Aging causes morphological alterations in astrocytes and microglia in human substantia nigra pars compacta

Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner

Schafer, D. P., Lehrman, E. K., Kautzman, A. G., Koyama, R., Mardinly, A. R., Yamasaki, R., Ransohoff, R. M., Greenberg, M. E., Barres, B. A., & Stevens, B. (2012) · Neuron · doi:10.1016/j.neuron.2012.03.026 · Cited by 4,089 · see citing works

Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease.

Griffin, W. S., Stanley, L. C., Ling, C., White, L., MacLeod, V, Perrot, L. J., White, C. L., & Araoz, C. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.19.7611 · Cited by 1,777 · see citing works

The Mystery and Magic of Glia: A Perspective on Their Roles in Health and Disease

Barres, B. A. (2008) · Neuron · doi:10.1016/j.neuron.2008.10.013 · Cited by 1,352 · see citing works

Aggregated α‐synuclein activates microglia: a process leading to disease progression in Parkinson's disease

Zhang, W., Wang, T., Pei, Z., Miller, D. S., Wu, X., Block, M. L., Wilson, B., Zhang, W., Zhou, Y., Hong, J.-S., et al. (2005) · The FASEB Journal · doi:10.1096/fj.04-2751com · Cited by 1,265 · see citing works

Disruption of Cnp1 uncouples oligodendroglial functions in axonal support and myelination

Lappe-Siefke, C., Goebbels, S., Gravel, M., Nicksch, E., Lee, J., Braun, P. E., Griffiths, I. R., & Nave, K.-A. (2003) · Nature Genetics · doi:10.1038/ng1095 · Cited by 1,036 · see citing works

Neuron-released oligomeric α-synuclein is an endogenous agonist of TLR2 for paracrine activation of microglia

Kim, C., Ho, D.-H., Suk, J.-E., You, S., Michael, S., Kang, J., Joong Lee, S., Masliah, E., Hwang, D., Lee, H.-J., et al. (2013) · Nature Communications · doi:10.1038/ncomms2534 · Cited by 856 · see citing works

Distribution of major histocompatibility complex class II-positive microglia and cytokine profile of Parkinson's disease brains

Imamura, K., Hishikawa, N., Sawada, M., Nagatsu, T., Yoshida, M., & Hashizume, Y. (2003) · Acta Neuropathologica · doi:10.1007/s00401-003-0766-2 · Cited by 791 · see citing works

Neuroinflammation in Parkinson's disease

Hirsch, E. C., Vyas, S., & Hunot, S. (2012) · Parkinsonism & Related Disorders · doi:10.1016/s1353-8020(11)70065-7 · Cited by 586 · see citing works

The substantia nigra of the human brain

Damier, P., Hirsch, É. C., Agid, Y., & Graybiel, A. M. (1999) · Brain · doi:10.1093/brain/122.8.1421 · Cited by 579 · see citing works

The effects of normal aging on myelin and nerve fibers: a review

Peters, A. (2002) · Journal of Neurocytology · doi:10.1023/a:1025731309829 · Cited by 577 · see citing works

Hypocretin (orexin) cell loss in Parkinson's disease

Thannickal, T. C., Lai, Y.-Y., & Siegel, J. M. (2007) · Brain · doi:10.1093/brain/awm097 · Cited by 566 · see citing works

Inflammatory Regulators in Parkinson's Disease: iNOS, Lipocortin-1, and Cyclooxygenases-1 and -2

Knott, C., Stern, G., & Wilkin, G. P. (2000) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.2000.0914 · Cited by 503 · see citing works

THE REGIONAL AND SUBCELLULAR DISTRIBUTION OF 2′,3′‐CYCLIC NUCLEOTIDE 3′‐PHOSPHOHYDROLASE IN THE CENTRAL NERVOUS SYSTEM

Kurihara, T., & Tsukada, Y. (1967) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1967.tb06164.x · Cited by 456 · see citing works

Ageing as a primary risk factor for Parkinson's disease: evidence from studies of non-human primates

Collier, T. J., Kanaan, N. M., & Kordower, J. H. (2011) · Nature reviews. Neuroscience · doi:10.1038/nrn3039 · Cited by 453 · see citing works

The Role of Glial Reaction and Inflammation in Parkinson's Disease

Hirsch, É. C., Breidert, T., Rousselet, E., Hunot, S., Hartmann, A., & Michel, P. P. (2003) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2003.tb07478.x · Cited by 449 · see citing works

Glial pathology but absence of apoptotic nigral neurons in long‐standing Parkinson's disease

Banati, R. B., Daniel, S. E., & Blunt, S. B. (1998) · Movement Disorders · doi:10.1002/mds.870130205 · Cited by 430 · see citing works

Presence of reactive microglia in monkey substantia nigra years after 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine administration

McGeer, P. L., Schwab, C., Parent, A., & Doudet, D. (2003) · Annals of Neurology · doi:10.1002/ana.10728 · Cited by 400 · see citing works

Activation of microglia by human neuromelanin is NF‐κB‐dependent and involves p38 mitogen‐activated protein kinase: implications for Parkinson's disease

Wilms, H., Rosenstiel, P. C., Sievers, J., Deuschl, G., Zecca, L., & Lucius, R. (2003) · The FASEB Journal · doi:10.1096/fj.02-0314fje · Cited by 337 · see citing works

The absence of reactive astrocytosis is indicative of a unique inflammatory process in Parkinson's disease

Mirza, B., Hadberg, H., Thomsen, P., & Moos, T. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00455-8 · Cited by 327 · see citing works

Selective microglial activation in the rat rotenone model of Parkinson's disease

Sherer, T., Betarbet, R. S., Kim, J.-H., & Greenamyre, J. T. (2003) · Neuroscience Letters · doi:10.1016/s0304-3940(03)00172-1 · Cited by 317 · see citing works

Matrix Metalloproteinase-3: A Novel Signaling Proteinase from Apoptotic Neuronal Cells That Activates Microglia

Kim, Y.-S., Kim, S. S., Cho, J., Choi, D.-H., Hwang, O., Shin, D., Hong, S.-C., Beal, M., & Joh, T. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.4346-04.2005 · Cited by 272 · see citing works

Actin-binding Proteins Coronin-1a and IBA-1 are Effective Microglial Markers for Immunohistochemistry

Ahmed, Z., Shaw, G., Sharma, V. P., Yang, C., McGowan, E., & Dickson, D. W. (2007) · Journal of Histochemistry & Cytochemistry · doi:10.1369/jhc.6a7156.2007 · Cited by 258 · see citing works

IFN-γ signaling, with the synergistic contribution of TNF-α, mediates cell specific microglial and astroglial activation in experimental models of Parkinson's disease

Barcia, C., Ros, C., Annese, V., Gómez, A., Ros-Bernal, F., Aguado-Yera, D., Martı́nez-Pagán, M., de Pablos, V., Fernández-Villalba, E., & Herrero, M. (2011) · Cell Death and Disease · doi:10.1038/cddis.2011.17 · Cited by 242 · see citing works

S100B Protein Stimulates Microglia Migration via RAGE-dependent Up-regulation of Chemokine Expression and Release

Bianchi, R., Kastrisianaki, E., Giambanco, I., & Donato, R. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.169342 · Cited by 241 · see citing works

Correlation of Astrocytic S100β Expression with Dystrophic Neurites in Amyloid Plaques of Alzheimerʼs Disease

Mrak, R. E., Sheng, J. G., & Griffin, W. S. T. (1996) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199603000-00002 · Cited by 224 · see citing works

α-Synuclein redistributes to neuromelanin lipid in the substantia nigra early in Parkinson's disease

Halliday, G. M., Ophof, A., Broe, M., Jensen, P. H., Kettle, E., Fedorow, H., Cartwright, M., Carew‐Jones, F., Shepherd, C. E., & Double, K. L. (2005) · Brain · doi:10.1093/brain/awh584 · Cited by 219 · see citing works

The calpains in aging and aging-related diseases

Nixon, R. A. (2003) · Ageing Research Reviews · doi:10.1016/s1568-1637(03)00029-1 · Cited by 211 · see citing works

Cellular and Subcellular Distribution of 2′,3′‐Cyclic Nucleotide 3′‐Phosphodiesterase and Its mRNA in the Rat Central Nervous System

Trapp, B. D., Bernier, L., Andrews, S., & Colman, D. (1988) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1988.tb01822.x · Cited by 211 · see citing works

S100B is increased in Parkinson’s disease and ablation protects against MPTP-induced toxicity through the RAGE and TNF-α pathway

Sathe, K., Maetzler, W., Lang, J. D., Mounsey, R. B., Fleckenstein, C., Martin, H. L., Schulte, C., Mustafa, S., Synofzik, M., Vukovic, Z., et al. (2012) · Brain · doi:10.1093/brain/aws250 · Cited by 202 · see citing works

S100β expression in Alzheimer's disease: Relation to neuropathology in brain regions

Eldik, L. J. V., & Griffin, W. S. T. (1994) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/0167-4889(94)90101-5 · Cited by 201 · see citing works

Age‐related decreases in Nurr1 immunoreactivity in the human substantia nigra

Chu, Y., Kompoliti, K., Cochran, E. J., Mufson, E. J., & Kordower, J. H. (2002) · The Journal of Comparative Neurology · doi:10.1002/cne.10261 · Cited by 201 · see citing works

S100β protein expression in Alzheimer disease: Potential role in the pathogenesis of neuritic plaques

Sheng, J. G., Mrak, R. E., & Griffin, W. S. T. (1994) · Journal of Neuroscience Research · doi:10.1002/jnr.490390406 · Cited by 188 · see citing works

Age-related changes in glial fibrillary acidic protein mRNA in the mouse brain

Goss, J. R., Finch, C. E., & Morgan, D. G. (1991) · Neurobiology of Aging · doi:10.1016/0197-4580(91)90056-p · Cited by 170 · see citing works

Preservation of midbrain catecholaminergic neurons in very old human subjects

Kubis, N., Faucheux, B. A., Ransmayr, G. N., Damier, P., Duyckaerts, C. J., Hénin, D., Forette, B., Charpentier, Y. L., Hauw, J., Agid, Y., et al. (2000) · Brain · doi:10.1093/brain/123.2.366 · Cited by 157 · see citing works

CNP is required for maintenance of axon-glia interactions at nodes of Ranvier in the CNS

Rasband, M. N., Tayler, J. E., Kaga, Y., Yang, Y., Lappe-Siefke, C., Nave, K., & Bansal, R. (2005) · Glia · doi:10.1002/glia.20165 · Cited by 149 · see citing works

Evaluation of Markers of Oxidative Stress, Antioxidant Function and Astrocytic Proliferation in the Striatum and Frontal Cortex of Parkinson’s Disease Brains

Mythri, R. B., Venkateshappa, C., Harish, G., Mahadevan, A., Muthane, U. B., Yasha, T. C., Bharath, M. M. S., & Shankar, S. K. (2011) · Neurochemical Research · doi:10.1007/s11064-011-0471-9 · Cited by 148 · see citing works

Unbiased morphometrical measurements show loss of pigmented nigral neurones with ageing

Ma, Röytt, Collan, & Rinne (1999) · Neuropathology and Applied Neurobiology · doi:10.1046/j.1365-2990.1999.00202.x · Cited by 133 · see citing works

Extracellular Calcium Sensing by Glial Cells: Low Extracellular Calcium Induces Intracellular Calcium Release and Intercellular Signaling

Zanotti, S. A., & Charles, A. C. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.69020594.x · Cited by 109 · see citing works

Marked microglial reaction in normal aging human substantia nigra: correlation with extraneuronal neuromelanin pigment deposits

Beach, T. G., Sue, L. I., Walker, D. G., Lue, L. F., Connor, D. J., Caviness, J. N., Sabbagh, M. N., & Adler, C. H. (2007) · Acta Neuropathologica · doi:10.1007/s00401-007-0250-5 · Cited by 101 · see citing works

Low numbers and no loss of melanized nigral neurons with increasing age in normal human brains from India

Muthane, U. B., Yasha, T. C., & Shankar, S. K. (1998) · Annals of Neurology · doi:10.1002/ana.410430304 · Cited by 97 · see citing works

Age‐dependent myelin degeneration and proteolysis of oligodendrocyte proteins is associated with the activation of calpain‐1 in the rhesus monkey

Sloane, J. A., Hinman, J. D., Lubonia, M., Hollander, W., & Abraham, C. R. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01541.x · Cited by 88 · see citing works

Aging Decreases L-Type Calcium Channel Currents and Pacemaker Firing Fidelity in Substantia Nigra Dopamine Neurons

Branch, S. Y., Sharma, R. V., & Beckstead, M. J. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.4228-13.2014 · Cited by 79 · see citing works

Age-related changes in glial cells of dopamine midbrain subregions in rhesus monkeys

Kanaan, N. M., Kordower, J. H., & Collier, T. J. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.07.006 · Cited by 78 · see citing works

GDNF is a major component of trophic activity in DA-depleted striatum for survival and neurite extension of DAergic neurons

Nakajima, K., Hida, H., Shimano, Y., Fujimoto, I., Hashitani, T., Kumazaki, M., Sakurai, T., & Nishino, H. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02866-9 · Cited by 78 · see citing works

Absence of age-related changes in nigral dopaminergic neurons of Asian Indians: Relevance to lower incidence of Parkinson's disease

Alladi, P. A., Mahadevan, A., Yasha, T. C., Raju, T. R., Shankar, S. K., & Muthane, U. B. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.11.051 · Cited by 78 · see citing works

Expression of S‐100 protein is related to neuronal damage in MPTP‐treated mice

Muramatsu, Y., Kurosaki, R., Watanabe, H., Michimata, M., Matsubara, M., Imai, Y., & Araki, T. (2003) · Glia · doi:10.1002/glia.10225 · Cited by 75 · see citing works

The Role of Astroglia on the Survival of Dopamine Neurons

Mena, M. A., de Bernardo, S., Casarejos, M. J., Canals, S., & Rodríguez‐Martín, E. (2002) · Molecular Neurobiology · doi:10.1385/mn:25:3:245 · Cited by 65 · see citing works

Age and region‐specific responses of microglia, but not astrocytes, suggest a role in selective vulnerability of dopamine neurons after 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine exposure in monkeys

Kanaan, N. M., Kordower, J. H., & Collier, T. J. (2008) · Glia · doi:10.1002/glia.20690 · Cited by 64 · see citing works

S-100β protein is upregulated in astrocytes and motor neurons in the spinal cord of patients with amyotrophic lateral sclerosis

Migheli, A., Cordera, S., Bendotti, C., Atzori, C., Piva, R., & Schiffer, D. (1999) · Neuroscience Letters · doi:10.1016/s0304-3940(98)01001-5 · Cited by 64 · see citing works

The Effect of Aging on Pars Compacta of the Substantia Nigra in Rhesus Monkey

Siddiqi, Z. A., & Peters, A. (1999) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199909000-00002 · Cited by 56 · see citing works

Human neuromelanin an endogenous microglial activator for dopaminergic neuron death

Zhang, W. (2012) · Frontiers in Bioscience-Elite · doi:10.2741/e591 · Cited by 53 · see citing works

Ageing enhances α-synuclein, ubiquitin and endoplasmic reticular stress protein expression in the nigral neurons of Asian Indians

Alladi, P. A., Mahadevan, A., Vijayalakshmi, K., Muthane, U. B., Shankar, S. K., & Raju, T. R. (2010) · Neurochemistry International · doi:10.1016/j.neuint.2010.06.018 · Cited by 44 · see citing works

Expression of GDNF receptors GFRα1 and RET is preserved in substantia nigra pars compacta of aging Asian Indians

Alladi, P. A., Mahadevan, A., Shankar, S. K., Raju, T. R., & Muthane, U. B. (2010) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2010.03.007 · Cited by 42 · see citing works

Morphological differentiation of cultured astrocytes is blocked by cadmium or cobalt

MacVicar, B. A. (1987) · Brain Research · doi:10.1016/0006-8993(87)90256-3 · Cited by 40 · see citing works

Ladostigil prevents age-related glial activation and spatial memory deficits in rats

Weinstock, M., Luques, L., Poltyrev, T., Bejar, C., & Shoham, S. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.06.004 · Cited by 36 · see citing works

The Na+‐Ca2+ Exchanger in Rat Brain Synaptosomes

Blaustein, M. P., Fontana, G. A., & ROGOWSKI, R. S. (1996) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1996.tb44803.x · Cited by 31 · see citing works

Evidence of oligodendrogliosis in 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP)‐induced Parkinsonism

Annese, V., Barcia, C., Ros‐Bernal, F., Gómez, A., Ros, C. M. B., de Pablos, V., Fernández‐Villalba, E., Stefano, M. E. D., & Herrero, M. T. (2012) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2012.01271.x · Cited by 27 · see citing works

Developing Substantia nigra in Human: A Qualitative Study

Sailaja, K., & Gopinath, G. (1994) · Developmental Neuroscience · doi:10.1159/000112087 · Cited by 22 · see citing works

Postnatal Development of Neurons, Interneurons and Glial Cells in the Substantia Nigra of Mice

Abe, M., Kimoto, H., Eto, R., Sasaki, T., Kato, H., Kasahara, J., & Araki, T. (2010) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-010-9521-0 · Cited by 21 · see citing works

Analysis of inflammation-related nigral degeneration and locomotor function in DJ-1 −/− mice

Nguyen, T. A., Frank-Cannon, T. C., Martinez, T. N., Ruhn, K. A., Marvin, M. A., Casey, B. H., Treviño, I., Hong, J. J., Goldberg, M. S., & Tansey, M. G. (2013) · Journal of Neuroinflammation · doi:10.1186/1742-2094-10-50 · Cited by 19 · see citing works

Analysis of Neuronal Nitric Oxide Synthase Expression and Increasing Astrogliosis in the Brain of Senescence-Accelerated-Prone 8 Mice

Han, S., Rudd, J. A., Hu, Z., Zhang, L., Yew, D. T. W., & Fang, M. (2010) · International Journal of Neuroscience · doi:10.3109/00207454.2010.503911 · Cited by 14 · see citing works

Increase of Secondary Processes of Microglial and Astroglial Cells After MPTP-Induced Degeneration in Substantia Nigra Pars Compacta of Non Human Primates

Barcia, C., Ros, C. M. B., Sauvage, M.-A. C.-D., Ros‐Bernal, F., Gómez, A., de Pablos, V., Bautista‐Hernández, V., Sánchez-Bahíllo, A., Fernández‐Villalba, E., & Herrero, M. T. (2009) · Springer eBooks · doi:10.1007/978-3-211-92660-4_20 · Cited by 11 · see citing works

Evidence of active nerve cell degeneration in the substantia nigra of humans years after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine exposure

Langston, J. W., Forno, L. S., Tetrud, J., Reeves, A. G., Kaplan, J. A., & Karluk, D. (1999) · Annals of Neurology · doi:10.1002/1531-8249(199910)46:4 · Cited by 1 · see citing works

Reactive astrocyte nomenclature, definitions, and future directions

Escartin, C., Galea, E., Lakatos, A., O’Callaghan, J. P., Petzold, G. C., Serrano-Pozo, A., Steinhäuser, C., Volterra, A., Carmignoto, G., Agarwal, A., et al. (2021) · Nature Neuroscience · doi:10.1038/s41593-020-00783-4 · Cited by 2,533 · see citing works

Gut instincts: microbiota as a key regulator of brain development, ageing and neurodegeneration

Dinan, T. G., & Cryan, J. F. (2017) · The Journal of Physiology · doi:10.1113/jp273106 · Cited by 813 · see citing works

Oxidative stress in the aging substantia nigra and the etiology of Parkinson's disease

Trist, B. G., Hare, D. J., & Double, K. L. (2019) · Aging Cell · doi:10.1111/acel.13031 · Cited by 778 · see citing works

Microbiome, probiotics and neurodegenerative diseases: deciphering the gut brain axis

Westfall, S., Lomis, N., Kahouli, I., Dia, S. Y., Singh, S. P., & Prakash, S. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2550-9 · Cited by 551 · see citing works

Neuroinflammation in the central nervous system: Symphony of glial cells

Yang, Q., & Zhou, J. (2018) · Glia · doi:10.1002/glia.23571 · Cited by 520 · see citing works

The landscape of aging

Cai, Y., Song, W., Li, J., Jing, Y., Liang, C., Zhang, L., Zhang, X., Zhang, W., Liu, B., An, Y., et al. (2022) · Science China Life Sciences · doi:10.1007/s11427-022-2161-3 · Cited by 436 · see citing works

Neuroinflammation in frontotemporal dementia

Bright, F., Werry, E. L., Dobson-Stone, C., Piguet, O., Ittner, L. M., Halliday, G. M., Hodges, J. R., Kiernan, M. C., Loy, C. T., Kassiou, M., et al. (2019) · Nature Reviews Neurology · doi:10.1038/s41582-019-0231-z · Cited by 280 · see citing works

Microglial phenotypes in Parkinson’s disease and animal models of the disease

Joers, V., Tansey, M. G., Mulas, G., & Carta, A. R. (2017) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2016.04.006 · Cited by 285 · see citing works

Astrocytes and Aging

Palmer, A. L., & Ousman, S. S. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00337 · Cited by 246 · see citing works

Microglia Gone Rogue: Impacts on Psychiatric Disorders across the Lifespan

Tay, T. L., Béchade, C., D’Andrea, I., St‐Pierre, M., Henry, M. S., Roumier, A., & Tremblay, M. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00421 · Cited by 211 · see citing works

Cellular correlates of cortical thinning throughout the lifespan

Vidal-Pineiro, D., Parker, N., Shin, J., French, L., Grydeland, H., Jackowski, A. P., Mowinckel, A. M., Patel, Y., Pausova, Z., Salum, G., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-78471-3 · Cited by 154 · see citing works

Glial phagocytic clearance in Parkinson’s disease

Tremblay, M., Cookson, M., & Civiero, L. (2019) · Molecular Neurodegeneration · doi:10.1186/s13024-019-0314-8 · Cited by 159 · see citing works

Region-Specific Transcriptional Control of Astrocyte Function Oversees Local Circuit Activities

Huang, A. Y.-S., Woo, J., Sardar, D., Lozzi, B., Huerta, N. A. B., Lin, C.-C. J., Felice, D., Jain, A., Paulucci-Holthauzen, A. A., & Deneen, B. (2020) · Neuron · doi:10.1016/j.neuron.2020.03.025 · Cited by 158 · see citing works

The Role of Gut Microbiota and Gut–Brain Interplay in Selected Diseases of the Central Nervous System

Doroszkiewicz, J., Groblewska, M., & Mroczko, B. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221810028 · Cited by 160 · see citing works

Postoperative cognitive dysfunction in the aged: the collision of neuroinflammaging with perioperative neuroinflammation

Luo, A., Yan, J., Tang, X., Zhao, Y., Zhou, B., & Li, S. (2019) · Inflammopharmacology · doi:10.1007/s10787-018-00559-0 · Cited by 144 · see citing works

Mechanobiology of the brain in ageing and Alzheimer's disease

Hall, C. M., Moeendarbary, E., & Sheridan, G. K. (2020) · European Journal of Neuroscience · doi:10.1111/ejn.14766 · Cited by 137 · see citing works

Role of the endolysosomal system in Parkinson’s disease

Vidyadhara, D. J., Lee, J. E., & Chandra, S. S. (2019) · Journal of Neurochemistry · doi:10.1111/jnc.14820 · Cited by 131 · see citing works

Astroglia-specific contributions to the regulation of synapses, cognition and behaviour

Augusto‐Oliveira, M., Arrifano, G. D. P., Takeda, P. Y., Lopes-Araújo, A., Santos-Sacramento, L., Anthony, D. C., Verkhratsky, A., & Lopez, M. E. C. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.07.039 · Cited by 107 · see citing works

Astroglial asthenia and loss of function, rather than reactivity, contribute to the ageing of the brain

Verkhratsky, A., Augusto‐Oliveira, M., Pivoriūnas, A., Popov, A., Brazhe, A., & Semyanov, A. V. (2020) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-020-02465-3 · Cited by 108 · see citing works

Diversity of Reactive Astrogliosis in CNS Pathology: Heterogeneity or Plasticity?

Moulson, A. J., Squair, J. W., Franklin, R. J. M., Tetzlaff, W., & Assinck, P. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.703810 · Cited by 90 · see citing works

A core transcriptional signature of human microglia: derivation and utility in describing region-dependent alterations associated with Alzheimer’s disease

Patir, A., Shih, B., McColl, B. W., & Freeman, T. C. (2019) · Glia · doi:10.1002/glia.23572 · Cited by 90 · see citing works

Astrocyte plasticity in mice ensures continued endfoot coverage of cerebral blood vessels following injury and declines with age

Mills, W. A., Woo, A. M., Jiang, S., Martin, J., Surendran, D., Bergstresser, M., Kimbrough, I. F., Eyo, U. B., Sofroniew, M. V., & Sontheimer, H. W. (2022) · Nature Communications · doi:10.1038/s41467-022-29475-2 · Cited by 91 · see citing works

The Role of Astrocytes in Remyelination

Rawji, K. S., Martinez, G. A. G., Sharma, A., & Franklin, R. J. M. (2020) · Trends in Neurosciences · doi:10.1016/j.tins.2020.05.006 · Cited by 78 · see citing works

Humanin, a Mitochondrial-Derived Peptide Released by Astrocytes, Prevents Synapse Loss in Hippocampal Neurons

Zárate, S., Traetta, M. E., Codagnone, M. G., Seilicovich, A., & Reinés, A. G. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00123 · Cited by 70 · see citing works

Prolonged Dysfunction of Astrocytes and Activation of Microglia Accelerate Degeneration of Dopaminergic Neurons in the Rat Substantia Nigra and Block Compensation of Early Motor Dysfunction Induced by 6-OHDA

Kuter, K., Olech, Ł., & Głowacka, U. (2017) · Molecular Neurobiology · doi:10.1007/s12035-017-0529-z · Cited by 65 · see citing works

Human gut microbiota Agathobaculum butyriciproducens improves cognitive impairment in LPS-induced and APP/PS1 mouse models of Alzheimer's disease

Go, J., Chang, D., Ryu, Y., Park, H., Lee, I.-B., Noh, J., Hwang, D. Y., Kim, B., Kim, K., & Lee, C. (2020) · Nutrition Research · doi:10.1016/j.nutres.2020.12.010 · Cited by 67 · see citing works

Modulation of Glial Function in Health, Aging, and Neurodegenerative Disease

Hanslik, K. L., Marino, K. M., & Ulland, T. K. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.718324 · Cited by 68 · see citing works

Regional Distributions of Iron, Copper and Zinc and Their Relationships With Glia in a Normal Aging Mouse Model

Ashraf, A., Michaelides, C., Walker, T. A., Ekonomou, A., Suessmilch, M., Sriskanthanathan, A., Abraha, S., Parkes, A., Parkes, H. G., Geraki, K., et al. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00351 · Cited by 64 · see citing works

She Doesn’t Even Go Here: The Role of Inflammatory Astrocytes in CNS Disorders

Reid, J. K., & Kuipers, H. F. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.704884 · Cited by 60 · see citing works

Gliotoxicity and Glioprotection: the Dual Role of Glial Cells

Quincozes‐Santos, A., Santos, C. L., Almeida, R. R. D. S., da Silva, A., Thomaz, N. K., Costa, N. L. F., Weber, F. B., Schmitz, I., Medeiros, L. S., Medeiros, L., et al. (2021) · Molecular Neurobiology · doi:10.1007/s12035-021-02574-9 · Cited by 57 · see citing works

An emerging role of astrocytes in aging/neuroinflammation and gut-brain axis with consequences on sleep and sleep disorders

Gudkov, S. V., Burmistrov, D. E., Kondakova, E. V., Sarimov, R. M., Yarkov, R. S., Franceschi, C., & Vedunova, M. V. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101775 · Cited by 56 · see citing works

Novel Microglia-based Therapeutic Approaches to Neurodegenerative Disorders

Zhang, L., Wang, Y., Liu, T., Mao, Y. Q., & Peng, B. (2023) · Neuroscience Bulletin · doi:10.1007/s12264-022-01013-6 · Cited by 56 · see citing works

Epigenetic Treatment of Neurodegenerative Disorders: Alzheimer and Parkinson Diseases

Irwin, M. H., Moos, W. H., Faller, D. V., Steliou, K., & Pinkert, C. A. (2016) · Drug Development Research · doi:10.1002/ddr.21294 · Cited by 56 · see citing works

Prospects and challenges of imaging neuroinflammation beyond TSPO in Alzheimer’s disease

Faculty, O. B. O. T. M., Boche, D., Gerhard, A., & Rodriguez-Vieitez, E. (2019) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-019-04462-w · Cited by 55 · see citing works

Dietary Restriction and Neuroinflammation: A Potential Mechanistic Link

Bok, E., Jo, M., Lee, S., Lee, B.-R., Kim, J., & Kim, H.-J. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20030464 · Cited by 53 · see citing works

Iron accumulation and microglia activation contribute to substantia nigra hyperechogenicity in the 6-OHDA-induced rat model of Parkinson's disease

Zhu, Y., Wang, B., Tao, K., Yang, H., Wang, Y., Zhou, T., Yang, Y., Yuan, L., Liu, X., & Duan, Y. (2017) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2017.01.003 · Cited by 51 · see citing works

Nanomaterials as Microglia Modulators in the Treatment of Central Nervous System Disorders

Battaglini, M., Marino, A., Montorsi, M., Carmignani, A., Ceccarelli, M. C., & Ciofani, G. (2023) · Advanced Healthcare Materials · doi:10.1002/adhm.202304180 · Cited by 52 · see citing works

Physiological and Pathological Ageing of Astrocytes in the Human Brain

Verkerke, M., Hol, E. M., & Middeldorp, J. (2021) · Neurochemical Research · doi:10.1007/s11064-021-03256-7 · Cited by 49 · see citing works

Glial aging and its impact on central nervous system myelin regeneration

Rawji, K. S., Neumann, B., & Franklin, R. J. M. (2022) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.14933 · Cited by 46 · see citing works

Glial Fibrillary Acidic Protein (GFAP): on the 45th Anniversary of Its Discovery

Tykhomyrov, A. A., Pavlova, A. S., & Nedzvetsky, V. S. (2016) · Neurophysiology · doi:10.1007/s11062-016-9568-8 · Cited by 45 · see citing works

The common marmoset as a model of neurodegeneration

Perez‐Cruz, C., & Rodríguez-Callejas, J. D. (2023) · Trends in Neurosciences · doi:10.1016/j.tins.2023.02.002 · Cited by 38 · see citing works

Glycomic and Proteomic Changes in Aging Brain Nigrostriatal Pathway

Raghunathan, R., Polinski, N. K., Klein, J., Hogan, J., Chun, S., Khatri, K., Leon, D. R., McComb, M. E., Manfredsson, F. P., Sortwell, C. E., et al. (2018) · Molecular & Cellular Proteomics · doi:10.1074/mcp.ra118.000680 · Cited by 41 · see citing works

Glial cells and adaptive immunity in frontotemporal dementia with tau pathology

Hartnell, I. J., Blum, D. L., Nicoll, J. A. R., Dorothée, G., & Boche, D. (2020) · Brain · doi:10.1093/brain/awaa457 · Cited by 40 · see citing works

Small molecule modulator of aggrephagy regulates neuroinflammation to curb pathogenesis of neurodegeneration

Suresh, S. N., Pandurangi, J., Murumalla, R. K., Vidyadhara, D. J., Garimella, L., Acharya, A., Rai, S., Paul, A., Yarreiphang, H., Pillai, M. S., et al. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2019.10.036 · Cited by 40 · see citing works

The role of cofilin in age-related neuroinflammation

Alsegiani, A. S., & Shah, Z. A. (2020) · Neural Regeneration Research · doi:10.4103/1673-5374.274330 · Cited by 39 · see citing works

Neuro-immune interactions across development: A look at glutamate in the prefrontal cortex

Macht, V. A. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.08.039 · Cited by 39 · see citing works

A Novel Parkinson’s Disease Drug Candidate with Potent Anti-neuroinflammatory Effects through the Src Signaling Pathway

Wang, Y.-D., Bao, X.-Q., Xu, S., Yu, W., Cao, S.-N., Hu, J., Li, Y., Wang, X., Zhang, D., & Yu, S. (2016) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.6b00976 · Cited by 36 · see citing works

Replenishing the Aged Brains: Targeting Oligodendrocytes and Myelination?

Zhang, X., Huang, N., Xiao, L., Wang, F., & Li, T. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.760200 · Cited by 31 · see citing works

Telomere shortening induces aging-associated phenotypes in hiPSC-derived neurons and astrocytes

Harley, J., Santosa, M. M., Ng, C. Y., Grinchuk, O. V., Hor, J., Liang, Y., Lim, V. J. W., Tee, W., Ong, D. S. T., & Ng, S. (2023) · Biogerontology · doi:10.1007/s10522-023-10076-5 · Cited by 35 · see citing works

Microglia changes associated to Alzheimer’s disease pathology in aged chimpanzees

Edler, M., Sherwood, C., Meindl, R., Munger, E. L., Hopkins, W. D., Ely, J., Erwin, J., Perl, D. P., Mufson, E., Hof, P. R., et al. (2018) · The Journal of comparative neurology · doi:10.1002/cne.24484 · Cited by 32 · see citing works

The role of glia in Parkinson's disease: Emerging concepts and therapeutic applications

Kuter, K. Z., Cenci, M. A., & Carta, A. R. (2020) · Progress in brain research · doi:10.1016/bs.pbr.2020.02.004 · Cited by 30 · see citing works

The neuropeptide‐12 improves recognition memory and neuronal plasticity of the limbic system in old rats

Hernández‐Hernández, E. M., Hernandez, K. C., Vázquez‐Roque, R. A., Díaz, A., de la Cruz, F., Florán, B., & Flores, G. (2018) · Synapse · doi:10.1002/syn.22036 · Cited by 30 · see citing works

Fecal Microbiota Transplantation from Aged Mice Render Recipient Mice Resistant to MPTP-Induced Nigrostriatal Degeneration Via a Neurogenesis-Dependent but Inflammation-Independent Manner

Qiao, C.-M., Zhou, Y., Quan, W., Ma, X., Zhao, L., Shi, Y. W., Hong, H., Wu, J., Niu, G.-Y., Chen, Y.-N., et al. (2023) · Neurotherapeutics · doi:10.1007/s13311-023-01420-1 · Cited by 30 · see citing works

Brains of rhesus monkeys display Aβ deposits and glial pathology while lacking Aβ dimers and other Alzheimer's pathologies

Zhang, J., Chen, B., Lu, J., Wu, Y., Wang, S., Yao, Z., Zhu, L., Qiao, Y., Sun, Q., Qin, W., et al. (2019) · Aging Cell · doi:10.1111/acel.12978 · Cited by 29 · see citing works

Admixing of MPTP-Resistant and Susceptible Mice Strains Augments Nigrostriatal Neuronal Correlates to Resist MPTP-Induced Neurodegeneration

Vidyadhara, D. J., Yarreiphang, H., Raju, T. R., & Alladi, P. A. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0158-y · Cited by 27 · see citing works

Towards early detection of neurodegenerative diseases: A gut feeling

Makdissi, S., Parsons, B., & Cara, F. D. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1087091 · Cited by 27 · see citing works

Pattern of tyrosine hydroxylase expression during aging of mesolimbic pathway of the rat

Norrara, B., Fiuza, F. P., Arrais, A. C., da Costa, I. M., dos Santos, J. R., Engelberth, R. C. G. J., Cavalcante, J. S., Gúzen, F. P., Cavalcanti, J. R. L. D. P., & Freire, M. A. M. (2018) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2018.05.004 · Cited by 25 · see citing works

The neuroimmune system – Where aging and excess alcohol intersect

Carlson, E. R., Guerin, S. P., Nixon, K., & Fonken, L. K. (2022) · Alcohol · doi:10.1016/j.alcohol.2022.08.009 · Cited by 24 · see citing works

Atrophic astrocytes in aged marmosets present tau hyperphosphorylation, RNA oxidation, and DNA fragmentation

Rodríguez-Callejas, J. D., Fuchs, E., & Perez‐Cruz, C. (2023) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2023.04.010 · Cited by 23 · see citing works

Astrocytes in the Optic Nerve Are Heterogeneous in Their Reactivity to Glaucomatous Injury

Zhu, Y., Wang, R., Pappas, A. C., Seifert, P. A., Savol, A. J., Sadreyev, R. I., Sun, D., & Jakobs, T. (2023) · Cells · doi:10.3390/cells12172131 · Cited by 23 · see citing works

Region-specific and age-related differences in astrocytes in the human brain

Man, J. H. K., Breur, M., van Gelder, C. A. G. H., Marcon, G., Maderna, E., Giaccone, G., Altelaar, M. A. F., van der Knaap, M. S., & Bugiani, M. (2024) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2024.02.016 · Cited by 22 · see citing works

Neuroprotective Effects and Mechanism of β‐Asarone against Aβ1–42‐Induced Injury in Astrocytes

Yang, Y., Xuan, L., Chen, H., Dai, S., Ji, L., Bao, Y., & Li, C. (2017) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2017/8516518 · Cited by 22 · see citing works

Second-generation antipsychotic olanzapine attenuates behavioral and prefrontal cortex synaptic plasticity deficits in a neurodevelopmental schizophrenia-related rat model

Apam-Castillejos, D. J., Tendilla‐Beltrán, H., Vázquez‐Roque, R. A., Vázquez-Hernández, A. J., Fuentes‐Medel, E., García‐Dolores, F., Díaz, A., & Flores, G. (2022) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2022.102166 · Cited by 21 · see citing works

Pax6 Binds to Promoter Sequence Elements Associated with Immunological Surveillance and Energy Homeostasis in Brain of Aging Mice

Maurya, S. K., & Mishra, R. (2017) · Annals of Neurosciences · doi:10.1159/000464419 · Cited by 21 · see citing works

Baseline striatal and nigral interneuronal protein levels in two distinct mice strains differ in accordance with their MPTP susceptibility

Bhaduri, B., Abhilash, P. L., & Alladi, P. A. (2018) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2018.04.005 · Cited by 19 · see citing works

Prolonged, Low-Level Exposure to the Marine Toxin, Domoic Acid, and Measures of Neurotoxicity in Nonhuman Primates

Petroff, R., WILLIAMS, C. R., Li, J., MacDonald, J. W., Bammler, T. K., Richards, T. L., English, C. N., Baldessari, A. E., Shum, S., Jing, J., et al. (2022) · Environmental Health Perspectives · doi:10.1289/ehp10923 · Cited by 20 · see citing works

Brain-Biomarker Changes in Body Fluids of Patients with Parkinson’s Disease

Cocco, C., Manai, A. L., Manca, E., & Noli, B. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241310932 · Cited by 19 · see citing works

Inhibiting Immune Crosstalk by Modulation of the Intracellular Function and Extracellular Environment of Diseased Microglia to Boost Parkinson’s Disease Therapy

Zheng, Q. Y., Gao, Y., Han, M., Wang, Y., Liu, H., Cao, G., Wang, T., Zhang, H., & Li, Z. (2025) · ACS Nano · doi:10.1021/acsnano.5c01068 · Cited by 18 · see citing works

Are cytoskeleton changes observed in astrocytes functionally linked to aging?

Villablanca, C., Vidal, R. L., & González-Billault, C. E. (2023) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2023.03.007 · Cited by 18 · see citing works

Astrocytes in Ageing

Verkhratsky, A., & Semyanov, A. V. (2023) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-3-031-26576-1_11 · Cited by 18 · see citing works

Changes in cytoplasmic and extracellular neuromelanin in human substantia nigra with normal aging

Korzhevsky, D. E., Kirik, O. V., Гусельникова, В. В., Цыба, Д. Л., Fedorova, E. A., & Grigor’ev, I. P. (2021) · European Journal of Histochemistry · doi:10.4081/ejh.2021.3283 · Cited by 18 · see citing works

SIRPα deficiency accelerates the pathologic process in models of Parkinson disease

Wang, J., Ding, X., Wu, X., Liu, J., Zhou, R., Wei, P., Zhang, Q., Zhang, C., Zen, K., & Li, L. (2019) · Glia · doi:10.1002/glia.23689 · Cited by 17 · see citing works

Robust differences in cortical cell type proportions across healthy human aging inferred through cross-dataset transcriptome analyses

Chen, Y., Hunter, E., Arbabi, K., Guet-McCreight, A., Consens, M. E., Felsky, D., Sibille, E. L., & Tripathy, S. J. (2023) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2023.01.013 · Cited by 16 · see citing works

Epigenetic regulation of iron metabolism and ferroptosis in Parkinson’s disease: Identifying novel epigenetic targets

Gao, X., Ding, J.-E., Xie, J., & Xu, H. (2025) · Acta Pharmacologica Sinica · doi:10.1038/s41401-025-01499-6 · Cited by 15 · see citing works

Effects of long-term resveratrol treatment in hypothalamic astrocyte cultures from aged rats

Sovrani, V., Bobermin, L. D., Santos, C. L., Brondani, M., Gonçalves, C., Leipnitz, G., & Quincozes‐Santos, A. (2022) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-022-04585-z · Cited by 15 · see citing works

Divergent Expression Patterns of Drp1 and HSD10 in the Nigro-Striatum of Two Mice Strains Based on their MPTP Susceptibility

Seshadri, A., & Alladi, P. A. (2019) · Neurotoxicity Research · doi:10.1007/s12640-019-00036-8 · Cited by 13 · see citing works

Crosstalk between neuroinflammation and ferroptosis: Implications for Parkinson’s disease progression

Guo, X., Wei, R., Yin, X., & Yang, G. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1528538 · Cited by 19 · see citing works

Pluchea lanceolata protects hippocampal neurons from endothelin-1 induced ischemic injury to ameliorate cognitive deficits

Mundugaru, R., Sivanesan, S., Popa‐Wagner, A., Udaykumar, P., Kirubagaran, R., Guruprasad, K. P., & Vidyadhara, D. J. (2018) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2018.09.002 · Cited by 13 · see citing works

Aging mildly affects dendritic arborisation and synaptic protein expression in human substantia nigra pars compacta

Naskar, A., Mahadevan, A., Philip, M., & Alladi, P. A. (2019) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2019.02.001 · Cited by 12 · see citing works

Contribution of Glial Cells to Polyglutamine Diseases: Observations from Patients and Mouse Models

Cvetanović, M., & Gray, M. (2023) · Neurotherapeutics · doi:10.1007/s13311-023-01357-5 · Cited by 12 · see citing works

Human Brain Cell‐Type‐Specific Aging Clocks Based on Single‐Nuclei Transcriptomics

Muralidharan, C., Zakar‐Polyák, E., Adami, A., Abbas, A. A., Sharma, Y., Garza, R., Johansson, J., Atacho, D. A. M., Renner, É., Palkovits, M., et al. (2025) · Advanced Science · doi:10.1002/advs.202506109 · Cited by 14 · see citing works

Selective brain neuronal and glial losses without changes in GFAP immunoreactivity: Young versus mature adult Wistar rats

Diene, L. D., Costa‐Ferro, Z. S. M., Barbosa, S., Milanesi, B. B., Lazzari, G. Z., Neves, L. T., Paz, L. V., Neves, P. F. R., Battisti, V., Martins, L. A., et al. (2019) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2019.111128 · Cited by 12 · see citing works

Reduction in Nesfatin-1 Levels in the Cerebrospinal Fluid and Increased Nigrostriatal Degeneration Following Ventricular Administration of Anti-nesfatin-1 Antibody in Mice

Chen, H., Li, X., Ma, H., Zheng, W., & Shen, X. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.621173 · Cited by 11 · see citing works

Understanding glaucoma as astrocyte-driven neurodegeneration in the optic nerve head: an integrative clinicopathological perspective

Lee, E. J., Park, D. Y., Han, J. C., & Kee, C. (2025) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2025.101379 · Cited by 10 · see citing works

The Impact of IgA and the Microbiota on CNS Disease

Pu, A., Lee, D. S. W., Isho, B., Naouar, I., & Gommerman, J. L. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.742173 · Cited by 9 · see citing works

Differences in Neuronal Numbers, Morphology, and Developmental Apoptosis in Mice Nigra Provide Experimental Evidence of Ontogenic Origin of Vulnerability to Parkinson’s Disease

Vidyadhara, D. J., Yarreiphang, H., Raju, T. R., & Alladi, P. A. (2021) · Neurotoxicity Research · doi:10.1007/s12640-021-00439-6 · Cited by 9 · see citing works

Effect of senescence on the tyrosine hydroxylase and S100B immunoreactivity in the nigrostriatal pathway of the rat

Rocha, G. S., Freire, M. A. M., Paiva, K. M., Oliveira, R. F., Norrara, B., Morais, P. L. A. D. G., de Oliveira, L. C., Engelberth, R. C. G. J., Cavalcante, J. S., & Cavalcanti, J. R. L. D. P. (2022) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2022.102136 · Cited by 9 · see citing works

Morphochemical changes in the substantia nigra cellular structures in Parkinson’s disease

Николаевич, С. В., Худоерков, Р. М., Воронков, Д. Н., Sobolev, V. B., & Kutukova, K. A. (2017) · Russian Journal of Archive of Pathology · doi:10.17116/patol20177953-9 · Cited by 6 · see citing works

Aging and MPTP Sensitivity Depend on Molecular and Ultrastructural Signatures of Astroglia and Microglia in Mice Substantia Nigra

Abhilash, P. L., Bharti, U., Rashmi, S. K., Philip, M., Raju, T. R., Kutty, B. M., Sagar, B. K. C., & Alladi, P. A. (2025) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-024-01528-8 · Cited by 6 · see citing works

Quantitative proteomic profiling of the rat substantia nigra places glial fibrillary acidic protein at the hub of proteins dysregulated during aging: Implications for idiopathic Parkinson's disease

Gómez‐Gálvez, Y., Fuller, H. R., Synowsky, S. A., Shirran, S. L., & Gates, M. A. (2020) · Journal of Neuroscience Research · doi:10.1002/jnr.24622 · Cited by 6 · see citing works

The Aging Substantia Nigra is Characterized by ROS Accumulation Potentially Resulting in Increased Neuroinflammation and Cytoskeletal Remodeling

Eggers, B., Steinbach, S., Aldea, I. G., Keers, S. M., Molina, M., Grinberg, L. T., Heinsen, H., Leite, R. E. P., Attems, J., May, C., et al. (2025) · Advanced Biology · doi:10.1002/adbi.202400814 · Cited by 5 · see citing works

Utility of manual fractional anisotropy measurements in the management of patients with Parkinson disease: a feasibility study with a 1.5-T magnetic resonance imaging system

de Oliveira, R. V., & Pereira, J. S. (2021) · Acta Radiologica Open · doi:10.1177/2058460121993477 · Cited by 5 · see citing works

Increased number and domain of interlaminar astrocytes in layer I of the temporal cortex in epilepsy.

Zhou, N., Fan, Z., Tong, Y., Xiao, X., Xie, Y., Qi, Z., & Chen, L. (2023) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12913 · Cited by 5 · see citing works

Apoptotic Factors and Mitochondrial Complexes Assist Determination of Strain-Specific Susceptibility of Mice to Parkinsonian Neurotoxin MPTP

Yarreiphang, H., Vidyadhara, D. J., Nambisan, A. K., Raju, T. R., Sagar, B. C., & Alladi, P. A. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03372-1 · Cited by 5 · see citing works

Systemic Rejuvenating Interventions: Perspectives on Neuroinflammation and Blood–Brain Barrier Integrity

de Rezende, V. L., da Costa, M. D. A., Martins, C. D., Mathias, K., Gonçalves, C. L., Barichello, T., & Petronilho, F. C. (2025) · Neurochemical Research · doi:10.1007/s11064-025-04361-7 · Cited by 5 · see citing works

The crosstalk between CNS resident glial cells and peripheral immune cells is critical for age-dependent demyelination and subsequent remyelination

Jana, R., & Sarma, J. D. (2025) · Biogerontology · doi:10.1007/s10522-025-10213-2 · Cited by 4 · see citing works

Neuroglia in aging

Semyanov, A. V., & Verkhratsky, A. (2025) · Handbook of clinical neurology · doi:10.1016/b978-0-443-19104-6.00002-4 · Cited by 4 · see citing works

Adolescent Alcohol and the Spectrum of Cognitive Dysfunction in Aging

Deak, T., Burzynski, H. E., Nunes, P. T., Day, S. M., & Savage, L. M. (2025) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-81908-7_12 · Cited by 3 · see citing works

2D Images of Astrocytes in the Human Principal Olivary Nucleus: Monofractal Analysis of the Morphology

Stojić, D., Radošević, D., Rajković, N., & Milošević, N. T. (2021) · Journal of Biosciences and Medicines · doi:10.4236/jbm.2021.99004 · Cited by 4 · see citing works

The C‐terminal fragment of the heavy chain of the tetanus toxin (Hc‐TeTx) improves motor activity and neuronal morphology in the limbic system of aged mice

Vázquez‐Roque, R. A., Pacheco‐Flores, M., Penagos-Corzo, J. C., Flores, G., Aguilera, J., Treviño, S., Guevara, J., Díaz, A., & Venegas, B. (2020) · Synapse · doi:10.1002/syn.22193 · Cited by 4 · see citing works

Heterogenous response to aging of astrocytes in murine Substantia Nigra pars compacta and pars reticulata

Bondi, H., Chiazza, F., Masante, I., Bortolotto, V., Canonico, P. L., & Grilli, M. (2022) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2022.12.010 · Cited by 13 · see citing works

Marked microglial reaction in normal aging human substantia nigra: correlation with extraneuronal neuromelanin pigment deposits

Beach, T. G., Sue, L. I., Walker, D. G., Lue, L. F., Connor, D. J., Caviness, J. N., Sabbagh, M. N., & Adler, C. H. (2007) · Acta Neuropathologica · doi:10.1007/s00401-007-0250-5 · Cited by 101 · see citing works

Age-related changes in glial cells of dopamine midbrain subregions in rhesus monkeys

Kanaan, N. M., Kordower, J. H., & Collier, T. J. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.07.006 · Cited by 78 · see citing works

Observations of the Morphological Evolution of Neuronal Intranuclear Rods in the Human Substantia Nigra Across the Age Spectrum

Khan, O. A., Capitano, M., Fan, S., & Woulfe, J. (2019) · American Journal of Clinical Pathology · doi:10.1093/ajcp/aqz114.001

Neurochemical and Morphological Changes in the Microstructures of the Compact Part of the Substantia Nigra of the Human Brain in Aging and Parkinson’s Disease (Literature Review)

Николаевич, С. В., & Худоерков, Р. М. (2019) · Advances in Gerontology · doi:10.1134/s207905701902019x · Cited by 4 · see citing works