Cited by 83Dementia and Cognitive Impairment ResearchDiabetes, Cardiovascular Risks, and LipoproteinsAdipokines, Inflammation, and Metabolic Diseases

Metabolism, mood and cognition in aging: the importance of lifestyle and dietary intervention

Hendrickx, Hilde, McEwen, Bruce S., Ouderaa, Frans van der·2005·Neurobiology of Aging

Abstract

We are witnessing an unprecedented rise in obesity and Type 2 diabetes. Until recently, study of the relation between metabolic dysregulation and higher brain function was limited. This paper summarizes the findings of a Spark workshop that focussed on the impact of obesity and diabetes on mood and cognition. Disturbances in peripheral glucose regulation are associated with cognitive impairment and depressed mood, especially in older adults. Multiple mechanisms and mediators underlie this association including insulin, glucose, neurotropic factors, glucocorticoids, inflammatory agents and reactive oxygen species. Importantly, prevention and even reversal of diabetes and obesity related cognitive impairment and depressive mood can be brought about by lifestyle modification. In particular, increasing physical fitness and moderating/changing food intake will have beneficial effects. Prevention of obesity and hyperglycemia by adopting a healthy lifestyle will contribute to the maintenance of functional integrity and mental health later in life.

Integrity signals

Registry

Crossref · 10.1016/j.neurobiolaging.2005.10.005

Cites

34 of 34 references verified0 citation errors · 0 not checkable

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  • Diabetes is associated with impaired hippocampal function.

    “diabetes is associated with impaired hippocampal function,87”

    From Sleep Deprivation and Circadian Disruption (2015) · cites this paper as [87]

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Authors
Hendrickx, H., McEwen, B. S., & Ouderaa, F. V. D.
Affiliations
  • Unilever (United Kingdom) (GB)
  • Rockefeller University (US)
Corresponding author
Hendrickx, Hilde
Venue
Neurobiology of Aging
Publisher
Elsevier BV
Published
2005-12
Volume
26
Issue
1
Pages
1-5
ISSN
0197-4580 (ISSN-L)
OpenAlex
W2146448412
Cited by
83
References
34
Citations by year
2026: 2 · 2025: 3 · 2024: 4 · 2023: 4 · 2022: 6 · 2021: 4 · 2020: 4 · 2019: 2 · 2018: 3 · 2017: 4 · 2016: 10 · 2015: 6 · 2014: 4 · 2013: 2 · 2012: 5
FWCI
0.27
Type
journal article
Language
en
Open access
closed
Locations
  • Neurobiology of Aging (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Keywords
aging, obesity, type 2 diabetes, cognitive impairment, depressive mood, glucose regulation, insulin, glucocorticoids, neuroinflammation, reactive oxygen species, neurotrophic factors, lifestyle modification, dietary intervention, physical fitness, hyperglycemia, older adults, mental health
MeSH terms
Affect, Aging, Animals, Cognition, Depression, Diabetes Mellitus, Type 2, Diet Therapy, Humans, Life Style, Obesity

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