Cited by 182Gastrointestinal motility and disordersParkinson's Disease Mechanisms and TreatmentsNeurological disorders and treatments

Gastroparesis and Parkinson’s disease: a systematic review

Heetun, Zaid S., Quigley, Eamonn M.M.·2012·Parkinsonism & Related Disorders

Abstract

Some of the gastrointestinal (GI) symptoms commonly experienced by patients with Parkinson's disease (PD) have been attributed to gastroparesis; however, the precise prevalence and relevance of gastric emptying delay in PD is unclear. The definition of gastroparesis varies; currently the most widely accepted definition (from the National Institute of Diabetes and Digestive and Kidney Diseases Gastroparesis Clinical Research Consortium) is the presence of appropriate symptoms (including nausea, retching, vomiting, stomach fullness, and inability to finish a meal) for ≥ 12 weeks, together with delayed gastric emptying on scintigraphy and the absence of any obstructive lesions on upper GI endoscopy. In PD patients, gastroparesis has the potential to affect nutrition and quality of life, as well as the absorption of PD medications, including L-dopa. This reduced absorption of L-dopa has implications for the control of the PD motor symptoms for which it is administered. We performed a systematic review of the literature on gastroparesis in PD with the aim of developing an evidence-based approach to its management. Based on this review, we conclude that while gastric emptying has been reported to be frequently delayed in PD, the existing data do not permit definitive conclusions concerning its true prevalence, relationship to the underlying disease process, relevance to PD management, or the optimal therapy of related GI symptoms. Further study of these important issues is, therefo…

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Crossref · 10.1016/j.parkreldis.2011.12.004

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70 of 70 references verified0 citation errors · 0 not checkable

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  • Systematic reviews support the association between Parkinson disease and gastroparesis.

    “Gastric motor dysfunction can impair levodopa pharmacokinetics and contribute to motor fluctuations (Pfeiffer et al., 2020); systematic reviews support the association between PD and gastroparesis (Heetun et al., 2012).”

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Authors
Heetun, Z. S., & Quigley, E. M. M.
Affiliations
University College Cork (IE)
Corresponding author
Quigley, Eamonn M.M.
Venue
Parkinsonism & Related Disorders
Publisher
Elsevier BV
Published
2012-06
Volume
18
Issue
5
Pages
433-440
ISSN
1353-8020 (ISSN-L)
OpenAlex
W2077886817
Cited by
182
References
72
Citations by year
2026: 10 · 2025: 18 · 2024: 7 · 2023: 16 · 2022: 15 · 2021: 20 · 2020: 12 · 2019: 12 · 2018: 9 · 2017: 13 · 2016: 15 · 2015: 13 · 2014: 11 · 2013: 7 · 2012: 4
FWCI
1.16
Type
journal article
Language
en
Open access
closed
Locations
  • Parkinsonism & Related Disorders (publishedVersion)
  • PubMed (publishedVersion)
Funders
UCB Pharma
Topics
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
  • Health Sciences › Medicine › Neurology › Neurological disorders and treatments
Keywords
gastroparesis, Parkinson's disease
MeSH terms
Antiparkinson Agents, Humans, Levodopa, Parkinson Disease, Quality of Life, Databases, Bibliographic, Gastroparesis

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