Gastroparesis and Parkinson’s disease: a systematic review
Abstract
Some of the gastrointestinal (GI) symptoms commonly experienced by patients with Parkinson's disease (PD) have been attributed to gastroparesis; however, the precise prevalence and relevance of gastric emptying delay in PD is unclear. The definition of gastroparesis varies; currently the most widely accepted definition (from the National Institute of Diabetes and Digestive and Kidney Diseases Gastroparesis Clinical Research Consortium) is the presence of appropriate symptoms (including nausea, retching, vomiting, stomach fullness, and inability to finish a meal) for ≥ 12 weeks, together with delayed gastric emptying on scintigraphy and the absence of any obstructive lesions on upper GI endoscopy. In PD patients, gastroparesis has the potential to affect nutrition and quality of life, as well as the absorption of PD medications, including L-dopa. This reduced absorption of L-dopa has implications for the control of the PD motor symptoms for which it is administered. We performed a systematic review of the literature on gastroparesis in PD with the aim of developing an evidence-based approach to its management. Based on this review, we conclude that while gastric emptying has been reported to be frequently delayed in PD, the existing data do not permit definitive conclusions concerning its true prevalence, relationship to the underlying disease process, relevance to PD management, or the optimal therapy of related GI symptoms. Further study of these important issues is, therefo…
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Systematic reviews support the association between Parkinson disease and gastroparesis.
“Gastric motor dysfunction can impair levodopa pharmacokinetics and contribute to motor fluctuations (Pfeiffer et al., 2020); systematic reviews support the association between PD and gastroparesis (Heetun et al., 2012).”
From Autonomic nervous system and gastrointestinal manifestations with an emphasis on gastric dysfunction (2026) · cites this paper as Heetun et al., 2012
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- Authors
- Heetun, Z. S., & Quigley, E. M. M.
- Affiliations
- University College Cork (IE)
- Corresponding author
- Quigley, Eamonn M.M.
- ORCID
- Quigley, Eamonn M.M.
- Venue
- Parkinsonism & Related Disorders
- Publisher
- Elsevier BV
- Published
- 2012-06
- Volume
- 18
- Issue
- 5
- Pages
- 433-440
- ISSN
- 1353-8020 (ISSN-L)
- OpenAlex
- W2077886817
- Cited by
- 182
- References
- 72
- Citations by year
- 2026: 10 · 2025: 18 · 2024: 7 · 2023: 16 · 2022: 15 · 2021: 20 · 2020: 12 · 2019: 12 · 2018: 9 · 2017: 13 · 2016: 15 · 2015: 13 · 2014: 11 · 2013: 7 · 2012: 4
- FWCI
- 1.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Parkinsonism & Related Disorders (publishedVersion)
- PubMed (publishedVersion)
- Funders
- UCB Pharma
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Keywords
- gastroparesis, Parkinson's disease
- MeSH terms
- Antiparkinson Agents, Humans, Levodopa, Parkinson Disease, Quality of Life, Databases, Bibliographic, Gastroparesis
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