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Cited by 91Hemispheric Asymmetry in NeuroscienceLanguage Development and DisordersNeurobiology of Language and Bilingualism

Gender differences in the left inferior frontal gyrus in normal children

Blanton, Rebecca E, Levitt, Jennifer G, Peterson, Jeffrey R, Fadale, David, Sporty, Mike L, Lee, Mimi, To, Dennis, Mormino, Elizabeth C +3 more·2004·NeuroImage
DOI 10.1016/j.neuroimage.2004.01.010
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Abstract

This study examined frontal lobe subregions in 46 normal children and adolescents (25 females, mean age: 11.08, SD: 3.07; and 21 males, mean age: 10.76, SD: 2.61) to assess the effects of age and gender on volumetric measures as well as hemispheric asymmetries. Superior, middle, inferior, and orbito-frontal gray, white, and cerebrospinal (CSF) volumes were manually delineated in high-resolution magnetic resonance imaging (MRI) data to assess possible morphological changes. We report a significant age-related increase in the white matter of the left inferior frontal gyrus (IFG) in boys (P = 0.007). Additionally, the left IFG was significantly larger in boys compared to girls (P = 0.004). Boys showed increased gray matter volume relative to girls even after correcting for total cerebral volume. Also, boys were found to have significant Right > Left asymmetry patterns with greater right hemispheric volumes for total cerebral volume, total cerebral white matter, MFG white matter, and SFG white matter (P < 0.001). Girls showed significant Right > Left asymmetry patterns in total cerebral and SFG white matter (P < 0.001). These findings suggest continued modification of the IFG during normal development in boys, and significant gender differences in IFG gray matter between boys and girls that may be possibly linked to gender differences in speech development and lateralization of language.

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  • A significant age-related increase in white matter volume in the left inferior frontal gyrus was found in boys, but no significant volumetric changes were found in girls in any frontal regions.

    “A significant age-related increase in white matter volume in the left IFG was found in boys but no significant volumetric changes were found in girls in any frontal regions (see Figure 3).”

    From Development of the adolescent brain: implications for executive function and social cognition (2006) · cites this paper as Blanton et al., 2004

  • Even after correcting for total cerebral volume, boys had significantly greater grey matter volume in the inferior frontal gyrus relative to girls.

    “Furthermore, even after correcting for total cerebral volume, boys had significantly greater grey matter volume in the IFG relative to girls.”

    From Development of the adolescent brain: implications for executive function and social cognition (2006) · cites this paper as Blanton et al., 2004

  • Blanton et al. (2004) cross-sectional MRI study of 46 children and adults revealed significant differences in grey and white matter between girls and boys, particularly in the inferior frontal gyrus.

    “A cross-sectional MRI study of 46 children and adults (mean age 11) revealed significant differences in grey and white matter between girls and boys, particularly in the inferior frontal gyrus (IFG) (Blanton et al., 2004).”

    From Development of the adolescent brain: implications for executive function and social cognition (2006) · cites this paper as Blanton et al., 2004

  • There is a significant linear relationship between age and IFG white matter for males.

    “A significant linear relationship was found between age and IFG white matter for males”

    From Development of the adolescent brain: implications for executive function and social cognition (2006) · cites this paper as Blanton et al., 2004

  • Changes in brain structure continue into adolescence and early adulthood.

    “The finding that changes in brain structure continue into adolescence and early adulthood challenged accepted views and has given rise to a recent spate of investigations into the way cognition might change as a consequence.”

    From Development of the adolescent brain: implications for executive function and social cognition (2006) · cites this paper as Blanton et al., 2004

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Authors
Blanton, R. E., Levitt, J. G., Peterson, J. R., Fadale, D., Sporty, M. L., Lee, M., To, D., Mormino, E. C., Thompson, P. M., McCracken, J. T., & Toga, A. W.
Affiliations
University of California, Los Angeles (US)
Corresponding author
Toga, Arthur W
ORCID
Venue
NeuroImage
Publisher
Elsevier BV
Published
2004-06
Volume
22
Issue
2
Pages
626-636
ISSN
1053-8119 (ISSN-L)
DOI
10.1016/j.neuroimage.2004.01.010
OpenAlex
W1967821029
Cited by
90
References
52
Citations by year
2025: 1 · 2023: 3 · 2022: 3 · 2021: 2 · 2020: 1 · 2019: 3 · 2018: 5 · 2017: 2 · 2016: 2 · 2015: 3 · 2014: 5 · 2013: 2 · 2012: 5
FWCI
3.04
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • NeuroImage (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5k08mh001385-02, 5t32mh019950-08)
  • National Institute of Mental Health (AK08 MH 01385, T32 MH19950)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (P01HD035482, 1 P01 HD35482-01)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Hemispheric Asymmetry in Neuroscience
  • Social Sciences › Psychology › Developmental and Educational Psychology › Language Development and Disorders
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neurobiology of Language and Bilingualism
Keywords
left inferior frontal gyrus, gender differences, brain development, hemispheric lateralization, gray matter volume, white matter volume, cerebrospinal fluid, brain aging, language lateralization, speech development, children and adolescents
MeSH terms
Age Factors, Child, Female, Humans, Image Processing, Computer-Assisted, Intelligence, Magnetic Resonance Imaging, Male, Periaqueductal Gray, Sex Characteristics, Dentate Gyrus

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