The DOI matches its Crossref record; 147 of the 149 references it cites were found in a registry or an index.
Therapeutic effects of non-invasive brain stimulation with direct currents (tDCS) in neuropsychiatric diseases
Abstract
Neuroplasticity, which is the dynamic structural and functional reorganization of central nervous system connectivity due to environmental and internal demands, is recognized as a major physiological basis for adaption of cognition, and behavior, and thus of utmost importance for normal brain function. Pathological alterations of plasticity are increasingly explored as pathophysiological foundation of diverse neurological and psychiatric diseases. Non-invasive brain stimulation techniques (NIBS), such as repetitive transcranial magnetic stimulation (rTMS), and transcranial direct current stimulation (tDCS), are able to induce and modulate neuroplasticity in humans. Therefore, they have potential to alter pathological plasticity on the one hand, and foster physiological plasticity on the other, in neuropsychiatric diseases to reduce symptoms, and enhance rehabilitation. tDCS is an emerging NIBS tool, which induces glutamatergic plasticity via application of relatively weak currents through the scalp in humans. In the last years its efficacy to treat neuropsychiatric diseases has been explored increasingly. In this review, we will give an overview of pathological alterations of plasticity in neuropsychiatric diseases, gather clinical studies involving tDCS to ameliorate symptoms, and discuss future directions of application, with an emphasis on optimizing stimulation effects.
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“Cognitive training effects with tDCS in other disorders and healthy subjects have been shown to last up to 6 months (Boggio et al., 2012; Kuo et al., 2014) and even 1 year (Katz et al., 2017).”
From Cognitive Neuroscience of Attention Deficit Hyperactivity Disorder (ADHD) and Its Clinical Translation (2018) · cites this paper as Kuo et al., 2014
In the citing paper
“Moreover, our stimulation method did not follow the usual tDCS protocols for the treatment of clinical symptoms during daytime as reviewed by [48,49]: a) in comparison to most other studies, we applied DC only in one single stimulation session; b) the applied current strength in our study was significantly lower than in other studies (0.25 mA vs. 1e2 mA); and c) DC stimulation in our study was not”
Citations
Cites
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Nitsche, M. A., Cohen, L. G., Wassermann, E. M., Priori, A., Lang, N., Antal, A., Paulus, W., Hummel, F., Boggio, P. S., Fregni, F., et al. (2008) · Brain Stimulation · doi:10.1016/j.brs.2008.06.004 · Cited by 3,057
Sustained excitability elevations induced by transcranial DC motor cortex stimulation in humans
Nitsche, M. A., & Paulus, W. (2001) · Neurology · doi:10.1212/wnl.57.10.1899 · Cited by 2,617
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Modulating Delay Discounting in ADHD: A Multi-Sessional tDCS InterventionPreprint
Agahi, Z., & Nejati, V. (2025) · Research Square · doi:10.21203/rs.3.rs-6330387/v1
Zamfirache, F., Prundaru, G. N., Dumitru, C., & Radu, B. M. (2025) · BRAIN BROAD RESEARCH IN ARTIFICIAL INTELLIGENCE AND NEUROSCIENCE · doi:10.70594/brain/16.2/2
Neural Stimulation of Prefrontal Cortex Improves Food‐Related Memory Suppression
Li, J., Gao, Y., Chen, J., Zhang, Y., Yang, Y., & Gao, X. (2025) · Obesity · doi:10.1002/oby.70052
“This is because the stimulation modulates dopaminergic activity in the prefrontal cortex [41], potentially enhancing cognitive control over intrusive memories.”
Smits, F., de Kort, G. J., & Geuze, E. (2021) · Figshare · doi:10.6084/m9.figshare.14037433
Rezakhani, S., Amiri, M., Hassani, A., Esmaeilpour, K., & Sheibani, V. (2024) · Figshare · doi:10.6084/m9.figshare.25139628
Pi, Y., Zhang, Q., Lyu, S., Beste, C., Colzato, L. S., & Hommel, B. (2026) · GeroScience · doi:10.1007/s11357-025-02077-8
“…that the neuromodulatory effects of atDCS do not linearly scale with baseline neural noise levels in each age group, where neurobiological factors such as cortical atrophy, white matter integrity, or neurotransmitter system alterations could modulate responsiveness to stimulation [25, 26, 28].”
Francesco, M. D., Milasi, C., Perrotti, G., Barberio, M., Menniti, P., Rocca, F., Contrada, M., Maggio, M. G., Segura-Garcia, C., Bosco, D., et al. (2026) · Appetite Disordered Eating · doi:10.1016/j.appde.2026.100004
Ye, T., Shuai, Y., Liu, Y., Liu, S., Tang, X., Tian, W., Zhang, Y., & Kong, Y. (2026) · Journal of Integrative Neuroscience · doi:10.31083/jin47145
Bayati, A., & Molla, R. Y. (2026) · Health Science Reports · doi:10.1002/hsr2.72833
“Because both kinematic studies [18, 28] primarily targeted sensorimotor‐related cortical regions during dynamic balance training, the observed effects may reflect enhanced integration between cortical motor planning and movement execution [39].”
Huang, M., Shi, D., Ni, J., Shi, Q., & Xu, R. (2026) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2026.1867202
Magical realism: toward teleportation in tourism via virtual reality and transcranial stimulation
Gomez, J. D., Villa, P. A., Taborda, J. A., & Lemus, J. P. T. (2026) · Frontiers in Sustainable Tourism · doi:10.3389/frsut.2026.1861821
勝也, 緒., & 飛松省三 (2015) · 計測と制御 · doi:10.11499/sicejl.54.106
Metadata
- Authors
- Kuo, M.-F., Paulus, W., & Nitsche, M. A.
- Affiliations
- Universitätsmedizin Göttingen (DE)
- Corresponding author
- Nitsche, Michael A.
- Venue
- NeuroImage
- Publisher
- Elsevier BV
- Published
- 2014-01
- Volume
- 85
- Pages
- 948-960
- ISSN
- 1053-8119 (ISSN-L)
- OpenAlex
- W2057070604
- Cited by
- 415
- References
- 149
- Citations by year
- 2026: 12 · 2025: 18 · 2024: 18 · 2023: 16 · 2022: 22 · 2021: 32 · 2020: 27 · 2019: 29 · 2018: 40 · 2017: 50 · 2016: 55 · 2015: 51 · 2014: 31
- FWCI
- 4.85
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- NeuroImage (publishedVersion)
- PubMed (publishedVersion)
- GRO (submittedVersion)
- Funders
- German Research Society (Ni 683/4-2, Ni 683/6-1)
- German Ministry for Education and Research (03IPT605E)
- Topics
- Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Electroconvulsive Therapy Studies
- Health Sciences › Medicine › Clinical Neurology › Deep Brain Stimulation and Movement Disorders
- Keywords
- transcranial direct current stimulation, non-invasive brain stimulation, neuroplasticity, neuropsychiatric disorders, stimulation optimization
- MeSH terms
- Mental Disorders, Electric Stimulation Therapy, Humans, Neuronal Plasticity, Tinnitus, Pain Management
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