Early and late onset Alzheimer’s disease patients have distinct patterns of white matter damage.
Abstract
We investigated patterns of white matter (WM) loss in 18 early onset (EO) and 24 late onset (LO) Alzheimer's disease (AD) patients compared with 42 healthy controls (HC), and explored relationships of WM atrophy and apolipoprotein E (ApoE) genotype. Subjects underwent magnetic resonance imaging (MRI). Patterns of WM were assessed using voxel-based morphometry. Compared with healthy controls, LOAD patients had a selective parahippocampal WM loss, while EOAD patients experienced a more widespread pattern of posterior WM atrophy. The distinct regional distribution of WM atrophy reflected the topography of gray matter (GM) loss. ApoE ε4 status was associated with a greater parahippocampal WM loss in both AD groups. The greater WM atrophy in EOAD than LOAD fits with the evidence that EOAD is a more aggressive form of the disease. The ApoE ε4 effect on WM damage in AD is restricted to specific WM regions and does not seem to be related to age of onset.
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EOAD patients tend to show widespread cortical atrophy even in the early stage, especially in the posterior parietal and lateral temporal cortices, with relatively less involvement of the medial temporal structures.
“EOAD patients tend to show widespread cortical atrophy even in the early stage, especially in the posterior parietal and lateral temporal cortices, with relatively less involvement of the medial temporal structures (Frisoni et al., 2005, 2007; Canu et al., 2012; Cho et al., 2013a).”
From Effects of Alzheimer’s and Vascular Pathologies on Structural Connectivity in Early- and Late-Onset Alzheimer’s Disease (2021) · cites this paper as Canu et al., 2012
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- Authors
- Canu, E., Frisoni, G. B., Agosta, F., Pievani, M., Bonetti, M., & Filippi, M.
- Affiliations
- IRCCS Ospedale San Raffaele (IT)
- Centro San Giovanni di Dio Fatebenefratelli (IT)
- Corresponding author
- Filippi, Massimo
- Venue
- Neurobiology of Aging
- Publisher
- Elsevier BV
- Published
- 2012-06
- Volume
- 33
- Issue
- 6
- Pages
- 1023-1033
- ISSN
- 0197-4580 (ISSN-L)
- OpenAlex
- W2090075355
- Cited by
- 67
- References
- 65
- Citations by year
- 2025: 1 · 2024: 4 · 2022: 1 · 2021: 3 · 2020: 4 · 2019: 1 · 2018: 4 · 2017: 7 · 2016: 8 · 2015: 8 · 2014: 5 · 2013: 10 · 2012: 7
- FWCI
- 4.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurobiology of Aging (publishedVersion)
- PubMed (publishedVersion)
- Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele (submittedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Keywords
- Alzheimer's disease, early-onset Alzheimer's disease, late-onset Alzheimer's disease, white matter atrophy, APOE ε4, gray matter loss, age of onset
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Brain, Cognition Disorders, Female, Humans, Male, Middle Aged, Nerve Fibers, Myelinated, Neuropsychological Tests
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