The DOI matches its Crossref record; 84 of the 85 references it cites were found in a registry or an index.
Functional implications of hippocampal volume and diffusivity in mild cognitive impairment
Abstract
Hippocampal atrophy has been related to mild cognitive impairment (MCI) and early Alzheimer disease (AD), but the diagnostic significance of cross-sectionally determined hippocampal volumes is still ambiguous. Diffusion-Tensor-Imaging (DTI) in MCI patients revealed an association of microstructural changes in hippocampal areas with verbal memory decline. MRI volumetry and DTI were combined to investigate 18 MCI patients attending a memory clinic, and 18 carefully age- and gender-matched healthy controls. Neuropsychological testing, high resolution T1-weighted volume MRI scans, and DTI scans with regions-of-interest in hippocampal areas were applied. Left hippocampal volume was significantly lower (-11%, P = 0.02) in MCI patients than in control subjects. No significant differences were found for the right hippocampus (-4%). Mean diffusivity (MD) was significantly elevated in MCI patients vs. controls in left (+10%, P = 0.002) and right hippocampal areas (+13%, P = 0.02). Hippocampal volume and MD values were not significantly correlated. Combining left hippocampal volume and MD measures showed that lower left hippocampal volumes were associated with poor verbal memory performance particularly when co-occurring with high MD values. No comparable associations could be found regarding the right hippocampal formation and with respect to non-verbal memory function. The results demonstrate that microstructural abnormalities as revealed by DTI are very sensitive early indicators of…
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“In this regard, the observed pattern of decreased FA and increased MD, RD, and AD values in P301L mice in the current study are in good agreement with DTI changes observed in human tauopathies such as progressive supranuclear palsy [21], frontotemporal dementia [22], mild cognitive impairment [24], and Alzheimer`s disease [18,25].”
From Diffusion tensor imaging reveals whole-brain microstructural changes in the P301L mouse model of tauopathy. (2020) · cites this paper as [22]
Citations
Cites
Neuropathological stageing of Alzheimer-related changes.
Braak, H., & Braak, E. (1991) · Acta Neuropathologica · doi:10.1007/bf00308809 · Cited by 16,123
The Clinical Dementia Rating (CDR): Current version and scoring rules
Morris, J. C. (1993) · Neurology · doi:10.1212/wnl.43.11.2412-a · Cited by 9,882
Mild Cognitive Impairment: Clinical Characterization and Outcome
Petersen, R. C., Smith, G. E., Waring, S. C., Ivnik, R. J., Tangalos, E. G., & Kokmen, E. (1999) · Archives of Neurology · doi:10.1001/archneur.56.3.303 · Cited by 8,980
The Mini‐Mental State Examination: A Comprehensive Review
Tombaugh, T. N., & McIntyre, N. J. (1992) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1992.tb01992.x · Cited by 5,152
Current concepts in mild cognitive impairment
Petersen, R. C., Doody, R., Kurz, A., Mohs, R. C., Morris, J. C., Rabins, P. V., Ritchie, K., Rossor, M., Thal, L., & Winblad, B. (2001) · Archives of Neurology · doi:10.1001/archneur.58.12.1985 · Cited by 4,781
The basis of anisotropic water diffusion in the nervous system—A technical review.
Beaulieu, C. (2002) · NMR in Biomedicine · doi:10.1002/nbm.782 · Cited by 4,628
Estimation of the Effective Self-Diffusion Tensor from the NMR Spin Echo
Basser, P. J., Mattiello, J., & Bihan, D. L. (1994) · Journal of Magnetic Resonance Series B · doi:10.1006/jmrb.1994.1037 · Cited by 3,656
Regional Brain Changes in Aging Healthy Adults: General Trends, Individual Differences and Modifiers
Raz, N., Lindenberger, U., Rodrigue, K. M., Kennedy, K. M., Head, D., Williamson, A., Dahle, C., Gerstorf, D., & Acker, J. D. (2005) · Cerebral Cortex · doi:10.1093/cercor/bhi044 · Cited by 2,875
Consortium to Establish a Registry for Alzheimer's Disease (CERAD)
Fillenbaum, G., & Heyman, A. (2002) · doi:10.1002/0470846410.ch42(iii · Cited by 2,859
Dysmyelination revealed through MRI as increased radial (but unchanged axial) diffusion of water
Song, S.-K., Sun, S.-W., Ramsbottom, M. J., Chang, C., Russell, J., & Cross, A. H. (2002) · NeuroImage · doi:10.1006/nimg.2002.1267 · Cited by 2,582
Research works printed but not linked: 1
- Thalmann, 1998, CERAD neuropsychological battery: a minimal data set to be used as a common assessment tool of dementia, Neurobiol. Aging, 19, S9
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Rathore, S., Habes, M., Iftikhar, M. A., Shacklett, A., & Davatzikos, C. (2017) · NeuroImage · doi:10.1016/j.neuroimage.2017.03.057 · Cited by 622
Shi, F., Liu, B., Zhou, Y., Yu, C., & Jiang, T. (2009) · Hippocampus · doi:10.1002/hipo.20573 · Cited by 470
Brain development under stress: Hypotheses of glucocorticoid actions revisited
Oitzl, M. S., Champagne, D. L., van der Veen, R., & de Kloet, E. R. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.07.006 · Cited by 372
Effectiveness of regional DTI measures in distinguishing Alzheimer’s disease, MCI, and normal aging
Nir, T. M., Jahanshad, N., Villalon-Reina, J. E., Toga, A. W., Jack, C. R., Weiner, M. W., & Thompson, P. M. (2013) · NeuroImage: Clinical · doi:10.1016/j.nicl.2013.07.006 · Cited by 348
Diffusion tensor imaging in mild cognitive impairment and Alzheimerʼs disease: a review
Chua, T. C., Wen, W., Slavin, M. J., & Sachdev, P. S. (2008) · Current Opinion in Neurology · doi:10.1097/wco.0b013e3282f4594b · Cited by 273
Metadata
- Authors
- Müller, M. J., Greverus, D., Dellani, P. R., Weibrich, C., Wille, P. R., Scheurich, A., Stoeter, P., & Fellgiebel, A.
- Affiliations
- Johannes Gutenberg University Mainz (DE)
- Corresponding author
- Müller, Matthias J.
- Venue
- NeuroImage
- Publisher
- Elsevier BV
- Published
- 2005-12
- Volume
- 28
- Issue
- 4
- Pages
- 1033-1042
- ISSN
- 1053-8119 (ISSN-L)
- OpenAlex
- W2045333811
- Cited by
- 210
- References
- 85
- Citations by year
- 2026: 7 · 2025: 8 · 2024: 12 · 2023: 6 · 2022: 10 · 2021: 8 · 2020: 14 · 2019: 6 · 2018: 10 · 2017: 17 · 2016: 7 · 2015: 9 · 2014: 7 · 2013: 8 · 2012: 11
- FWCI
- 7.02
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- NeuroImage (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Health Sciences › Medicine › Oncology › Cancer-related cognitive impairment studies
- Keywords
- mild cognitive impairment, hippocampal volume, hippocampal atrophy, mean diffusivity, diffusion tensor imaging, verbal memory, hippocampal asymmetry, early detection of neurodegeneration, Alzheimer's disease
- MeSH terms
- Aged, Atrophy, Cognition Disorders, Female, Hippocampus, Humans, Male, Memory, Psychomotor Performance, Mental Recall, Reproducibility of Results, Infarction, Middle Cerebral Artery, Diffusion Magnetic Resonance Imaging
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