Concurrent hippocampal induction of MHC II pathway components and glial activation with advanced aging is not correlated with cognitive impairment

Origin and physiological roles of inflammation

Medzhitov, R. (2008) · Nature · doi:10.1038/nature07201 · Cited by 6,618 · see citing works

Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo

Nimmerjahn, A., Kirchhoff, F., & Helmchen, F. (2005) · Science · doi:10.1126/science.1110647 · Cited by 5,827 · see citing works

Microglia: Active sensor and versatile effector cells in the normal and pathologic brain

Hanisch, U.-K., & Kettenmann, H. (2007) · Nature Neuroscience · doi:10.1038/nn1997 · Cited by 3,676 · see citing works

DAMPs, PAMPs and alarmins: all we need to know about danger

Bianchi, M. E. (2007) · Journal of Leukocyte Biology · doi:10.1189/jlb.0306164 · Cited by 2,794 · see citing works

Insights into the ageing mind: a view from cognitive neuroscience

Hedden, T., & Gabrieli, J. D. E. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1323 · Cited by 2,223 · see citing works

The ageing systemic milieu negatively regulates neurogenesis and cognitive function

Villeda, S. A., Luo, J., Mosher, K. I., Zou, B., Britschgi, M., Bieri, G., Stan, T. M., Fainberg, N., Ding, Z., Eggel, A., et al. (2011) · Nature · doi:10.1038/nature10357 · Cited by 1,763 · see citing works

Immune modulation of learning, memory, neural plasticity and neurogenesis

Yirmiya, R., & Goshen, I. (2011) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2010.10.015 · Cited by 1,483 · see citing works

Debris clearance by microglia: an essential link between degeneration and regeneration

Neumann, H., Kotter, M. R., & Franklin, R. J. M. (2008) · Brain · doi:10.1093/brain/awn109 · Cited by 1,111 · see citing works

Gene-expression profile of the ageing brain in mice

Lee, C.-K., Weindruch, R., & Prolla, T. A. (2000) · Nature Genetics · doi:10.1038/77046 · Cited by 1,055 · see citing works

Exaggerated neuroinflammation and sickness behavior in aged mice after activation of the peripheral innate immune system

Godbout, J. P., Chen, J., Abraham, J., Richwine, A. F., Berg, B. M., Kelley, K. W., & Johnson, R. W. (2005) · The FASEB Journal · doi:10.1096/fj.05-3776fje · Cited by 813 · see citing works

Methods of Behavior Analysis in Neuroscience

(2008) · CRC Press eBooks · doi:10.1201/9780367802622 · Cited by 777 · see citing works

Meta-analysis of age-related gene expression profiles identifies common signatures of aging

de Magalhães, J. P., Curado, J., & Church, G. M. (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp073 · Cited by 737 · see citing works

Intellectual Development in Adulthood: The Seattle Longitudinal Study

Schaie, K. W., & Baltes, P. B. (1996) · Medical Entomology and Zoology · Cited by 687 · see citing works

Immune activation in brain aging and neurodegeneration: too much or too little?

Lucin, K. M., & Wyss-Coray, T. (2009) · Neuron · doi:10.1016/j.neuron.2009.08.039 · Cited by 679 · see citing works

Cytokines and cognition–the case for a head-to-toe inflammatory paradigm.

Wilson, C. J., Finch, C. E., & Cohen, H. J. (2002) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2002.50619.x · Cited by 637 · see citing works

Gene expression changes in the course of normal brain aging are sexually dimorphic

Berchtold, N. C., Cribbs, D. H., Coleman, P. D., Rogers, J., Head, E., Kim, R., Beach, T., Miller, C., Troncoso, J., Trojanowski, J. Q., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0806883105 · Cited by 626 · see citing works

Gene Microarrays in Hippocampal Aging: Statistical Profiling Identifies Novel Processes Correlated with Cognitive Impairment

Blalock, E. M., Chen, K.-C., Sharrow, K., Herman, J. P., Porter, N. M., Foster, T. C., & Landfield, P. W. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-09-03807.2003 · Cited by 570 · see citing works

Oxidative stress and protein aggregation during biological aging

Squier, T. C. (2001) · Experimental Gerontology · doi:10.1016/s0531-5565(01)00139-5 · Cited by 511 · see citing works

Microglial control of neuronal death and synaptic properties

Bessis, A., Béchade, C., Bernard, D., & Roumier, A. (2006) · Glia · doi:10.1002/glia.20459 · Cited by 454 · see citing works

THE USE OF ANIMAL MODELS TO STUDY THE EFFECTS OF AGING ON COGNITION

Gallagher, M., & Rapp, P. R. (1997) · Annual Review of Psychology · doi:10.1146/annurev.psych.48.1.339 · Cited by 430 · see citing works

Brain Aging: Models, Methods, and Mechanisms

Root-Bernstein, R. S. (2007) · JAMA · doi:10.1001/jama.298.23.2798 · Cited by 396 · see citing works

Role of inflammation in cognitive impairment: results of observational epidemiological studies and clinical trials

Gorelick, P. B. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05726.x · Cited by 361 · see citing works

Multistability of cognitive maps in the hippocampus of old rats

Barnes, C. A., Suster, M. S., Shen, J., & McNaughton, B. L. (1997) · Nature · doi:10.1038/40859 · Cited by 360 · see citing works

Methods of Behavior Analysis in Neuroscience

(2000) · CRC Press eBooks · doi:10.1201/9781420041811 · Cited by 345 · see citing works

Microglia in the Aging Brain

Conde, J. R., & Streit, W. J. (2006) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/01.jnen.0000202887.22082.63 · Cited by 344 · see citing works

mRNA up-regulation of MHC II and pivotal pro-inflammatory genes in normal brain aging

Frank, M. G., Barrientos, R. M., Biedenkapp, J. C., Rudy, J. W., Watkins, L. R., & Maier, S. F. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.03.013 · Cited by 327 · see citing works

Decreases in cerebral microvasculature with age are associated with the decline in growth hormone and insulin-like growth factor 1

Sonntag, W. E., Lynch, C. D., Cooney, P. T., & Hutchins, P. M. (1997) · Endocrinology · doi:10.1210/endo.138.8.5330 · Cited by 307 · see citing works

Microglia Are More Efficient Than Astrocytes in Antigen Processing and in Th1 But Not Th2 Cell Activation

Aloisi, F., Ria, F., Penna, G., & Adorini, L. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.160.10.4671 · Cited by 276 · see citing works

Microglial Expression of MHC Class II Increases in Normal Aging of Nonhuman Primates

Sheffield, L. G., & Berman, N. E. J. (1998) · Neurobiology of Aging · doi:10.1016/s0197-4580(97)00168-1 · Cited by 234 · see citing works

Glia: The many ways to modulate synaptic plasticity

Achour, S. B., & Pascual, O. (2010) · Neurochemistry International · doi:10.1016/j.neuint.2010.02.013 · Cited by 232 · see citing works

What is the most sensitive measure of water maze probe test performance?

Maei, H. R. (2009) · Frontiers in Integrative Neuroscience · doi:10.3389/neuro.07.004.2009 · Cited by 224 · see citing works

Sustained hippocampal IL-1β overexpression impairs contextual and spatial memory in transgenic mice

Hein, A. M., Stasko, M. R., Matousek, S. B., Scott-McKean, J. J., Maier, S. F., Olschowka, J. A., Costa, A. C. S., & O’Banion, M. K. (2009) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2009.10.002 · Cited by 223 · see citing works

Brain Aging

(2007) · CRC Press eBooks · doi:10.1201/9781420005523 · Cited by 222 · see citing works

Patterns of Astroglial Hypertrophy and Neuronal Degeneration in the Hippocampus of Aged, Memory-deficient Rats

Landfield, P. W., Rose, G., Sandles, L., Wohlstadter, T. C., & LYNCH, G. S. (1977) · Journal of Gerontology · doi:10.1093/geronj/32.1.3 · Cited by 221 · see citing works

Exaggerated sickness behavior and brain proinflammatory cytokine expression in aged mice in response to intracerebroventricular lipopolysaccharide

Huang, Y., Henry, C. J., Dantzer, R., Johnson, R. W., & Godbout, J. P. (2007) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.04.012 · Cited by 218 · see citing works

Neuroinflammation and Cognitive Aging

Ownby, R. L. (2010) · Current Psychiatry Reports · doi:10.1007/s11920-009-0082-1 · Cited by 212 · see citing works

Hippocampal Expression Analyses Reveal Selective Association of Immediate-Early, Neuroenergetic, and Myelinogenic Pathways with Cognitive Impairment in Aged Rats

Rowe, W. B., Blalock, E. M., Chen, K.-C., Kadish, I., Wang, D., Barrett, J. E., Thibault, O., Porter, N. M., Rose, G. M., & Landfield, P. W. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.4163-06.2007 · Cited by 211 · see citing works

Increased microglial activation and protein nitration in white matter of the aging monkey☆

Sloane, J. A., Hollander, W., Moss, M. B., Rosene, D. L., & Abraham, C. R. (1999) · Neurobiology of Aging · doi:10.1016/s0197-4580(99)00066-4 · Cited by 208 · see citing works

Neuronal Death Induced by Nanomolar Amyloid β Is Mediated by Primary Phagocytosis of Neurons by Microglia

Neniškytė, U., Neher, J. J., & Brown, G. C. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.267583 · Cited by 208 · see citing works

Cellular environment facilitates protein accumulation in aged rat hippocampus

Gavilán, M. P., Vela, J. M., Castaño, A., Ramos, B., del Río, J. C., Vitórica, J., & Ruano, D. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.05.010 · Cited by 201 · see citing works

Hippocampal Subfield Volumes: Age, Vascular Risk, and Correlation with Associative Memory

Shing, Y. L., Rodrigue, K. M., Kennedy, K. M., Fandakova, Y., Bodammer, N., Werkle‐Bergner, M., Lindenberger, U., & Raz, N. (2011) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2011.00002 · Cited by 200 · see citing works

Metabolic and Cognitive Response to Human Traumatic Brain Injury: A Quantitative Proton Magnetic Resonance Study

Brooks, W. M., Stidley, C. A., Petropoulos, H., Jung, R. E., Weers, D. C., Friedman, S. D., Barlow, M. A., Sibbitt, W. L., & Yeo, R. A. (2000) · Journal of Neurotrauma · doi:10.1089/089771500415382 · Cited by 193 · see citing works

Valproate Administered after Traumatic Brain Injury Provides Neuroprotection and Improves Cognitive Function in Rats

Dash, P. K., Orsi, S. A., Zhang, M., Grill, R. J., Pati, S., Zhao, J., & Moore, A. N. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011383 · Cited by 193 · see citing works

Effects of ageing on microglia in the normal rat brain: immunohistochemical observations

Ogura, K., Ogawa, M., & Yoshida, M. (1994) · Neuroreport · doi:10.1097/00001756-199406020-00016 · Cited by 181 · see citing works

Signatures of hippocampal oxidative stress in aged spatial learning-impaired rodents

Nicolle, M. M., Gonzalez, J., Sugaya, K., Baskerville, K. A., Bryan, D., Lund, K. C., Gallagher, M., & McKinney, M. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00374-8 · Cited by 177 · see citing works

A role for microglia in synaptic plasticity?

Tremblay, M.-È., & Majewska, A. K. (2011) · Communicative & Integrative Biology · doi:10.4161/cib.4.2.14506 · Cited by 176 · see citing works

Phagocytic Clearance of Apoptotic Neurons by Microglia/Brain Macrophages In Vitro

Witting, A., Müller, P. K., Herrmann, A., Kettenmann, H., & Nolte, C. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0751060.x · Cited by 175 · see citing works

Innate immune receptor expression in normal brain aging

Letiembre, M., Hao, W., Liu, Y., Walter, S., Mihaljevic, I., Rivest, S., Hartmann, T., & Fassbender, K. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.01.004 · Cited by 175 · see citing works

MHC class II molecules on the move for successful antigen presentation

Rocha, N., & Neefjes, J. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601945 · Cited by 167 · see citing works

Stereological analysis of astrocyte and microglia in aging mouse hippocampus

Long, J. M., Kalehua, A. N., Muth, N. J., Calhoun, M. E., Jucker, M., Hengemihle, J. M., Ingram, D. K., & Mouton, P. R. (1998) · Neurobiology of Aging · doi:10.1016/s0197-4580(98)00088-8 · Cited by 163 · see citing works

Increased expression of heat shock proteins in rat brain during aging: relationship with mitochondrial function and glutathione redox state

Calabrese, V. (2004) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2004.01.003 · Cited by 162 · see citing works

Activated astroglia during chronic inflammation in Alzheimer's disease—Do they neglect their neurosupportive roles?

Fuller, S. L., Steele, M. L., & Münch, G. W. (2009) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2009.08.016 · Cited by 155 · see citing works

Aging alters the expression of neurotransmission‐regulating proteins in the hippocampal synaptoproteome

VanGuilder, H. D., Yan, H., Farley, J. A., Sonntag, W. E., & Freeman, W. M. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.06719.x · Cited by 154 · see citing works

Hippocampal and Cognitive Aging across the Lifespan: A Bioenergetic Shift Precedes and Increased Cholesterol Trafficking Parallels Memory Impairment

Kadish, I., Thibault, O., Blalock, E. M., Chen, K.-C., Gant, J. C., Porter, N. M., & Landfield, P. W. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.4599-08.2009 · Cited by 152 · see citing works

The concentration of glial fibrillary acidic protein increases with age in the mouse and rat brain

O'Callaghan, J. P., & Miller, D. B. (1991) · Neurobiology of Aging · doi:10.1016/0197-4580(91)90057-q · Cited by 152 · see citing works

Multiple Sclerosis: A Role for Astroglia in Active Demyelination Suggested by Class II MHC Expression and Ultrastructural Study

Lee, S. C., Moore, G. R. W., Golenwsky, G., & Raine, C. S. (1990) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199003000-00005 · Cited by 149 · see citing works

Microglial activation in white matter lesions and nonlesional white matter of ageing brains

Simpson, J. E., Ince, P. G., Higham, C. E., Gelsthorpe, C., Fernando, M. S., Matthews, F. E., Forster, G., O'Brien, J. T., Barber, R., Kalaria, R. N., et al. (2007) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2007.00890.x · Cited by 146 · see citing works

Long-term treadmill exposure protects against age-related neurodegenerative change in the rat hippocampus.

O'Callaghan, R. M., Griffin, É. W., & Kelly, Á. M. (2009) · Hippocampus · doi:10.1002/hipo.20591 · Cited by 146 · see citing works

Glial reaction in the hippocampal formation is highly correlated with aging in human brain

David, J., Ghozali, F., Fallet‐Bianco, C., Wattez, A., Delaine, S. C., Boniface, B., Menza, C. D., & Delacourte, A. (1997) · Neuroscience Letters · doi:10.1016/s0304-3940(97)00708-8 · Cited by 145 · see citing works

Hippocampal dysregulation of synaptic plasticity-associated proteins with age-related cognitive decline

VanGuilder, H. D., Farley, J. A., Han, Y., Kirk, C. A. V., Mitschelen, M. C., Sonntag, W. E., & Freeman, W. M. (2011) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.03.012 · Cited by 144 · see citing works

Proteomics analysis provides insight into caloric restriction mediated oxidation and expression of brain proteins associated with age-related impaired cellular processes: Mitochondrial dysfunction, glutamate dysregulation and impaired protein synthesis

Poon, H. F., Shepherd, H. M., Reed, T. T., Calabrese, V., Stella, A. G., Pennisi, G., Cai, J., Pierce, W. M. J., Klein, J. B., & Butterfield, D. A. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.05.014 · Cited by 127 · see citing works

Cognitive and neuroinflammatory consequences of mild repeated stress are exacerbated in aged mice

Buchanan, J. B., Sparkman, N. L., Chen, J., & Johnson, R. W. (2008) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2008.02.013 · Cited by 126 · see citing works

Spatial Navigation (Water Maze) Tasks

Terry, A. V. (2008) · Frontiers in neuroscience · doi:10.1201/noe1420052343.ch13 · Cited by 116 · see citing works

Immune response gene expression increases in the aging murine hippocampus

Terao, A., Apte-Deshpande, A. D., Dousman, L., Morairty, S. R., Eynon, B. P., Kilduff, T. S., & Freund, Y. R. (2002) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(02)00317-x · Cited by 111 · see citing works

Microglial—Neuronal interactions

Streit, W. J. (1993) · Journal of Chemical Neuroanatomy · doi:10.1016/0891-0618(93)90047-8 · Cited by 110 · see citing works

Image analysis of GFA-positive astrocytes from adolescence to senescence

Bj�rklund, H., Eriksdotter-Nilsson, M., Dahl, D. R., Rose, G., Hoffer, B. J., & Olson, L. (1985) · Experimental Brain Research · doi:10.1007/bf00238964 · Cited by 109 · see citing works

Whole genome assessment of the retinal response to diabetes reveals a progressive neurovascular inflammatory response

Brucklacher, R. M., Patel, K. M., VanGuilder, H. D., Bixler, G. V., Barber, A. J., Antonetti, D. A., Lin, C., LaNoue, K. F., Gardner, T. W., Bronson, S. K., et al. (2008) · BMC Medical Genomics · doi:10.1186/1755-8794-1-26 · Cited by 107 · see citing works

Phenotypic and gene expression modification with normal brain aging in GFAP-positive astrocytes and neural stem cells

Bernal, G. M., & Peterson, D. A. (2011) · Aging Cell · doi:10.1111/j.1474-9726.2011.00694.x · Cited by 102 · see citing works

Hypertrophy of astroglial processes in the dentate gyrus of the senescent rat

Geinisman, Y., Bondareff, W., & Dodge, J. T. (1978) · American Journal of Anatomy · doi:10.1002/aja.1001530405 · Cited by 96 · see citing works

Differential Effects of Aging and Insulin-like Growth Factor-1 on Synapses in CA1 of Rat Hippocampus

Shi, L., Linville, M. C., Tucker, E. W., Sonntag, W. E., & Brunso‐Bechtold, J. K. (2004) · Cerebral Cortex · doi:10.1093/cercor/bhh158 · Cited by 95 · see citing works

Astrocytic hypertrophy and altered GFAP degradation with age in subcortical white matter of the rhesus monkey

Sloane, J. A., Hollander, W., Rosene, D. L., Moss, M. B., Kemper, T. L., & Abraham, C. R. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02059-x · Cited by 85 · see citing works

Molecular and cellular characterization of the age‐related neuroinflammatory processes occurring in normal rat hippocampus: potential relation with the loss of somatostatin GABAergic neurons

Gavilán, M. P., Revilla, E., Pintado, C., Castaño, A., Vizuete, M., Moreno‐González, I., Baglietto‐Vargas, D., Sanchez-Varo, R. M., Vitórica, J., Gutiérrez, A., et al. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04787.x · Cited by 77 · see citing works

Astrocyte Function is Modified by Alzheimer's Disease-like Pathology in Aged Mice

Peters, O., Schipke, C. G., Philipps, A., Haas, B., Pannasch, U., Wang, L. P., Benedetti, B., Kingston, A. E., & Kettenmann, H. (2009) · Journal of Alzheimer's Disease · doi:10.3233/jad-2009-1140 · Cited by 76 · see citing works

The Hippocampal Neuroproteome with Aging and Cognitive Decline: Past Progress and Future Directions

VanGuilder, H. D., & Freeman, W. M. (2011) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2011.00008 · Cited by 76 · see citing works

Aging Effects on the Limits and Stability of Long-Term Synaptic Potentiation and Depression in Rat Hippocampal Area CA1

Kumar, A., Thinschmidt, J. S., Foster, T. C., & King, M. A. (2007) · Journal of Neurophysiology · doi:10.1152/jn.00249.2007 · Cited by 69 · see citing works

Aging-Related Gene Expression in Hippocampus Proper Compared with Dentate Gyrus Is Selectively Associated with Metabolic Syndrome Variables in Rhesus Monkeys

Blalock, E. M., Grondin, R., Chen, K.-C., Thibault, O., Thibault, V., Pandya, J. D., Dowling, A. L. S., Zhang, Z., Sullivan, P. G., Porter, N. M., et al. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.3956-09.2010 · Cited by 61 · see citing works

Caloric restriction does not reverse aging-related changes in hippocampal BDNF

Newton, I. G., Forbes, M. E., Legault, C., Johnson, J. E., Brunso‐Bechtold, J. K., & Riddle, D. R. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2004.06.005 · Cited by 55 · see citing works

Distinct regulation of MHC molecule expression on astrocytes and microglia during viral encephalomyelitis

Hamo, L., Stohlman, S. A., Otto‐Duessel, M., & Bergmann, C. C. (2007) · Glia · doi:10.1002/glia.20538 · Cited by 51 · see citing works

Multi-Modal Proteomic Analysis of Retinal Protein Expression Alterations in a Rat Model of Diabetic Retinopathy

VanGuilder, H. D., Bixler, G. V., Kutzler, L., Brucklacher, R. M., Bronson, S. K., Kimball, S. R., & Freeman, W. M. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016271 · Cited by 50 · see citing works

Effects of age and insulin-like growth factor-1 on neuron and synapse numbers in area CA3 of hippocampus

Poe, B., Linville, C., Riddle, D. R., Sonntag, W. E., & Brunso-Bechtold, J. K. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00341-4 · Cited by 49 · see citing works

Effects of age on the glucose metabolic changes in mild cognitive impairment

Kantarci, K., Senjem, M. L., Lowe, V. J., Wiste, H. J., Weigand, S. D., Kemp, B. J., Frank, A. R., Shiung, M. M., Boeve, B. F., Knopman, D. S., et al. (2010) · American Journal of Neuroradiology · doi:10.3174/ajnr.a2070 · Cited by 47 · see citing works

Neurophysiology of Old Neurons and Synapses

Kumar, A., & Foster, T. C. (2007) · CRC Press eBooks · doi:10.1201/9781420005523-10 · Cited by 45 · see citing works

Cognitive Impairment in the Septic Brain

Comim, C. M., Constantino, L. C., Barichello, T., STRECK, E. L., Quevedo, J., & Dal‐Pizzol, F. (2009) · Current Neurovascular Research · doi:10.2174/156720209788970045 · Cited by 45 · see citing works

Cognitive performance and age-related changes in the hippocampal proteome

Freeman, W. M., VanGuilder, H. D., Bennett, C., & Sonntag, W. E. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.12.004 · Cited by 42 · see citing works

Basal and hypercapnia-altered cerebrovascular perfusion predict mild cognitive impairment in aging rodents

Mitschelen, M. C., Garteiser, P., Carnes, B. A., Farley, J. A., Doblas, S., DeMoe, J. H., Warrington, J. P., Yan, H., Nicolle, M. M., Towner, R. A., et al. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.08.070 · Cited by 36 · see citing works

Age-related alterations in retinal neurovascular and inflammatory transcripts.

Kirk, C. A. V., VanGuilder, H. D., Young, M. M., Farley, J. A., Sonntag, W. E., & Freeman, W. M. (2011) · Europe PMC (PubMed Central) · Cited by 30 · see citing works

Chronic insulin treatment of diabetes does not fully normalize alterations in the retinal transcriptome

Bixler, G. V., VanGuilder, H. D., Brucklacher, R. M., Kimball, S. R., Bronson, S. K., & Freeman, W. M. (2011) · BMC Medical Genomics · doi:10.1186/1755-8794-4-40 · Cited by 28 · see citing works

Cognitive and Functional Impairment After Severe Sepsis

Khandaker, G. M. (2011) · JAMA · doi:10.1001/jama.2011.142 · Cited by 24 · see citing works

Spatial Navigation (Water Maze) Tasks -- Methods of Behavior Analysis in Neuroscience

Jj, B. (2009) · Cited by 15 · see citing works

Neurophysiology of Old Neurons and Synapses -- Brain Aging: Models, Methods, and Mechanisms

Dr, R. (2007) · Cited by 3 · see citing works

Untitled work

Mattson, M. (1999) · doi:10.1002/(sici)1097-4547(19991001)58:1

Review: microglia of the aged brain: primed to be activated and resistant to regulation

Norden, D. M., & Godbout, J. P. (2013) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2012.01306.x · Cited by 792 · see citing works

Microglia across the lifespan: from origin to function in brain development, plasticity and cognition

Tay, T. L., Savage, J. C., Hui, C. W., Bisht, K., & Tremblay, M. (2017) · The Journal of Physiology · doi:10.1113/jp272134 · Cited by 562 · see citing works

Microglial priming and enhanced reactivity to secondary insult in aging, and traumatic CNS injury, and neurodegenerative disease

Norden, D. M., Muccigrosso, M. M., & Godbout, J. P. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.10.028 · Cited by 413 · see citing works

Microglia Priming with Aging and Stress

Niraula, A., Sheridan, J. F., & Godbout, J. P. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.185 · Cited by 398 · see citing works

Microglia Phenotypes in Aging and Neurodegenerative Diseases

Wendimu, M. Y., & Hooks, S. B. (2022) · Cells · doi:10.3390/cells11132091 · Cited by 336 · see citing works

Aging Microglia—Phenotypes, Functions and Implications for Age-Related Neurodegenerative Diseases

Spittau, B. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00194 · Cited by 258 · see citing works

Priming the Inflammatory Pump of the CNS after Traumatic Brain Injury

Witcher, K. G., Eiferman, D. S., & Godbout, J. P. (2015) · Trends in Neurosciences · doi:10.1016/j.tins.2015.08.002 · Cited by 222 · see citing works

HDAC1 modulates OGG1-initiated oxidative DNA damage repair in the aging brain and Alzheimer’s disease

Pao, P.-C., Patnaik, D., Watson, L. A., Gao, F., Pan, L., Wang, J., Adaikkan, C., Penney, J., Cam, H. P., Huang, W.-C., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-16361-y · Cited by 216 · see citing works

Sexually divergent induction of microglial-associated neuroinflammation with hippocampal aging

Mangold, C. A., Wronowski, B., Du, M., Masser, D. R., Hadad, N., Bixler, G. V., Brucklacher, R. M., Ford, M. M., Sonntag, W. E., & Freeman, W. M. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-0920-8 · Cited by 203 · see citing works

Age-related variations in the methylome associated with gene expression in human monocytes and T cells

Reynolds, L. M., Taylor, J. R., Ding, J., Lohman, K., Johnson, C. W., Siscovick, D. S., Burke, G. L., Post, W. S., Shea, S., Jacobs, D. R., et al. (2014) · Nature Communications · doi:10.1038/ncomms6366 · Cited by 201 · see citing works

Microglia as modulators of cognition and neuropsychiatric disorders

Blank, T., & Prinz, M. (2012) · Glia · doi:10.1002/glia.22372 · Cited by 185 · see citing works

Cellular correlates of cortical thinning throughout the lifespan

Vidal-Pineiro, D., Parker, N., Shin, J., French, L., Grydeland, H., Jackowski, A. P., Mowinckel, A. M., Patel, Y., Pausova, Z., Salum, G., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-78471-3 · Cited by 154 · see citing works

Inflammation in Traumatic Brain Injury

Postolache, T. T., Wadhawan, A., Can, A., Lowry, C. A., Woodbury, M., Makkar, H., Hoisington, A. J., Scott, A. J., Potocki, E., Benros, M. E., et al. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-191150 · Cited by 150 · see citing works

Exploring Sex-Related Differences in Microglia May Be a Game-Changer in Precision Medicine

Lynch, M. A. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.868448 · Cited by 146 · see citing works

Forced turnover of aged microglia induces an intermediate phenotype but does not rebalance CNS environmental cues driving priming to immune challenge

O’Neil, S. M., Witcher, K. G., McKim, D. B., & Godbout, J. P. (2018) · Acta Neuropathologica Communications · doi:10.1186/s40478-018-0636-8 · Cited by 138 · see citing works

Neuroinflammation as Fuel for Axonal Regeneration in the Injured Vertebrate Central Nervous System

Bollaerts, I., houcke, J. V., Andries, L., Groef, L. D., & Moons, L. (2017) · Mediators of Inflammation · doi:10.1155/2017/9478542 · Cited by 137 · see citing works

Insulin-like growth factor-1 in CNS and cerebrovascular aging

Sonntag, W. E., Deák, F., Ashpole, N. M., Tóth, P., Csiszár, A., Freeman, W. M., & Ungvari, Z. I. (2013) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2013.00027 · Cited by 136 · see citing works

Cholinergic Modulation of Glial Function During Aging and Chronic Neuroinflammation

Gamage, R. V., Wagnon, I. M., Rossetti, I., Childs, R., Niedermayer, G., Chesworth, R., & Gyengési, E. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.577912 · Cited by 133 · see citing works

The Inflammatory Continuum of Traumatic Brain Injury and Alzheimer’s Disease

Kokiko-Cochran, O. N., & Godbout, J. P. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00672 · Cited by 128 · see citing works

Acute in utero exposure to lipopolysaccharide induces inflammation in the pre- and postnatal brain and alters the glial cytoarchitecture in the developing amygdala

O’Loughlin, E., Pakan, J. M. P., Yilmazer-Hanke, D., & McDermott, K. W. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-0981-8 · Cited by 127 · see citing works

Microglia in Aging and Alzheimer’s Disease: A Comparative Species Review

Edler, M. K., Mhatre-Winters, I., & Richardson, J. R. (2021) · Cells · doi:10.3390/cells10051138 · Cited by 126 · see citing works

GFAP expression in injured astrocytes in rats

Zhang, S., Wu, M., Peng, C., Zhao, G., & Gu, R. (2017) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2017.4760 · Cited by 123 · see citing works

Inflammatory mechanisms in neurodegeneration

Nichols, M. R., St‐Pierre, M., Wendeln, A., Makoni, N. J., Gouwens, L. K., Garrad, E. C., Sohrabi, M., Neher, J. J., Tremblay, M., & Combs, C. K. (2019) · Journal of Neurochemistry · doi:10.1111/jnc.14674 · Cited by 122 · see citing works

Sexually dimorphic microglia and ischemic stroke

Kerr, N. A., Dietrich, D. W., Bramlett, H. M., & Raval, A. P. (2019) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.13267 · Cited by 110 · see citing works

Redox Signaling in Neurotransmission and Cognition During Aging

Kumar, A., Yegla, B., & Foster, T. C. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7111 · Cited by 104 · see citing works

Developmental microglial priming in postmortem autism spectrum disorder temporal cortex

Lee, A. S., Azmitia, E. C., & Whitaker‐Azmitia, P. M. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.01.019 · Cited by 96 · see citing works

Glia: victims or villains of the aging brain?

Salas, I. H., Burgado, J., & Allen, N. J. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.105008 · Cited by 96 · see citing works

Reactive gliosis in traumatic brain injury: a comprehensive review

Amlerova, Z., Chmelová, M., Anděrová, M., & Vargová, L. (2024) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2024.1335849 · Cited by 86 · see citing works

Microglial priming and Alzheimer’s disease: a possible role for (early) immune challenges and epigenetics?

Hoeijmakers, L., Heinen, Y., van Dam, A.-M., Lucassen, P. J., & Korosi, A. (2016) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2016.00398 · Cited by 85 · see citing works

The old guard: Age-related changes in microglia and their consequences

Costa, J., Martins, S., Ferreira, P. A., Cardoso, A. M., Guedes, J. R., Peça, J., & Cardoso, A. L. (2021) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2021.111512 · Cited by 84 · see citing works

Korean Red Ginseng and Ginsenoside-Rb1/-Rg1 Alleviate Experimental Autoimmune Encephalomyelitis by Suppressing Th1 and Th17 Cells and Upregulating Regulatory T Cells

Lee, M. J., Jang, M., Choi, J., Chang, B. S., ‍Kim, D. Y., Kim, S., Kwak, Y.-S., Oh, S., Lee, J., Chang, B., et al. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9131-4 · Cited by 82 · see citing works

n-3 Polyunsaturated Fatty Acids and Their Derivates Reduce Neuroinflammation during Aging

Joffre, C., Dinel, A., Chataigner, M., Pallet, V., & Layé, S. (2020) · Nutrients · doi:10.3390/nu12030647 · Cited by 74 · see citing works

Insensitivity of astrocytes to interleukin 10 signaling following peripheral immune challenge results in prolonged microglial activation in the aged brain

Norden, D. M., Trojanowski, P. J., Walker, F. R., & Godbout, J. P. (2016) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2016.04.014 · Cited by 73 · see citing works

Inflammation: Bridging Age, Menopause and APOEε4 Genotype to Alzheimer’s Disease

Mishra, A., & Brinton, R. D. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00312 · Cited by 69 · see citing works

Bee Venom Acupuncture Alleviates Experimental Autoimmune Encephalomyelitis by Upregulating Regulatory T Cells and Suppressing Th1 and Th17 Responses

Lee, M. J., Jang, M., Choi, J., Lee, G., Min, H. J., Chung, W., Kim, J., Jee, Y., Chae, Y., Kim, S., et al. (2015) · Molecular Neurobiology · doi:10.1007/s12035-014-9012-2 · Cited by 68 · see citing works

Neuroglial Expression of the MHCI Pathway and PirB Receptor Is Upregulated in the Hippocampus with Advanced Aging

Starkey, H. D. V., Kirk, C. A. V., Bixler, G. V., Imperio, C. G., Kale, V. P., Serfass, J. M., Farley, J. A., Han, Y., Warrington, J. P., Han, S. I., et al. (2012) · Journal of Molecular Neuroscience · doi:10.1007/s12031-012-9783-8 · Cited by 66 · see citing works

Microglia recapitulate a hematopoietic master regulator network in the aging human frontal cortex

Wehrspaun, C. C., Haerty, W., & Ponting, C. P. (2015) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2015.04.008 · Cited by 64 · see citing works

DNA Methylation of Synaptic Genes in the Prefrontal Cortex Is Associated with Aging and Age-Related Cognitive Impairment

Ianov, L., Riva, A., Kumar, A., & Foster, T. C. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00249 · Cited by 64 · see citing works

Functional and Phenotypic Diversity of Microglia: Implication for Microglia-Based Therapies for Alzheimer’s Disease

Xu, Y., Au, N. P. B., & Ma, C. H. E. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.896852 · Cited by 63 · see citing works

Ageing neuroinflammation and neurodegeneration

Ward, R. J. (2015) · Frontiers in Bioscience-Scholar · doi:10.2741/s433 · Cited by 63 · see citing works

Unraveling Parkinson’s Disease Neurodegeneration: Does Aging Hold the Clues?

Coleman, C., & Martin, I. (2022) · Journal of Parkinson s Disease · doi:10.3233/jpd-223363 · Cited by 59 · see citing works

Age-Dependent Changes in the Activation and Regulation of Microglia

Cornejo, F., & Rommy von Bernhardi, M. (2016) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-40764-7_10 · Cited by 59 · see citing works

Coordinated Gene Expression of Neuroinflammatory and Cell Signaling Markers in Dorsolateral Prefrontal Cortex during Human Brain Development and Aging

Primiani, C. T., Ryan, V. H., Rao, J. S., Cam, M. C., Ahn, K., Modi, H. R., & Rapoport, S. I. (2014) · PLoS ONE · doi:10.1371/journal.pone.0110972 · Cited by 56 · see citing works

Investigation of Sex Differences in the Microglial Response to Binge Ethanol and Exercise

Barton, E. A., Baker, C., & Leasure, J. L. (2017) · Brain Sciences · doi:10.3390/brainsci7100139 · Cited by 55 · see citing works

Transcription Profile of Aging and Cognition-Related Genes in the Medial Prefrontal Cortex

Ianov, L., Rani, A., Beas, B. S., Kumar, A., & Foster, T. C. (2016) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2016.00113 · Cited by 54 · see citing works

Altered function of neuronal L-type calcium channels in ageing and neuroinflammation: Implications in age-related synaptic dysfunction and cognitive decline

Navakkode, S., Liu, C., & Soong, T. W. (2018) · Ageing Research Reviews · doi:10.1016/j.arr.2018.01.001 · Cited by 53 · see citing works

Aging with a traumatic brain injury: Could behavioral morbidities and endocrine symptoms be influenced by microglial priming?

Ziebell, J. M., Rowe, R. K., Muccigrosso, M. M., Reddaway, J., Adelson, P. D., Godbout, J. P., & Lifshitz, J. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.03.008 · Cited by 52 · see citing works

Extracellular HMGB1 Modulates Glutamate Metabolism Associated with Kainic Acid-Induced Epilepsy-Like Hyperactivity in Primary Rat Neural Cells

Kaneko, Y., Pappas, C. A., Malapira, T., Vale, F. Ĺ., Tajiri, N., & Borlongan, C. V. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000460513 · Cited by 51 · see citing works

Novel Players in the Aging Synapse: Impact on Cognition

Temido‐Ferreira, M., Coelho, J. E., Pousinha, P. A., & Lopes, L. V. (2019) · Journal of Caffeine and Adenosine Research · doi:10.1089/caff.2019.0013 · Cited by 51 · see citing works

Innate immunity and cellular senescence: The good and the bad in the developmental and aged brain

Santoro, A., Spinelli, C. C., Martucciello, S., Nori, S. L., Capunzo, M., Puca, A. A., & Ciaglia, E. (2018) · Journal of Leukocyte Biology · doi:10.1002/jlb.3mr0118-003r · Cited by 50 · see citing works

Neuroinflammaging and the Immune Landscape: The Role of Autophagy and Senescence in Aging Brain

Tamatta, R., Pai, V., Jaiswal, C., Singh, I., & Singh, A. K. (2025) · Biogerontology · doi:10.1007/s10522-025-10199-x · Cited by 49 · see citing works

Hippocampal expression of myelin‐associated inhibitors is induced with age‐related cognitive decline and correlates with deficits of spatial learning and memory

VanGuilder, H. D., Bixler, G. V., Sonntag, W. E., & Freeman, W. M. (2012) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2012.07671.x · Cited by 49 · see citing works

Age and Sex Influence the Hippocampal Response and Recovery Following Sepsis

Barter, J., Kumar, A., Stortz, J. A., Hollen, M. K., Nacionales, D. C., Efron, P. A., Moldawer, L. L., & Foster, T. C. (2019) · Molecular Neurobiology · doi:10.1007/s12035-019-01681-y · Cited by 49 · see citing works

Hippocampal Subregions Exhibit Both Distinct and Shared Transcriptomic Responses to Aging and Nonneurodegenerative Cognitive Decline

Masser, D. R., Bixler, G. V., Brucklacher, R. M., Yan, H., Giles, C. B., Wren, J. D., Sonntag, W. E., & Freeman, W. M. (2014) · The Journals of Gerontology Series A · doi:10.1093/gerona/glu091 · Cited by 48 · see citing works

Temporal Course of Changes in Gene Expression Suggests a Cytokine-Related Mechanism for Long-Term Hippocampal Alteration after Controlled Cortical Impact

Almeida-Suhett, C. P., Li, Z., Marini, A. M., Braga, M. F. M., & Eiden, L. E. (2013) · Journal of Neurotrauma · doi:10.1089/neu.2013.3029 · Cited by 47 · see citing works

Riluzole Partially Rescues Age-Associated, but not LPS-Induced, Loss of Glutamate Transporters and Spatial Memory

Brothers, H. M., Bardou, I., Hopp, S. C., Kaercher, R. M., Corona, A. W., Fenn, A. M., Godbout, J. P., & Wenk, G. L. (2013) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-013-9476-2 · Cited by 44 · see citing works

Neuroinflammation: Integrated Nervous Tissue Response through Intercellular Interactions at the “Whole System” Scale

Nosi, D., Lana, D., Giovannini, M. G., Delfino, G., & Zecchi‐Orlandini, S. (2021) · Cells · doi:10.3390/cells10051195 · Cited by 41 · see citing works

Differentially Severe Cognitive Effects of Compromised Cerebral Blood Flow in Aged Mice: Association with Myelin Degradation and Microglia Activation

Wolf, G., Lotan, A., Lifschytz, T., Ben-Ari, H., Kreisel, T., Tatarskyy, P., Valitzky, M., Mernick, B., Avidan, E., Koroukhov, N., et al. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00191 · Cited by 39 · see citing works

Sericin modulates learning and memory behaviors by tuning of antioxidant, inflammatory, and apoptotic markers in the hippocampus of aged mice

Seyedaghamiri, F., Farajdokht, F., Vatandoust, S. M., Mahmoudi, J., Khabbaz, A., & Sadigh‐Eteghad, S. (2021) · Molecular Biology Reports · doi:10.1007/s11033-021-06195-2 · Cited by 38 · see citing works

Aged-Related Changes in Microglia and Neurodegenerative Diseases: Exploring the Connection

Borrajo, A. (2024) · Biomedicines · doi:10.3390/biomedicines12081737 · Cited by 36 · see citing works

Expression of HLA-DR, CD80, and CD86 in Healthy Aging and Alzheimer’s Disease

Busse, S., Steiner, J. H., Alter, J., Dobrowolny, H., Mawrin, C., Bogerts, B., Hartig, R., & Busse, M. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-150217 · Cited by 36 · see citing works

Intracerebroventricular Administration of a 2′-O-Methyl Phosphorothioate Antisense Oligonucleotide Results in Activation of the Innate Immune System in Mouse Brain

Toonen, L. J. A., Casaca-Carreira, J., Pellisé-Tintoré, M., Mei, H., Temel, Y., Jahanshahi, A., & van Roon‐Mom, W. (2018) · Nucleic Acid Therapeutics · doi:10.1089/nat.2017.0705 · Cited by 36 · see citing works

Senescent accelerated prone 8 (SAMP8) mice as a model of age dependent neuroinflammation

Fernández, A., Quintana, E., Velasco, P., Moreno-Jimenez, B., de Andrés, B., Gaspar, M.-L., Liste, I., Vilar, M., Mira, H., & Cano, E. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02104-3 · Cited by 35 · see citing works

Suicide in bipolar disorder patients is associated with hippocampal microglia activation and reduction of lymphocytes-activation gene 3 (LAG3) microglial checkpoint expression

Naggan, L., Robinson, E., Dinur, E., Goldenberg, H., Kozela, E., & Yirmiya, R. (2023) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2023.02.021 · Cited by 35 · see citing works

Microglia changes associated to Alzheimer’s disease pathology in aged chimpanzees

Edler, M., Sherwood, C., Meindl, R., Munger, E. L., Hopkins, W. D., Ely, J., Erwin, J., Perl, D. P., Mufson, E., Hof, P. R., et al. (2018) · The Journal of comparative neurology · doi:10.1002/cne.24484 · Cited by 32 · see citing works

Chronic Gq activation of ventral hippocampal neurons and astrocytes differentially affects memory and behavior

Suthard, R. L., Jellinger, A. L., Surets, M., Shpokayte, M., Pyo, A. Y., Buzharsky, M. D., Senne, R. A., Dorst, K. E., Leblanc, H., & Ramirez, S. (2022) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2023.01.007 · Cited by 33 · see citing works

Microglial distribution, branching, and clearance activity in aged rat hippocampus are affected by astrocyte meshwork integrity: evidence of a novel cell‐cell interglial interaction

Lana, D., Ugolini, F., Wenk, G. L., Giovannini, M. G., Zecchi‐Orlandini, S., & Nosi, D. (2018) · The FASEB Journal · doi:10.1096/fj.201801539r · Cited by 32 · see citing works

PDE inhibition in distinct cell types to reclaim the balance of synaptic plasticity

Rombaut, B., Kessels, S., Schepers, M., Tiane, A., Paes, D., Solomina, Y., Piccart, E., van den Hove, D., Brône, B., Prickaerts, J., et al. (2020) · Theranostics · doi:10.7150/thno.50701 · Cited by 32 · see citing works

Neuroglia in Ageing

Verkhratsky, A., Zorec, R., Rodriguez, J. J., & Parpura, V. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-9913-8_8 · Cited by 31 · see citing works

Long‐term priming of hypothalamic microglia is associated with energy balance disturbances under diet‐induced obesity

Fernández‐Arjona, M. D. M., León‐Rodríguez, A., Grondona, J. M., & López-Ávalos, M. D. (2022) · Glia · doi:10.1002/glia.24217 · Cited by 28 · see citing works

Litter size, age-related memory impairments, and microglial changes in rat dentate gyrus: Stereological analysis and three dimensional morphometry

Viana, L. C., de Lima, C. M., Oliveira, M. A., Borges, R. P., Cardoso, T., Almeida, I., Diniz, D. G., Bento‐Torres, J., Pereira, A., Hornsby, M. B.-D.-O., et al. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.02.019 · Cited by 28 · see citing works

Application of mesenchymal stem cells for anti-senescence and clinical challenges

Wang, Y., Gao, T., & Wang, B. (2023) · Stem Cell Research & Therapy · doi:10.1186/s13287-023-03497-z · Cited by 27 · see citing works

LXR activation protects hippocampal microvasculature in very old triple transgenic mouse model of Alzheimer’s disease

Sandoval-Hernández, A. G., Restrepo, A., Cardona‐Gómez, G. P., & Arboleda, G. (2016) · Neuroscience Letters · doi:10.1016/j.neulet.2016.04.007 · Cited by 27 · see citing works

Increased oxidative stress, hyperphosphorylation of tau, and dystrophic microglia in the hippocampus of aged Tupaia belangeri

Rodríguez-Callejas, J. D., Fuchs, E., & Perez‐Cruz, C. (2020) · Glia · doi:10.1002/glia.23804 · Cited by 26 · see citing works

Three‐dimensional morphometric analysis of microglial changes in a mouse model of virus encephalitis: age and environmental influences

de Sousa, A. A., dos Reis, R. R., de Lima, C. M., Augusto‐Oliveira, M., Fernandes, T. N., Gomes, G. F., Diniz, D. G., Magalhães, N. G. D. M., Diniz, C. G., Sosthenes, M. C. K., et al. (2015) · European Journal of Neuroscience · doi:10.1111/ejn.12951 · Cited by 26 · see citing works

Increased hippocampal NgR1 signaling machinery in aged rats with deficits of spatial cognition

Starkey, H. D. V., Sonntag, W. E., & Freeman, W. M. (2013) · European Journal of Neuroscience · doi:10.1111/ejn.12165 · Cited by 25 · see citing works

FK506-Binding Protein 12.6/1b, a Negative Regulator of [Ca2+], Rescues Memory and Restores Genomic Regulation in the Hippocampus of Aging Rats

Gant, J. C., Blalock, E. M., Chen, K.-C., Kadish, I., Thibault, O., Porter, N. M., & Landfield, P. W. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.2234-17.2017 · Cited by 25 · see citing works

The Effects of Modified Curcumin Preparations on Glial Morphology in Aging and Neuroinflammation

Ullah, F., Gamage, R. V., Sen, M. K., & Gyengési, E. (2022) · Neurochemical Research · doi:10.1007/s11064-021-03499-4 · Cited by 21 · see citing works

Gintonin, a Panax ginseng-derived LPA receptor ligand, attenuates kainic acid-induced seizures and neuronal cell death in the hippocampus via anti-inflammatory and anti-oxidant activities

Choi, J. H., Kwon, T. W., Jo, H.-S., Ha, Y., & Cho, I. (2022) · Journal of Ginseng Research · doi:10.1016/j.jgr.2022.11.001 · Cited by 21 · see citing works

The immune marker CD68 correlates with cognitive impairment in normally aged rats

Farso, M. C., Ménard, C., Colby-Milley, J., & Quirion, R. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.02.008 · Cited by 21 · see citing works

Age-Induced Spatial Memory Deficits in Rats Are Correlated with Specific Brain Region Alterations in Microglial Morphology and Gene Expression

Shoham, S., Linial, M., & Weinstock, M. (2018) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-018-9817-2 · Cited by 21 · see citing works

Microglia-Synapse Pathways: Promising Therapeutic Strategy for Alzheimer’s Disease

Xie, J., Wang, H., Lin, T., & Bi, B. (2017) · BioMed Research International · doi:10.1155/2017/2986460 · Cited by 21 · see citing works

The differential impact of acute microglia activation on the excitability of cholinergic neurons in the mouse medial septum

Kékesi, O., Liang, H., Münch, G. W., Morley, J. W., Gyengési, E., & Buskila, Y. (2019) · Brain Structure and Function · doi:10.1007/s00429-019-01905-w · Cited by 19 · see citing works

Central Activation of Alpha7 Nicotinic Signaling Attenuates LPS-Induced Neuroinflammation and Sickness Behavior in Adult but Not in Aged Animals

Navarro, E., Norden, D. M., Trojanowski, P. J., Godbout, J. P., & López, M. G. (2021) · Molecules · doi:10.3390/molecules26082107 · Cited by 19 · see citing works

MP Resulting in Autophagic Cell Death of Microglia through Zinc Changes against Spinal Cord Injury

Li, D., Wang, G., Han, D., Bi, J., Li, C., Wang, H., Liu, Z., Gao, W., Gao, K., Yao, T., et al. (2016) · BioMed Research International · doi:10.1155/2016/6090316 · Cited by 19 · see citing works

Hallmarks of healthy cognitive aging: inter-individual differences in aging trajectories.

Abrous, D., Blin, N., Boraxbekk, C., Catheline, G., Fitzsimons, C., Hilscher, M., Lemoine, M., Lopes, L. V., Maass, A., Nilsson, M., et al. (2026) · Ageing Research Reviews · doi:10.1016/j.arr.2026.103102 · Cited by 17 · see citing works

Dual Roles of Microglia in the Basal Ganglia in Parkinson’s Disease

Choudhury, M. E., Kigami, Y., & Tanaka, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22083907 · Cited by 18 · see citing works

Expression of NgR1-Antagonizing Proteins Decreases with Aging and Cognitive Decline in Rat Hippocampus

Starkey, H. D. V., Bixler, G. V., Sonntag, W. E., & Freeman, W. M. (2013) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-013-9929-4 · Cited by 18 · see citing works

Operationally defining cognitive reserve genes

Yegla, B., & Foster, T. C. (2021) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2021.08.015 · Cited by 17 · see citing works

Transcriptional profiling reveals progeroid Ercc1 -/Δ mice as a model system for glomerular aging

Schermer, B., Bartels, V., Frommolt, P., Habermann, B. H., Braun, F., Schultze, J. L., Roodbergen, M., Hoeijmakers, J. H. J., Schumacher, B., Nürnberg, P., et al. (2013) · BMC Genomics · doi:10.1186/1471-2164-14-559 · Cited by 17 · see citing works

Modulation of the Microglial Nogo-A/NgR Signaling Pathway as a Therapeutic Target for Multiple Sclerosis

Nheu, D., Ellen, O., Ye, S., Ozturk, E., Pagnin, M., Kertadjaja, S., Theotokis, P., Grigoriadis, N., Mclean, C. A., & Petratos, S. (2022) · Cells · doi:10.3390/cells11233768 · Cited by 14 · see citing works

Expression of the purine biosynthetic enzyme phosphoribosyl formylglycinamidine synthase in neurons

Mangold, C. A., Yao, P. J., Du, M., Freeman, W. M., Benkovic, S. J., & SZPARA, M. L. (2018) · Journal of Neurochemistry · doi:10.1111/jnc.14304 · Cited by 16 · see citing works

Quantitative, structural and molecular changes in neuroglia of aging mammals: A review

Pannese, E. (2021) · European Journal of Histochemistry · doi:10.4081/ejh.2021.3249 · Cited by 16 · see citing works

Searching for differentially expressed proteins in spinal cord injury based on the proteomics analysis

Ding, H. D., Yu, J. H., Chang, W., Liu, F., & He, Z. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.117235 · Cited by 15 · see citing works

Heterozygous knockout of the Bmi-1 gene causes an early onset of phenotypes associated with brain aging

Gu, M., Shen, L., Bai, L., Gao, J., Marshall, C., Wu, T., Ding, J., Miao, D., & Xiao, M. (2013) · AGE · doi:10.1007/s11357-013-9552-9 · Cited by 14 · see citing works

Proton irradiation impacts age-driven modulations of cancer progression influenced by immune system transcriptome modifications from splenic tissue

Wage, J., Ma, L., Peluso, M. J., Lamont, C., Evens, A. M., Hahnfeldt, P., Hlatky, L., & Beheshti, A. (2015) · Journal of Radiation Research · doi:10.1093/jrr/rrv043 · Cited by 13 · see citing works

Advanced age attenuates the antihyperalgesic effect of morphine and decreases μ-opioid receptor expression and binding in the rat midbrain periaqueductal gray in male and female rats

Fullerton, E. F., Rubaharan, M., Karom, M. C., Hanberry, R. I., & Murphy, A. Z. (2020) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2020.10.020 · Cited by 12 · see citing works

Oriental Medicine Woohwangchungsimwon Attenuates Kainic Acid-Induced Seizures and Neuronal Cell Death in the Hippocampus

Choi, J. H., Jang, M., Kim, E.-J., Kim, H., Ye, S.-K., & Cho, I. (2016) · Rejuvenation Research · doi:10.1089/rej.2015.1779 · Cited by 11 · see citing works

Altered expression of myelin-associated inhibitors and their receptors after traumatic brain injury in the mouse

Israelsson, C., Flygt, J., Ästrand, E., Kiwanuka, O., Bengtsson, H., & Marklund, N. (2014) · Restorative Neurology and Neuroscience · doi:10.3233/rnn-140419 · Cited by 11 · see citing works

Cellular and Molecular Mechanisms for Age-Related Cognitive Decline

Barter, J., & Foster, T. C. (2019) · Cambridge University Press eBooks · doi:10.1017/9781108554350.003 · Cited by 10 · see citing works

The immune marker CD68 correlates with cognitive impairment in normally aged rats

Farso, M. C., Ménard, C., Colby-Milley, J., & Quirion, R. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.02.008 · Cited by 21 · see citing works

Neuroglial Expression of the MHCI Pathway and PirB Receptor Is Upregulated in the Hippocampus with Advanced Aging

Starkey, H. D. V., Kirk, C. A. V., Bixler, G. V., Imperio, C. G., Kale, V. P., Serfass, J. M., Farley, J. A., Han, Y., Warrington, J. P., Han, S. I., et al. (2012) · Journal of Molecular Neuroscience · doi:10.1007/s12031-012-9783-8 · Cited by 66 · see citing works

Impact of age-related neuroglial cell responses on hippocampal deterioration

Ojo, J. O., Rezaie, P., Gabbott, P. L. A., & Stewart, M. G. (2015) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2015.00057 · Cited by 81 · see citing works

The neuron-astrocyte-microglia triad in normal brain aging and a model of neuroinflammation in the rat.

Lana, D., Cerbai, F., Nosi, D., Kirova, P. P., Zecchi, S., Wenk, G. L., & Giovannini, M. G. (2011) · Florence Research (University of Florence)

Hippocampal expression of myelin‐associated inhibitors is induced with age‐related cognitive decline and correlates with deficits of spatial learning and memory

VanGuilder, H. D., Bixler, G. V., Sonntag, W. E., & Freeman, W. M. (2012) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2012.07671.x · Cited by 49 · see citing works