The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Reward anticipation and outcomes in adult males with attention-deficit/hyperactivity disorder
Abstract
Attention-deficit/hyperactivity disorder (ADHD) has been suggested to involve deficits in reward processing. We used functional magnetic resonance imaging (fMRI) to compare the neural responses to reward anticipation and outcomes in 10 adults with ADHD and 10 controls as they played a monetary incentive delay task. Adults with ADHD were unmedicated, and groups were matched for age, verbal IQ and smoking habits. Adults with ADHD showed decreased activation in the ventral striatum during the anticipation of gain, but increased activation of the orbitofrontal cortex in response to gain outcomes. Ventral striatal activation in adults with ADHD during gain anticipation was negatively correlated with self-rated symptoms of hyperactivity and impulsivity. These findings suggest that male adults with ADHD show neural signs of abnormal reward processing. Future studies will have to investigate whether these dysfunctional patterns might be normalized by treatment.
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In the citing paper
“Amygdala hyperactivation has also been reported in ADHD during the processing of delayed rewards, perhaps consistent with the delay aversion found in some behavioral studies (38, 99-101).”
From Emotion Dysregulation in Attention Deficit Hyperactivity Disorder (2014) · cites this paper as [99]
In the citing paper
“At the same time, some studies have found a stronger response to reward outcome either in striatum (Furukawa et al., 2014; von Rhein et al., 2015) or in the OFC (Strohle et al., 2008) in ADHD patients vs. controls.”
From Top-Down Dysregulation—From ADHD to Emotional Instability (2016) · cites this paper as Strohle et al., 2008
In the citing paper
“These studies have shown decreased ventral striatum activation during monetary-reward anticipation [484-487], atypical orbitofrontal activation during monetary-reward outcome [487,488], and decreased DCN and amygdala activation during delayed reward outcome [485,489].”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [487]
In the citing paper
“Children with ADHD have reduced NAc activity when anticipating monetary rewards [18,486,487], which is seen particularly in drug-naive children [490], in carriers of the DAT nine-repeat allele [491], and in response to seeking gains rather than avoiding losses [492].”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [487]
In the citing paper
“This finding is consistent with recent fMRI data showing ventrostriatal hyporesponsiveness during immediate and delayed reward processing in adults with ADHD (Plichta et al, 2009;Strohle et al, 2008).”
From Understanding the Effects of Stimulant Medications on Cognition in Individuals with Attention-Deficit Hyperactivity Disorder: A Decade of Progress (2011) · cites this paper as Strohle et al, 2008
In the citing paper
“Recent studies have further indicated deficits in the dopamine reward circuitry,3–5 as predicted by developmental neurobiological models of the disorder.6–8”
From Striatal sensitivity during reward processing in attention-deficit/hyperactivity disorder (2012) · cites this paper as [4]
In the citing paper
“The caudate nucleus is a core region of the dopamine reward-circuit,42 implicated in ADHD-control differences,4 and genetic variation in DAT1 is reported to affect its function and structure 26,43”
From Striatal sensitivity during reward processing in attention-deficit/hyperactivity disorder (2012) · cites this paper as [4]
In the citing paper
“In adults with ADHD most studies report reduced activation in the ventral striatum (VS) during anticipation of monetary gains compared to controls,4,21,22 with one exception.23”
From Striatal sensitivity during reward processing in attention-deficit/hyperactivity disorder (2012) · cites this paper as [4]
In the citing paper
“Studies that investigated activation in the outcome phase reported increased activation in adults with ADHD (compared to controls) in the caudate nucleus and the orbitofrontal cortex4 or no differences.23”
From Striatal sensitivity during reward processing in attention-deficit/hyperactivity disorder (2012) · cites this paper as [4]
In the citing paper
“Although in agreement with previous evidence from adults with ADHD,4 the single previous study that examined outcome-related activation in adolescents with ADHD had focused solely on the VS and did not find group differences.3”
From Striatal sensitivity during reward processing in attention-deficit/hyperactivity disorder (2012) · cites this paper as [4]
In the citing paper
“MILT differed from MID-type paradigms used in earlier ADHD research in two ways: first, the conditioned cues predicted successful outcomes with greater certainty (∼80%, compared to ∼66%3,4).”
From Striatal sensitivity during reward processing in attention-deficit/hyperactivity disorder (2012) · cites this paper as [4]
Citations
Cites
The assessment and analysis of handedness: The Edinburgh inventory
Oldfield, R. C. (1971) · Neuropsychologia · doi:10.1016/0028-3932(71)90067-4 · Cited by 35,900
A neural substrate of prediction and reward
Schultz, W., Dayan, P., & Montague, P. R. (1997) · Science · doi:10.1126/science.275.5306.1593 · Cited by 9,388
Insensitivity to future consequences following damage to human prefrontal cortex
Bechara, A., Damasio, A. R., Damasio, H., & Anderson, S. W. (1994) · Cognition · doi:10.1016/0010-0277(94)90018-3 · Cited by 6,128
Meeting of minds: the medial frontal cortex and social cognition
Amodio, D. M., & Frith, C. D. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1884 · Cited by 3,782 · cited 1×
“In addition, the OFC plays a role in monitoring the value of reward by modulating behavioral inhibition in situations in which previously rewarded stimuli no longer indicate upcoming reward (Amodio and Frith, 2006).”
BackgroundAnticipation of Increasing Monetary Reward Selectively Recruits Nucleus Accumbens
Knutson, B., Adams, C. M., Fong, G. W., & Hommer, D. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-16-j0002.2001 · Cited by 2,244
Self-citationAbstract reward and punishment representations in the human orbitofrontal cortex
O'Doherty, J., Kringelbach, M. L., Rolls, E. T., Hornak, J., & Andrews, C. (2001) · Nature Neuroscience · doi:10.1038/82959 · Cited by 2,003
(1993) · American Journal of Psychiatry · doi:10.1176/ajp.150.6.885 · Cited by 1,421
Dissociation of reward anticipation and outcome with event-related fMRI
Knutson, B., Fong, G. W., Adams, C. M., Varner, J. L., & Hommer, D. (2001) · Neuroreport · doi:10.1097/00001756-200112040-00016 · Cited by 1,300
Self-citationsagvolden, T., johansen, E. B., aase, H., & russell, V. A. (2005) · Behavioral and Brain Sciences · doi:10.1017/s0140525x05000075 · Cited by 1,035
Rubia, K., Overmeyer, S., Taylor, E., Brammer, M., Williams, S. C. R., Simmons, A., & Bullmore, E. T. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.6.891 · Cited by 1,010
Sonuga-Barke, E. J. S. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.09.008 · Cited by 962
Impulsive choice induced in rats by lesions of the nucleus accumbens core
Cardinal, R. N., Pennicott, D. R., Lakmali, C., Sugathapala, Robbins, T. W., & Everitt, B. J. (2001) · Science · doi:10.1126/science.1060818 · Cited by 923
Psychological heterogeneity in AD/HD—a dual pathway model of behaviour and cognition
Sonuga-Barke, E. J. S. (2002) · Behavioural Brain Research · doi:10.1016/s0166-4328(01)00432-6 · Cited by 901
Knutson, B. D., Fong, G., Bennett, S. M., Adams, C. M., & Hommer, D. W. (2003) · NeuroImage · doi:10.1016/s1053-8119(02)00057-5 · Cited by 868
Self-citationVaidya, C. J., Austin, G., Kirkorian, G., Ridlehuber, H. W., Desmond, J. E., Glover, G. H., & Gabrieli, J. D. E. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.24.14494 · Cited by 845
Kringelbach, M. L. (2003) · Cerebral Cortex · doi:10.1093/cercor/13.10.1064 · Cited by 824
How specific is a deficit of executive functioning for attention-deficit/hyperactivity disorder?
Sergeant, J. A., Geurts, H., & Oosterlaan, J. (2002) · Behavioural Brain Research · doi:10.1016/s0166-4328(01)00430-2 · Cited by 784 · cited 1×
“Previous studies have mainly postulated executive dysfunctions , especially deficient inhibitory control, as the etiological cause of ADHD (for review see Sergeant et al., 2002).”
BackgroundParametric Analysis of fMRI Data Using Linear Systems Methods
Cohen, M. S. (1997) · NeuroImage · doi:10.1006/nimg.1997.0278 · Cited by 723
Bush, G., Valera, E. M., & Seidman, L. J. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.01.034 · Cited by 714
Structural Brain Imaging of Attention-Deficit/Hyperactivity Disorder
Seidman, L. J., Valera, E. M., & Makris, N. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.11.019 · Cited by 676
Solanto, M. V., Abikoff, H., Sonuga-Barke, E., Schachar, R., Logan, G. D., Wigal, T., Hechtman, L., Hinshaw, S., & Turkel, E. (2001) · Journal of Abnormal Child Psychology · doi:10.1023/a:1010329714819 · Cited by 639
O'Doherty, J., Critchley, H., Deichmann, R., & Dolan, R. J. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-21-07931.2003 · Cited by 611
Different representations of pleasant and unpleasant odours in the human brain
Rolls, E. T., Kringelbach, M. L., & de Araújo, I. E. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02779.x · Cited by 605
Scheres, A., Milham, M. P., Knutson, B., & Castellanos, F. X. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.04.042 · Cited by 499
Self-citationA review of the biological bases of ADHD: What have we learned from imaging studies?
Durston, S. (2003) · Mental Retardation and Developmental Disabilities Research Reviews · doi:10.1002/mrdd.10079 · Cited by 388
Linking nucleus accumbens dopamine and blood oxygenation
Knutson, B., & Gibbs, S. E. B. (2007) · Psychopharmacology · doi:10.1007/s00213-006-0686-7 · Cited by 337
Self-citationSchulz, K. P., Fan, J., Tang, C. Y., Newcorn, J. H., Buchsbaum, M. S., Cheung, A. M., & Halperin, J. M. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.9.1650 · Cited by 262
Neural substrates of decision making in adults with attention deficit hyperactivity disorder
Ernst, M., Kimes, A. S., London, E. D., Matochik, J. A., Eldreth, D., Tata, S., Contoreggi, C., Leff, M., & Bolla, K. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.6.1061 · Cited by 254
Anderson, S. W., Barrash, J., Bechara, A., & Tranel, D. (2006) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617706060346 · Cited by 236
Johansen, E. B., Aase, H., Meyer, A., & Sagvolden, T. (2002) · Behavioural Brain Research · doi:10.1016/s0166-4328(01)00434-x · Cited by 195
Sensitivity to Reward Frequency in Boys With Attention Deficit Hyperactivity Disorder
Tripp, G., & Alsop, B. (1999) · Journal of Clinical Child Psychology · doi:10.1207/s15374424jccp280309 · Cited by 190
Spencer, T. J., Biederman, J., Madras, B. K., Faraone, S. V., Dougherty, D. D., Bonab, A. A., & Fischman, A. J. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.03.036 · Cited by 185
Different neural systems adjust motor behavior in response to reward and punishment
Wrase, J., Kahnt, T., Schlagenhauf, F., Beck, A., Cohen, M. X., Knutson, B., & Heinz, A. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.04.001 · Cited by 172
Self-citationFunctional MRI in attention-deficit hyperactivity disorder: Evidence for hypofrontality
Zang, Y., Jin, Z. H., Weng, X., Zhang, L., Zeng, Y., Yang, L., Wang, Y., Seidman, L. J., & Faraone, S. V. (2005) · Brain and Development · doi:10.1016/j.braindev.2004.11.009 · Cited by 149
Primate orbitofrontal cortex and adaptive behaviour
Roberts, A. (2005) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2005.12.002 · Cited by 107
Kollins, S. H., Shapiro, S. K., Newland, M. C., & Abramowitz, A. J. (1998) · Experimental and Clinical Psychopharmacology · doi:10.1037/1064-1297.6.4.375 · Cited by 23
Flagged first, then by citations
Research works printed but not linked: 1
- Ward, 1993, The Wender Utah Rating Scale: an aid in the retrospective diagnosis of childhood attention deficit hyperactivity disorder, Am. J. Psychiatry, 150, 885
Cited by
Sorted by citations
Emotion Dysregulation in Attention Deficit Hyperactivity Disorder
Shaw, P., Stringaris, A., Nigg, J., & Leibenluft, E. (2014) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2013.13070966 · Cited by 1,232
Liu, X., Hairston, J., Schrier, M., & Fan, J. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.12.012 · Cited by 916
Evaluating Dopamine Reward Pathway in ADHD: Clinical Implications
Volkow, N. D., Wang, G.-J., Kollins, S. H., Wigal, T. L., Newcorn, J. H., Telang, F., Fowler, J. S., Zhu, W., Logan, J., Ma, Y., et al. (2009) · JAMA · doi:10.1001/jama.2009.1308 · Cited by 728
“Indeed recent functional magnetic resonanceimaging(fMRI)studiesshoweddecreased nucleus accumbens activation withprocessingofrewardinparticipants withADHD.(16,17) However, toourknowledgenostudyhasdirectlymeasuredsynaptic dopamine markers in the accumbens region of individuals with ADHD.”
Anticipatory affect: neural correlates and consequences for choice
Knutson, B. D., & Greer, S. M. (2008) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2008.0155 · Cited by 720
Self-citationThe neurobiology of psychopathic traits in youths
Blair, J. (2013) · Nature reviews. Neuroscience · doi:10.1038/nrn3577 · Cited by 666
Metadata
- Authors
- Ströhle, A., Stoy, M., Wrase, J., Schwarzer, S., Schlagenhauf, F., Huss, M., Hein, J., Nedderhut, A., Neumann, B., Gregor, A., Juckel, G., Knutson, B., Lehmkuhl, U., Bauer, M., & Heinz, A.
- Affiliations
- Stiftung Charité (DE)
- Charité – Universitätsmedizin Berlin (DE)
- Stanford University (US)
- Corresponding author
- Ströhle, Andreas
- ORCID
- Venue
- NeuroImage
- Publisher
- Elsevier BV
- Published
- 2008-02
- Volume
- 39
- Issue
- 3
- Pages
- 966-972
- ISSN
- 1053-8119 (ISSN-L)
- OpenAlex
- W2130141507
- Cited by
- 323
- References
- 36
- Citations by year
- 2026: 9 · 2025: 5 · 2024: 6 · 2023: 12 · 2022: 7 · 2021: 8 · 2020: 12 · 2019: 17 · 2018: 13 · 2017: 16 · 2016: 23 · 2015: 18 · 2014: 26 · 2013: 31 · 2012: 29
- FWCI
- 12.72
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- NeuroImage (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- attention deficit hyperactivity disorder, reward processing, reward anticipation, reward outcome, ventral striatum, orbitofrontal cortex, monetary incentive delay task, hyperactivity, impulsivity
- MeSH terms
- Adult, Attention Deficit Disorder with Hyperactivity, Data Interpretation, Statistical, Humans, Male, Motivation, Neuropsychological Tests, Psychiatric Status Rating Scales, Reward, Neostriatum, Prefrontal Cortex
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