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Cited by 142Multiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration MechanismsNeurogenesis and neuroplasticity mechanisms

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Differences in the early inflammatory responses to toxin-induced demyelination are associated with the age-related decline in CNS remyelination

Zhao, Chao, Li, Wen-Wu, Franklin, Robin J.M.·2006·Neurobiology of Aging
DOI 10.1016/j.neurobiolaging.2005.06.008
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Abstract

CNS remyelination occurs more rapidly in young adult rats than in old rats. Since the inflammatory response initiated by demyelination is an important trigger for remyelination, we address whether ageing changes in remyelination are associated with changes in the inflammatory response. Using a toxin model of demyelination, where the inflammatory response largely comprises macrophages, we show that there is a delay in both recruitment and activation of OX-42+ and macrophage scavenger receptor B+ macrophages following demyelination in older rats (10-13 months) compared to young rats (8-10 weeks). This difference is associated with a slower onset of increased expression of several chemokine mRNAs. However, many inflammatory cytokines have similar mRNA expression patterns, with the exception of IL-1beta, IL-6 and TNF-alpha, which have prolonged expression in the older animals. Differences in IL-1beta mRNA expression, a cytokine specifically implicated in CNS remyelination, are not reflected in differences in protein expression detected by immunocytochemistry. These data relate the age-associated delay in remyelination efficiency to changes in the macrophage and inflammatory mediator response to demyelination.

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  1. Arnett, 2003, Functional genomic analysis of remyelination reveals importance of inflammation in oligodendrocyte regeneration, J Neurosci, 23, 9824, 10.1523/JNEUROSCI.23-30-09824.2003 · DOI · Paper page
  2. Benveniste, 1986, Stimulation of oligodendroglial proliferation and maturation by interleukin-2, Nature, 321, 610, 10.1038/321610a0 · DOI
  3. Bieber, 2003, Efficient central nervous system remyelination requires T cells, Ann Neurol, 53, 680, 10.1002/ana.10578 · DOI · Paper page
  4. Chari, 2003, Decline in rate of colonization of oligodendrocyte progenitor cell (OPC)-depleted tissue by adult OPCs with age, J Neuropathol Exp Neurol, 62, 908, 10.1093/jnen/62.9.908 · DOI
  5. Decker, 2002, Growth factor treatment promotes mobilization of young but not aged adult subventricular zone precursors in response to demyelination, J Neurosci Res, 69, 763, 10.1002/jnr.10411 · DOI
  6. Fancy SPJ, 2004, Increased expression of Nkx2.2 and Olig2 identifies reactive oligodendrocyte progenitor cells responding to demyelination in the adult CNS, Mol Cell Neurosci, 27, 247, 10.1016/j.mcn.2004.06.015 · DOI
  7. Ferrandez, 1999, Effects of age, sex and physical exercise on the phagocytic process of murine peritoneal macrophages, Acta Physiol Scand, 166, 47, 10.1046/j.1365-201x.1999.00535.x · DOI
  8. Franklin, 2004, Remyelination by endogenous glia, vol. 1, 173
  9. Franklin RJM, 2002, Ageing and CNS remyelination, Neuroreport, 13, 923, 10.1097/00001756-200205240-00001 · DOI
  10. Gilson, 1993, Failure of remyelination in areas of demyelination produced in the spinal cord of old rats, Neuropath Appl Neurobiol, 19, 173, 10.1111/j.1365-2990.1993.tb00424.x · DOI
  11. Graca, 1986, Delayed remyelination in the rat spinal cord following ethidium bromide injection, Neuropath Appl Neurobiol, 12, 593, 10.1111/j.1365-2990.1986.tb00162.x · DOI
  12. Hinks, 1999, Distinctive patterns of PDGF-A, FGF-2, IGF-I and TGF-beta1 gene expression during remyelination of experimentally-induced spinal cord demyelination, Mol Cell Neurosci, 14, 153, 10.1006/mcne.1999.0771 · DOI
  13. Hinks, 2000, Delayed changes in growth factor gene expression during slow remyelination in the CNS of aged rats, Mol Cell Neurosci, 16, 542, 10.1006/mcne.2000.0897 · DOI
  14. Kotter, 2005, Macrophage-depletion induced impairment of experimental CNS remyelination is associated with a reduced oligodendrocyte progenitor cell response and altered growth factor expression, Neurobiol Dis, 18, 166, 10.1016/j.nbd.2004.09.019 · DOI · Paper page
  15. Krabbe, 2004, Inflammatory mediators in the elderly, Exp Gerontol, 39, 687, 10.1016/j.exger.2004.01.009 · DOI · Paper page
  16. Kyrkanides, 2001, Enhanced glial activation and expression of specific CNS inflammation-related molecules in aged versus young rats following cortical stab injury, J Neuroimmunol, 119, 269, 10.1016/S0165-5728(01)00404-0 · DOI
  17. Lassmann, 1997, Remyelination in multiple sclerosis, Mult Scler, 3, 133, 10.1177/135245859700300213 · DOI · Paper page
  18. Li, 2005, Minocycline-mediated inhibition of microglia activation impairs oligodendrocyte progenitor cell responses and remyelination in a non-immune model of demyelination, J Neuroimmunol, 158, 58, 10.1016/j.jneuroim.2004.08.011 · DOI
  19. Ludwin, 1980, Chronic demyelination inhibits remyelination in the central nervous system, Lab Invest, 43, 382
  20. Mason, 2001, Interleukin-1beta promotes repair of the CNS, J Neurosci, 21, 7046, 10.1523/JNEUROSCI.21-18-07046.2001 · DOI · Paper page
  21. McMahon, 2002, Peripheral macrophage recruitment in cuprizone-induced CNS demyelination despite an intact blood–brain barrier, J Neuroimmunol, 130, 32, 10.1016/S0165-5728(02)00205-9 · DOI · Paper page
  22. Merrill, 1996, Cytokines in inflammatory brain lesions: helpful and harmful, Trends Neurosci, 19, 331, 10.1016/0166-2236(96)10047-3 · DOI
  23. Messersmith, 2000, Fibroblast growth factor 2 (FGF2) and FGF receptor expression in an experimental demyelinating disease with extensive remyelination, J Neurosci Res, 62, 241, 10.1002/1097-4547(20001015)62:2<241::AID-JNR9>3.0.CO;2-D · DOI
  24. Ousman, 2000, Lysophosphatidylcholine induces rapid recruitment and activation of macrophages in the adult mouse spinal cord, Glia, 30, 92, 10.1002/(SICI)1098-1136(200003)30:1<92::AID-GLIA10>3.0.CO;2-W · DOI
  25. Ousman, 2001, MIP-1alpha, MCP-1, GM-CSF, and TNF-alpha control the immune cell response that mediates rapid phagocytosis of myelin from the adult mouse spinal cord, J Neurosci, 21, 4649, 10.1523/JNEUROSCI.21-13-04649.2001 · DOI
  26. Prineas, 1993, Multiple sclerosis: pathology of recurrent lesions, Brain, 116, 681, 10.1093/brain/116.3.681 · DOI
  27. Redwine, 1998, In vivo proliferation of oligodendrocyte progenitors expressing PDGF-alphaR during early remyelination, J Neurobiol, 37, 413, 10.1002/(SICI)1097-4695(19981115)37:3<413::AID-NEU7>3.0.CO;2-8 · DOI
  28. Robinson, 1998, The chemokine growth-regulated oncogene-a promotes spinal cord oligodendrocyte precursor proliferation, J Neurosci, 18, 10457, 10.1523/JNEUROSCI.18-24-10457.1998 · DOI
  29. Rozovsky, 1998, Age-related activation of microglia and astrocytes: in vitro studies show persistent phenotypes of aging, increased proliferation, and resistance to down-regulation, Neurobiol Aging, 19, 97, 10.1016/S0197-4580(97)00169-3 · DOI
  30. Shields, 1999, Remyelination occurs as extensively but more slowly in old rats compared to young rats following gliotoxin-induced CNS demyelination, Glia, 28, 77, 10.1002/(SICI)1098-1136(199910)28:1<77::AID-GLIA9>3.0.CO;2-F · DOI
  31. Sim, 2002, The age-related decrease in CNS remyelination efficiency is attributable to an impairment of both oligodendrocyte progenitor recruitment and differentiation, J Neurosci, 22, 2451, 10.1523/JNEUROSCI.22-07-02451.2002 · DOI · Paper page
  32. Smith, 2002, The role of nitric oxide in multiple sclerosis, Lancet Neurol, 1, 232, 10.1016/S1474-4422(02)00102-3 · DOI
  33. Tsai, 2002, The chemokine receptor CXCR2 controls positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration, Cell, 110, 373, 10.1016/S0092-8674(02)00838-3 · DOI
  34. Vela, 2002, Interleukin-1 regulates proliferation and differentiation of oligodendrocyte progenitor cells, Mol Cell Neurosci, 20, 489, 10.1006/mcne.2002.1127 · DOI · Paper page
  35. Woodruff, 2004, Platelet-derived growth factor regulates oligodendrocyte progenitor numbers in adult CNS and their response following CNS demyelination, Mol Cell Neurosci, 25, 252, 10.1016/j.mcn.2003.10.014 · DOI · Paper page
  36. Ye, 1999, Increased interleukin-6 expression by microglia from brain of aged mice, J Neuroimmunol, 93, 139, 10.1016/S0165-5728(98)00217-3 · DOI
  37. Yu, 2002, Phenotypic and functional changes in glial cells as a function of age, Neurobiol Aging, 23, 105, 10.1016/S0197-4580(01)00258-5 · DOI

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Metadata

Authors
Zhao, C., Li, W.-W., & Franklin, R. J. M.
Affiliations
University of Cambridge (GB)
Corresponding author
Franklin, Robin J.M.
ORCID
Venue
Neurobiology of Aging
Publisher
Elsevier BV
Published
2006-09
Volume
27
Issue
9
Pages
1298-1307
ISSN
0197-4580 (ISSN-L)
DOI
10.1016/j.neurobiolaging.2005.06.008
OpenAlex
W2158151457
Cited by
142
References
45
Citations by year
2026: 1 · 2025: 1 · 2024: 2 · 2023: 3 · 2022: 5 · 2021: 7 · 2020: 8 · 2019: 16 · 2018: 10 · 2017: 11 · 2016: 10 · 2015: 10 · 2014: 8 · 2013: 8 · 2012: 4
FWCI
3.79
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Neurobiology of Aging (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Wellcome Trust
  • Multiple Sclerosis Society
  • European Commission
Topics
  • Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords
demyelination, aging, neuroinflammation, macrophages, OX-42, chemokines, inflammatory cytokines, IL-1β, interleukin-6, TNF-α, myelin oligodendrocyte glycoprotein, age-related decline
MeSH terms
Aging, Animals, Cell Count, Central Nervous System, Demyelinating Diseases, Disease Models, Animal, Female, Immunohistochemistry, Inflammation, Lysophosphatidylcholines, Macrophages, RNA, Messenger, Spinal Cord Diseases, Toxins, Biological, Gene Expression, Cytokines, Rats, Sprague-Dawley, In Situ Hybridization, Recovery of Function, Reverse Transcriptase Polymerase Chain Reaction, CD11b Antigen, Microarray Analysis, Rats

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