Elevation of brain magnesium prevents synaptic loss and reverses cognitive deficits in Alzheimer’s disease mouse model

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By suppressing the expression of anterior pharynx‐defective‐1α and ‐1β and inhibiting the aggregation of β‐amyloid protein, magnesium ions inhibit the cognitive decline of amyloid precursor protein/presenilin 1 transgenic mice

Yu, X., Guan, P., Guo, J., Wang, Y., Cao, L., Xu, G., Κωνσταντόπουλος, Κ., Wang, Z., & Wang, P. (2015) · The FASEB Journal · doi:10.1096/fj.15-275578 · Cited by 36 · see citing works

Examining the homeostatic distribution of metals and Zn isotopes in Göttingen minipigs

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Sodium selenate regulates the brain ionome in a transgenic mouse model of Alzheimer’s disease

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Can magnesium reduce central neurodegeneration in Alzheimer's disease? Basic evidences and research needs

Toffa, D. H., Magnerou, M. A., Kassab, A., Djibo, F. H., & Sow, A. D. (2019) · Neurochemistry International · doi:10.1016/j.neuint.2019.03.014 · Cited by 33 · see citing works

Synergistic effects of magnesium ions and simvastatin on attenuation of high-fat diet-induced bone loss

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A Novel Theanine Complex, Mg-L-Theanine Improves Sleep Quality via Regulating Brain Electrochemical Activity

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Particulate matter and Alzheimer’s disease: an intimate connection

O’Piela, D. R., Durisek, G., Escobar, Y.-N. H., Mackos, A. R., & Wold, L. E. (2022) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2022.06.004 · Cited by 32 · see citing works

Magnesium and Cognitive Health in Adults: A Systematic Review and Meta-Analysis

Chen, F., Wang, J., Cheng, Y., Li, R., Wang, Y., Chen, Y., Scott, T. M., & Tucker, K. L. (2024) · Advances in Nutrition · doi:10.1016/j.advnut.2024.100272 · Cited by 31 · see citing works

Ca:Mg Ratio, APOE Cytosine Modifications, and Cognitive Function: Results from a Randomized Trial

Zhu, X., Borenstein, A. R., Zheng, Y., Zhang, W., Seidner, D. L., Ness, R. M., Murff, H. J., Li, B., Shrubsole, M. J., Yu, C., et al. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-191223 · Cited by 29 · see citing works

Autophagy is involved in oral rAAV/Aβ vaccine-induced Aβ clearance in APP/PS1 transgenic mice

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Magnesium Elevation Promotes Neuronal Differentiation While Suppressing Glial Differentiation of Primary Cultured Adult Mouse Neural Progenitor Cells through ERK/CREB Activation

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The Causal Role of Magnesium Deficiency in the Neuroinflammation, Pain Hypersensitivity and Memory/Emotional Deficits in Ovariectomized and Aged Female Mice

Zhang, J., Zhang, J., Mai, C.-L., Xiong, Y., Lin, Z.-J., Jie, Y.-T., Mai, J.-Z., Liu, C., Xie, M.-X., & Zhou, X. (2021) · Journal of Inflammation Research · doi:10.2147/jir.s330894 · Cited by 28 · see citing works

Trace element levels are associated with neuroinflammatory markers in children with autistic spectrum disorder

Skalny, A. V., Симашкова, Н. В., Skalnaya, A. A., Klyushnik, T. P., Zhegalova, I. V., Grabeklis, A. R., Геннадиевна, С. М., & Tinkov, A. A. (2018) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2018.04.031 · Cited by 26 · see citing works

A Fundamental Role for Oxidants and Intracellular Calcium Signals in Alzheimer’s Pathogenesis—And How a Comprehensive Antioxidant Strategy May Aid Prevention of This Disorder

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Glutamate Metabolism in Mitochondria is Closely Related to Alzheimer’s Disease

Song, J., Yang, X., Zhang, M., Wang, C., & Chen, L. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-210595 · Cited by 27 · see citing works

Neuroprotective effects of magnesium l-threonate in a hypoxic zebrafish model

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Molecular and microstructural biomarkers of neuroplasticity in neurodegenerative disorders through preclinical and diffusion magnetic resonance imaging studies

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Effects of nutrient and bioactive food components on Alzheimer's disease and epigenetic

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Physical & mental activities enhance the neuroprotective effect of vinpocetine & coenzyme Q10 combination against Alzheimer & bone remodeling in rats

Ali, A. A., El-Ella, D. M. A., El‐Emam, S. Z., Shahat, A. S., & El‐Sayed, R. M. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.05.006 · Cited by 24 · see citing works

Serum Magnesium and Cognitive Function Among Qatari Adults

Al-Ghazali, K., Eltayeb, S., Musleh, A., Al-Abdi, T., Ganji, V., & Shi, Z. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.00101 · Cited by 22 · see citing works

Dietary magnesium intake is related to larger brain volumes and lower white matter lesions with notable sex differences

Alateeq, K., Walsh, E., & Cherbuin, N. (2023) · European Journal of Nutrition · doi:10.1007/s00394-023-03123-x · Cited by 22 · see citing works

Urinary metabolomic changes and microbiotic alterations in presenilin1/2 conditional double knockout mice

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Elevation of Brain Magnesium Potentiates Neural Stem Cell Proliferation in the Hippocampus of Young and Aged Mice

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Inhibition of Mg2+ Extrusion Attenuates Glutamate Excitotoxicity in Cultured Rat Hippocampal Neurons

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Breakdown and repair of metabolism in the aging brain

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Amelioration of cognitive impairments in APPswe/PS1dE9 mice is associated with metabolites alteration induced by total salvianolic acid

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Oral administration of trace element magnesium significantly improving the cognition and locomotion in hepatic encephalopathy rats

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The distinct role of NR2B subunit in the enhancement of visual plasticity in adulthood

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Long-term potentiation in the hippocampus: From magnesium to memory

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Deficits in object-in-place but not relative recency performance in the APPswe/PS1dE9 mouse model of Alzheimer’s disease: Implications for object recognition

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Relationship between Whole-Blood Magnesium and Cognitive Performance among Chinese Adults

Lu, Z.-J., He, R., Zhang, Y., Li, B., Li, F., Fu, Y., & Rong, S. (2023) · Nutrients · doi:10.3390/nu15122706 · Cited by 17 · see citing works

The impact of brain cell metabolism and extracellular matrix on magnesium degradation

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Multifactorial determinants of cognition — Thyroid function is not the only one

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Neural depolarization triggers Mg2+ influx in rat hippocampal neurons

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Enriched environment as a nonpharmacological neuroprotective strategy

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Regulation of density of functional presynaptic terminals by local energy supply

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Associations of Cognitive Function with Serum Magnesium and Phosphate in Hemodialysis Patients: A Cross-Sectional Analysis of the Osaka Dialysis Complication Study (ODCS)

Shoji, T., Mori, K., Nagakura, Y., Kabata, D., Kuriu, K., Nakatani, S., Uedono, H., Nagata, Y., Fujii, H., Imanishi, Y., et al. (2024) · Nutrients · doi:10.3390/nu16213776 · Cited by 14 · see citing works

Investigation of the roles of trace elements during hepatitis C virus infection using protein-protein interactions and a shortest path algorithm

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A Relationship between the Structures and Neurotoxic Effects of Aβ Oligomers Stabilized by Different Metal Ions

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Nature's Toolbox for Alzheimer's Disease: A Review on the Potential of Natural Products as Alzheimer's Disease Drugs

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Effects of Magnesium Orotate, Benfotiamine and a Combination of Vitamins on Mitochondrial and Cholinergic Function in the TgF344-AD Rat Model of Alzheimer’s Disease

Viel, C., Brandtner, A. T., Weißhaar, A., Lehto, A., Fuchs, M., & Klein, J. (2021) · Pharmaceuticals · doi:10.3390/ph14121218 · Cited by 12 · see citing works

Effects of electroacupuncture on urinary metabolome and microbiota in presenilin1/2 conditional double knockout mice

Gao, J., Zhou, N., Lu, M., Wang, Q., Zhao, C., Wang, J., Zhou, M., & Xu, Y. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.1047121 · Cited by 12 · see citing works

Associations of Serum Magnesium with Brain Morphology and Subclinical Cerebrovascular Disease: The Atherosclerosis Risk in Communities-Neurocognitive Study

Alam, A. B., Thomas, D. S., Lutsey, P. L., Shrestha, S., & Alonso, Á. (2021) · Nutrients · doi:10.3390/nu13124496 · Cited by 11 · see citing works

Type VI adenylyl cyclase negatively regulates GluN2B-mediated LTD and spatial reversal learning

Chang, C., Lee, C.-T., Hou, W., Lin, M.-S., Lai, H., Chien, C.-L., Chang, C., Cheng, P., Lien, C., & Chern, Y. (2016) · Scientific Reports · doi:10.1038/srep22529 · Cited by 11 · see citing works

Causal association between plasma metabolites and diverse autoimmune diseases: a two-sample bidirectional mendelian randomization study

Yuan, X., Yang, P., Hu, J., Cai, D.-X., Hu, B., Rui, G., & Lin, Z. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1437688 · Cited by 10 · see citing works

Influence of magnesium supplementation on movement side effects related to typical antipsychotic treatment in rats

Kronbauer, M., Metz, V. G., Roversi, K., Dias, V. T., Antoniazzi, C. T. D. D., Barcelos, R. C. S., & Bürger, M. E. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.10.049 · Cited by 10 · see citing works

Research Progress of Magnesium Alloys and Its Alloys in Medical Applications

Meng, X., Liu, A., Wu, C., Han, X., Qianqian, Y., Qiu, H., Li, X., Cai, M., Duan, T., & Wang, Z. (2025) · International Journal of General Medicine · doi:10.2147/ijgm.s565096 · Cited by 9 · see citing works

Higher Habitual Nuts Consumption Is Associated with Better Cognitive Function among Qatari Adults

Nafea, H., Abdelmegid, O., Qaddourah, S., Abdulwahab, Z., Moawad, J., & Shi, Z. (2021) · Nutrients · doi:10.3390/nu13103580 · Cited by 9 · see citing works

Cordyceps cicadae NTTU 868 Mycelium with The Addition of Bioavailable Forms of Magnesium from Deep Ocean Water Prevents the Aβ40 and Streptozotocin-Induced Memory Deficit via Suppressing Alzheimer’s Disease Risk Factors and Increasing Magnesium Uptake of Brain

Wu, Y.-Z., & Lee, C.-L. (2021) · Fermentation · doi:10.3390/fermentation7010039 · Cited by 9 · see citing works

Anxiolytic effect of chronic intake of supplemental magnesium chloride in rat

Macías-Carballo, M., Navarro, S. R., López‐Meraz, M. L., Beltrán‐Parrazal, L., & Morgado‐Valle, C. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2021.113460 · Cited by 9 · see citing works

Comparison the Effect of Zinc Oxide and Magnesium Oxide Nano Particles on Long Term Memory in Adult Male Mice

Kesmati, M., nootarki, Z. S., Issapareh, N., & Torabi, M. (2016) · Zahedan Journal of Research in Medical Sciences · doi:10.17795/zjrms-3473 · Cited by 9 · see citing works

Time or place? Dissociation between object-in-place and relative recency in young APPswe/PS1dE9 mice.

Bonardi, C., Pardon, M., & Armstrong, P. (2021) · Behavioral Neuroscience · doi:10.1037/bne0000431 · Cited by 7 · see citing works

Association between serum magnesium levels and cognitive function in patients undergoing hemodialysis

Kato, K., Nakashima, A., Shinagawa, S., Kobayashi, A., Ohkido, I., Urashima, M., & Yokoo, T. (2024) · Clinical and Experimental Nephrology · doi:10.1007/s10157-024-02528-0 · Cited by 8 · see citing works

Metabolomic biomarkers discovery across chronic gastritis to gastric cancer progression

Yang, L., Wang, J., Li, P., Guo, Y., Li, S., Liu, S., Lou, Y., Qi, J., & Yang, Q. (2025) · Scientific Reports · doi:10.1038/s41598-025-19005-7 · Cited by 8 · see citing works

Effect of oral administration of Magnesium N-Acetyltaurinate on synaptic plasticity in rodents

Fassin, M., Danhier, P., & Ris, L. (2020) · Magnesium Research · doi:10.1684/mrh.2021.0475 · Cited by 8 · see citing works

Combination of magnesium supplementation with treadmill exercise improves memory deficit in aged rats by enhancing hippocampal neurogenesis and plasticity: a functional and histological study

El-Domiaty, H. F., El-Roghy, E. S., & Salem, H. R. (2022) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2021-0133 · Cited by 8 · see citing works

An 8-week open label trial of l-Threonic Acid Magnesium Salt in patients with mild to moderate dementia

Wroolie, T., Chen, K., Watson, K. T., Iagaru, A. H., Sonni, I., Snyder, N. L., Lee, W., Reiman, E. M., & Rasgon, N. (2017) · Personalized Medicine in Psychiatry · doi:10.1016/j.pmip.2017.07.001 · Cited by 8 · see citing works

Recent advances in pharmacological management of attention-deficit/hyperactivity disorder: moving beyond stimulants

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Effect of bioactive extracts from Eucalyptus globulus leaves in experimental models of Alzheimer’s disease

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Hippocampal synaptic dysfunction and spatial memory impairment in omeprazole-treated rats

Thongon, N., & Chamniansawat, S. (2022) · Metabolic Brain Disease · doi:10.1007/s11011-022-01088-0 · Cited by 7 · see citing works

((E)-N-(4-(((2-Amino-5-phenylpyridin-3-yl)imino)methyl)pyridin-2-yl)cyclopropanecarboxamide) Ameliorated Aβ1–42-Induced Alzheimer’s Disease in SD Rats by Inhibiting Oxidative Stress and Apoptosis

Ding, Y., Wang, X., Ji, J., Zhang, X., Chen, M., Li, S., Zhang, Q., & Liu, P. (2021) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.0c00655 · Cited by 7 · see citing works

Magnesium-L-threonate Ameliorates Cognitive Deficit by Attenuating Adult Hippocampal Neurogenesis Impairment in a Mouse Model of Alzheimer’s Disease

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Magnesium may be an effective therapy for Alzheimer’s disease

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Magnesium deficiency and its interaction with the musculoskeletal system, exercise, and connective tissue: an evidence synthesis

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Prevention of cognitive deficits in Alzheimer’s mouse model by elevating brain magnesium

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By suppressing the expression of anterior pharynx‐defective‐1α and ‐1β and inhibiting the aggregation of β‐amyloid protein, magnesium ions inhibit the cognitive decline of amyloid precursor protein/presenilin 1 transgenic mice

Yu, X., Guan, P., Guo, J., Wang, Y., Cao, L., Xu, G., Κωνσταντόπουλος, Κ., Wang, Z., & Wang, P. (2015) · The FASEB Journal · doi:10.1096/fj.15-275578 · Cited by 36 · see citing works

Magnesium Protects Cognitive Functions and Synaptic Plasticity in Streptozotocin-Induced Sporadic Alzheimer’s Model

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P2‐042: MAGNESIUM PREVENTS COGNITIVE DEFICITS AND SYNAPTIC LOSS IN STREPTOZOTOCIN‐INDUCED SPORADIC AD

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Magnesium and Alzheimer's disease

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