P50 gating deficit in Alzheimer dementia correlates to frontal neuropsychological function
Abstract
Background Cognitive inhibition processes were found to be deficient early in the clinical course of Alzheimer's disease (AD). The inhibition of redundant information is a precondition for efficient cognitive processing and presumably modulated by prefrontal attentional networks. Deficits in the suppression of the evoked potential P50 response to paired clicks are well known in schizophrenic patients and undergo cholinergic modulation. In this study, we aimed to investigate inhibitory gating deficits of P50 in AD and their relation to neuropsychological measures.Method P50 suppression was assessed in 19 AD-patients in comparison to a young and elderly control group (n=17 each) and related to MMSE and specific neuropsychological assessments.Results Patients showed reduced sensory gating compared to healthy elderly (p<0.021) and exhibited significantly higher N40-P50-amplitudes. There were no age or gender effects in controls. Frontal neuropsychological tests (TMT-B, verbal fluency) and working memory requiring inhibition, but not declarative memory functions, were significantly correlated with inhibitory gating and test amplitude in both, AD-patients and controls.Conclusions The results support an early inhibitory deficit interfering with executive functions and working memory in AD independent from physiological aging. P50 gating might be applicable as a marker for inhibition deficits and thereby be important for prognosis estimation.
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In adults with Alzheimer's disease, reduced auditory sensory gating is associated with worse executive function task performance.
“Reduced auditory sensory gating has been found to coincide with poorer performance on executive function tasks in adults with autism [25] and Alzheimer’s disease [24].”
From Sensory processing in preterm preschoolers and its association with executive function (2015) · cites this paper as [24]
Several other clinical populations show links between atypical sensory processing and executive or adaptive function impairment.
“Associations between atypical sensory processing and impairment in either executive function or adaptive function have been found in several other clinical populations [2, 5, 24, 25].”
From Sensory processing in preterm preschoolers and its association with executive function (2015) · cites this paper as [24]
The associations found between sensory processing symptoms and executive function impairment in preterm children are consistent with previous studies documenting similar associations in other clinical populations.
“Our findings of associations between sensory processing symptoms and executive function impairment in preterm children are consistent with the results of previous studies documenting similar associations in other clinical populations [5, 24, 25].”
From Sensory processing in preterm preschoolers and its association with executive function (2015) · cites this paper as [24]
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- Authors
- Thomas, C., vom Berg, I., Rupp, A., Seidl, U., Schröder, J., Roesch-Ely, D., Kreisel, S. H., Mundt, C., & Weisbrod, M.
- Affiliations
- Heidelberg University (DE)
- Evangelisches Krankenhaus Bielefeld (DE)
- Corresponding author
- Thomas, Christine
- Venue
- Neurobiology of Aging
- Publisher
- Elsevier BV
- Published
- 2010-03
- Volume
- 31
- Issue
- 3
- Pages
- 416-424
- ISSN
- 0197-4580 (ISSN-L)
- OpenAlex
- W1968042661
- Cited by
- 88
- References
- 49
- Citations by year
- 2025: 3 · 2024: 5 · 2023: 3 · 2022: 3 · 2021: 9 · 2020: 9 · 2019: 4 · 2018: 8 · 2017: 1 · 2016: 3 · 2015: 9 · 2014: 3 · 2013: 4 · 2012: 8
- FWCI
- 3.74
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurobiology of Aging (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Universität Heidelberg
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- Alzheimer's disease, P50, sensory gating, cognitive inhibition, executive function, working memory, neuropsychological markers, cholinergic modulation
- MeSH terms
- Adult, Aged, Aging, Alzheimer Disease, Attention, Auditory Perception, Brain, Cognition, Evoked Potentials, Auditory, Female, Humans, Male, Neuropsychological Tests, Psychiatric Status Rating Scales, Time Factors
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