abstract

In normal brain aging, CNS resident macrophages exhibit increased expression of major histocompatibility complex (MHC) II expression. However, the transcriptional basis for this observation has not been clarified nor have age-related alterations in pivotal pro-inflammatory genes been characterized. Age-related mRNA alterations in MHC II, MHC II accessory molecules and several pro-inflammatory mediators were measured in older (24 months) and younger (3 months) male F344xBN F1 rats. Real time RT-PCR was utilized to measure steady state mRNA levels in hippocampus. Older as compared to younger animals exhibited increased mRNA levels of MHC II, CD86, CIITA and IFN-gamma. Furthermore, IL-10 and CD200 mRNA, molecules that down-regulate macrophage activation, was decreased in older animals. The present results indicate that normal brain aging is characterized by a shift towards a pro-inflammatory microenvironment in the CNS.

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Authors: Frank, M. G., Barrientos, R. M., Biedenkapp, J. C., Rudy, J. W., Watkins, L. R., & Maier, S. F.
Affiliations: University of Colorado Boulder (US)
Corresponding author: Frank, Matthew G.
ORCID: Frank, Matthew G.
Barrientos, Ruth M.
Biedenkapp, Joseph C.
Rudy, Jerry W.
Watkins, Linda R.
Maier, Steven F.
Venue: Neurobiology of Aging
Publisher: Elsevier BV
Published: 2006-05
Volume: 27
Issue: 5
Pages: 717-722
ISSN: 0197-4580 (ISSN-L)
DOI: 10.1016/j.neurobiolaging.2005.03.013
OpenAlex: W2078514181
Cited by: 327
References: 51
Citations by year: 2026: 7 · 2025: 7 · 2024: 12 · 2023: 15 · 2022: 20 · 2021: 24 · 2020: 21 · 2019: 17 · 2018: 19 · 2017: 13 · 2016: 24 · 2015: 18 · 2014: 17 · 2013: 13 · 2012: 18
FWCI: 6.24
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neurobiology of Aging (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5f32mh064339-03)
National Institute of Mental Health (5 F32 MH064339-03)
National Institute on Drug Abuse (F32DA015591)
Topics: Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
Keywords: brain aging, MHC class II, microglia, pro-inflammatory genes, hippocampus, CD86, CIITA, interferon-gamma, IL-10, CD200, macrophage activation, neuroinflammation, gene expression
MeSH terms: Aging, Animals, Brain, Genes, MHC Class II, Inflammation, Male, Neurons, Rats, Inbred F344, Receptors, Immunologic, RNA, Messenger, Antigens, CD, Up-Regulation, DNA Primers, DNA, Complementary, Gene Expression Regulation, Developmental, Reverse Transcriptase Polymerase Chain Reaction, Rats

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mRNA up-regulation of MHC II and pivotal pro-inflammatory genes in normal brain aging

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