The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
Diffusion tensor imaging detects early Wallerian degeneration of the pyramidal tract after ischemic stroke
Abstract
We used diffusion tensor imaging (DTI) to assess Wallerian degeneration of the pyramidal tract within the first 2 weeks after ischemic stroke, and correlated the extent of Wallerian degeneration with the motor deficit. Nine patients with middle cerebral artery stroke were examined 2-16 days after stroke by DTI and T2-weighted MRI. We measured fractional anisotropy (FA), averaged diffusivity (Dav), eigenvalues of the diffusion tensor and T2-weighted signal in the cerebral peduncle and compared these values between the affected and the unaffected side and between patients and six controls. FA was significantly reduced on the affected side compared to the unaffected side and compared to the control group. The largest eigenvalue was reduced, whereas the smallest eigenvalue was elevated on the affected side. There was no significant difference in T2-weighted signal and Dav. The decrease of anisotropy correlated positively with the motor deficit at the time of DTI study and 90 days after stroke. The reduction of anisotropy mirrors the disintegration of axonal structures, as it occurs in the early phase of Wallerian degeneration. DTI detects changes of water diffusion related to beginning pyramidal tract degeneration within the first 2 weeks after stroke that are not yet visible in conventional T2-weighted or orientationally averaged diffusion weighted MRI. We demonstrated for the first time a correlation of early DTI findings of pyramidal tract damage with the motor deficit. DTI can help prognosing recovery of motor function after stroke within the early subacute phase.
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“Changes in FA signal one or many microstructural alterations, such as Wallerian degeneration (Pierpaoli et al., 2001; Thomalla et al., 2004) or decreased neuronal membrane permeability (Jones, KnöSche, & Turner, 2013).”
From Substance abuse and white matter: Findings, limitations, and future of diffusion tensor imaging research (2019) · cites this paper as Thomalla et al., 2004
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Ferris, J. K., Greeley, B., Yeganeh, N. M., Rinat, S., Ramirez, J., Black, S. E., & Boyd, L. A. (2022) · NeuroImage Clinical · doi:10.1016/j.nicl.2022.103174 · Cited by 32
“In this study we indexed processing speed and set shifting, a component of executive function, with the trail making test (TMT), a widely used (Tombaugh, 2004) and sensitive (Rasmusson et al., 1998) neuropsychological assessment.”
MethodPhal, P. M., Steward, C. E., Nichols, A. D., Kokkinos, C., Desmond, P. M., Danesh-Meyer, H. V., Sufaro, Y. Z., Kaye, A. H., & Moffat, B. A. (2016) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.15-18734 · Cited by 29
“For example, in the assessment of the early stages of Wallerian degeneration of the motor tracts post ischemic stroke, it has been demonstrated that a decrease in FA is evident earlier than the increased T2 signal and atrophy within the cerebral peduncle.(29) To date there have been no studies of the utility of serial…”
BackgroundXie, M., Wang, Q., Wu, T., Song, S.-K., & Sun, S. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.09.042 · Cited by 30
“…axonal deterioration process after various neural damages, including the cerebral ischemia (Hall and Yonkers, 1989; Brunelli and Brunelli, 1995; Thomalla et al., 2004; Sylaja et al., 2007; Puig et al., 2010), trauma (Hall and Yonkers, 1989; Fox and Faden, 1998; Kelley et al., 2006), multiple…”
BackgroundXekardaki, A., Giannakopoulos, P., & Haller, S. (2011) · Journal of Aging Research · doi:10.4061/2011/286564 · Cited by 28
“These findings were further confirmed by more recent studies [15, 16], yet basic research is still needed in this domain.”
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Simão, G. N., Mahmoodabadi, S. Z., Snead, O. C., et al. (2010) · American Journal of Neuroradiology · doi:10.3174/ajnr.a2224 · Cited by 27
“Changes in D reflect axonal integrity and have been observed in cases of wallerian degeneration.(9) In contrast, D reflects alteration in myelination.”
BackgroundImagerie en tenseur de diffusion et tractographie de l’encéphale et de la moelle
Oppenheim, C., Ducreux, D., Rodrigo, S., et al. (2007) · Journal de Radiologie · doi:10.1016/s0221-0363(07)89850-7 · Cited by 27
White matter hyperintensities induce distal deficits in the connected fibers
Liu, Y., Xia, Y., Wang, X., Wang, Y., Zhang, D., Nguchu, B. A., He, J., Wang, Y., Yang, L., Wang, Y., et al. (2021) · Human Brain Mapping · doi:10.1002/hbm.25338 · Cited by 23
“The observed deficits in the remote WM tracts might be explained by axonal loss, a Wallerian-like or retrograde degeneration (Munoz Maniega et al., 2019; Thomalla et al., 2004).”
BackgroundAbhinav, K., Yeh, F.-C. F., El‐Dokla, A., Ferrando, L. M., Chang, Y., Lacomis, D., Friedlander, R. M., & Fernandez-Miranda, J. C. (2014) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2014.00270 · Cited by 26
“1 Department of Neurological Surgery, University of Pittsburgh School of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA 2 Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA, USA 3 Department of Neurology, University of Pittsburgh Medical Center,…”
BackgroundMethodMagnetic resonance imaging in ischemic stroke
von Kummer, R., Back, T., & Bonneville, F. (2006) · Journal de Radiologie · doi:10.1016/s0221-0363(06)74047-1 · Cited by 26
White Matter Water Diffusion Changes in Primary Sjogren Syndrome
Tzarouchi, L. C., Zikou, A. K., Tsifetaki, N., Astrakas, L. G., Konitsiotis, S., Voulgari, P. V., Drosos, A. A., & Argyropoulou, M. I. (2013) · American Journal of Neuroradiology · doi:10.3174/ajnr.a3756 · Cited by 25
“Loss of axonal structure may result in less restricted diffusion perpendicular to the main direction of fibers and consequently give rise to elevated RD.(22,34) The membrane disintegration and cellular debris create new diffusion barriers that lead to a decrease in diffusivity parallel to the main fiber direction and…”
BackgroundInternal capsule stroke in the common marmoset
Puentes, S., Kaido, T., Hanakawa, T., et al. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.10.015 · Cited by 25
“Recent imaging studies done in stroke survivors have highlighted the importance of WM damage, demonstrating that corticospinal tract (CST) integrity can be considered as a reliable predictor of stroke severity and clinical outcome (Thomalla et al., 2004; Puig et al., 2011; Rosso et al., 2013).”
Koyama, T., Marumoto, K., Miyake, H., et al. (2013) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2013.02.017 · Cited by 25
“Previous studies have indicated a requirement of 2 weeks for the reliable detection of signal changes.(3,4,9) Accordingly, we collected DTI data on days 14-18 from stroke onset.”
MethodWagner, J., Schoene‐Bake, J., Witt, J., Helmstaedter, C., Malter, M. P., Stoecker, W., Probst, C., Weber, B., & Elger, C. E. (2016) · Epilepsia · doi:10.1111/epi.13297 · Cited by 25
Nickerson, J. P., Salmela, M. B., Koski, C. J., Andrews, T. J., & Filippi, C. G. (2010) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.22228 · Cited by 25
Mårtensson, J., Lätt, J., Åhs, F., Fredrikson, M., Söderlund, H., Schiöth, H. B., Kok, J., Kremer, B., van Westen, D., Larsson, E.-M., et al. (2018) · Magnetic Resonance Imaging · doi:10.1016/j.mri.2017.03.007 · Cited by 27
Lim, J. Y., Oh, M.-K., Park, J., et al. (2020) · Neural Plasticity · doi:10.1155/2020/8883839 · Cited by 24
“Assessing CST integrity using diffusion tensor imaging (DTI) may reflect white matter degeneration by measuring the decrease in fractional anisotropy distal to the stroke area and by quantifying the involved number of CST fibers [8, 10].”
Li, Y., Yu, Z., Wu, P., & Chen, J. (2021) · BMC Neuroscience · doi:10.1186/s12868-021-00652-1 · Cited by 24
“Similar findings have been reported by previous studies showing that the SMA is involved in recovery from stroke and that the initial activation in the SMA has some correlations with poststroke motor recovery [61, 62].”
ResultMagnetic Resonance Techniques for the Brainstem
Alvarez-Linera, J. (2010) · Seminars in Ultrasound CT and MRI · doi:10.1053/j.sult.2010.03.003 · Cited by 24
Liu, X., Tian, W., Li, L., et al. (2011) · European Journal of Radiology · doi:10.1016/j.ejrad.2010.12.053 · Cited by 24
Diffusion Tensor Imaging for Predicting Hand Motor Outcome in Chronic Stroke Patients
Song, F., Zhang, F., Yin, D.-Z., et al. (2012) · Journal of International Medical Research · doi:10.1177/147323001204000113 · Cited by 24
Okamoto, Y., Ishii, D., Yamamoto, S., Ishibashi, K., Wakatabi, M., Kohno, Y., & Numata, K. (2021) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2021.105889 · Cited by 27
Zhang, W., Li, X., Zhang, J., Luft, A. R., Hanley, D. F., van Zijl, P. C. M., Miller, M. I., Laurent Younes, B., & Mori, S. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.09.013 · Cited by 23
“The decrease of diffusion anisotropy of the corticospinal tract after stroke, due to Wallerian degeneration and correlationwith motor functions, has been reported in the past (Khong et al., 2004; Moller et al., 2007; Mukherjee, 2005; Pierpaoli et al., 2001; Thomalla et al., 2004; Werring et al., 2000).”
Rong, D., Zhang, M., Ma, Q., Lu, J., & Li, K. (2014) · BioMed Research International · doi:10.1155/2014/524096 · Cited by 23
“However, the left CST descended from the affected hemisphere traveling Ta bl e 2: FA Va lu es of co rt ic os pi na lt ra ct in th ep at ie nt sw ith m ed ul la ry in fa rc tio n. Pa tie nt M ed ul la C er eb ra lp ed un cle In te rn al ca ps ul e 7d 14 d 30 d 7d 14 d 30 d 7d 14 d 30 d 1 Ip…”
BackgroundKoyama, T., Marumoto, K., Miyake, H., & Domen, K. (2014) · Journal of Stroke & Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2014.05.017 · Cited by 21
Diffusion tensor tracking of callosal fibers several years after callosotomy
Pizzini, F. B., Polonara, G., Mascioli, G., Beltramello, A., Foroni, R. I., Paggi, A., Salvolini, U., Tassinari, G., & Fabri, M. (2009) · Brain Research · doi:10.1016/j.brainres.2009.11.030 · Cited by 23
“DTI parameters have previously been used asmarkers of axon degeneration soon after stroke (Werring et al., 2000, Thomalla et al., 2004) or partial callosotomy (Concha et al., 2006).”
Wang, P., Chou, K., Lirng, J.-F., Lin, K.-N., Chen, W., & Lin, C. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2012-111304 · Cited by 23
“Decrease in FA has been found in various pathologies [12–15], and crossing fibers also produces variations in FA.”
Advanced neuroimaging to quantify myelin in vivo: Application to mild TBI
Jurick, S., Bangen, K., Evangelista, N., Sanderson-Cimino, M., Delano-Wood, L., & Jak, A. (2016) · Brain Injury · doi:10.1080/02699052.2016.1219064 · Cited by 21
“specific measure of myelin from DTI [67,68].”
Liu, X., Tian, W., Qiu, X., et al. (2011) · Journal of Neuroimaging · doi:10.1111/j.1552-6569.2011.00617.x · Cited by 22
Delayed atrophy in posterior cingulate cortex and apathy after stroke
Matsuoka, K., Yasuno, F., Taguchi, A., Yamamoto, A., Kajimoto, K., Kazui, H., Kudo, T., Sekiyama, A., Kitamura, S., Kiuchi, K., et al. (2014) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.4185 · Cited by 21
“This finding may reflect degeneration secondary to neuronal loss, possibly due to Wallerian degeneration, which is a degeneration of distal parts of nerve axons after injury of the proximal axon or cell body (Thomalla et al., 2004).”
BackgroundAssessment of Axonal Degeneration Along the Human Visual Pathway Using Diffusion Trace Analysis
Ueki, S., Fujii, Y., Matsuzawa, H., et al. (2006) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2006.05.042 · Cited by 21
Diffusion Tensor Imaging in the Study of Aging and Age-Associated Neural Disease
Salat, D. H. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-396460-1.00012-3 · Cited by 21
Holmegaard, L., Jensen, C., Pedersén, A., Blomstrand, C., Blennow, K., Zetterberg, H., Jood, K., & Jern, C. (2024) · Scientific Reports · doi:10.1038/s41598-024-67232-1 · Cited by 20
“Here, one could have expected differences after lesions at different locations due to variation in the cellular architecture and connectivity to remote areas, variation in the vascular supply, and variation in the degree of postischemic Wallerian degeneration 6,22–25 .”
BackgroundSuetomi, Y., Kanchiku, T., Nishijima, S., Imajo, Y., Suzuki, H., Yoshida, Y., Nishida, N., & Taguchi, T. (2015) · Spinal Cord · doi:10.1038/sc.2015.192 · Cited by 21
Lindberg, P. G., Bensmaïl, D., Bussel, B., Maier, M. A., & Feydy, A. (2010) · Journal of Neuroimaging · doi:10.1111/j.1552-6569.2009.00409.x · Cited by 19
The effects of noise over the complete space of diffusion tensor shape
Gahm, J. K., Kindlmann, G., & Ennis, D. B. (2013) · Medical Image Analysis · doi:10.1016/j.media.2013.10.009 · Cited by 20
“…tremendous volume of literature that analyzes DTMRI data by evaluating the tensor trace ðK1Þ and FA ðR2Þ, which has given rise to a body of knowledge and expectation about the values of these invariants and how they are altered by disease (Sotak, 2002; Thomalla et al., 2004; Jolapara et al., 2009).”
BackgroundSchulz, R., Bönstrup, M., Guder, S., et al. (2021) · Stroke · doi:10.1161/strokeaha.121.034344 · Cited by 19
Self-citationWallerian Degeneration of Pyramidal Tract after Paramedian Pons Infarct
Gräβel, D., Ringer, T. M., Fitzek, C., Fitzek, S., Kohl, M., Kaiser, W. A., Witte, O. W., & Axer, H. (2010) · Cerebrovascular Diseases · doi:10.1159/000319573 · Cited by 20
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“This includes a disinhibition of the non-affected hemisphere, altered reorganisation of motor maps and the degeneration of pathways due to disuse and changes in projections from supraspinal centres (see Møller et al., 2007; Nudo, 1999, 2006; Thomalla et al., 2004, 2005).”
BackgroundCohen‐Adad, J., Buchbinder, B. R., & Oaklander, A. L. (2012) · Pain · doi:10.1016/j.pain.2012.07.028 · Cited by 20
“Animal studies [4–6,10,26,27,30,43,44,54] and human studies [8,13,35,46] of Wallerian degeneration suggest that changes in axial diffusivity are relatively specific for axonal degeneration and changes in radial diffusivity are relatively specific for demyelination.”
BackgroundWhite matter structural connectivity is associated with sensorimotor function in stroke survivors
Kalinosky, B. T., Schindler-Ivens, S., & Schmit, B. D. (2013) · NeuroImage Clinical · doi:10.1016/j.nicl.2013.05.009 · Cited by 21
“2010; Schaechter and Fricker, 2009; Thomalla et al., 2004; Vargas et al., 2012).”
BackgroundYu, X., Jiaerken, Y., Wang, S., Hong, H., Jackson, A., Yuan, L., Lou, M., Jiang, Q., Zhang, M., & Huang, P. (2020) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.27066 · Cited by 18
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Imaging white matter diffusion changes with development and recovery from brain injury
Bosnell, R., Giorgio, A., & Johansen‐Berg, H. (2008) · Developmental Neurorehabilitation · doi:10.1080/17518420802289065 · Cited by 18
Alteration of diffusion tensor parameters in postmortem brain
Widjaja, E., Wei, X., Vidarsson, L., Moineddin, R., Macgowan, C. K., & Nilsson, D. (2009) · Magnetic Resonance Imaging · doi:10.1016/j.mri.2008.11.009 · Cited by 18
“Changes in λmajor reflect axonal integrity and have been observed in cases of Wallerian degeneration [20].”
Tsuda, K., Tsuji, T., Ishida, T., et al. (2018) · Epilepsia Open · doi:10.1002/epi4.12222 · Cited by 17
Yu, J. H., Bai, X., Jiang, B., Guo, Z., & Mu, Q. (2022) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2022.829688 · Cited by 17
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“The images were processed using the FMRIB Software Library (FSL; ver.”
InfluentialSimon, J. H. (2005) · Physical Medicine and Rehabilitation Clinics of North America · doi:10.1016/j.pmr.2005.01.012 · Cited by 17
Tractography of the Median Nerve
Taşdelen, N., Kovanlıkaya, A., & Kovanlıkaya, İ. (2009) · Seminars in Musculoskeletal Radiology · doi:10.1055/s-0029-1202241 · Cited by 16
“The decrease of anisotropy correlated positively with the motor deficit at the time of DTI study.(32,33) In a similar manner, as an example for peripheral nerves, decreased anisotropy but unaffected diffusivity levels were shown in crushed and transected sciatic nerves in animal studies.”
BackgroundDiffusion MRI in Neurological Disorders
Bodini, B., & Ciccarelli, O. (2009) · Elsevier eBooks · doi:10.1016/b978-0-12-374709-9.00009-2 · Cited by 18
Moulton, E. J., Valabrègue, R., Díaz, B., Kemlin, C., Leder, S., Lehéricy, S., Samson, Y., & Rosso, C. (2018) · NeuroImage · doi:10.1016/j.neuroimage.2018.08.002 · Cited by 17
MRI Texture Analysis and Diffusion Tensor Imaging in Chronic Right Hemisphere Ischemic Stroke
Sikiö, M., Kölhi, P., Ryymin, P., et al. (2014) · Journal of Neuroimaging · doi:10.1111/jon.12185 · Cited by 17
Altered Brain White Matter Integrity in Temporal Lobe Epilepsy: A TBSS Study
Liu, Z., Xu, Y., An, J., et al. (2014) · Journal of Neuroimaging · doi:10.1111/jon.12154 · Cited by 17
Cao, X., Wang, Z., Chen, X., Liu, Y., Wang, W., Wang, W., Abdoulaye, I. A., Zhang, S., Guo, X., Wu, S., et al. (2021) · Human Brain Mapping · doi:10.1002/hbm.25583 · Cited by 19
“Reduced anisotropy along the CST far from the original lesions has been interpreted as WD (Thomalla et al., 2004).”
BackgroundLongitudinal evolution of diffusion metrics after left hemisphere ischaemic stroke
Boucher, J., Marcotte, K., Bedetti, C., Houzé, B., Descoteaux, M., Brisebois, A., García, A. O., Rochon, E. A., Léonard, C., Désautels, A., et al. (2023) · Brain Communications · doi:10.1093/braincomms/fcad313 · Cited by 21
“For instance, several studies reported low FA values in the infarct site 8–10 or perilesional WM 7,11–13 in the early stages of stroke.”
BackgroundStewart, J. C., O’Donnell, M., Handlery, K., & Winstein, C. J. (2017) · Neurorehabilitation and neural repair · doi:10.1177/1545968317712467 · Cited by 15
“Additionally, the structural integrity of the corticospinal tract in the lesioned hemisphere was decreased compared to the same tract in the nonlesioned hemisphere consistent with previous studies.(5,41,42) However, variability in reach performance between individuals did not correlate with variability in corticospina…”
ResultLewis, A. F., Myers, M., Heiser, J., Kolar, M. B., Baird, J. F., & Stewart, J. C. (2020) · Human Brain Mapping · doi:10.1002/hbm.24961 · Cited by 16
“Individuals were excluded if they had any acute medical problems, severe ideomotor apraxia as defined by a score ≤ 65 on the Test of Upper Limb Apraxia (Vanbellingen et al., 2010), hemispatial neglect with 52 on the BIT Star Cancelation Test (Hartman-Maeir & Katz, 1995), significant arm pain that interfered with movem…”
MethodArcher, D. B., Patten, C., & Coombes, S. A. (2017) · Human Brain Mapping · doi:10.1002/hbm.23681 · Cited by 16
“…of the CST drew regions of interest (ROIs) in the posterior limb of the internal capsule (PLIC) and cerebral peduncle (CP) using anatomical landmarks and FA maps to guide ROI placement [Lindenberg et al., 2010, 2012; Schaechter et al., 2008, 2009; Stinear et al., 2007; Thomalla et al., 2004].”
BackgroundMethodH2S-RhoA/ROCK Pathway and Glial Cells in Axonal Remyelination After Ischemic Stroke
Lu, W., & Wen, J. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03422-8 · Cited by 15
Diffusion tensor imaging of pyramidal tract reorganization after pediatric stroke
George, E., Heier, L., Kovanlıkaya, İ., et al. (2014) · Child s Nervous System · doi:10.1007/s00381-013-2351-x · Cited by 15
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Chin, Y., Sato, Y., Mase, M., Kato, T., Herculano, B., Sekino, M., Ohsaki, H., Ageyama, N., Ono, F., Terao, K., et al. (2010) · Neuroscience Research · doi:10.1016/j.neures.2010.01.001 · Cited by 15
“It has enabled investigators to assess the integrity of the WM following nerve injuries, such as stroke or spinal cord injury (Thomalla et al., 2004; Kunimatsu et al., 2007; Zhang et al., 2009; Fujiyoshi et al., 2007; Takagi et al., 2009) and revealed both the degeneration and the regeneration of…”
Extraction of corticospinal tract microstructural properties in chronic stroke
Feldman, S. J., Boyd, L. A., Neva, J. L., et al. (2018) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2018.03.001 · Cited by 15
Ruiman, X., Fang, M., Zhou, L., et al. (2012) · PubMed · doi:10.3969/j.issn.1673-5374.2012.12.004 · Cited by 15
“The results showed that the occurrence of reduced FA values in our study was earlier than that reported in previous studies [8-10] .”
BackgroundResultDiffusion Tensor Imaging: Technique, Clinical and Research Applications
Thomas, B., & Sunaert, S. G. (2005) · Rivista di Neuroradiologia · doi:10.1177/197140090501800403 · Cited by 15
Petoe, M. A., Byblow, W. D., de Vries, E. J. M., et al. (2014) · NeuroImage Clinical · doi:10.1016/j.nicl.2013.12.006 · Cited by 14
“Furthermore, the FA asymmetry measures produced by both methods were ecologically valid, as they correlated as expected with clinical scores (Table 2) (Jang et al., 2005; Stinear et al., 2012; Thomalla et al., 2004; Watanabe et al., 2001; Yu et al., 2009).”
BackgroundDarwish, H. S., Elshafey, R. A., & Kamel, H. A. (2021) · Indian journal of radiology and imaging - new series/Indian journal of radiology and imaging/Indian Journal of Radiology & Imaging · doi:10.1055/s-0041-1729671 · Cited by 13
Microstructural abnormalities in white matter and their effect on depressive symptoms after stroke
Yasuno, F., Taguchi, A., Yamamoto, A., Kajimoto, K., Kazui, H., Sekiyama, A., Matsuoka, K., Kitamura, S., Kiuchi, K., Kosaka, J., et al. (2014) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2014.04.009 · Cited by 14
Transient Ischemic Attack and Stroke Can Be Differentiated by Analyzing the Diffusion Tensor Imaging
Tong, T., Zhenwei, Y., & Xiaoyuan, F. (2011) · Korean Journal of Radiology · doi:10.3348/kjr.2011.12.3.280 · Cited by 14
“Reduced anisotropy along the corticospinal tract (CST) remote from a cerebral infarct has been interpreted as Wallerian degeneration (WD) (5, 6).”
BackgroundYamada, N., Ueda, R., Kakuda, W., Momosaki, R., Kondo, T., Hada, T., Sasaki, N., Hara, T., Senoo, A., & Abo, M. (2018) · Neural Plasticity · doi:10.1155/2018/3901016 · Cited by 14
Zhang, Z., Liu, Z., Qin, W., et al. (2018) · Chinese Medical Journal · doi:10.4103/0366-6999.226890 · Cited by 14
“[1] It has been reported that WD may occur in the 1st week after stroke (at the earliest), and that corticospinal tracts are commonly involved.[1,2] The nerve fibers in the pons are concentrated and complex, particularly in the basis pontis.”
BackgroundPantano, P., Totaro, P., & Raz, E. (2008) · Neurological Sciences · doi:10.1007/s10072-008-1006-2 · Cited by 14
Diffusion tensor imaging correlates with lesion volume in cerebral hemisphere infarctions
Rossi, M. E., Jason, E., Marchesotti, S., Dastidar, P., Ollikainen, J., & Soimakallio, S. (2010) · BMC Medical Imaging · doi:10.1186/1471-2342-10-21 · Cited by 14
“DTI parameters have been reported to show early signs of Wallerian degeneration [5] and to correlate with the results of neurological tests [6].”
ResultAmarreh, I., Dabbs, K., Jackson, D. C., Jones, J. E., Meyerand, M. E., Stafstrom, C. E., Hsu, D., Seidenberg, M., & Hermann, B. P. (2013) · Epilepsy Research · doi:10.1016/j.eplepsyres.2013.09.012 · Cited by 14
“…myelin degradation (Beaulieu, 2002; Luis Concha, et al., 2006; Song, et al., 2002; Song, et al., 2003), decreased AD, which is λmajor and represents the magnitude of principle diffusivity, is considered to reflect axonal degeneration (Kim et al., 2007; Song, et al., 2003; Thomalla et al., 2004).”
BackgroundPredictors of motor outcome after childhood arterial ischemic stroke
Blackburn, E., D’Arco, F., Devito, A., et al. (2021) · Developmental Medicine & Child Neurology · doi:10.1111/dmcn.14914 · Cited by 13
Meng, X., Jun, C., Wang, Q., et al. (2013) · Clinical Radiology · doi:10.1016/j.crad.2013.03.009 · Cited by 13
Longitudinal diffusion tensor imaging of the rat brain after hexachlorophene exposure
Ramu, J., Konak, T., Paule, M. G., Hanig, J. P., & Liachenko, S. M. (2016) · NeuroToxicology · doi:10.1016/j.neuro.2016.08.011 · Cited by 13
“Previous studies have shown clear correlations between AD and RD metrics to axonal integrity and myelination (Song et al., 2002; Thomalla et al., 2004; Nair et al., 2005; Feldman et al., 2010; Alexander et al., 2011; Feldman et al., 2012).”
BackgroundMcCourt, R., Misaghi, E., Tu, W. Y., et al. (2021) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2021.117317 · Cited by 12
Self-citationNägele, F. L., Petersen, M., Mayer, C., Bönstrup, M., Schulz, R., Gerloff, C. P., Thomalla, G., & Cheng, B. (2024) · Human Brain Mapping · doi:10.1002/hbm.26722 · Cited by 12
“Various diffusion tensor imaging (DTI) studies show that white matter degeneration occurs not only at the site of injury, but also in distant areas during the weeks after stroke (Buch et al., 2016; Cheng et al., 2021; Crofts et al., 2011; Radlinska et al., 2010; Thomalla et al., 2004).”
BackgroundSelf-citationDistant white-matter diffusion changes caused by tumor growth
Zolal, A., Hejčl, A., Malucelli, A., et al. (2013) · Journal of Neuroradiology · doi:10.1016/j.neurad.2012.05.006 · Cited by 12
Kancheva, I. K., Buma, F. E., Kwakkel, G., Kancheva, A. K., Ramsey, N. F., & Raemaekers, M. A. H. (2022) · NeuroImage Clinical · doi:10.1016/j.nicl.2022.102945 · Cited by 13
Magnetic Resonance Imaging-Based Mouse Brain Atlas and Its Applications
Aggarwal, M., Zhang, J., & Mori, S. (2010) · Methods in molecular biology · doi:10.1007/978-1-61737-992-5_12 · Cited by 12
Indja, B., Fanning, J. P., Maller, J. J., Fraser, J. F., Bannon, P. G., Vallely, M. P., & Grieve, S. M. (2017) · British Journal of Anaesthesia · doi:10.1093/bja/aex088 · Cited by 12
Zedde, M., Grisendi, I., Assenza, F., et al. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13071969 · Cited by 11
“Thomalla et al. [12] documented a 13% reduction in mean FA in the cerebral peduncle on the affected side 2–16 days after stroke.”
BackgroundMethodInfluentialZhang, H., Zhao, J. Y., Fan, L., et al. (2024) · Neurorehabilitation and neural repair · doi:10.1177/15459683241249115 · Cited by 11
Liu, G., Peng, K., Dang, C., et al. (2018) · Restorative Neurology and Neuroscience · doi:10.3233/rnn-170747 · Cited by 11
“(Thomalla et al., 2004; Pierpaoli et al., 2001) FA incorporates the magnitude of RD, which may explain why no significant changes in FA occurred in the acute stage after stroke.”
Nassir, C. M. N. C. M., Ghazali, M. M., Safri, A. A., Jaffer, U., Abdullah, W. Z., Idris, N. S., & Mustapha, M. (2021) · Brain Sciences · doi:10.3390/brainsci11020133 · Cited by 12
Yan, S., Zhang, G., Zhou, Y., Tian, T., Qin, Y., Wu, D., Lu, J., Zhang, S., Liu, W. V., & Zhu, W. (2021) · Academic Radiology · doi:10.1016/j.acra.2021.08.011 · Cited by 11
Suzuki, Y., Hori, M., Kamiya, K., Fukunaga, I., Aoki, S., & CAUTEREN, M. V. (2015) · Magnetic Resonance in Medical Sciences · doi:10.2463/mrms.2014-0141 · Cited by 11
“[5] and [9] to account for the diffusion in both the EAS and IAS:”
BackgroundLai, C., Zhou, H., Ma, X., & Zhang, H. (2013) · Acta Radiologica · doi:10.1177/0284185113492456 · Cited by 13
“The occurrence of axonal degeneration in central motor neurons is closely related to the treatment and prognosis of patients with cerebral stroke, especially associated with the long-lasting damage to their motor functions (1).”
BackgroundDiffusion Tensor Imaging of Chronic Right Cerebral Hemisphere Infarctions
Jason, E., Dastidar, P., Kalliokoski, A., Luukkaala, T. H., & Soimakallio, S. (2010) · Journal of Neuroimaging · doi:10.1111/j.1552-6569.2010.00513.x · Cited by 11
Zheng, X., Zhang, Y., Man, Y., Hu, Z., Zhang, N., & Pan, S. (2020) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2020.105480 · Cited by 11
Chen, Y., Chen, H., Jiang, L., Zhang, H., Zhang, Y., Geng, W., Feng, Y., Chen, Q., & Yin, X. (2018) · Neurology India · doi:10.4103/0028-3886.232281 · Cited by 11
Wallerian-Like Degeneration After Ischemic Stroke Revealed by Diffusion - Weighted Imaging
Sylaja, P. N., Goyal, M., Watson, T., et al. (2007) · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · doi:10.1017/s0317167100006120 · Cited by 10
Correlation of DTI-Derived Measures to Therapy-Mediated Recovery after Stroke: Preliminary Findings
Bhasin, A., Srivastava, M. V. P., & Kumaran, S. S. (2021) · Neurology India · doi:10.4103/0028-3886.329584 · Cited by 10
Bildgebung beim Schlaganfall – eine Übersicht und Empfehlungen des Kompetenznetzes Schlaganfall
Thomalla, G., Audebert, H. J., Berger, K., Fiebach, J. B., Fiehler, J., Kaps, M., Neumann‐Haefelin, T., Schellinger, P. D., Siebler, M., Sobesky, J., et al. (2009) · Aktuelle Neurologie · doi:10.1055/s-0029-1220430 · Cited by 10
Self-citationCorticospinal premotor fibers facilitate complex motor control after stroke
Paul, T., Cieslak, M., Hensel, L., Wiemer, V. M., Tscherpel, C., Grefkes, C., Grafton, S. T., Fink, G. R., & Volz, L. J. (2024) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.52159 · Cited by 13
“39,45 Of note, the correlation between motor control and the M1 sub-tract was also driven by z-slices closer to the cortex (Fig.”
BackgroundYoo, Y. J., Lim, S. H., Kim, Y., et al. (2023) · Neurorehabilitation and neural repair · doi:10.1177/15459683231177607 · Cited by 9
Metadata
- Authors
- Thomalla, G., Glauche, V., Koch, M. A., Beaulieu, C., Weiller, C., & Röther, J.
- Affiliations
- University Medical Center Hamburg-Eppendorf (DE)
- University of Alberta (CA)
- Corresponding author
- Thomalla, Götz
- ORCID
- Venue
- NeuroImage
- Publisher
- Elsevier BV
- Published
- 2004-08
- Volume
- 22
- Issue
- 4
- Pages
- 1767-1774
- ISSN
- 1053-8119 (ISSN-L)
- OpenAlex
- W2059177186
- Cited by
- 438
- References
- 46
- Citations by year
- 2026: 9 · 2025: 10 · 2024: 13 · 2023: 15 · 2022: 12 · 2021: 24 · 2020: 15 · 2019: 17 · 2018: 15 · 2017: 16 · 2016: 23 · 2015: 18 · 2014: 33 · 2013: 25 · 2012: 21
- FWCI
- 18.44
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- NeuroImage (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Health Sciences › Medicine › Clinical Neurology › Acute Ischemic Stroke Management
- Health Sciences › Medicine › Rehabilitation › Stroke Rehabilitation and Recovery
- Keywords
- Wallerian degeneration, corticospinal tract, ischemic stroke, middle cerebral artery stroke, diffusion tensor imaging, fractional anisotropy, motor impairment, cerebral peduncle
- MeSH terms
- Aged, Axons, Dominance, Cerebral, Female, Humans, Image Processing, Computer-Assisted, Male, Middle Aged, Movement Disorders, Neurologic Examination, Prognosis, Pyramidal Tracts, Reference Values, Statistics as Topic, Wallerian Degeneration, Anisotropy, Infarction, Middle Cerebral Artery, Diffusion Magnetic Resonance Imaging
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