CoChat
Sign Up
Cited by 365

The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.

Inducing Autophagy by Rapamycin Before, but Not After, the Formation of Plaques and Tangles Ameliorates Cognitive Deficits

Majumder, Smita, Richardson, Arlan, Strong, Randy, Oddo, Salvatore·2011·PLoS ONE
DOI 10.1371/journal.pone.0025416PMC PMC3182203
Open this paper in CoChat — free account

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1371/journal.pone.0025416

Cites

28 of 28 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • While rapamycin itself is not a strong inducer of autophagy compared to mTOR kinase inhibitors, the effects of rapamycin on the pathology of mouse models of Alzheimer's disease has been attributed in part to increased autophagy.

    “While rapamycin itself is not a strong inducer of autophagy compared to mTOR kinase inhibitors 53, the effects of rapamycin on the pathology of mouse models of Alzheimer’s disease has been attributed in part to increased autophagy 79,80.”

    From Targeting the biology of aging with mTOR inhibitors (2023) · cites this paper as [79]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Flagged first, then by citations

Research works printed but not linked: 68

  1. [4]Kuchibhotla KV Goldman ST Lattarulo CR Wu HY Hyman BT 2008 Abeta plaques lead to aberrant regulation of calcium homeostasis in vivo resulting in structural and functional disruption of neuronal networks. Neuron 59 214 225 18667150 PMC2578820
  2. [5]Ling D Salvaterra PM 2009 A central role for autophagy in Alzheimer-type neurodegeneration. Autophagy 5 738 740 19395865
  3. [6]Ling D Salvaterra PM 2011 Brain aging and Abeta neurotoxicity converge via deterioration in autophagy-lysosomal system: a conditional Drosophila model linking Alzheimer's neurodegeneration with aging. Acta Neuropathol 121 183 191 21076961
  4. [7]Madeo F Eisenberg T Kroemer G 2009 Autophagy for the avoidance of neurodegeneration. Genes Dev 23 2253 2259 19797764 PMC2758740
  5. [8]Wong E Cuervo AM 2010 Autophagy gone awry in neurodegenerative diseases. Nat Neurosci 13 805 811 20581817 PMC4038747
  6. [9]Martinez-Vicente M Cuervo AM 2007 Autophagy and neurodegeneration: when the cleaning crew goes on strike. Lancet Neurol 6 352 361 17362839
  7. [10]Tanida I 2011 Autophagy basics. Microbiol Immunol 55 1 11 21175768
  8. [11]Mizushima N Noda T Yoshimori T Tanaka Y Ishii T 1998 A protein conjugation system essential for autophagy. Nature 395 395 398 9759731
  9. [13]Suzuki K Kirisako T Kamada Y Mizushima N Noda T 2001 The pre-autophagosomal structure organized by concerted functions of APG genes is essential for autophagosome formation. EMBO J 20 5971 5981 11689437 PMC125692
  10. [17]Jia K Chen D Riddle DL 2004 The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span. Development 131 3897 3906 15253933
  11. [18]Kaeberlein M Powers RW 3rd Steffen KK Westman EA Hu D 2005 Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients. Science 310 1193 1196 16293764
  12. [19]Kapahi P Zid BM Harper T Koslover D Sapin V 2004 Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway. Curr Biol 14 885 890 15186745 PMC2754830
  13. [20]Powers RW 3rd Kaeberlein M Caldwell SD Kennedy BK Fields S 2006 Extension of chronological life span in yeast by decreased TOR pathway signaling. Genes Dev 20 174 184 16418483 PMC1356109
  14. [22]Wullschleger S Loewith R Hall MN 2006 TOR signaling in growth and metabolism. Cell 124 471 484 16469695
  15. [23]An WL Cowburn RF Li L Braak H Alafuzoff I 2003 Up-regulation of phosphorylated/activated p70 S6 kinase and its relationship to neurofibrillary pathology in Alzheimer's disease. Am J Pathol 163 591 607 12875979 PMC1868198
  16. [25]Onuki R Bando Y Suyama E Katayama T Kawasaki H 2004 An RNA-dependent protein kinase is involved in tunicamycin-induced apoptosis and Alzheimer's disease. Embo J 23 959 968 14765129 PMC380987
  17. [26]Peel AL Bredesen DE 2003 Activation of the cell stress kinase PKR in Alzheimer's disease and human amyloid precursor protein transgenic mice. Neurobiol Dis 14 52 62 13678666
  18. [27]Pei JJ Bjorkdahl C Zhang H Zhou X Winblad B 2008 p70 S6 kinase and tau in Alzheimer's disease. J Alzheimers Dis 14 385 392 18688088
  19. [28]Caccamo A Maldonado MA Majumder S Medina DX Holbein W 2011 Naturally secreted amyloid-beta increases mammalian target of rapamycin (mTOR) activity via a PRAS40-mediated mechanism. J Biol Chem 286 8924 8932 21266573 PMC3058958
  20. [29]Caccamo A Majumder S Richardson A Strong R Oddo S 2010 Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-beta, and Tau: effects on cognitive impairments. J Biol Chem 285 13107 13120 20178983 PMC2857107
  21. [31]Oddo S Caccamo A Tseng B Cheng D Vasilevko V 2008 Blocking Abeta42 accumulation delays the onset and progression of tau pathology via the C terminus of heat shock protein70-interacting protein: a mechanistic link between Abeta and tau pathology. J Neurosci 28 12163 12175 19020010 PMC6671718
  22. [33]Oddo S Vasilevko V Caccamo A Kitazawa M Cribbs DH 2006 Reduction of soluble Abeta and tau, but not soluble Abeta alone, ameliorates cognitive decline in transgenic mice with plaques and tangles. J Biol Chem 281 39413 39423 17056594
  23. [35]Brown MW Aggleton JP 2001 Recognition memory: what are the roles of the perirhinal cortex and hippocampus? Nat Rev Neurosci 2 51 61 11253359
  24. [36]Winters BD Forwood SE Cowell RA Saksida LM Bussey TJ 2004 Double dissociation between the effects of peri-postrhinal cortex and hippocampal lesions on tests of object recognition and spatial memory: heterogeneity of function within the temporal lobe. J Neurosci 24 5901 5908 15229237 PMC6729235
  25. [37]Blagosklonny MV 2010 Increasing healthy lifespan by suppressing aging in our lifetime: preliminary proposal. Cell Cycle 9 4788 4794 21150328
  26. [40]Khan AA Mao XO Banwait S Jin K Greenberg DA 2007 Neuroglobin attenuates beta-amyloid neurotoxicity in vitro and transgenic Alzheimer phenotype in vivo. Proc Natl Acad Sci U S A 104 19114 19119 18025470 PMC2141917
  27. [42]Nunomura A Tamaoki T Tanaka K Motohashi N Nakamura M 2010 Intraneuronal amyloid beta accumulation and oxidative damage to nucleic acids in Alzheimer disease. Neurobiol Dis 37 731 737 20034567 PMC2825655
  28. [44]Oddo S Caccamo A Cheng D Jouleh B Torp R 2007 Genetically augmenting tau levels does not modulate the onset or progression of Abeta pathology in transgenic mice. J Neurochem 102 1053 1063 17472708
  29. [45]Zheng-Fischhofer Q Biernat J Mandelkow EM Illenberger S Godemann R 1998 Sequential phosphorylation of Tau by glycogen synthase kinase-3beta and protein kinase A at Thr212 and Ser214 generates the Alzheimer-specific epitope of antibody AT100 and requires a paired-helical-filament-like conformation. Eur J Biochem 252 542 552 9546672
  30. [47]Galimberti D Scarpini E 2011 Inflammation and oxidative damage in Alzheimer's disease: friend or foe? Front Biosci (Schol Ed) 3 252 266 21196374
  31. [49]McCoy MK Tansey MG 2008 TNF signaling inhibition in the CNS: implications for normal brain function and neurodegenerative disease. J Neuroinflammation 5 45 18925972 PMC2577641
  32. [50]Cameron B Landreth GE 2010 Inflammation, microglia, and Alzheimer's disease. Neurobiol Dis 37 503 509 19833208 PMC2823849
  33. [52]Huang S Bjornsti MA Houghton PJ 2003 Rapamycins: mechanism of action and cellular resistance. Cancer Biol Ther 2 222 232 12878853
  34. [53]Das F Ghosh-Choudhury N Mahimainathan L Venkatesan B Feliers D 2008 Raptor-rictor axis in TGFbeta-induced protein synthesis. Cell Signal 20 409 423 18068336
  35. [54]Guertin DA Sabatini DM 2007 Defining the role of mTOR in cancer. Cancer Cell 12 9 22 17613433
  36. [55]Hay N 2005 The Akt-mTOR tango and its relevance to cancer. Cancer Cell 8 179 183 16169463
  37. [56]Hay N Sonenberg N 2004 Upstream and downstream of mTOR. Genes Dev 18 1926 1945 15314020
  38. [58]Kwon CH Zhu X Zhang J Baker SJ 2003 mTor is required for hypertrophy of Pten-deficient neuronal soma in vivo. Proc Natl Acad Sci U S A 100 12923 12928 14534328 PMC240720
  39. [59]Serkova N Jacobsen W Niemann CU Litt L Benet LZ 2001 Sirolimus, but not the structurally related RAD (everolimus), enhances the negative effects of cyclosporine on mitochondrial metabolism in the rat brain. Br J Pharmacol 133 875 885 11454661 PMC1572850
  40. [60]Supko JG Malspeis L 1994 Dose-dependent pharmacokinetics of rapamycin-28-N,N-dimethylglycinate in the mouse. Cancer Chemother Pharmacol 33 325 330 8281627
  41. [61]Cuervo AM 2004 Autophagy: many paths to the same end. Mol Cell Biochem 263 55 72 27520665
  42. [62]Jung CH Jun CB Ro SH Kim YM Otto NM 2009 ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery. Mol Biol Cell 20 1992 2003 19225151 PMC2663920
  43. [63]Klionsky DJ Emr SD 2000 Autophagy as a regulated pathway of cellular degradation. Science 290 1717 1721 11099404 PMC2732363
  44. [66]Glabe CC 2005 Amyloid accumulation and pathogensis of Alzheimer's disease: significance of monomeric, oligomeric and fibrillar Abeta. Subcell Biochem 38 167 177 15709478
  45. [67]Klein WL 2002 Abeta toxicity in Alzheimer's disease: globular oligomers (ADDLs) as new vaccine and drug targets. Neurochem Int 41 345 352 12176077
  46. [68]Nixon RA Yang DS 2011 Autophagy failure in Alzheimer's disease-locating the primary defect. Neurobiol Dis 43 38 45 21296668 PMC3096679
  47. [69]Yu WH Cuervo AM Kumar A Peterhoff CM Schmidt SD 2005 Macroautophagy–a novel Beta-amyloid peptide-generating pathway activated in Alzheimer's disease. J Cell Biol 171 87 98 16203860 PMC2171227
  48. [70]Pickford F Masliah E Britschgi M Lucin K Narasimhan R 2008 The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice. J Clin Invest 118 2190 2199 18497889 PMC2391284
  49. [71]Lafay-Chebassier C Paccalin M Page G Barc-Pain S Perault-Pochat MC 2005 mTOR/p70S6k signalling alteration by Abeta exposure as well as in APP-PS1 transgenic models and in patients with Alzheimer's disease. J Neurochem 94 215 225 15953364
  50. [72]Lafay-Chebassier C Perault-Pochat MC Page G Rioux Bilan A Damjanac M 2006 The immunosuppressant rapamycin exacerbates neurotoxicity of Abeta peptide. J Neurosci Res 84 1323 1334 16955484
  51. [73]Hung SY Huang WP Liou HC Fu WM 2009 Autophagy protects neuron from Abeta-induced cytotoxicity. Autophagy 5 502 510 19270530
  52. [74]Ling D Song HJ Garza D Neufeld TP Salvaterra PM 2009 Abeta42-induced neurodegeneration via an age-dependent autophagic-lysosomal injury in Drosophila. PLoS One 4 e4201 19145255 PMC2626277
  53. [75]Khandelwal PJ Herman AM Hoe HS Rebeck GW Moussa CE 2011 Parkin mediates beclin-dependent autophagic clearance of defective mitochondria and ubiquitinated Abeta in AD models. Hum Mol Genet 20 2091 2102 21378096 PMC3090189
  54. [76]Yang DS Stavrides P Mohan PS Kaushik S Kumar A 2011 Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits. Brain 134 258 277 21186265 PMC3009842
  55. [77]Vezina C Kudelski A Sehgal SN 1975 Rapamycin (AY-22,989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle. J Antibiot (Tokyo) 28 721 726 1102508
  56. [78]Geissler EK Schlitt HJ 2010 The potential benefits of rapamycin on renal function, tolerance, fibrosis, and malignancy following transplantation. Kidney Int 78 1075 1079 20861822
  57. [79]Fasolo A Sessa C 2011 Current and future directions in mammalian target of rapamycin inhibitors development. Expert Opin Investig Drugs 20 381 394 21299441
  58. [80]Cao K Graziotto JJ Blair CD Mazzulli JR Erdos MR 2011 Rapamycin reverses cellular phenotypes and enhances mutant protein clearance in hutchinson-gilford progeria syndrome cells. Sci Transl Med 3 89ra58 21715679
  59. [82]Oddo S Caccamo A Cheng D LaFerla FM 2009 Genetically altering Abeta distribution from the brain to the vasculature ameliorates tau pathology. Brain Pathol 19 421 430 18657136 PMC4072242
  60. [84]Meske V Albert F Ohm TG 2008 Coupling of mammalian target of rapamycin with phosphoinositide 3-kinase signaling pathway regulates protein phosphatase 2A- and glycogen synthase kinase-3 -dependent phosphorylation of Tau. J Biol Chem 283 100 109 17971449
  61. [86]Pei JJ Hugon J 2008 mTOR-dependent signalling in Alzheimer's disease. J Cell Mol Med 12 2525 2532 19210753 PMC3828871
  62. [88]Rubinsztein DC Gestwicki JE Murphy LO Klionsky DJ 2007 Potential therapeutic applications of autophagy. Nat Rev Drug Discov 6 304 312 17396135
  63. [89]Sarkar S Perlstein EO Imarisio S Pineau S Cordenier A 2007 Small molecules enhance autophagy and reduce toxicity in Huntington's disease models. Nat Chem Biol 3 331 338 17486044 PMC2635561
  64. [90]Michiorri S Gelmetti V Giarda E Lombardi F Romano F 2010 The Parkinson-associated protein PINK1 interacts with Beclin1 and promotes autophagy. Cell Death Differ 17 962 974 20057503
  65. [91]Herrup K 2010 Reimagining Alzheimer's disease–an age-based hypothesis. J Neurosci 30 16755 16762 21159946 PMC3004746
  66. [92]Medina DX Caccamo A Oddo S 2011 Methylene blue reduces abeta levels and rescues early cognitive deficit by increasing proteasome activity. Brain Pathol 21 140 149 20731659 PMC2992595
  67. [93]Caccamo A Majumder S Deng JJ Bai Y Thornton FB 2009 Rapamycin rescues TDP-43 mislocalization and the associated low molecular mass neurofilament instability. J Biol Chem 284 27416 27424 19651785 PMC2785671
  68. [95]Caccamo A Maldonado MA Bokov AF Majumder S Oddo S 2010 CBP gene transfer increases BDNF levels and ameliorates learning and memory deficits in a mouse model of Alzheimer's disease. Proc Natl Acad Sci U S A 107 22687 22692 21149712 PMC3012497

Cited by

Sorted by citations

Metadata

Authors
Majumder, S., Richardson, A., Strong, R., & Oddo, S.
Venue
PLoS ONE
Publisher
Public Library of Science (PLoS)
Published
2011-09-28
Volume
6
Issue
9
Pages
e25416
ISSN
1932-6203
DOI
10.1371/journal.pone.0025416
PMC
PMC3182203
Cited by
365
References
28
Language
en
Licence
creativecommons.org/licenses/by/4.0/ (unspecified)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review