Exercise, cognition, and the aging brain

Kramer, Arthur F.; Erickson, Kirk I.; Colcombe, Stanley J.

doi:10.1152/japplphysiol.00500.2006

Cited by 719Physical Activity and HealthDementia and Cognitive Impairment ResearchCardiovascular and exercise physiology

Exercise, cognition, and the aging brain

Kramer, Arthur F., Erickson, Kirk I., Colcombe, Stanley J.·2006·Journal of Applied Physiology

DOI 10.1152/japplphysiol.00500.2006

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Abstract

We provide a brief review of the literature on exercise effects on brain and cognition. To this end, we focus on both prospective and retrospective human epidemiological studies that have examined the influence of exercise and physical activity on cognition and dementia. We then examine the relatively small set of human randomized clinical trials that have, for the most part, focused on exercise training effects on cognition. Next, we discuss animal research that has examined the molecular, cellular, and behavioral effects of exercise training. Finally, we conclude with a summary and brief discussion of important future directions of research on fitness cognition and brain.

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These improvements extended to corresponding increases in the activity of supporting prefrontal cortical substrates, further replicating seminal findings on the neurocognitive benefit of physical activity.
“These improvements extended to corresponding increases in the activity of supporting prefrontal cortical substrates, further replicate seminal findings on the neurocognitive benefit of physical activity (26–28).”
From Evidence for Neurocognitive Plasticity in At-Risk Older Adults: The Experience Corps Program (2009) · cites this paper as [27]
Aerobic exercise may have important clinical relevance in counteracting the cognitive decline associated with aging or dementia.
“The capacity to promote cognitive performance in this way implies that AE may have an important clinical relevance in counteracting the cognitive decline associated with aging or dementia (Kramer et al., 2006) and has catalyzed its systematic investigation.”
From Aerobic Exercise as a Tool to Improve Hippocampal Plasticity and Function in Humans: Practical Implications for Mental Health Treatment (2016) · cites this paper as Kramer et al., 2006

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Authors: Kramer, A. F., Erickson, K. I., & Colcombe, S. J.
Affiliations: University of Illinois Urbana-Champaign (US)
Corresponding author: Kramer, Arthur F.
ORCID: Kramer, Arthur F.
Venue: Journal of Applied Physiology
Publisher: American Physiological Society
Published: 2006-10
Volume: 101
Issue: 4
Pages: 1237-1242
ISSN: 0161-7567 (ISSN-L)
8750-7587
1522-1601
DOI: 10.1152/japplphysiol.00500.2006
OpenAlex: W16778001
Cited by: 719
References: 42
Citations by year: 2026: 9 · 2025: 16 · 2024: 20 · 2023: 20 · 2022: 25 · 2021: 22 · 2020: 36 · 2019: 37 · 2018: 35 · 2017: 57 · 2016: 39 · 2015: 40 · 2014: 75 · 2013: 55 · 2012: 67
FWCI: 2.95
Type: journal article
Language: en
Open access: closed
Locations: Journal of Applied Physiology (publishedVersion)
PubMed (publishedVersion)
Research Explorer (The University of Manchester) (submittedVersion)
Funders: National Institute on Aging (R01AG025032, R01AG25032, R37 AG-25667, R37AG025667)
Topics: Health Sciences › Medicine › Physiology › Physical Activity and Health
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
Keywords: physical activity, cognition, brain aging, dementia, exercise training, brain health
MeSH terms: Adaptation, Physiological, Aging, Animals, Brain, Cognition, Humans, Physical Fitness, Exercise, Randomized Controlled Trials as Topic, Models, Animal

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Exercise, cognition, and the aging brain

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